Propionylcarnitine

Propionylcarnitine is a lipid of Fatty Acyls (FA) class. Propionylcarnitine is associated with abnormalities such as Failure to Thrive. The involved functions are known as Functional disorder. Propionylcarnitine often locates in Body tissue.

Cross Reference

Introduction

To understand associated biological information of Propionylcarnitine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Propionylcarnitine?

Propionylcarnitine is suspected in Failure to Thrive and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Propionylcarnitine

MeSH term MeSH ID Detail
Reperfusion Injury D015427 65 associated lipids
Body Weight D001835 333 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Amino Acid Metabolism, Inborn Errors D000592 16 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Starvation D013217 47 associated lipids
Pregnancy Complications D011248 19 associated lipids
Penile Induration D010411 4 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with Propionylcarnitine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Propionylcarnitine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Propionylcarnitine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Propionylcarnitine?

There are no associated biomedical information in the current reference collection.

What genes are associated with Propionylcarnitine?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Propionylcarnitine?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Propionylcarnitine

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Authors Title Published Journal PubMed Link
Gómez-Amores L et al. Antioxidant activity of propionyl-L-carnitine in liver and heart of spontaneously hypertensive rats. 2006 Life Sci. pmid:16263137
Bene J et al. Changes of plasma fasting carnitine ester profile in patients with ulcerative colitis. 2006 World J. Gastroenterol. pmid:16440427
Loffredo L et al. Imbalance between nitric oxide generation and oxidative stress in patients with peripheral arterial disease: effect of an antioxidant treatment. 2006 J. Vasc. Surg. pmid:16950429
Signorelli SS et al. Propionyl-L-carnitine therapy: effects on endothelin-1 and homocysteine levels in patients with peripheral arterial disease and end-stage renal disease. 2006 Kidney Blood Press. Res. pmid:16809937
Kendler BS Supplemental conditionally essential nutrients in cardiovascular disease therapy. 2006 Jan-Feb J Cardiovasc Nurs pmid:16407731
Silvestro A et al. Effect of propionylcarnitine on changes in endothelial function and plasma levels of adhesion molecules induced by acute exercise in patients with intermittent claudication. 2006 Mar-Apr Angiology pmid:16518521
la Marca G et al. Rapid 2nd-tier test for measurement of 3-OH-propionic and methylmalonic acids on dried blood spots: reducing the false-positive rate for propionylcarnitine during expanded newborn screening by liquid chromatography-tandem mass spectrometry. 2007 Clin. Chem. pmid:17510301
Aleisa AM et al. Reversal of cisplatin-induced carnitine deficiency and energy starvation by propionyl-L-carnitine in rat kidney tissues. 2007 Clin. Exp. Pharmacol. Physiol. pmid:17973863
Montisci R et al. Effect of a single IV administration of L-propionylcarnitine on myocardial microcirculation assessed by coronary flow velocity reserve measurement in patients with systemic sclerosis: a pilot study. 2007 Clin Ther pmid:17379056
Alvarez de Sotomayor M et al. Effect of L-carnitine and propionyl-L-carnitine on endothelial function of small mesenteric arteries from SHR. 2007 J. Vasc. Res. pmid:17483601
Morano S et al. Antioxidant treatment associated with sildenafil reduces monocyte activation and markers of endothelial damage in patients with diabetic erectile dysfunction: a double-blind, placebo-controlled study. 2007 Eur. Urol. pmid:17478034
Salonia A Editorial comment on: Antioxidant treatment associated with sildenafil reduces monocyte activation and markers of endothelial damage in patients with diabetic erectile dysfunction: a double-blind, placebo-controlled study. 2007 Eur. Urol. pmid:17478035
Pickard R Editorial comment on: Antioxidant treatment associated with sildenafil reduces monocyte activation and markers of endothelial damage in patients with diabetic erectile dysfunction: a double-blind, placebo-controlled study. 2007 Eur. Urol. pmid:17478036
Al-Majed AA Carnitine deficiency provokes cisplatin-induced hepatotoxicity in rats. 2007 Basic Clin. Pharmacol. Toxicol. pmid:17309516
de Sotomayor MA et al. l-carnitine and its propionate: improvement of endothelial function in SHR through superoxide dismutase-dependent mechanisms. 2007 Free Radic. Res. pmid:17654045
Delgado C et al. Subacute presentation of propionic acidemia. 2007 J. Child Neurol. pmid:18174561
Orlandi A et al. Propionyl-L-carnitine prevents age-related myocardial remodeling in the rabbit. 2007 J. Cardiovasc. Pharmacol. pmid:17703133
Safarinejad MR et al. Comparison of vitamin E and propionyl-L-carnitine, separately or in combination, in patients with early chronic Peyronie's disease: a double-blind, placebo controlled, randomized study. 2007 J. Urol. pmid:17706714
Wikoff WR et al. Metabolomics identifies perturbations in human disorders of propionate metabolism. 2007 Clin. Chem. pmid:17951291
