Dihydrolipoamide

Dihydrolipoamide is a lipid of Fatty Acyls (FA) class. Dihydrolipoamide is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as Citric Acid Cycle, Electron Transport, NADH oxidation, Oxidation and Oxidants. Dihydrolipoamide often locates in Mitochondria, Mitochondrial matrix and Chloroplasts. The associated genes with Dihydrolipoamide are Mutant Proteins, Recombinant Proteins, mycothione reductase, Genes, Mitochondrial and alanylproline.

Cross Reference

Introduction

To understand associated biological information of Dihydrolipoamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Dihydrolipoamide?

Dihydrolipoamide is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Dihydrolipoamide

MeSH term MeSH ID Detail
Parkinsonian Disorders D020734 20 associated lipids
Total 1

PubChem Associated disorders and diseases

What pathways are associated with Dihydrolipoamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Dihydrolipoamide?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Dihydrolipoamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Dihydrolipoamide?

There are no associated biomedical information in the current reference collection.

What genes are associated with Dihydrolipoamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Dihydrolipoamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Dihydrolipoamide

Download all related citations
Per page 10 20 50 100 | Total 435
Authors Title Published Journal PubMed Link
Sahlman L and Williams CH Lipoamide dehydrogenase from Escherichia coli. Steady-state kinetics of the physiological reaction. 1989 J. Biol. Chem. pmid:2498307
Brautigam CA et al. Structural and thermodynamic basis for weak interactions between dihydrolipoamide dehydrogenase and subunit-binding domain of the branched-chain alpha-ketoacid dehydrogenase complex. 2011 J. Biol. Chem. pmid:21543315
Hall BS et al. Nifurtimox activation by trypanosomal type I nitroreductases generates cytotoxic nitrile metabolites. 2011 J. Biol. Chem. pmid:21345801
Vaubel RA et al. Mutations in the dimer interface of dihydrolipoamide dehydrogenase promote site-specific oxidative damages in yeast and human cells. 2011 J. Biol. Chem. pmid:21930696
Smolle M et al. A new level of architectural complexity in the human pyruvate dehydrogenase complex. 2006 J. Biol. Chem. pmid:16679318
Foster MW and Stamler JS New insights into protein S-nitrosylation. Mitochondria as a model system. 2004 J. Biol. Chem. pmid:15069080
Petrat F et al. Reduction of Fe(III) ions complexed to physiological ligands by lipoyl dehydrogenase and other flavoenzymes in vitro: implications for an enzymatic reduction of Fe(III) ions of the labile iron pool. 2003 J. Biol. Chem. pmid:12963736
Rahmatullah M and Roche TE Component requirements for NADH inhibition and spermine stimulation of pyruvate dehydrogenaseb phosphatase activity. 1988 J. Biol. Chem. pmid:2836411
Hiromasa Y et al. Organization of the cores of the mammalian pyruvate dehydrogenase complex formed by E2 and E2 plus the E3-binding protein and their capacities to bind the E1 and E3 components. 2004 J. Biol. Chem. pmid:14638692
MacDonald MJ et al. Immunochemical identification of coenzyme Q0-dihydrolipoamide adducts in the E2 components of the alpha-ketoglutarate and pyruvate dehydrogenase complexes partially explains the cellular toxicity of coenzyme Q0. 2004 J. Biol. Chem. pmid:15075342
Chi F et al. Identification of IbeR as a stationary-phase regulator in meningitic Escherichia coli K1 that carries a loss-of-function mutation in rpoS. 2009 J. Biomed. Biotechnol. pmid:19300523
Raddatz G and Bisswanger H Receptor site and stereospecifity of dihydrolipoamide dehydrogenase for R- and S-lipoamide: a molecular modeling study. 1997 J. Biotechnol. pmid:9383983
Li M et al. Effect of lpdA gene knockout on the metabolism in Escherichia coli based on enzyme activities, intracellular metabolite concentrations and metabolic flux analysis by 13C-labeling experiments. 2006 J. Biotechnol. pmid:16310273
Deres P et al. Prevention of doxorubicin-induced acute cardiotoxicity by an experimental antioxidant compound. 2005 J. Cardiovasc. Pharmacol. pmid:15613977
Li W et al. Proteomic analysis of metabolic, cytoskeletal and stress response proteins in human heart failure. 2012 J. Cell. Mol. Med. pmid:21545686
Deghmane AE et al. Lipoamide dehydrogenase mediates retention of coronin-1 on BCG vacuoles, leading to arrest in phagosome maturation. 2007 J. Cell. Sci. pmid:17652161
Thangthaeng N et al. Nongradient blue native gel analysis of serum proteins and in-gel detection of serum esterase activities. 2011 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:21237726
Goswami A and Rosenberg IN Iodothyronine 5'-deiodinase in rat kidney microsomes. Kinetic behavior at low substrate concentrations. 1984 J. Clin. Invest. pmid:6439742
Olsson C Distribution and effects of PACAP, VIP, nitric oxide and GABA in the gut of the African clawed frog Xenopus laevis. 2002 J. Exp. Biol. pmid:11919271
