Propionylcarnitine

Propionylcarnitine is a lipid of Fatty Acyls (FA) class. Propionylcarnitine is associated with abnormalities such as Failure to Thrive. The involved functions are known as Functional disorder. Propionylcarnitine often locates in Body tissue.

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Introduction

To understand associated biological information of Propionylcarnitine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Propionylcarnitine?

Propionylcarnitine is suspected in Failure to Thrive and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Propionylcarnitine

MeSH term MeSH ID Detail
Reperfusion Injury D015427 65 associated lipids
Body Weight D001835 333 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Amino Acid Metabolism, Inborn Errors D000592 16 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Starvation D013217 47 associated lipids
Pregnancy Complications D011248 19 associated lipids
Penile Induration D010411 4 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with Propionylcarnitine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Propionylcarnitine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Propionylcarnitine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Propionylcarnitine?

There are no associated biomedical information in the current reference collection.

What genes are associated with Propionylcarnitine?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Propionylcarnitine?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Propionylcarnitine

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Authors Title Published Journal PubMed Link
Tang YM et al. Urine and serum metabolomic profiling reveals that bile acids and carnitine may be potential biomarkers of primary biliary cirrhosis. 2015 Int. J. Mol. Med. pmid:26046127
Scioli MG et al. Propionyl-L-Carnitine Enhances Wound Healing and Counteracts Microvascular Endothelial Cell Dysfunction. 2015 PLoS ONE pmid:26473356
pmid:26913383
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pmid:27216769
pmid:27240302
Forny P et al. Novel Mouse Models of Methylmalonic Aciduria Recapitulate Phenotypic Traits with a Genetic Dosage Effect. 2016 J. Biol. Chem. pmid:27519416
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Brass EP and Ruff LJ Effect of carnitine on propionate metabolism in the vitamin B-12--deficient rat. 1989 J. Nutr. pmid:2778544
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Brass EP and Beyerinck RA Interactions of propionate and carnitine metabolism in isolated rat hepatocytes. 1987 Metab. Clin. Exp. pmid:3110541
Sherry AD et al. Propionate metabolism in the rat heart by 13C n.m.r. spectroscopy. 1988 Biochem. J. pmid:3178775
Brass EP and Stabler SP Carnitine metabolism in the vitamin B-12-deficient rat. 1988 Biochem. J. pmid:3196310
Neri B et al. Differences between carnitine derivatives and coenzyme Q10 in preventing in vitro doxorubicin-related cardiac damages. 1988 Oncology pmid:3368201
Liedtke AJ et al. Effects of L-propionylcarnitine on mechanical recovery during reflow in intact hearts. 1988 Am. J. Physiol. pmid:3394817
Cooper TG et al. Characteristics of the transport of carnitine into the cauda epididymidis of the rat as ascertained by luminal perfusion in vitro. 1986 Int. J. Androl. pmid:3570531
Hokland BM and Bremer J Metabolism and excretion of carnitine and acylcarnitines in the perfused rat kidney. 1986 Biochim. Biophys. Acta pmid:3697382
Brass EP et al. Inhibition of oxidative metabolism by propionic acid and its reversal by carnitine in isolated rat hepatocytes. 1986 Biochem. J. pmid:3790065
Chalmers RA et al. Urinary excretion of l-carnitine and acylcarnitines by patients with disorders of organic acid metabolism: evidence for secondary insufficiency of l-carnitine. 1984 Pediatr. Res. pmid:6441143
Yergey AL et al. Thermospray liquid chromatography/mass spectrometry for the analysis of L-carnitine and its short-chain acyl derivatives. 1984 Anal. Biochem. pmid:6476364
Roe CR et al. Metabolic response to carnitine in methylmalonic aciduria. An effective strategy for elimination of propionyl groups. 1983 Arch. Dis. Child. pmid:6651329
Di Donato S et al. Propionylcarnitine excretion in propionic and methylmalonic acidurias: a cause of carnitine deficiency. 1984 Clin. Chim. Acta pmid:6723070
