Dihydrolipoamide

Dihydrolipoamide is a lipid of Fatty Acyls (FA) class. Dihydrolipoamide is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as Citric Acid Cycle, Electron Transport, NADH oxidation, Oxidation and Oxidants. Dihydrolipoamide often locates in Mitochondria, Mitochondrial matrix and Chloroplasts. The associated genes with Dihydrolipoamide are Mutant Proteins, Recombinant Proteins, mycothione reductase, Genes, Mitochondrial and alanylproline.

Cross Reference

Introduction

To understand associated biological information of Dihydrolipoamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Dihydrolipoamide?

Dihydrolipoamide is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Dihydrolipoamide

MeSH term MeSH ID Detail
Parkinsonian Disorders D020734 20 associated lipids
Total 1

PubChem Associated disorders and diseases

What pathways are associated with Dihydrolipoamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Dihydrolipoamide?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Dihydrolipoamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Dihydrolipoamide?

There are no associated biomedical information in the current reference collection.

What genes are associated with Dihydrolipoamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Dihydrolipoamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Dihydrolipoamide

Download all related citations
Per page 10 20 50 100 | Total 435
Authors Title Published Journal PubMed Link
Rodrigues DF et al. Architecture of thermal adaptation in an Exiguobacterium sibiricum strain isolated from 3 million year old permafrost: a genome and transcriptome approach. 2008 BMC Genomics pmid:19019206
Cruz-García C et al. Fnr (EtrA) acts as a fine-tuning regulator of anaerobic metabolism in Shewanella oneidensis MR-1. 2011 BMC Microbiol. pmid:21450087
Folsom JP et al. Physiology of Pseudomonas aeruginosa in biofilms as revealed by transcriptome analysis. 2010 BMC Microbiol. pmid:21083928
He M et al. Characterization and genomic analysis of chromate resistant and reducing Bacillus cereus strain SJ1. 2010 BMC Microbiol. pmid:20723231
Ma M and Liu LZ Quantitative transcription dynamic analysis reveals candidate genes and key regulators for ethanol tolerance in Saccharomyces cerevisiae. 2010 BMC Microbiol. pmid:20537179
McLeod A et al. Global transcriptome response in Lactobacillus sakei during growth on ribose. 2011 BMC Microbiol. pmid:21702908
Li M et al. AI-2-dependent gene regulation in Staphylococcus epidermidis. 2008 BMC Microbiol. pmid:18182108
Vilei EM et al. Beta-D-glucoside utilization by Mycoplasma mycoides subsp. mycoides SC: possible involvement in the control of cytotoxicity towards bovine lung cells. 2007 BMC Microbiol. pmid:17439646
Jordan P et al. Diversity in coding tandem repeats in related Neisseria spp. 2003 BMC Microbiol. pmid:14611665
Laia ML et al. New genes of Xanthomonas citri subsp. citri involved in pathogenesis and adaptation revealed by a transposon-based mutant library. 2009 BMC Microbiol. pmid:19149882
Geisler DA et al. Antimycin A treatment decreases respiratory internal rotenone-insensitive NADH oxidation capacity in potato leaves. 2004 BMC Plant Biol. pmid:15140267
Smith AC and Robinson AJ A metabolic model of the mitochondrion and its use in modelling diseases of the tricarboxylic acid cycle. 2011 BMC Syst Biol pmid:21714867
Sun J et al. Constraint-based modeling analysis of the metabolism of two Pelobacter species. 2010 BMC Syst Biol pmid:21182788
