Propionylcarnitine

Propionylcarnitine is a lipid of Fatty Acyls (FA) class. Propionylcarnitine is associated with abnormalities such as Failure to Thrive. The involved functions are known as Functional disorder. Propionylcarnitine often locates in Body tissue.

Cross Reference

Introduction

To understand associated biological information of Propionylcarnitine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Propionylcarnitine?

Propionylcarnitine is suspected in Failure to Thrive and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Propionylcarnitine

MeSH term MeSH ID Detail
Reperfusion Injury D015427 65 associated lipids
Body Weight D001835 333 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Amino Acid Metabolism, Inborn Errors D000592 16 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Starvation D013217 47 associated lipids
Pregnancy Complications D011248 19 associated lipids
Penile Induration D010411 4 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with Propionylcarnitine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Propionylcarnitine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Propionylcarnitine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Propionylcarnitine?

There are no associated biomedical information in the current reference collection.

What genes are associated with Propionylcarnitine?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Propionylcarnitine?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Propionylcarnitine

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Authors Title Published Journal PubMed Link
Di Biase M et al. Electrophysiologic evaluation of intravenous L-propionylcarnitine in man. 1991 Int. J. Cardiol. pmid:2055673
Lagioia R et al. Propionyl-L-carnitine: a new compound in the metabolic approach to the treatment of effort angina. 1992 Int. J. Cardiol. pmid:1737667
Cooper TG et al. Characteristics of the transport of carnitine into the cauda epididymidis of the rat as ascertained by luminal perfusion in vitro. 1986 Int. J. Androl. pmid:3570531
Bloomer RJ et al. Glycine propionyl-L-carnitine modulates lipid peroxidation and nitric oxide in human subjects. 2009 Int J Vitam Nutr Res pmid:20209464
Mauriello A et al. Effect of long-term treatment with propionyl-L-carnitine on smooth muscle cell polyploidy in spontaneously hypertensive rats. 1996 Hypertension pmid:8707378
Yorifuji T et al. Unexpectedly high prevalence of the mild form of propionic acidemia in Japan: presence of a common mutation and possible clinical implications. 2002 Hum. Genet. pmid:12189489
Guenzel AJ et al. Long-term sex-biased correction of circulating propionic acidemia disease markers by adeno-associated virus vectors. 2015 Hum. Gene Ther. pmid:25654275
Campbell CD et al. Two newborns with nutritional vitamin B12 deficiency: challenges in newborn screening for vitamin B12 deficiency. 2005 Haematologica pmid:16464760
de Sotomayor MA et al. l-carnitine and its propionate: improvement of endothelial function in SHR through superoxide dismutase-dependent mechanisms. 2007 Free Radic. Res. pmid:17654045
Palmieri L et al. Identification of the mitochondrial carnitine carrier in Saccharomyces cerevisiae. 1999 FEBS Lett. pmid:10622748
Doggrell SA Pharmacotherapy of intermittent claudication. 2001 Expert Opin Pharmacother pmid:11825312
Andreozzi GM Propionyl l-carnitine: intermittent claudication and peripheral arterial disease. 2009 Expert Opin Pharmacother pmid:19827991
Morano S et al. Antioxidant treatment associated with sildenafil reduces monocyte activation and markers of endothelial damage in patients with diabetic erectile dysfunction: a double-blind, placebo-controlled study. 2007 Eur. Urol. pmid:17478034
Salonia A Editorial comment on: Antioxidant treatment associated with sildenafil reduces monocyte activation and markers of endothelial damage in patients with diabetic erectile dysfunction: a double-blind, placebo-controlled study. 2007 Eur. Urol. pmid:17478035
Pickard R Editorial comment on: Antioxidant treatment associated with sildenafil reduces monocyte activation and markers of endothelial damage in patients with diabetic erectile dysfunction: a double-blind, placebo-controlled study. 2007 Eur. Urol. pmid:17478036
Micheletti R et al. Effect of propionyl-l-carnitine and enalapril on cardiac function of pressure-overloaded rats during increase in load. 1995 Eur. J. Pharmacol. pmid:8605951
Hotta N et al. Effect of propionyl-L-carnitine on oscillatory potentials in electroretinogram in streptozotocin-diabetic rats. 1996 Eur. J. Pharmacol. pmid:8891600
Maresca P et al. Positive action of propionyl-L-carnitine on mechanical performance of papillary muscle from Syrian hamsters with hereditary dilated cardiomyopathy. 1995 Eur. J. Pharmacol. pmid:8991805
Schönekess BO et al. Propionyl L-carnitine improvement of hypertrophied rat heart function is associated with an increase in cardiac efficiency. 1995 Eur. J. Pharmacol. pmid:8605952
Terada R et al. Effects of propionyl-L-carnitine on cardiac dysfunction in streptozotocin-diabetic rats. 1998 Eur. J. Pharmacol. pmid:9797035
