Propionylcarnitine

Propionylcarnitine is a lipid of Fatty Acyls (FA) class. Propionylcarnitine is associated with abnormalities such as Failure to Thrive. The involved functions are known as Functional disorder. Propionylcarnitine often locates in Body tissue.

Cross Reference

Introduction

To understand associated biological information of Propionylcarnitine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Propionylcarnitine?

Propionylcarnitine is suspected in Failure to Thrive and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Propionylcarnitine

MeSH term MeSH ID Detail
Reperfusion Injury D015427 65 associated lipids
Body Weight D001835 333 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Amino Acid Metabolism, Inborn Errors D000592 16 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Starvation D013217 47 associated lipids
Pregnancy Complications D011248 19 associated lipids
Penile Induration D010411 4 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with Propionylcarnitine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Propionylcarnitine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Propionylcarnitine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Propionylcarnitine?

There are no associated biomedical information in the current reference collection.

What genes are associated with Propionylcarnitine?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Propionylcarnitine?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Propionylcarnitine

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Authors Title Published Journal PubMed Link
Zhang Y et al. Prenatal diagnosis of methylmalonic aciduria by analysis of organic acids and total homocysteine in amniotic fluid. 2008 Chin. Med. J. pmid:18298912
Broderick TL ATP production and TCA activity are stimulated by propionyl-L-carnitine in the diabetic rat heart. 2008 Drugs R D pmid:18298127
Perna AF et al. L-Propionyl carnitine, homocysteine and S-adenosylhomocysteine in hemodialysis. 2007 Jan-Feb J. Nephrol. pmid:17347975
la Marca G et al. Rapid 2nd-tier test for measurement of 3-OH-propionic and methylmalonic acids on dried blood spots: reducing the false-positive rate for propionylcarnitine during expanded newborn screening by liquid chromatography-tandem mass spectrometry. 2007 Clin. Chem. pmid:17510301
Aleisa AM et al. Reversal of cisplatin-induced carnitine deficiency and energy starvation by propionyl-L-carnitine in rat kidney tissues. 2007 Clin. Exp. Pharmacol. Physiol. pmid:17973863
Montisci R et al. Effect of a single IV administration of L-propionylcarnitine on myocardial microcirculation assessed by coronary flow velocity reserve measurement in patients with systemic sclerosis: a pilot study. 2007 Clin Ther pmid:17379056
Alvarez de Sotomayor M et al. Effect of L-carnitine and propionyl-L-carnitine on endothelial function of small mesenteric arteries from SHR. 2007 J. Vasc. Res. pmid:17483601
Morano S et al. Antioxidant treatment associated with sildenafil reduces monocyte activation and markers of endothelial damage in patients with diabetic erectile dysfunction: a double-blind, placebo-controlled study. 2007 Eur. Urol. pmid:17478034
Salonia A Editorial comment on: Antioxidant treatment associated with sildenafil reduces monocyte activation and markers of endothelial damage in patients with diabetic erectile dysfunction: a double-blind, placebo-controlled study. 2007 Eur. Urol. pmid:17478035
Pickard R Editorial comment on: Antioxidant treatment associated with sildenafil reduces monocyte activation and markers of endothelial damage in patients with diabetic erectile dysfunction: a double-blind, placebo-controlled study. 2007 Eur. Urol. pmid:17478036
Al-Majed AA Carnitine deficiency provokes cisplatin-induced hepatotoxicity in rats. 2007 Basic Clin. Pharmacol. Toxicol. pmid:17309516
de Sotomayor MA et al. l-carnitine and its propionate: improvement of endothelial function in SHR through superoxide dismutase-dependent mechanisms. 2007 Free Radic. Res. pmid:17654045
Delgado C et al. Subacute presentation of propionic acidemia. 2007 J. Child Neurol. pmid:18174561
Orlandi A et al. Propionyl-L-carnitine prevents age-related myocardial remodeling in the rabbit. 2007 J. Cardiovasc. Pharmacol. pmid:17703133
Safarinejad MR et al. Comparison of vitamin E and propionyl-L-carnitine, separately or in combination, in patients with early chronic Peyronie's disease: a double-blind, placebo controlled, randomized study. 2007 J. Urol. pmid:17706714
Wikoff WR et al. Metabolomics identifies perturbations in human disorders of propionate metabolism. 2007 Clin. Chem. pmid:17951291
Orlandi A et al. Propionyl-L-carnitine reduces proliferation and potentiates Bax-related apoptosis of aortic intimal smooth muscle cells by modulating nuclear factor-kappaB activity. 2007 J. Biol. Chem. pmid:17178728
Silvestro A et al. Effect of propionylcarnitine on changes in endothelial function and plasma levels of adhesion molecules induced by acute exercise in patients with intermittent claudication. 2006 Mar-Apr Angiology pmid:16518521
Kendler BS Supplemental conditionally essential nutrients in cardiovascular disease therapy. 2006 Jan-Feb J Cardiovasc Nurs pmid:16407731
Signorelli SS et al. A randomised, controlled clinical trial evaluating changes in therapeutic efficacy and oxidative parameters after treatment with propionyl L-carnitine in patients with peripheral arterial disease requiring haemodialysis. 2006 Drugs Aging pmid:16608381