Stobbe MD et al. Critical assessment of human metabolic pathway databases: a stepping stone for future integration. 2011 BMC Syst Biol pmid:21999653
Zaman G et al. Loading-related regulation of gene expression in bone in the contexts of estrogen deficiency, lack of estrogen receptor alpha and disuse. 2010 Bone pmid:19857613
Richardson AR et al. Multiple targets of nitric oxide in the tricarboxylic acid cycle of Salmonella enterica serovar typhimurium. 2011 Cell Host Microbe pmid:21767810
Venugopal A et al. Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes. 2011 Cell Host Microbe pmid:21238944
Chen HJ et al. Lipoyl dehydrogenase catalyzes reduction of nitrated DNA and protein adducts using dihydrolipoic acid or ubiquinol as the cofactor. 2002 Chem. Biol. Interact. pmid:12204577
Becker DM et al. Optimal conditions for the assay of lipoamide dehydrogenase in homogenized human platelets. 1982 Clin. Chim. Acta pmid:6805984
Zuñiga J et al. Cellular and humoral mechanisms involved in the control of tuberculosis. 2012 Clin. Dev. Immunol. pmid:22666281
Wu YY et al. Proteinase 3 and dihydrolipoamide dehydrogenase (E3) are major autoantigens in hepatitis C virus (HCV) infection. 2002 Clin. Exp. Immunol. pmid:11985526
Cicek G et al. Analysis of mitochondrial antigens reveals inner membrane succinate dehydrogenase flavoprotein subunit as autoantigen to antibodies in anti-M7 sera. 2002 Clin. Exp. Immunol. pmid:11982594
Marie SK and Shinjo SM Metabolism and brain cancer. 2011 Clinics (Sao Paulo) pmid:21779721
Min CK et al. Genome-based construction of the metabolic pathways of Orientia tsutsugamushi and comparative analysis within the Rickettsiales order. 2008 Comp. Funct. Genomics pmid:18528528
Keyes BE and Burke DJ Irc15 Is a microtubule-associated protein that regulates microtubule dynamics in Saccharomyces cerevisiae. 2009 Curr. Biol. pmid:19285398
Brown RM et al. Pyruvate dehydrogenase E3 binding protein (protein X) deficiency. 2006 Dev Med Child Neurol pmid:16904023
Phelps PE et al. Evidence for a cell-specific action of Reelin in the spinal cord. 2002 Dev. Biol. pmid:11900467
Pang S et al. Regulation of fasting fuel metabolism by toll-like receptor 4. 2010 Diabetes pmid:20855545
Yan LJ et al. Histochemical staining and quantification of dihydrolipoamide dehydrogenase diaphorase activity using blue native PAGE. 2007 Electrophoresis pmid:17315258
Kato M et al. A synchronized substrate-gating mechanism revealed by cubic-core structure of the bovine branched-chain alpha-ketoacid dehydrogenase complex. 2006 EMBO J. pmid:17124494
Sawada K et al. Cytosolic cofactors and dihydrolipoamide stimulate hepatic microsomal 5'-deiodination. 1985 Endocrinology pmid:3926468
Goswami A and Rosenberg IN Stimulation of iodothyronine outer ring monodeiodinase by dihydrolipoamide. 1983 Endocrinology pmid:6187559
Hirani TA et al. Asp295 stabilizes the active-site loop structure of pyruvate dehydrogenase, facilitating phosphorylation of ser292 by pyruvate dehydrogenase-kinase. 2011 Enzyme Res pmid:21318135
Mukherjee M et al. Proteins of the glycine decarboxylase complex in the hydrogenosome of Trichomonas vaginalis. 2006 Eukaryotic Cell pmid:17158739
Ono K et al. cDNA cloning of the chicken branched-chain alpha-keto acid dehydrogenase complex. Chicken-specific residues of the acyltransferase affect the overall activity and the interaction with the dehydrogenase. 2001 Eur. J. Biochem. pmid:11168412
Faure M et al. Interaction between the lipoamide-containing H-protein and the lipoamide dehydrogenase (L-protein) of the glycine decarboxylase multienzyme system 2. Crystal structures of H- and L-proteins. 2000 Eur. J. Biochem. pmid:10806386
