Propionylcarnitine

Propionylcarnitine is a lipid of Fatty Acyls (FA) class. Propionylcarnitine is associated with abnormalities such as Failure to Thrive. The involved functions are known as Functional disorder. Propionylcarnitine often locates in Body tissue.

Cross Reference

Introduction

To understand associated biological information of Propionylcarnitine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Propionylcarnitine?

Propionylcarnitine is suspected in Failure to Thrive and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Propionylcarnitine

MeSH term MeSH ID Detail
Reperfusion Injury D015427 65 associated lipids
Body Weight D001835 333 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Amino Acid Metabolism, Inborn Errors D000592 16 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Starvation D013217 47 associated lipids
Pregnancy Complications D011248 19 associated lipids
Penile Induration D010411 4 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with Propionylcarnitine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Propionylcarnitine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Propionylcarnitine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Propionylcarnitine?

There are no associated biomedical information in the current reference collection.

What genes are associated with Propionylcarnitine?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Propionylcarnitine?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Propionylcarnitine

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Authors Title Published Journal PubMed Link
Caruso A et al. Protective effect of propionyl-L-carnitine against PAF-induced rat paw oedema. 1995 Pharmacol. Res. pmid:7784308
Al-Majed AA et al. Propionyl-L-carnitine prevents the progression of cisplatin-induced cardiomyopathy in a carnitine-depleted rat model. 2006 Pharmacol. Res. pmid:16436331
Sayed-Ahmed MM et al. Propionyl-L-carnitine as potential protective agent against adriamycin-induced impairment of fatty acid beta-oxidation in isolated heart mitochondria. 2000 Pharmacol. Res. pmid:10623482
Marciani P et al. L-carnitine and carnitine ester transport in the rat small intestine. 1991 Pharmacol. Res. pmid:2062791
Vargiu R et al. Enhancement of muscular performance by a coformulation of propionyl-L-carnitine, coenzyme Q10, nicotinamide, riboflavin and pantothenic acid in the rat. 2002 Physiol. Behav. pmid:12044598
Scioli MG et al. Propionyl-L-Carnitine Enhances Wound Healing and Counteracts Microvascular Endothelial Cell Dysfunction. 2015 PLoS ONE pmid:26473356
Mingorance C et al. Propionyl-L-carnitine corrects metabolic and cardiovascular alterations in diet-induced obese mice and improves liver respiratory chain activity. 2012 PLoS ONE pmid:22457831
Vermeulen RC and Scholte HR Exploratory open label, randomized study of acetyl- and propionylcarnitine in chronic fatigue syndrome. 2004 Mar-Apr Psychosom Med pmid:15039515
Stroh R et al. L-propionyl carnitine, an endogenous ester in fatty acid metabolism, exerts anti-shock and endothelial protective effects in rat splanchnic ischemia-reperfusion injury. 1998 Shock pmid:9525330
Morand R et al. Effect of short- and long-term treatment with valproate on carnitine homeostasis in humans. 2012 Ther Drug Monit pmid:22743351
Luo T et al. A study on the efficacy and safety assessment of propionyl-L-carnitine tablets in treatment of intermittent claudication. 2013 Thromb. Res. pmid:23998557
Giovannini L et al. Acute CYA-induced ATP depletion is prevented by pretreatment with L-propionylcarnitine in isolated and perfused rat kidney. 1998 Transplant. Proc. pmid:9723376
Cavallini G et al. Acetyl-L-carnitine plus propionyl-L-carnitine improve efficacy of sildenafil in treatment of erectile dysfunction after bilateral nerve-sparing radical retropubic prostatectomy. 2005 Urology pmid:16286128
Mingorance C et al. Critical update for the clinical use of L-carnitine analogs in cardiometabolic disorders. 2011 Vasc Health Risk Manag pmid:21490942
Capecchi PL et al. Carnitines increase plasma levels of adenosine and ATP in humans. 1997 Vasc Med pmid:9546959
Taylor DJ et al. Changes in energy metabolism of calf muscle in patients with intermittent claudication assessed by 31P magnetic resonance spectroscopy: a phase II open study. 1996 Vasc Med pmid:9552578
Brass EP et al. A systematic review and meta-analysis of propionyl-L-carnitine effects on exercise performance in patients with claudication. 2013 Vasc Med pmid:23321261
Ning WH and Zhao K Propionyl-L-carnitine induces eNOS activation and nitric oxide synthesis in endothelial cells via PI3 and Akt kinases. 2013 Sep-Oct Vascul. Pharmacol. pmid:23850990
Bene J et al. Changes of plasma fasting carnitine ester profile in patients with ulcerative colitis. 2006 World J. Gastroenterol. pmid:16440427
Merra G et al. Propionyl-L-carnitine hydrochloride for treatment of mild to moderate colonic inflammatory bowel diseases. 2012 World J. Gastroenterol. pmid:23049215
Wagner CC et al. Plasma pharmacokinetics and gastrointestinal transit of a new propionyl-L-carnitine controlled release formulation. 2011 Xenobiotica pmid:21810044
Huang Z et al. [Outcomes of patients with combined methylmalonic acidemia and homocystinuria after treatment]. 2013 Zhonghua Er Ke Za Zhi pmid:23751581
Wu SN et al. [Analysis of propionylcarnitine in blood and methylmalonic acid in urine of 162 patients with methylmalonic acidemia]. 2013 Zhonghua Yi Xue Za Zhi pmid:23663331