Roe CR et al. L-carnitine enhances excretion of propionyl coenzyme A as propionylcarnitine in propionic acidemia. 1984 J. Clin. Invest. pmid:6725560
Davis EJ et al. Pyruvate carboxylase and propionyl-CoA carboxylase as anaplerotic enzymes in skeletal muscle mitochondria. 1980 Eur. J. Biochem. pmid:6777158
Kotaka K et al. Reversal of ischemia-induced mitochondrial dysfunction after coronary reperfusion. 1982 J. Mol. Cell. Cardiol. pmid:7108975
Duncker DJ et al. L-propionylcarnitine does not affect myocardial metabolic or functional response to chronotropic and inotropic stimulation after repetitive ischemia in anesthetized pigs. 1993 J. Cardiovasc. Pharmacol. pmid:7504143
Schönekess BO et al. Propionyl L-carnitine improvement of hypertrophied heart function is accompanied by an increase in carbohydrate oxidation. 1995 Circ. Res. pmid:7554119
Brevetti G et al. Propionyl-L-carnitine in intermittent claudication: double-blind, placebo-controlled, dose titration, multicenter study. 1995 J. Am. Coll. Cardiol. pmid:7594063
Spagnoli LG et al. Propionyl-L-carnitine prevents the progression of atherosclerotic lesions in aged hyperlipemic rabbits. 1995 Atherosclerosis pmid:7605374
Odiet JA et al. Carnitine palmitoyl transferase-I activity in the aging mouse heart. 1995 Mech. Ageing Dev. pmid:7616763
Corsi C et al. L-propionylcarnitine effect on postexercise and postischemic hyperemia in patients affected by peripheral vascular disease. 1995 Angiology pmid:7639417
Cotter MA et al. Effects of acetyl- and proprionyl-L-carnitine on peripheral nerve function and vascular supply in experimental diabetes. 1995 Metab. Clin. Exp. pmid:7666797
Li P et al. Myocyte performance during evolution of myocardial infarction in rats: effects of propionyl-L-carnitine. 1995 Am. J. Physiol. pmid:7733374
Reggiani C et al. Effect of propionyl-L-carnitine (PLC) on the kinetic properties of the myofibrillar system in pressure overload cardiac hypertrophy. 1995 Ann. N. Y. Acad. Sci. pmid:7755261
Maresca P et al. Propionyl-L-carnitine improves mechanical performance of papillary muscle from dilated cardiomyopathic hamsters. 1995 Ann. N. Y. Acad. Sci. pmid:7755262
Caruso A et al. Protective effect of propionyl-L-carnitine against PAF-induced rat paw oedema. 1995 Pharmacol. Res. pmid:7784308
Russell RR et al. Propionyl-L-carnitine-mediated improvement in contractile function of rat hearts oxidizing acetoacetate. 1995 Am. J. Physiol. pmid:7840294
Bartels GL et al. Effects of L-propionylcarnitine on ischemia-induced myocardial dysfunction in men with angina pectoris. 1994 Am. J. Cardiol. pmid:8023775
Micheletti R et al. Propionyl-L-carnitine prevents myocardial mechanical alterations due to pressure overload in rats. 1994 Am. J. Physiol. pmid:8023981
Di Lisa F et al. Contrasting effects of propionate and propionyl-L-carnitine on energy-linked processes in ischemic hearts. 1994 Am. J. Physiol. pmid:8067396
De Maria P et al. Effect of the addition of electrolytes on the partition coefficients, activity coefficients, and acid dissociation constants of carnitine and its acetyl and propionyl derivatives. 1994 J Pharm Sci pmid:8071833
Tassani V et al. Anaplerotic effect of propionyl carnitine in rat heart mitochondria. 1994 Biochem. Biophys. Res. Commun. pmid:8135845
Minkler PE and Hoppel CL Quantification of free carnitine, individual short- and medium-chain acylcarnitines, and total carnitine in plasma by high-performance liquid chromatography. 1993 Anal. Biochem. pmid:8214594
Riva E and Leopaldi D Control of the cardiac consequences of myocardial ischemia and reperfusion by L-propionylcarnitine: age-response and dose-response studies in the rat heart. 1993 Pediatr. Res. pmid:8255679
Brass EP et al. Carnitine delays rat skeletal muscle fatigue in vitro. 1993 J. Appl. Physiol. pmid:8282608
Mancinelli R L-propionylcarnitine and synchronization of spontaneous activity in rat isolated portal vein. 1993 Arch Ital Biol pmid:8338391
Arduini A et al. Effects of L-carnitine and its acetate and propionate esters on the molecular dynamics of human erythrocyte membrane. 1993 Biochim. Biophys. Acta pmid:8383998
Micheletti R et al. Propionyl-L-carnitine limits chronic ventricular dilation after myocardial infarction in rats. 1993 Am. J. Physiol. pmid:8476087
Davenport RJ et al. Propionyl-L-carnitine: labelling in the N-methyl position with carbon-11 and pharmacokinetic studies in rats. 1995 Nucl. Med. Biol. pmid:8535330