Bonomi F and Pagani S Removal of ferritin-bound iron by DL-dihydrolipoate and DL-dihydrolipoamide. 1986 Eur. J. Biochem. pmid:3082624
Tozawa K et al. Solution structure of the lipoyl domain of the chimeric dihydrolipoyl dehydrogenase P64K from Neisseria meningitidis. 2001 Eur. J. Biochem. pmid:11559360
Xia L et al. Reduction of ubiquinone by lipoamide dehydrogenase. An antioxidant regenerating pathway. 2001 Eur. J. Biochem. pmid:11231302
Kumar A et al. Redox homeostasis in mycobacteria: the key to tuberculosis control? 2011 Expert Rev Mol Med pmid:22172201
Stensballe A et al. The amyloplast proteome of potato tuber. 2008 FEBS J. pmid:18331355
Allen MD and Perham RN The catalytic domain of dihydrolipoyl acetyltransferase from the pyruvate dehydrogenase multienzyme complex of Bacillus stearothermophilus. Expression, purification and reversible denaturation. 1997 FEBS Lett. pmid:9280309
Kareyeva AV et al. Molecular identification of the enzyme responsible for the mitochondrial NADH-supported ammonium-dependent hydrogen peroxide production. 2011 FEBS Lett. pmid:21168410
Bunik VI et al. Brain pyruvate and 2-oxoglutarate dehydrogenase complexes are mitochondrial targets of the CoA ester of the Refsum disease marker phytanic acid. 2006 FEBS Lett. pmid:16737698
Bittel C et al. The oxidant-responsive diaphorase of Rhodobacter capsulatus is a ferredoxin (flavodoxin)-NADP(H) reductase. 2003 FEBS Lett. pmid:14572660
Kleemann R et al. Specific reduction of insulin disulfides by macrophage migration inhibitory factor (MIF) with glutathione and dihydrolipoamide: potential role in cellular redox processes. 1998 FEBS Lett. pmid:9688536
Igamberdiev AU et al. Dihydrolipoamide dehydrogenase from porcine heart catalyzes NADH-dependent scavenging of nitric oxide. 2004 FEBS Lett. pmid:15196936
Batista AP et al. The dihydrolipoamide dehydrogenase from the crenarchaeon Acidianus ambivalens. 2008 FEMS Microbiol. Lett. pmid:18312361
Opperman DJ and van Heerden E A membrane-associated protein with Cr(VI)-reducing activity from Thermus scotoductus SA-01. 2008 FEMS Microbiol. Lett. pmid:18218019
Brown SE et al. Targeting lipoic acid to mitochondria: synthesis and characterization of a triphenylphosphonium-conjugated alpha-lipoyl derivative. 2007 Free Radic. Biol. Med. pmid:17512456
Szabados E et al. Enhanced ADP-ribosylation and its diminution by lipoamide after ischemia-reperfusion in perfused rat heart. 1999 Free Radic. Biol. Med. pmid:10569643
Korotchkina LG et al. Protection by thiols of the mitochondrial complexes from 4-hydroxy-2-nonenal. 2001 Free Radic. Biol. Med. pmid:11316579
Gutiérrez-Correa J Trypanosoma cruzi dihydrolipoamide dehydrogenase as target of reactive metabolites generated by cytochrome c/hydrogen peroxide (or linoleic acid hydroperoxide)/phenol systems. 2010 Free Radic. Res. pmid:20815787
Vanguilder HD and Freeman WM The hippocampal neuroproteome with aging and cognitive decline: past progress and future directions. 2011 Front Aging Neurosci pmid:21647399
Mangold S et al. Sulfur metabolism in the extreme acidophile acidithiobacillus caldus. 2011 Front Microbiol pmid:21687411
Sharma A et al. Interactomic and pharmacological insights on human sirt-1. 2012 Front Pharmacol pmid:22470339
Finnegan PM and Chen W Arsenic toxicity: the effects on plant metabolism. 2012 Front Physiol pmid:22685440
Kim SY and Kim J Roles of dihydrolipoamide dehydrogenase Lpd1 in Candida albicans filamentation. 2010 Fungal Genet. Biol. pmid:20601046
