Dihydrolipoamide

Dihydrolipoamide is a lipid of Fatty Acyls (FA) class. Dihydrolipoamide is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as Citric Acid Cycle, Electron Transport, NADH oxidation, Oxidation and Oxidants. Dihydrolipoamide often locates in Mitochondria, Mitochondrial matrix and Chloroplasts. The associated genes with Dihydrolipoamide are Mutant Proteins, Recombinant Proteins, mycothione reductase, Genes, Mitochondrial and alanylproline.

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Introduction

To understand associated biological information of Dihydrolipoamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Dihydrolipoamide?

Dihydrolipoamide is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Dihydrolipoamide

MeSH term MeSH ID Detail
Parkinsonian Disorders D020734 20 associated lipids
Total 1

PubChem Associated disorders and diseases

What pathways are associated with Dihydrolipoamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with Dihydrolipoamide?

Related references are published most in these journals:

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What functions are associated with Dihydrolipoamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Dihydrolipoamide?

There are no associated biomedical information in the current reference collection.

What genes are associated with Dihydrolipoamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Dihydrolipoamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Dihydrolipoamide

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Authors Title Published Journal PubMed Link
Brautigam CA et al. Subunit and catalytic component stoichiometries of an in vitro reconstituted human pyruvate dehydrogenase complex. 2009 J. Biol. Chem. pmid:19240034
Rajashankar KR et al. Crystal structure and functional analysis of lipoamide dehydrogenase from Mycobacterium tuberculosis. 2005 J. Biol. Chem. pmid:16093239
Sundquist AR and Fahey RC The novel disulfide reductase bis-gamma-glutamylcystine reductase and dihydrolipoamide dehydrogenase from Halobacterium halobium: purification by immobilized-metal-ion affinity chromatography and properties of the enzymes. 1988 J. Bacteriol. pmid:3136140
Gao H et al. The E1beta and E2 subunits of the Bacillus subtilis pyruvate dehydrogenase complex are involved in regulation of sporulation. 2002 J. Bacteriol. pmid:11976308
Shen CJ et al. Proteomic identification of membrane proteins regulating antimicrobial peptide resistance in Vibrio parahaemolyticus. 2010 J. Appl. Microbiol. pmid:19796120
Moraes N et al. NADPH-diaphorase activity and nitric oxide synthase isoforms in the trophoblast of Calomys callosus. 2001 J. Anat. pmid:11327206
Jiang Y and Wang X Comparative mitochondrial proteomics: perspective in human diseases. 2012 J Hematol Oncol pmid:22424240
Packer L and Cadenas E Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling. 2011 J Clin Biochem Nutr pmid:21297908
Vernon SD and Reeves WC Evaluation of autoantibodies to common and neuronal cell antigens in Chronic Fatigue Syndrome. 2005 J Autoimmune Dis pmid:15916704
Barbieri E et al. Morphofunctional and Biochemical Approaches for Studying Mitochondrial Changes during Myoblasts Differentiation. 2011 J Aging Res pmid:21629710
Jeffery CJ Proteins with neomorphic moonlighting functions in disease. 2011 IUBMB Life pmid:21698752
Golas A et al. Sperm mitochondria diaphorase activity--a gene mapping study of recombinant inbred strains of mice. 2010 Int. J. Dev. Biol. pmid:20209439
Ninomiya M et al. PBC: Animal Models of Cholangiopathies and Possible Endogenous Viral Infections. 2012 Int J Hepatol pmid:22007316
Sasaki M and Nakanuma Y Novel approach to bile duct damage in primary biliary cirrhosis: participation of cellular senescence and autophagy. 2012 Int J Hepatol pmid:21994884
Trofimova L et al. Behavioral impact of the regulation of the brain 2-oxoglutarate dehydrogenase complex by synthetic phosphonate analog of 2-oxoglutarate: implications into the role of the complex in neurodegenerative diseases. 2010 Int J Alzheimers Dis pmid:21049004
Chadwick W et al. Complex and multidimensional lipid raft alterations in a murine model of Alzheimer's disease. 2010 Int J Alzheimers Dis pmid:21151659
Kunieda T et al. Carbohydrate metabolism genes and pathways in insects: insights from the honey bee genome. 2006 Insect Mol. Biol. pmid:17069632
Odièvre MH et al. A novel mutation in the dihydrolipoamide dehydrogenase E3 subunit gene (DLD) resulting in an atypical form of alpha-ketoglutarate dehydrogenase deficiency. 2005 Hum. Mutat. pmid:15712224
Mersey BD et al. Human microRNA (miR29b) expression controls the amount of branched chain alpha-ketoacid dehydrogenase complex in a cell. 2005 Hum. Mol. Genet. pmid:16203741
Schlüter A et al. Functional genomic analysis unravels a metabolic-inflammatory interplay in adrenoleukodystrophy. 2012 Hum. Mol. Genet. pmid:22095690