Broughton BR and Donald JA Nitric oxide regulation of the central aortae of the toad Bufo marinus occurs independently of the endothelium. 2002 J. Exp. Biol. pmid:12200412
Ortega-Galisteo AP et al. S-Nitrosylated proteins in pea (Pisum sativum L.) leaf peroxisomes: changes under abiotic stress. 2012 J. Exp. Bot. pmid:22213812
Schriek S et al. Detection of an L-amino acid dehydrogenase activity in Synechocystis sp. PCC 6803. 2009 J. Exp. Bot. pmid:19213808
Aranjuelo I et al. Plant physiology and proteomics reveals the leaf response to drought in alfalfa (Medicago sativa L.). 2011 J. Exp. Bot. pmid:20797998
Vasquez-Robinet C et al. Physiological and molecular adaptations to drought in Andean potato genotypes. 2008 J. Exp. Bot. pmid:18535297
Norton GJ et al. Rice-arsenate interactions in hydroponics: whole genome transcriptional analysis. 2008 J. Exp. Bot. pmid:18453530
Katz E et al. Label-free shotgun proteomics and metabolite analysis reveal a significant metabolic shift during citrus fruit development. 2011 J. Exp. Bot. pmid:21841177
Hallström T et al. Dihydrolipoamide dehydrogenase of Pseudomonas aeruginosa is a surface-exposed immune evasion protein that binds three members of the factor H family and plasminogen. 2012 J. Immunol. pmid:23071278
Quintana E et al. Dihydrolipoamide dehydrogenase (DLD) deficiency in a Spanish patient with myopathic presentation due to a new mutation in the interface domain. 2010 J. Inherit. Metab. Dis. pmid:20652410
Lee EH et al. A Korean female patient with thiamine-responsive pyruvate dehydrogenase complex deficiency due to a novel point mutation (Y161C)in the PDHA1 gene. 2006 J. Korean Med. Sci. pmid:17043409
Gerards M et al. Defective complex I assembly due to C20orf7 mutations as a new cause of Leigh syndrome. 2010 J. Med. Genet. pmid:19542079
Brautigam CA et al. Crystal structure of human dihydrolipoamide dehydrogenase: NAD+/NADH binding and the structural basis of disease-causing mutations. 2005 J. Mol. Biol. pmid:15946682
Vijayakrishnan S et al. Solution structure and characterisation of the human pyruvate dehydrogenase complex core assembly. 2010 J. Mol. Biol. pmid:20361979
MacGregor P and Matthews KR New discoveries in the transmission biology of sleeping sickness parasites: applying the basics. 2010 J. Mol. Med. pmid:20526573
Ambrus A et al. Inhibition of the alpha-ketoglutarate dehydrogenase-mediated reactive oxygen species generation by lipoic acid. 2009 J. Neurochem. pmid:19393031
Katsuki H et al. Superoxide dismutase activity in organotypic midbrain-striatum co-cultures is associated with resistance of dopaminergic neurons to excitotoxicity. 2001 J. Neurochem. pmid:11238718
Klivenyi P et al. Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3-nitropropionic acid neurotoxicity. 2004 J. Neurochem. pmid:15009635
Starkov AA et al. Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species. 2004 J. Neurosci. pmid:15356189
Ramos EI et al. 2,3-diphenyl-1,4-naphthoquinone: a potential chemotherapeutic agent against Trypanosoma cruzi. 2009 J. Parasitol. pmid:18788881
Campanucci VA et al. A novel O2-sensing mechanism in rat glossopharyngeal neurones mediated by a halothane-inhibitable background K+ conductance. 2003 J. Physiol. (Lond.) pmid:12640017
Holbrook ED et al. Definition of the extracellular proteome of pathogenic-phase Histoplasma capsulatum. 2011 J. Proteome Res. pmid:21291285
Shaco-Levy R et al. On appropriate pathology for photothermal surgery. 2004 Lasers Surg Med pmid:15278925
Koti RS et al. Effect of ischemic preconditioning on hepatic microcirculation and function in a rat model of ischemia reperfusion injury. 2002 Liver Transpl. pmid:12474159
Chavarría M et al. Regulatory tasks of the phosphoenolpyruvate-phosphotransferase system of Pseudomonas putida in central carbon metabolism. 2012 MBio pmid:22434849
Yan LJ et al. Changes in dihydrolipoamide dehydrogenase expression and activity during postnatal development and aging in the rat brain. 2008 Mech. Ageing Dev. pmid:18316113
Patel MS et al. Dihydrolipoamide dehydrogenase: activity assays. 1995 Meth. Enzymol. pmid:7476353
Patel MS and Hong YS Lipoic acid as an antioxidant. The role of dihydrolipoamide dehydrogenase. 1998 Methods Mol. Biol. pmid:9921542
Gallo G et al. Differential proteomic analysis highlights metabolic strategies associated with balhimycin production in Amycolatopsis balhimycina chemostat cultivations. 2010 Microb. Cell Fact. pmid:21110849
Lu X et al. The intra- and extracellular proteome of Aspergillus niger growing on defined medium with xylose or maltose as carbon substrate. 2010 Microb. Cell Fact. pmid:20406453
Peano C et al. Comparative genomics and transcriptional profiles of Saccharopolyspora erythraea NRRL 2338 and a classically improved erythromycin over-producing strain. 2012 Microb. Cell Fact. pmid:22401291
Yao R et al. Catabolic regulation analysis of Escherichia coli and its crp, mlc, mgsA, pgi and ptsG mutants. 2011 Microb. Cell Fact. pmid:21831320