Wang N et al. Cloning, expression and characterization of alcohol dehydrogenases in the silkworm Bombyx mori. 2011 Genet. Mol. Biol. pmid:21734824
Griffin JL and Des Rosiers C Applications of metabolomics and proteomics to the mdx mouse model of Duchenne muscular dystrophy: lessons from downstream of the transcriptome. 2009 Genome Med pmid:19341503
Bull TJ et al. A rhodanine agent active against non-replicating intracellular Mycobacterium avium subspecies paratuberculosis. 2009 Gut Pathog pmid:20030828
Sasaki M and Nakanuma Y Biliary epithelial apoptosis, autophagy, and senescence in primary biliary cirrhosis. 2010 Hepat Res Treat pmid:21152179
Ottosson F et al. Genetic variation in three species of Hordeum, and the selection of accessions for the Barley Core Collection. 2002 Hereditas pmid:12564627
Vasiliou V et al. Update of the NAD(P)H:quinone oxidoreductase (NQO) gene family. 2006 Hum. Genomics pmid:16595077
Mersey BD et al. Human microRNA (miR29b) expression controls the amount of branched chain alpha-ketoacid dehydrogenase complex in a cell. 2005 Hum. Mol. Genet. pmid:16203741
Schlüter A et al. Functional genomic analysis unravels a metabolic-inflammatory interplay in adrenoleukodystrophy. 2012 Hum. Mol. Genet. pmid:22095690
Narisawa A et al. Mutations in genes encoding the glycine cleavage system predispose to neural tube defects in mice and humans. 2012 Hum. Mol. Genet. pmid:22171071
Odièvre MH et al. A novel mutation in the dihydrolipoamide dehydrogenase E3 subunit gene (DLD) resulting in an atypical form of alpha-ketoglutarate dehydrogenase deficiency. 2005 Hum. Mutat. pmid:15712224
Kunieda T et al. Carbohydrate metabolism genes and pathways in insects: insights from the honey bee genome. 2006 Insect Mol. Biol. pmid:17069632
Trofimova L et al. Behavioral impact of the regulation of the brain 2-oxoglutarate dehydrogenase complex by synthetic phosphonate analog of 2-oxoglutarate: implications into the role of the complex in neurodegenerative diseases. 2010 Int J Alzheimers Dis pmid:21049004
Chadwick W et al. Complex and multidimensional lipid raft alterations in a murine model of Alzheimer's disease. 2010 Int J Alzheimers Dis pmid:21151659
Ninomiya M et al. PBC: Animal Models of Cholangiopathies and Possible Endogenous Viral Infections. 2012 Int J Hepatol pmid:22007316
Sasaki M and Nakanuma Y Novel approach to bile duct damage in primary biliary cirrhosis: participation of cellular senescence and autophagy. 2012 Int J Hepatol pmid:21994884
Golas A et al. Sperm mitochondria diaphorase activity--a gene mapping study of recombinant inbred strains of mice. 2010 Int. J. Dev. Biol. pmid:20209439
Jeffery CJ Proteins with neomorphic moonlighting functions in disease. 2011 IUBMB Life pmid:21698752
Barbieri E et al. Morphofunctional and Biochemical Approaches for Studying Mitochondrial Changes during Myoblasts Differentiation. 2011 J Aging Res pmid:21629710
Vernon SD and Reeves WC Evaluation of autoantibodies to common and neuronal cell antigens in Chronic Fatigue Syndrome. 2005 J Autoimmune Dis pmid:15916704
Packer L and Cadenas E Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling. 2011 J Clin Biochem Nutr pmid:21297908
Jiang Y and Wang X Comparative mitochondrial proteomics: perspective in human diseases. 2012 J Hematol Oncol pmid:22424240
Moraes N et al. NADPH-diaphorase activity and nitric oxide synthase isoforms in the trophoblast of Calomys callosus. 2001 J. Anat. pmid:11327206
