Propionylcarnitine

Propionylcarnitine is a lipid of Fatty Acyls (FA) class. Propionylcarnitine is associated with abnormalities such as Failure to Thrive. The involved functions are known as Functional disorder. Propionylcarnitine often locates in Body tissue.

Cross Reference

Introduction

To understand associated biological information of Propionylcarnitine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Propionylcarnitine?

Propionylcarnitine is suspected in Failure to Thrive and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Propionylcarnitine

MeSH term MeSH ID Detail
Reperfusion Injury D015427 65 associated lipids
Body Weight D001835 333 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Amino Acid Metabolism, Inborn Errors D000592 16 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Starvation D013217 47 associated lipids
Pregnancy Complications D011248 19 associated lipids
Penile Induration D010411 4 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with Propionylcarnitine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Propionylcarnitine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Propionylcarnitine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Propionylcarnitine?

There are no associated biomedical information in the current reference collection.

What genes are associated with Propionylcarnitine?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Propionylcarnitine?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Propionylcarnitine

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Authors Title Published Journal PubMed Link
Wu SN et al. [Analysis of propionylcarnitine in blood and methylmalonic acid in urine of 162 patients with methylmalonic acidemia]. 2013 Zhonghua Yi Xue Za Zhi pmid:23663331
Huang Z et al. [Outcomes of patients with combined methylmalonic acidemia and homocystinuria after treatment]. 2013 Zhonghua Er Ke Za Zhi pmid:23751581
Wagner CC et al. Plasma pharmacokinetics and gastrointestinal transit of a new propionyl-L-carnitine controlled release formulation. 2011 Xenobiotica pmid:21810044
Bene J et al. Changes of plasma fasting carnitine ester profile in patients with ulcerative colitis. 2006 World J. Gastroenterol. pmid:16440427
Merra G et al. Propionyl-L-carnitine hydrochloride for treatment of mild to moderate colonic inflammatory bowel diseases. 2012 World J. Gastroenterol. pmid:23049215
Ning WH and Zhao K Propionyl-L-carnitine induces eNOS activation and nitric oxide synthesis in endothelial cells via PI3 and Akt kinases. 2013 Sep-Oct Vascul. Pharmacol. pmid:23850990
Capecchi PL et al. Carnitines increase plasma levels of adenosine and ATP in humans. 1997 Vasc Med pmid:9546959
Taylor DJ et al. Changes in energy metabolism of calf muscle in patients with intermittent claudication assessed by 31P magnetic resonance spectroscopy: a phase II open study. 1996 Vasc Med pmid:9552578
Brass EP et al. A systematic review and meta-analysis of propionyl-L-carnitine effects on exercise performance in patients with claudication. 2013 Vasc Med pmid:23321261
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Cavallini G et al. Acetyl-L-carnitine plus propionyl-L-carnitine improve efficacy of sildenafil in treatment of erectile dysfunction after bilateral nerve-sparing radical retropubic prostatectomy. 2005 Urology pmid:16286128
Giovannini L et al. Acute CYA-induced ATP depletion is prevented by pretreatment with L-propionylcarnitine in isolated and perfused rat kidney. 1998 Transplant. Proc. pmid:9723376
Luo T et al. A study on the efficacy and safety assessment of propionyl-L-carnitine tablets in treatment of intermittent claudication. 2013 Thromb. Res. pmid:23998557
Morand R et al. Effect of short- and long-term treatment with valproate on carnitine homeostasis in humans. 2012 Ther Drug Monit pmid:22743351
Stroh R et al. L-propionyl carnitine, an endogenous ester in fatty acid metabolism, exerts anti-shock and endothelial protective effects in rat splanchnic ischemia-reperfusion injury. 1998 Shock pmid:9525330
Vermeulen RC and Scholte HR Exploratory open label, randomized study of acetyl- and propionylcarnitine in chronic fatigue syndrome. 2004 Mar-Apr Psychosom Med pmid:15039515
Scioli MG et al. Propionyl-L-Carnitine Enhances Wound Healing and Counteracts Microvascular Endothelial Cell Dysfunction. 2015 PLoS ONE pmid:26473356
Mingorance C et al. Propionyl-L-carnitine corrects metabolic and cardiovascular alterations in diet-induced obese mice and improves liver respiratory chain activity. 2012 PLoS ONE pmid:22457831
Vargiu R et al. Enhancement of muscular performance by a coformulation of propionyl-L-carnitine, coenzyme Q10, nicotinamide, riboflavin and pantothenic acid in the rat. 2002 Physiol. Behav. pmid:12044598