Orlandi A et al. Propionyl-L-carnitine reduces proliferation and potentiates Bax-related apoptosis of aortic intimal smooth muscle cells by modulating nuclear factor-kappaB activity. 2007 J. Biol. Chem. pmid:17178728
Perna AF et al. L-Propionyl carnitine, homocysteine and S-adenosylhomocysteine in hemodialysis. 2007 Jan-Feb J. Nephrol. pmid:17347975
Azzollini N et al. Propionyl-L-carnitine prevents early graft dysfunction in allogeneic rat kidney transplantation. 2008 Kidney Int. pmid:19008910
Chapman KA et al. Increased C3-carnitine in a healthy premature infant. 2008 Clin. Chem. pmid:18957557
Vargiu R et al. Positive inotropic effect of coenzyme Q10, omega-3 fatty acids and propionyl-L-carnitine on papillary muscle force-frequency responses of BIO TO-2 cardiomyopathic Syrian hamsters. 2008 Biofactors pmid:19096109
Zhang Y et al. Prenatal diagnosis of methylmalonic aciduria by analysis of organic acids and total homocysteine in amniotic fluid. 2008 Chin. Med. J. pmid:18298912
Broderick TL ATP production and TCA activity are stimulated by propionyl-L-carnitine in the diabetic rat heart. 2008 Drugs R D pmid:18298127
Marble M et al. Neonatal vitamin B12 deficiency secondary to maternal subclinical pernicious anemia: identification by expanded newborn screening. 2008 J. Pediatr. pmid:18410783
Andreozzi GM et al. Levo-propionyl-carnitine improves the effectiveness of supervised physical training on the absolute claudication distance in patients with intermittent claudication. 2008 Feb-Mar Angiology pmid:18319227
Allegra C et al. Propionyl-L-carnitine in Leriche-Fontaine stage II peripheral arterial obstructive disease. 2008 Jul-Aug Ann Vasc Surg pmid:18502605
Mingorance C et al. Oral supplementation of propionyl-l-carnitine reduces body weight and hyperinsulinaemia in obese Zucker rats. 2009 Br. J. Nutr. pmid:19545458
Milio G et al. Pharmacological treatment of patients with chronic critical limb ischemia: L-propionyl-carnitine enhances the short-term effects of PGE-1. 2009 Cardiovasc Drugs Ther pmid:19548076
Gentile V et al. Effect of propionyl-L-carnitine, L-arginine and nicotinic acid on the efficacy of vardenafil in the treatment of erectile dysfunction in diabetes. 2009 Curr Med Res Opin pmid:19624286
Bloomer RJ et al. Glycine propionyl-L-carnitine modulates lipid peroxidation and nitric oxide in human subjects. 2009 Int J Vitam Nutr Res pmid:20209464
Andreozzi GM Propionyl l-carnitine: intermittent claudication and peripheral arterial disease. 2009 Expert Opin Pharmacother pmid:19827991
Chen PW et al. Stabilization of blood methylmalonic acid level in methylmalonic acidemia after liver transplantation. 2010 Pediatr Transplant pmid:19686300
Shigematsu Y et al. Useful second-tier tests in expanded newborn screening of isovaleric acidemia and methylmalonic aciduria. 2010 J. Inherit. Metab. Dis. pmid:20440648
Cheng KH et al. Newborn screening for methylmalonic aciduria by tandem mass spectrometry: 7 years' experience from two centers in Taiwan. 2010 J Chin Med Assoc pmid:20603089
De Jesús VR et al. Comparison of amino acids and acylcarnitines assay methods used in newborn screening assays by tandem mass spectrometry. 2010 Clin. Chim. Acta pmid:20122909
Riccioni C et al. Rehabilitative treatment in peripheral artery disease: protocol application and follow-up. 2010 Minerva Cardioangiol pmid:20948502
Stasi MA et al. Propionyl-L-carnitine improves postischemic blood flow recovery and arteriogenetic revascularization and reduces endothelial NADPH-oxidase 4-mediated superoxide production. 2010 Arterioscler. Thromb. Vasc. Biol. pmid:20056909
Wang F et al. Clinical, biochemical, and molecular analysis of combined methylmalonic acidemia and hyperhomocysteinemia (cblC type) in China. 2010 J. Inherit. Metab. Dis. pmid:20924684
Vargiu R et al. Enhancement of shortening velocity, power, and acto-myosin crossbridge (CB) kinetics following long-term treatment with propionyl-L-carnitine, coenzyme Q10, and omega-3 fatty acids in BIO TO-2 cardiomyopathic Syrian hamsters papillary muscle. 2010 May-Jun Biofactors pmid:20533397
Dhir RR et al. Combination therapy for erectile dysfunction: an update review. 2011 Asian J. Androl. pmid:21423198
Sarafoglou K et al. Expanded newborn screening for detection of vitamin B12 deficiency. 2011 JAMA pmid:21427371
Mingorance C et al. Pharmacological effects and clinical applications of propionyl-L-carnitine. 2011 Nutr. Rev. pmid:21521230
Mingorance C et al. Critical update for the clinical use of L-carnitine analogs in cardiometabolic disorders. 2011 Vasc Health Risk Manag pmid:21490942
Hozyasz KK et al. Whole blood propionylcarnitine in newborns with orofacial cleft. 2011 Matern Child Nutr pmid:21470367
Laviano A et al. Carnitine administration reduces cytokine levels, improves food intake, and ameliorates body composition in tumor-bearing rats. 2011 Cancer Invest. pmid:22085273
Wagner CC et al. Plasma pharmacokinetics and gastrointestinal transit of a new propionyl-L-carnitine controlled release formulation. 2011 Xenobiotica pmid:21810044
Mikhailova TL et al. Randomised clinical trial: the efficacy and safety of propionyl-L-carnitine therapy in patients with ulcerative colitis receiving stable oral treatment. 2011 Aliment. Pharmacol. Ther. pmid:21929562