Shen CJ et al. Proteomic identification of membrane proteins regulating antimicrobial peptide resistance in Vibrio parahaemolyticus. 2010 J. Appl. Microbiol. pmid:19796120
Sundquist AR and Fahey RC The novel disulfide reductase bis-gamma-glutamylcystine reductase and dihydrolipoamide dehydrogenase from Halobacterium halobium: purification by immobilized-metal-ion affinity chromatography and properties of the enzymes. 1988 J. Bacteriol. pmid:3136140
Gao H et al. The E1beta and E2 subunits of the Bacillus subtilis pyruvate dehydrogenase complex are involved in regulation of sporulation. 2002 J. Bacteriol. pmid:11976308
Matthews RG A love affair with vitamins. 2009 J. Biol. Chem. pmid:19596855
Brautigam CA et al. Structural and thermodynamic basis for weak interactions between dihydrolipoamide dehydrogenase and subunit-binding domain of the branched-chain alpha-ketoacid dehydrogenase complex. 2011 J. Biol. Chem. pmid:21543315
Hall BS et al. Nifurtimox activation by trypanosomal type I nitroreductases generates cytotoxic nitrile metabolites. 2011 J. Biol. Chem. pmid:21345801
Vaubel RA et al. Mutations in the dimer interface of dihydrolipoamide dehydrogenase promote site-specific oxidative damages in yeast and human cells. 2011 J. Biol. Chem. pmid:21930696
Islam MM et al. A novel branched-chain amino acid metabolon. Protein-protein interactions in a supramolecular complex. 2007 J. Biol. Chem. pmid:17314104
Ciszak EM et al. How dihydrolipoamide dehydrogenase-binding protein binds dihydrolipoamide dehydrogenase in the human pyruvate dehydrogenase complex. 2006 J. Biol. Chem. pmid:16263718
Mitra K et al. Novelty of the pyruvate metabolic enzyme dihydrolipoamide dehydrogenase in spermatozoa: correlation of its localization, tyrosine phosphorylation, and activity during sperm capacitation. 2005 J. Biol. Chem. pmid:15888450
Sauer SW et al. Bioenergetics in glutaryl-coenzyme A dehydrogenase deficiency: a role for glutaryl-coenzyme A. 2005 J. Biol. Chem. pmid:15840571
Li XJ et al. Crucial role of two potential cytosolic regions of Nox2, 191TSSTKTIRRS200 and 484DESQANHFAVHHDEEKD500, on NADPH oxidase activation. 2005 J. Biol. Chem. pmid:15684431
O'Connor TP et al. 13C nuclear magnetic resonance study of the pyruvate dehydrogenase-catalyzed acetylation of dihydrolipoamide. 1982 J. Biol. Chem. pmid:6801041
Pessach I et al. Essential requirement of cytosolic phospholipase A(2) for stimulation of NADPH oxidase-associated diaphorase activity in granulocyte-like cells. 2001 J. Biol. Chem. pmid:11432850
HÃ¥kansson AP and Smith AW Enzymatic characterization of dihydrolipoamide dehydrogenase from Streptococcus pneumoniae harboring its own substrate. 2007 J. Biol. Chem. pmid:17690105
Rajashankar KR et al. Crystal structure and functional analysis of lipoamide dehydrogenase from Mycobacterium tuberculosis. 2005 J. Biol. Chem. pmid:16093239
Klyachko NL et al. pH-dependent substrate preference of pig heart lipoamide dehydrogenase varies with oligomeric state: response to mitochondrial matrix acidification. 2005 J. Biol. Chem. pmid:15710613
Argyrou A et al. Characterization of a new member of the flavoprotein disulfide reductase family of enzymes from Mycobacterium tuberculosis. 2004 J. Biol. Chem. pmid:15456792
Rocheleau JV et al. Quantitative NAD(P)H/flavoprotein autofluorescence imaging reveals metabolic mechanisms of pancreatic islet pyruvate response. 2004 J. Biol. Chem. pmid:15148320
Gazaryan IG et al. Zinc is a potent inhibitor of thiol oxidoreductase activity and stimulates reactive oxygen species production by lipoamide dehydrogenase. 2002 J. Biol. Chem. pmid:11744691