Gómez-Amores L et al. Antioxidant activity of propionyl-L-carnitine in liver and heart of spontaneously hypertensive rats. 2006 Life Sci. pmid:16263137
Santo SS et al. Effect of PLC on functional parameters and oxidative profile in type 2 diabetes-associated PAD. 2006 Diabetes Res. Clin. Pract. pmid:16446007
Al-Majed AA et al. Propionyl-L-carnitine prevents the progression of cisplatin-induced cardiomyopathy in a carnitine-depleted rat model. 2006 Pharmacol. Res. pmid:16436331
Bene J et al. Changes of plasma fasting carnitine ester profile in patients with ulcerative colitis. 2006 World J. Gastroenterol. pmid:16440427
Origlia N et al. Protective effect of L-propionylcarnitine in chronic cyclosporine-a induced nephrotoxicity. 2006 Biomed. Pharmacother. pmid:16472963
Loffredo L et al. Imbalance between nitric oxide generation and oxidative stress in patients with peripheral arterial disease: effect of an antioxidant treatment. 2006 J. Vasc. Surg. pmid:16950429
Al-Majed AA et al. Carnitine esters prevent oxidative stress damage and energy depletion following transient forebrain ischaemia in the rat hippocampus. 2006 Clin. Exp. Pharmacol. Physiol. pmid:16895547
Signorelli SS et al. Propionyl-L-carnitine therapy: effects on endothelin-1 and homocysteine levels in patients with peripheral arterial disease and end-stage renal disease. 2006 Kidney Blood Press. Res. pmid:16809937
Cavallini G et al. Acetyl-L-carnitine plus propionyl-L-carnitine improve efficacy of sildenafil in treatment of erectile dysfunction after bilateral nerve-sparing radical retropubic prostatectomy. 2005 Urology pmid:16286128
Mancinelli A et al. Uptake of L-carnitine and its short-chain ester propionyl-L-carnitine in the isolated perfused rat liver. 2005 J. Pharmacol. Exp. Ther. pmid:15951397
Bueno R et al. L-carnitine and propionyl-L-carnitine improve endothelial dysfunction in spontaneously hypertensive rats: different participation of NO and COX-products. 2005 Life Sci. pmid:15958269
Lango R et al. Propionyl-L-carnitine improves hemodynamics and metabolic markers of cardiac perfusion during coronary surgery in diabetic patients. 2005 Cardiovasc Drugs Ther pmid:16187006
Hasegawa Y et al. Prenatal diagnosis for organic acid disorders using two mass spectrometric methods, gas chromatography mass spectrometry and tandem mass spectrometry. 2005 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:15908288
Campbell CD et al. Two newborns with nutritional vitamin B12 deficiency: challenges in newborn screening for vitamin B12 deficiency. 2005 Haematologica pmid:16464760
Vermeulen RC and Scholte HR Exploratory open label, randomized study of acetyl- and propionylcarnitine in chronic fatigue syndrome. 2004 Mar-Apr Psychosom Med pmid:15039515
Gentile V et al. Preliminary observations on the use of propionyl-L-carnitine in combination with sildenafil in patients with erectile dysfunction and diabetes. 2004 Curr Med Res Opin pmid:15383186
Ragozzino G et al. Effects of propionyl-carnitine in patients with type 2 diabetes and peripheral vascular disease: results of a pilot trial. 2004 Drugs R D pmid:15230623
Broderick TL et al. Effects of propionyl-carnitine on mitochondrial respiration and post-ischaemic cardiac function in the ischaemic underperfused diabetic rat heart. 2004 Drugs R D pmid:15230624
Sethi R et al. Improvement of cardiac function and beta-adrenergic signal transduction by propionyl L-carnitine in congestive heart failure due to myocardial infarction. 2004 Coron. Artery Dis. pmid:15201623
Kuster T et al. Filter paper cards contaminated with EMLA cream produce artefacts on acylcarnitine analysis. 2004 J. Inherit. Metab. Dis. pmid:15669691
Ferrari R et al. Therapeutic effects of L-carnitine and propionyl-L-carnitine on cardiovascular diseases: a review. 2004 Ann. N. Y. Acad. Sci. pmid:15591005
Hiatt WR Carnitine and peripheral arterial disease. 2004 Ann. N. Y. Acad. Sci. pmid:15591006
D'Acquarica I et al. Enantio- and chemo-selective HPLC separations by chiral-achiral tandem-columns approach: the combination of CHIROBIOTIC TAG and SCX columns for the analysis of propionyl carnitine and related impurities. 2004 J Chromatogr A pmid:15641359
Ferrari R et al. Metabolic modulation and optimization of energy consumption in heart failure. 2003 Med. Clin. North Am. pmid:12693736
Arafa HM and Sayed-Ahmed MM Protective role of carnitine esters against alcohol-induced gastric lesions in rats. 2003 Pharmacol. Res. pmid:12860448
Koh SG et al. Exercise intolerance during post-MI heart failure in rats: prevention with supplemental dietary propionyl-L-carnitine. 2003 Cardiovasc Drugs Ther pmid:12843682
Cui J et al. Effects of L-carnitine and its derivatives on postischemic cardiac function, ventricular fibrillation and necrotic and apoptotic cardiomyocyte death in isolated rat hearts. 2003 Mol. Cell. Biochem. pmid:14674702
Kushnir MM et al. Serum acylcarnitines and vitamin B12 deficiency. 2002 Clin. Chem. pmid:12089192
Mister M et al. Propionyl-L-carnitine prevents renal function deterioration due to ischemia/reperfusion. 2002 Kidney Int. pmid:11849462
Cavallini G et al. Oral propionyl-l-carnitine and intraplaque verapamil in the therapy of advanced and resistant Peyronie's disease. 2002 BJU Int. pmid:12010235