Propionylcarnitine

Propionylcarnitine is a lipid of Fatty Acyls (FA) class. Propionylcarnitine is associated with abnormalities such as Failure to Thrive. The involved functions are known as Functional disorder. Propionylcarnitine often locates in Body tissue.

Cross Reference

Introduction

To understand associated biological information of Propionylcarnitine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Propionylcarnitine?

Propionylcarnitine is suspected in Failure to Thrive and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Propionylcarnitine

MeSH term MeSH ID Detail
Reperfusion Injury D015427 65 associated lipids
Body Weight D001835 333 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Amino Acid Metabolism, Inborn Errors D000592 16 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Starvation D013217 47 associated lipids
Pregnancy Complications D011248 19 associated lipids
Penile Induration D010411 4 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with Propionylcarnitine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Propionylcarnitine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Propionylcarnitine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Propionylcarnitine?

There are no associated biomedical information in the current reference collection.

What genes are associated with Propionylcarnitine?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Propionylcarnitine?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Propionylcarnitine

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Authors Title Published Journal PubMed Link
Andreozzi GM Propionyl l-carnitine: intermittent claudication and peripheral arterial disease. 2009 Expert Opin Pharmacother pmid:19827991
Stasi MA et al. Propionyl-L-carnitine improves postischemic blood flow recovery and arteriogenetic revascularization and reduces endothelial NADPH-oxidase 4-mediated superoxide production. 2010 Arterioscler. Thromb. Vasc. Biol. pmid:20056909
De Jesús VR et al. Comparison of amino acids and acylcarnitines assay methods used in newborn screening assays by tandem mass spectrometry. 2010 Clin. Chim. Acta pmid:20122909
Bloomer RJ et al. Glycine propionyl-L-carnitine modulates lipid peroxidation and nitric oxide in human subjects. 2009 Int J Vitam Nutr Res pmid:20209464
pmid:20299794
Barbieri M et al. Lack of correlation between the antiarrhythmic effect of L-propionylcarnitine on reoxygenation-induced arrhythmias and its electrophysiological properties. 1991 Br. J. Pharmacol. pmid:2043933
Shigematsu Y et al. Useful second-tier tests in expanded newborn screening of isovaleric acidemia and methylmalonic aciduria. 2010 J. Inherit. Metab. Dis. pmid:20440648
Vargiu R et al. Enhancement of shortening velocity, power, and acto-myosin crossbridge (CB) kinetics following long-term treatment with propionyl-L-carnitine, coenzyme Q10, and omega-3 fatty acids in BIO TO-2 cardiomyopathic Syrian hamsters papillary muscle. 2010 May-Jun Biofactors pmid:20533397
Di Biase M et al. Electrophysiologic evaluation of intravenous L-propionylcarnitine in man. 1991 Int. J. Cardiol. pmid:2055673
Cheng KH et al. Newborn screening for methylmalonic aciduria by tandem mass spectrometry: 7 years' experience from two centers in Taiwan. 2010 J Chin Med Assoc pmid:20603089
Marciani P et al. L-carnitine and carnitine ester transport in the rat small intestine. 1991 Pharmacol. Res. pmid:2062791
Hiatt WR et al. Effect of propionyl-L-carnitine on a background of monitored exercise in patients with claudication secondary to peripheral artery disease. 2011 Mar-Apr J Cardiopulm Rehabil Prev pmid:20861750
Wang F et al. Clinical, biochemical, and molecular analysis of combined methylmalonic acidemia and hyperhomocysteinemia (cblC type) in China. 2010 J. Inherit. Metab. Dis. pmid:20924684
Riccioni C et al. Rehabilitative treatment in peripheral artery disease: protocol application and follow-up. 2010 Minerva Cardioangiol pmid:20948502
Dhir RR et al. Combination therapy for erectile dysfunction: an update review. 2011 Asian J. Androl. pmid:21423198
Sarafoglou K et al. Expanded newborn screening for detection of vitamin B12 deficiency. 2011 JAMA pmid:21427371
Hozyasz KK et al. Whole blood propionylcarnitine in newborns with orofacial cleft. 2011 Matern Child Nutr pmid:21470367
Mingorance C et al. Critical update for the clinical use of L-carnitine analogs in cardiometabolic disorders. 2011 Vasc Health Risk Manag pmid:21490942