Davis EJ et al. Pyruvate carboxylase and propionyl-CoA carboxylase as anaplerotic enzymes in skeletal muscle mitochondria. 1980 Eur. J. Biochem. pmid:6777158
Ragozzino G et al. Effects of propionyl-carnitine in patients with type 2 diabetes and peripheral vascular disease: results of a pilot trial. 2004 Drugs R D pmid:15230623
Broderick TL et al. Effects of propionyl-carnitine on mitochondrial respiration and post-ischaemic cardiac function in the ischaemic underperfused diabetic rat heart. 2004 Drugs R D pmid:15230624
Broderick TL ATP production and TCA activity are stimulated by propionyl-L-carnitine in the diabetic rat heart. 2008 Drugs R D pmid:18298127
Signorelli SS et al. A randomised, controlled clinical trial evaluating changes in therapeutic efficacy and oxidative parameters after treatment with propionyl L-carnitine in patients with peripheral arterial disease requiring haemodialysis. 2006 Drugs Aging pmid:16608381
Wiseman LR and Brogden RN Propionyl-L-carnitine. 1998 Drugs Aging pmid:9534023
Mancinelli A et al. Disposition of L-carnitine and its short-chain esters, acetyl-L-carnitine and propionyl-L-carnitine, in the rat isolated perfused liver. 2000 Drug Metab. Dispos. pmid:11095575
Felix C et al. Effects of propionyl-L-carnitine on isolated mitochondrial function in the reperfused diabetic rat heart. 2001 Diabetes Res. Clin. Pract. pmid:11378209
Santo SS et al. Effect of PLC on functional parameters and oxidative profile in type 2 diabetes-associated PAD. 2006 Diabetes Res. Clin. Pract. pmid:16446007
Malaguarnera M Carnitine derivatives: clinical usefulness. 2012 Curr. Opin. Gastroenterol. pmid:22333562
Gentile V et al. Preliminary observations on the use of propionyl-L-carnitine in combination with sildenafil in patients with erectile dysfunction and diabetes. 2004 Curr Med Res Opin pmid:15383186
Gentile V et al. Effect of propionyl-L-carnitine, L-arginine and nicotinic acid on the efficacy of vardenafil in the treatment of erectile dysfunction in diabetes. 2009 Curr Med Res Opin pmid:19624286
Sethi R et al. Improvement of cardiac function and beta-adrenergic signal transduction by propionyl L-carnitine in congestive heart failure due to myocardial infarction. 2004 Coron. Artery Dis. pmid:15201623
Aleisa AM et al. Reversal of cisplatin-induced carnitine deficiency and energy starvation by propionyl-L-carnitine in rat kidney tissues. 2007 Clin. Exp. Pharmacol. Physiol. pmid:17973863
Al-Majed AA et al. Carnitine esters prevent oxidative stress damage and energy depletion following transient forebrain ischaemia in the rat hippocampus. 2006 Clin. Exp. Pharmacol. Physiol. pmid:16895547
De Jesús VR et al. Comparison of amino acids and acylcarnitines assay methods used in newborn screening assays by tandem mass spectrometry. 2010 Clin. Chim. Acta pmid:20122909
Libert R et al. Identification of undescribed medium-chain acylcarnitines present in urine of patients with propionic and methylmalonic acidemias. 2000 Clin. Chim. Acta pmid:10767396
Di Donato S et al. Propionylcarnitine excretion in propionic and methylmalonic acidurias: a cause of carnitine deficiency. 1984 Clin. Chim. Acta pmid:6723070
Kushnir MM et al. Serum acylcarnitines and vitamin B12 deficiency. 2002 Clin. Chem. pmid:12089192
Chace DH et al. Rapid diagnosis of methylmalonic and propionic acidemias: quantitative tandem mass spectrometric analysis of propionylcarnitine in filter-paper blood specimens obtained from newborns. 2001 Clin. Chem. pmid:11673377
la Marca G et al. Rapid 2nd-tier test for measurement of 3-OH-propionic and methylmalonic acids on dried blood spots: reducing the false-positive rate for propionylcarnitine during expanded newborn screening by liquid chromatography-tandem mass spectrometry. 2007 Clin. Chem. pmid:17510301
Chapman KA et al. Increased C3-carnitine in a healthy premature infant. 2008 Clin. Chem. pmid:18957557
Wikoff WR et al. Metabolomics identifies perturbations in human disorders of propionate metabolism. 2007 Clin. Chem. pmid:17951291
Montisci R et al. Effect of a single IV administration of L-propionylcarnitine on myocardial microcirculation assessed by coronary flow velocity reserve measurement in patients with systemic sclerosis: a pilot study. 2007 Clin Ther pmid:17379056
Brevetti G et al. Muscle carnitine deficiency in patients with severe peripheral vascular disease. 1991 Circulation pmid:1914091
Schönekess BO et al. Propionyl L-carnitine improvement of hypertrophied heart function is accompanied by an increase in carbohydrate oxidation. 1995 Circ. Res. pmid:7554119
Zhang Y et al. Prenatal diagnosis of methylmalonic aciduria by analysis of organic acids and total homocysteine in amniotic fluid. 2008 Chin. Med. J. pmid:18298912
Vanella A et al. L -propionyl-carnitine as superoxide scavenger, antioxidant, and DNA cleavage protector. 2000 Cell Biol. Toxicol. pmid:10917565
Lango R et al. Propionyl-L-carnitine improves hemodynamics and metabolic markers of cardiac perfusion during coronary surgery in diabetic patients. 2005 Cardiovasc Drugs Ther pmid:16187006
De Marchi S et al. Propionyl-L-carnitine improves endothelial function, microcirculation and pain management in critical limb ischemia. 2012 Cardiovasc Drugs Ther pmid:22936457