Narisawa A et al. Mutations in genes encoding the glycine cleavage system predispose to neural tube defects in mice and humans. 2012 Hum. Mol. Genet. pmid:22171071
Vasiliou V et al. Update of the NAD(P)H:quinone oxidoreductase (NQO) gene family. 2006 Hum. Genomics pmid:16595077
Ottosson F et al. Genetic variation in three species of Hordeum, and the selection of accessions for the Barley Core Collection. 2002 Hereditas pmid:12564627
Sasaki M and Nakanuma Y Biliary epithelial apoptosis, autophagy, and senescence in primary biliary cirrhosis. 2010 Hepat Res Treat pmid:21152179
Bull TJ et al. A rhodanine agent active against non-replicating intracellular Mycobacterium avium subspecies paratuberculosis. 2009 Gut Pathog pmid:20030828
Griffin JL and Des Rosiers C Applications of metabolomics and proteomics to the mdx mouse model of Duchenne muscular dystrophy: lessons from downstream of the transcriptome. 2009 Genome Med pmid:19341503
Wang N et al. Cloning, expression and characterization of alcohol dehydrogenases in the silkworm Bombyx mori. 2011 Genet. Mol. Biol. pmid:21734824
Kim SY and Kim J Roles of dihydrolipoamide dehydrogenase Lpd1 in Candida albicans filamentation. 2010 Fungal Genet. Biol. pmid:20601046
Finnegan PM and Chen W Arsenic toxicity: the effects on plant metabolism. 2012 Front Physiol pmid:22685440
Sharma A et al. Interactomic and pharmacological insights on human sirt-1. 2012 Front Pharmacol pmid:22470339
Mangold S et al. Sulfur metabolism in the extreme acidophile acidithiobacillus caldus. 2011 Front Microbiol pmid:21687411
Vanguilder HD and Freeman WM The hippocampal neuroproteome with aging and cognitive decline: past progress and future directions. 2011 Front Aging Neurosci pmid:21647399
Gutiérrez-Correa J Trypanosoma cruzi dihydrolipoamide dehydrogenase as target of reactive metabolites generated by cytochrome c/hydrogen peroxide (or linoleic acid hydroperoxide)/phenol systems. 2010 Free Radic. Res. pmid:20815787
Brown SE et al. Targeting lipoic acid to mitochondria: synthesis and characterization of a triphenylphosphonium-conjugated alpha-lipoyl derivative. 2007 Free Radic. Biol. Med. pmid:17512456
Szabados E et al. Enhanced ADP-ribosylation and its diminution by lipoamide after ischemia-reperfusion in perfused rat heart. 1999 Free Radic. Biol. Med. pmid:10569643
Korotchkina LG et al. Protection by thiols of the mitochondrial complexes from 4-hydroxy-2-nonenal. 2001 Free Radic. Biol. Med. pmid:11316579
Batista AP et al. The dihydrolipoamide dehydrogenase from the crenarchaeon Acidianus ambivalens. 2008 FEMS Microbiol. Lett. pmid:18312361
Opperman DJ and van Heerden E A membrane-associated protein with Cr(VI)-reducing activity from Thermus scotoductus SA-01. 2008 FEMS Microbiol. Lett. pmid:18218019
Allen MD and Perham RN The catalytic domain of dihydrolipoyl acetyltransferase from the pyruvate dehydrogenase multienzyme complex of Bacillus stearothermophilus. Expression, purification and reversible denaturation. 1997 FEBS Lett. pmid:9280309
Kareyeva AV et al. Molecular identification of the enzyme responsible for the mitochondrial NADH-supported ammonium-dependent hydrogen peroxide production. 2011 FEBS Lett. pmid:21168410
Bunik VI et al. Brain pyruvate and 2-oxoglutarate dehydrogenase complexes are mitochondrial targets of the CoA ester of the Refsum disease marker phytanic acid. 2006 FEBS Lett. pmid:16737698
Bittel C et al. The oxidant-responsive diaphorase of Rhodobacter capsulatus is a ferredoxin (flavodoxin)-NADP(H) reductase. 2003 FEBS Lett. pmid:14572660
Kleemann R et al. Specific reduction of insulin disulfides by macrophage migration inhibitory factor (MIF) with glutathione and dihydrolipoamide: potential role in cellular redox processes. 1998 FEBS Lett. pmid:9688536
Igamberdiev AU et al. Dihydrolipoamide dehydrogenase from porcine heart catalyzes NADH-dependent scavenging of nitric oxide. 2004 FEBS Lett. pmid:15196936
Stensballe A et al. The amyloplast proteome of potato tuber. 2008 FEBS J. pmid:18331355
Kumar A et al. Redox homeostasis in mycobacteria: the key to tuberculosis control? 2011 Expert Rev Mol Med pmid:22172201
Ono K et al. cDNA cloning of the chicken branched-chain alpha-keto acid dehydrogenase complex. Chicken-specific residues of the acyltransferase affect the overall activity and the interaction with the dehydrogenase. 2001 Eur. J. Biochem. pmid:11168412
Faure M et al. Interaction between the lipoamide-containing H-protein and the lipoamide dehydrogenase (L-protein) of the glycine decarboxylase multienzyme system 2. Crystal structures of H- and L-proteins. 2000 Eur. J. Biochem. pmid:10806386
Tozawa K et al. Solution structure of the lipoyl domain of the chimeric dihydrolipoyl dehydrogenase P64K from Neisseria meningitidis. 2001 Eur. J. Biochem. pmid:11559360
Xia L et al. Reduction of ubiquinone by lipoamide dehydrogenase. An antioxidant regenerating pathway. 2001 Eur. J. Biochem. pmid:11231302