Propionylcarnitine

Propionylcarnitine is a lipid of Fatty Acyls (FA) class. Propionylcarnitine is associated with abnormalities such as Failure to Thrive. The involved functions are known as Functional disorder. Propionylcarnitine often locates in Body tissue.

Cross Reference

Introduction

To understand associated biological information of Propionylcarnitine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Propionylcarnitine?

Propionylcarnitine is suspected in Failure to Thrive and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Propionylcarnitine

MeSH term MeSH ID Detail
Reperfusion Injury D015427 65 associated lipids
Body Weight D001835 333 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Amino Acid Metabolism, Inborn Errors D000592 16 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Starvation D013217 47 associated lipids
Pregnancy Complications D011248 19 associated lipids
Penile Induration D010411 4 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with Propionylcarnitine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Propionylcarnitine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Propionylcarnitine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Propionylcarnitine?

There are no associated biomedical information in the current reference collection.

What genes are associated with Propionylcarnitine?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Propionylcarnitine?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Propionylcarnitine

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Authors Title Published Journal PubMed Link
pmid:
Cipolla MJ et al. Propionyl-L-carnitine dilates human subcutaneous arteries through an endothelium-dependent mechanism. 1999 J. Vasc. Surg. pmid:10359944
Wu X et al. Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. 1999 J. Pharmacol. Exp. Ther. pmid:10454528
Triggiani M et al. Inhibition of platelet-activating factor synthesis in human neutrophils and platelets by propionyl-L-carnitine. 1999 Biochem. Pharmacol. pmid:10487538
Brevetti G et al. European multicenter study on propionyl-L-carnitine in intermittent claudication. 1999 J. Am. Coll. Cardiol. pmid:10551714
Löster H et al. Effects of L-carnitine and its acetyl and propionyl esters on ATP and PCr levels of isolated rat hearts perfused without fatty acids and investigated by means of 31P-NMR spectroscopy. 1999 Mol. Cell. Biochem. pmid:10569188
Palmieri L et al. Identification of the mitochondrial carnitine carrier in Saccharomyces cerevisiae. 1999 FEBS Lett. pmid:10622748
Sayed-Ahmed MM et al. Propionyl-L-carnitine as potential protective agent against adriamycin-induced impairment of fatty acid beta-oxidation in isolated heart mitochondria. 2000 Pharmacol. Res. pmid:10623482
Ganapathy ME et al. beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. 2000 J. Biol. Chem. pmid:10636865
Roe DS et al. Evidence for a short-chain carnitine-acylcarnitine translocase in mitochondria specifically related to the metabolism of branched-chain amino acids. 2000 Mol. Genet. Metab. pmid:10655160
Libert R et al. Identification of undescribed medium-chain acylcarnitines present in urine of patients with propionic and methylmalonic acidemias. 2000 Clin. Chim. Acta pmid:10767396
Broderick TL et al. Propionyl-L-carnitine effects on postischemic recovery of heart function and substrate oxidation in the diabetic rat. 2000 Mol. Cell. Biochem. pmid:10839205
Vanella A et al. L -propionyl-carnitine as superoxide scavenger, antioxidant, and DNA cleavage protector. 2000 Cell Biol. Toxicol. pmid:10917565
Pace S et al. Pharmacokinetics of propionyl-L-carnitine in humans: evidence for saturable tubular reabsorption. 2000 Br J Clin Pharmacol pmid:11069438
Mancinelli A et al. Disposition of L-carnitine and its short-chain esters, acetyl-L-carnitine and propionyl-L-carnitine, in the rat isolated perfused liver. 2000 Drug Metab. Dispos. pmid:11095575
Felix C et al. Effects of propionyl-L-carnitine on isolated mitochondrial function in the reperfused diabetic rat heart. 2001 Diabetes Res. Clin. Pract. pmid:11378209
Hiatt WR et al. Propionyl-L-carnitine improves exercise performance and functional status in patients with claudication. 2001 Am. J. Med. pmid:11382369
Sayed-Ahmed MM et al. Propionyl-L-carnitine as protector against adriamycin-induced cardiomyopathy. 2001 Pharmacol. Res. pmid:11419959
Giancaterini A et al. Effects of propyonil-l-carnitine topical irrigation in distal ulcerative colitis: a preliminary report. 2001 Am. J. Gastroenterol. pmid:11467678
Barker GA et al. Effect of propionyl-L-carnitine on exercise performance in peripheral arterial disease. 2001 Med Sci Sports Exerc pmid:11528327
Signorelli SS et al. Effects of ischaemic stress on leukocyte activation processes in patients with chronic peripheral occlusive arterial disease: role of L-propionyl carnitine administration. 2001 Pharmacol. Res. pmid:11592865
