Propionylcarnitine

Propionylcarnitine is a lipid of Fatty Acyls (FA) class. Propionylcarnitine is associated with abnormalities such as Failure to Thrive. The involved functions are known as Functional disorder. Propionylcarnitine often locates in Body tissue.

Cross Reference

Introduction

To understand associated biological information of Propionylcarnitine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Propionylcarnitine?

Propionylcarnitine is suspected in Failure to Thrive and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Propionylcarnitine

MeSH term MeSH ID Detail
Reperfusion Injury D015427 65 associated lipids
Body Weight D001835 333 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Amino Acid Metabolism, Inborn Errors D000592 16 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Starvation D013217 47 associated lipids
Pregnancy Complications D011248 19 associated lipids
Penile Induration D010411 4 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with Propionylcarnitine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Propionylcarnitine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Propionylcarnitine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Propionylcarnitine?

There are no associated biomedical information in the current reference collection.

What genes are associated with Propionylcarnitine?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Propionylcarnitine?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Propionylcarnitine

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Mikhailova TL et al. Randomised clinical trial: the efficacy and safety of propionyl-L-carnitine therapy in patients with ulcerative colitis receiving stable oral treatment. 2011 Aliment. Pharmacol. Ther. pmid:21929562
Brevetti G et al. Effect of propionyl-L-carnitine on quality of life in intermittent claudication. 1997 Am. J. Cardiol. pmid:9070558
Bartels GL et al. Effects of L-propionylcarnitine on ischemia-induced myocardial dysfunction in men with angina pectoris. 1994 Am. J. Cardiol. pmid:8023775
Giancaterini A et al. Effects of propyonil-l-carnitine topical irrigation in distal ulcerative colitis: a preliminary report. 2001 Am. J. Gastroenterol. pmid:11467678
Hiatt WR et al. Propionyl-L-carnitine improves exercise performance and functional status in patients with claudication. 2001 Am. J. Med. pmid:11382369
Di Lisa F et al. Contrasting effects of propionate and propionyl-L-carnitine on energy-linked processes in ischemic hearts. 1994 Am. J. Physiol. pmid:8067396
Li P et al. Myocyte performance during evolution of myocardial infarction in rats: effects of propionyl-L-carnitine. 1995 Am. J. Physiol. pmid:7733374
Micheletti R et al. Propionyl-L-carnitine limits chronic ventricular dilation after myocardial infarction in rats. 1993 Am. J. Physiol. pmid:8476087
Micheletti R et al. Propionyl-L-carnitine prevents myocardial mechanical alterations due to pressure overload in rats. 1994 Am. J. Physiol. pmid:8023981
Russell RR et al. Propionyl-L-carnitine-mediated improvement in contractile function of rat hearts oxidizing acetoacetate. 1995 Am. J. Physiol. pmid:7840294
El Alaoui-Talibi Z et al. Control of oxidative metabolism in volume-overloaded rat hearts: effect of propionyl-L-carnitine. 1997 Am. J. Physiol. pmid:9139943
Pierce GN et al. Na(+)-H+ exchange in cardiac sarcolemmal vesicles isolated from diabetic rats. 1990 Am. J. Physiol. pmid:2154133
Sassen LM et al. L-propionylcarnitine increases postischemic blood flow but does not affect recovery of energy charge. 1991 Am. J. Physiol. pmid:1858918
Liedtke AJ et al. Effects of L-propionylcarnitine on mechanical recovery during reflow in intact hearts. 1988 Am. J. Physiol. pmid:3394817
Naccarato A et al. Identification and assay of underivatized urinary acylcarnitines by paper spray tandem mass spectrometry. 2013 Anal Bioanal Chem pmid:23907684
Yergey AL et al. Thermospray liquid chromatography/mass spectrometry for the analysis of L-carnitine and its short-chain acyl derivatives. 1984 Anal. Biochem. pmid:6476364
Minkler PE and Hoppel CL Quantification of free carnitine, individual short- and medium-chain acylcarnitines, and total carnitine in plasma by high-performance liquid chromatography. 1993 Anal. Biochem. pmid:8214594
Gianfrilli D et al. Propionyl-L-carnitine, L-arginine and niacin in sexual medicine: a nutraceutical approach to erectile dysfunction. 2012 Andrologia pmid:21966881
Corsi C et al. L-propionylcarnitine effect on postexercise and postischemic hyperemia in patients affected by peripheral vascular disease. 1995 Angiology pmid:7639417
Silvestro A et al. Effect of propionylcarnitine on changes in endothelial function and plasma levels of adhesion molecules induced by acute exercise in patients with intermittent claudication. 2006 Mar-Apr Angiology pmid:16518521
Andreozzi GM et al. Levo-propionyl-carnitine improves the effectiveness of supervised physical training on the absolute claudication distance in patients with intermittent claudication. 2008 Feb-Mar Angiology pmid:18319227
Allegra C et al. Propionyl-L-carnitine in Leriche-Fontaine stage II peripheral arterial obstructive disease. 2008 Jul-Aug Ann Vasc Surg pmid:18502605
Reggiani C et al. Effect of propionyl-L-carnitine (PLC) on the kinetic properties of the myofibrillar system in pressure overload cardiac hypertrophy. 1995 Ann. N. Y. Acad. Sci. pmid:7755261
Maresca P et al. Propionyl-L-carnitine improves mechanical performance of papillary muscle from dilated cardiomyopathic hamsters. 1995 Ann. N. Y. Acad. Sci. pmid:7755262
Ferrari R et al. Therapeutic effects of L-carnitine and propionyl-L-carnitine on cardiovascular diseases: a review. 2004 Ann. N. Y. Acad. Sci. pmid:15591005
Hiatt WR Carnitine and peripheral arterial disease. 2004 Ann. N. Y. Acad. Sci. pmid:15591006
Davenport RJ et al. Automated chemoenzymatic synthesis of no-carrier-added [carbonyl-11C]propionyl L-carnitine for pharmacokinetic studies. 1997 Appl Radiat Isot pmid:9376826
Mancinelli R L-propionylcarnitine and synchronization of spontaneous activity in rat isolated portal vein. 1993 Arch Ital Biol pmid:8338391
Packer L et al. Free radical scavenging is involved in the protective effect of L-propionyl-carnitine against ischemia-reperfusion injury of the heart. 1991 Arch. Biochem. Biophys. pmid:1654837
Reznick AZ et al. Antiradical effects in L-propionyl carnitine protection of the heart against ischemia-reperfusion injury: the possible role of iron chelation. 1992 Arch. Biochem. Biophys. pmid:1321584
Roe CR et al. Metabolic response to carnitine in methylmalonic aciduria. An effective strategy for elimination of propionyl groups. 1983 Arch. Dis. Child. pmid:6651329
Sakuma T Alteration of urinary carnitine profile induced by benzoate administration. 1991 Arch. Dis. Child. pmid:1863104
Stasi MA et al. Propionyl-L-carnitine improves postischemic blood flow recovery and arteriogenetic revascularization and reduces endothelial NADPH-oxidase 4-mediated superoxide production. 2010 Arterioscler. Thromb. Vasc. Biol. pmid:20056909
Dhir RR et al. Combination therapy for erectile dysfunction: an update review. 2011 Asian J. Androl. pmid:21423198