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Signorelli SS et al. Effects of ischaemic stress on leukocyte activation processes in patients with chronic peripheral occlusive arterial disease: role of L-propionyl carnitine administration. 2001 Pharmacol. Res. pmid:11592865
Sayed-Ahmed MM et al. Propionyl-L-carnitine as protector against adriamycin-induced cardiomyopathy. 2001 Pharmacol. Res. pmid:11419959
Arafa HM and Sayed-Ahmed MM Protective role of carnitine esters against alcohol-induced gastric lesions in rats. 2003 Pharmacol. Res. pmid:12860448
Al-Majed AA et al. Propionyl-L-carnitine prevents the progression of cisplatin-induced cardiomyopathy in a carnitine-depleted rat model. 2006 Pharmacol. Res. pmid:16436331
Sayed-Ahmed MM et al. Propionyl-L-carnitine as potential protective agent against adriamycin-induced impairment of fatty acid beta-oxidation in isolated heart mitochondria. 2000 Pharmacol. Res. pmid:10623482
Marciani P et al. L-carnitine and carnitine ester transport in the rat small intestine. 1991 Pharmacol. Res. pmid:2062791
Riva E and Leopaldi D Control of the cardiac consequences of myocardial ischemia and reperfusion by L-propionylcarnitine: age-response and dose-response studies in the rat heart. 1993 Pediatr. Res. pmid:8255679
Chalmers RA et al. Urinary excretion of l-carnitine and acylcarnitines by patients with disorders of organic acid metabolism: evidence for secondary insufficiency of l-carnitine. 1984 Pediatr. Res. pmid:6441143
Chen PW et al. Stabilization of blood methylmalonic acid level in methylmalonic acidemia after liver transplantation. 2010 Pediatr Transplant pmid:19686300
Kasahara M et al. Living-donor liver transplantation for propionic acidemia. 2012 Pediatr Transplant pmid:22151065
Neri B et al. Differences between carnitine derivatives and coenzyme Q10 in preventing in vitro doxorubicin-related cardiac damages. 1988 Oncology pmid:3368201
Mingorance C et al. Pharmacological effects and clinical applications of propionyl-L-carnitine. 2011 Nutr. Rev. pmid:21521230
Davenport RJ et al. Propionyl-L-carnitine: labelling in the N-methyl position with carbon-11 and pharmacokinetic studies in rats. 1995 Nucl. Med. Biol. pmid:8535330
Roe DS et al. Evidence for a short-chain carnitine-acylcarnitine translocase in mitochondria specifically related to the metabolism of branched-chain amino acids. 2000 Mol. Genet. Metab. pmid:10655160
Löster H et al. Effects of L-carnitine and its acetyl and propionyl esters on ATP and PCr levels of isolated rat hearts perfused without fatty acids and investigated by means of 31P-NMR spectroscopy. 1999 Mol. Cell. Biochem. pmid:10569188
Broderick TL et al. Propionyl-L-carnitine effects on postischemic recovery of heart function and substrate oxidation in the diabetic rat. 2000 Mol. Cell. Biochem. pmid:10839205
Cui J et al. Effects of L-carnitine and its derivatives on postischemic cardiac function, ventricular fibrillation and necrotic and apoptotic cardiomyocyte death in isolated rat hearts. 2003 Mol. Cell. Biochem. pmid:14674702
Motterlini R et al. Functional and metabolic effects of propionyl-L-carnitine in the isolated perfused hypertrophied rat heart. 1992 Mol. Cell. Biochem. pmid:1480142
Pekkinen J et al. Betaine supplementation causes increase in carnitine metabolites in the muscle and liver of mice fed a high-fat diet as studied by nontargeted LC-MS metabolomics approach. 2013 Mol Nutr Food Res pmid:23868375
Riccioni C et al. Rehabilitative treatment in peripheral artery disease: protocol application and follow-up. 2010 Minerva Cardioangiol pmid:20948502
Cotter MA et al. Effects of acetyl- and proprionyl-L-carnitine on peripheral nerve function and vascular supply in experimental diabetes. 1995 Metab. Clin. Exp. pmid:7666797
Brass EP and Beyerinck RA Interactions of propionate and carnitine metabolism in isolated rat hepatocytes. 1987 Metab. Clin. Exp. pmid:3110541
Ferrari R et al. Metabolic modulation and optimization of energy consumption in heart failure. 2003 Med. Clin. North Am. pmid:12693736
Barker GA et al. Effect of propionyl-L-carnitine on exercise performance in peripheral arterial disease. 2001 Med Sci Sports Exerc pmid:11528327
Odiet JA et al. Carnitine palmitoyl transferase-I activity in the aging mouse heart. 1995 Mech. Ageing Dev. pmid:7616763
Hozyasz KK et al. Whole blood propionylcarnitine in newborns with orofacial cleft. 2011 Matern Child Nutr pmid:21470367
Gómez-Amores L et al. Antioxidant activity of propionyl-L-carnitine in liver and heart of spontaneously hypertensive rats. 2006 Life Sci. pmid:16263137
Bueno R et al. L-carnitine and propionyl-L-carnitine improve endothelial dysfunction in spontaneously hypertensive rats: different participation of NO and COX-products. 2005 Life Sci. pmid:15958269