Mingorance C et al. Pharmacological effects and clinical applications of propionyl-L-carnitine. 2011 Nutr. Rev. pmid:21521230
Pierce GN et al. Na(+)-H+ exchange in cardiac sarcolemmal vesicles isolated from diabetic rats. 1990 Am. J. Physiol. pmid:2154133
Elliott GR et al. The effect of acute feeding of carnitine, acetyl carnitine and propionyl carnitine on basal and A23187-stimulated eicosanoid release from rat carrageenan-elicited peritoneal macrophages. 1990 Br. J. Nutr. pmid:2171633
Wagner CC et al. Plasma pharmacokinetics and gastrointestinal transit of a new propionyl-L-carnitine controlled release formulation. 2011 Xenobiotica pmid:21810044
Mikhailova TL et al. Randomised clinical trial: the efficacy and safety of propionyl-L-carnitine therapy in patients with ulcerative colitis receiving stable oral treatment. 2011 Aliment. Pharmacol. Ther. pmid:21929562
Gianfrilli D et al. Propionyl-L-carnitine, L-arginine and niacin in sexual medicine: a nutraceutical approach to erectile dysfunction. 2012 Andrologia pmid:21966881
Laviano A et al. Carnitine administration reduces cytokine levels, improves food intake, and ameliorates body composition in tumor-bearing rats. 2011 Cancer Invest. pmid:22085273
Kasahara M et al. Living-donor liver transplantation for propionic acidemia. 2012 Pediatr Transplant pmid:22151065
Malaguarnera M Carnitine derivatives: clinical usefulness. 2012 Curr. Opin. Gastroenterol. pmid:22333562
Mingorance C et al. Propionyl-L-carnitine corrects metabolic and cardiovascular alterations in diet-induced obese mice and improves liver respiratory chain activity. 2012 PLoS ONE pmid:22457831
Morand R et al. Effect of short- and long-term treatment with valproate on carnitine homeostasis in humans. 2012 Ther Drug Monit pmid:22743351
De Marchi S et al. Propionyl-L-carnitine improves endothelial function, microcirculation and pain management in critical limb ischemia. 2012 Cardiovasc Drugs Ther pmid:22936457
Merra G et al. Propionyl-L-carnitine hydrochloride for treatment of mild to moderate colonic inflammatory bowel diseases. 2012 World J. Gastroenterol. pmid:23049215
Brass EP et al. A systematic review and meta-analysis of propionyl-L-carnitine effects on exercise performance in patients with claudication. 2013 Vasc Med pmid:23321261
Wu SN et al. [Analysis of propionylcarnitine in blood and methylmalonic acid in urine of 162 patients with methylmalonic acidemia]. 2013 Zhonghua Yi Xue Za Zhi pmid:23663331
Huang Z et al. [Outcomes of patients with combined methylmalonic acidemia and homocystinuria after treatment]. 2013 Zhonghua Er Ke Za Zhi pmid:23751581
Huang Q et al. Metabolic characterization of hepatocellular carcinoma using nontargeted tissue metabolomics. 2013 Cancer Res. pmid:23824744
Ning WH and Zhao K Propionyl-L-carnitine induces eNOS activation and nitric oxide synthesis in endothelial cells via PI3 and Akt kinases. 2013 Sep-Oct Vascul. Pharmacol. pmid:23850990
Pekkinen J et al. Betaine supplementation causes increase in carnitine metabolites in the muscle and liver of mice fed a high-fat diet as studied by nontargeted LC-MS metabolomics approach. 2013 Mol Nutr Food Res pmid:23868375
Naccarato A et al. Identification and assay of underivatized urinary acylcarnitines by paper spray tandem mass spectrometry. 2013 Anal Bioanal Chem pmid:23907684
Luo T et al. A study on the efficacy and safety assessment of propionyl-L-carnitine tablets in treatment of intermittent claudication. 2013 Thromb. Res. pmid:23998557
pmid:24337254
Hailemariam D et al. Identification of predictive biomarkers of disease state in transition dairy cows. 2014 J. Dairy Sci. pmid:24630653
Aomine M et al. Electrophysiologic effects of a short-chain acyl carnitine, L-propionylcarnitine, on isolated canine Purkinje fibers. 1989 J. Cardiovasc. Pharmacol. pmid:2471897
pmid:25204964
pmid:25401479
Bogusiewicz A et al. In HepG2 cells, coexisting carnitine deficiency masks important indicators of marginal biotin deficiency. 2015 J. Nutr. pmid:25527659
Guenzel AJ et al. Long-term sex-biased correction of circulating propionic acidemia disease markers by adeno-associated virus vectors. 2015 Hum. Gene Ther. pmid:25654275
pmid:25748407
Huemer M et al. Newborn screening for homocystinurias and methylation disorders: systematic review and proposed guidelines. 2015 J. Inherit. Metab. Dis. pmid:25762406
pmid:25835239
pmid:25982642