Chace DH et al. Rapid diagnosis of methylmalonic and propionic acidemias: quantitative tandem mass spectrometric analysis of propionylcarnitine in filter-paper blood specimens obtained from newborns. 2001 Clin. Chem. pmid:11673377
Orlandi A et al. Propionyl-L-carnitine reduces intimal hyperplasia after injury in normocholesterolemic rabbit carotid artery by modulating proliferation and caspase 3-dependent apoptosis of vascular smooth muscle cells. 2002 Atherosclerosis pmid:11755925
Doggrell SA Pharmacotherapy of intermittent claudication. 2001 Expert Opin Pharmacother pmid:11825312
Mister M et al. Propionyl-L-carnitine prevents renal function deterioration due to ischemia/reperfusion. 2002 Kidney Int. pmid:11849462
Cavallini G et al. Oral propionyl-l-carnitine and intraplaque verapamil in the therapy of advanced and resistant Peyronie's disease. 2002 BJU Int. pmid:12010235
Vargiu R et al. Enhancement of muscular performance by a coformulation of propionyl-L-carnitine, coenzyme Q10, nicotinamide, riboflavin and pantothenic acid in the rat. 2002 Physiol. Behav. pmid:12044598
Kushnir MM et al. Serum acylcarnitines and vitamin B12 deficiency. 2002 Clin. Chem. pmid:12089192
Kuhara T et al. Gas chromatographic-mass spectrometric newborn screening for propionic acidaemia by targeting methylcitrate in dried filter-paper urine samples. 2002 J. Inherit. Metab. Dis. pmid:12118533
Yorifuji T et al. Unexpectedly high prevalence of the mild form of propionic acidemia in Japan: presence of a common mutation and possible clinical implications. 2002 Hum. Genet. pmid:12189489
Ferrari R et al. Metabolic modulation and optimization of energy consumption in heart failure. 2003 Med. Clin. North Am. pmid:12693736
Koh SG et al. Exercise intolerance during post-MI heart failure in rats: prevention with supplemental dietary propionyl-L-carnitine. 2003 Cardiovasc Drugs Ther pmid:12843682
Arafa HM and Sayed-Ahmed MM Protective role of carnitine esters against alcohol-induced gastric lesions in rats. 2003 Pharmacol. Res. pmid:12860448
Reznick AZ et al. Antiradical effects in L-propionyl carnitine protection of the heart against ischemia-reperfusion injury: the possible role of iron chelation. 1992 Arch. Biochem. Biophys. pmid:1321584
Bartels GL et al. Acute improvement of cardiac function with intravenous L-propionylcarnitine in humans. 1992 J. Cardiovasc. Pharmacol. pmid:1383625
Yang XP et al. Hemodynamic and metabolic activities of propionyl-L-carnitine in rats with pressure-overload cardiac hypertrophy. 1992 J. Cardiovasc. Pharmacol. pmid:1383636
Cui J et al. Effects of L-carnitine and its derivatives on postischemic cardiac function, ventricular fibrillation and necrotic and apoptotic cardiomyocyte death in isolated rat hearts. 2003 Mol. Cell. Biochem. pmid:14674702
Motterlini R et al. Functional and metabolic effects of propionyl-L-carnitine in the isolated perfused hypertrophied rat heart. 1992 Mol. Cell. Biochem. pmid:1480142
Sakuma T et al. The urinary acylcarnitine profile in three cases of transient hyperammonemia of the newborn. 1992 Acta Paediatr. pmid:1498512
Vermeulen RC and Scholte HR Exploratory open label, randomized study of acetyl- and propionylcarnitine in chronic fatigue syndrome. 2004 Mar-Apr Psychosom Med pmid:15039515
Sethi R et al. Improvement of cardiac function and beta-adrenergic signal transduction by propionyl L-carnitine in congestive heart failure due to myocardial infarction. 2004 Coron. Artery Dis. pmid:15201623
Ragozzino G et al. Effects of propionyl-carnitine in patients with type 2 diabetes and peripheral vascular disease: results of a pilot trial. 2004 Drugs R D pmid:15230623
Broderick TL et al. Effects of propionyl-carnitine on mitochondrial respiration and post-ischaemic cardiac function in the ischaemic underperfused diabetic rat heart. 2004 Drugs R D pmid:15230624
Gentile V et al. Preliminary observations on the use of propionyl-L-carnitine in combination with sildenafil in patients with erectile dysfunction and diabetes. 2004 Curr Med Res Opin pmid:15383186
Ferrari R et al. Therapeutic effects of L-carnitine and propionyl-L-carnitine on cardiovascular diseases: a review. 2004 Ann. N. Y. Acad. Sci. pmid:15591005
Hiatt WR Carnitine and peripheral arterial disease. 2004 Ann. N. Y. Acad. Sci. pmid:15591006
D'Acquarica I et al. Enantio- and chemo-selective HPLC separations by chiral-achiral tandem-columns approach: the combination of CHIROBIOTIC TAG and SCX columns for the analysis of propionyl carnitine and related impurities. 2004 J Chromatogr A pmid:15641359
Kuster T et al. Filter paper cards contaminated with EMLA cream produce artefacts on acylcarnitine analysis. 2004 J. Inherit. Metab. Dis. pmid:15669691
Hasegawa Y et al. Prenatal diagnosis for organic acid disorders using two mass spectrometric methods, gas chromatography mass spectrometry and tandem mass spectrometry. 2005 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:15908288
Mancinelli A et al. Uptake of L-carnitine and its short-chain ester propionyl-L-carnitine in the isolated perfused rat liver. 2005 J. Pharmacol. Exp. Ther. pmid:15951397