lysophosphatidic acid

lysophosphatidic acid is a lipid of Glycerophospholipids (GP) class. Lysophosphatidic acid is associated with abnormalities such as Atherosclerosis, Alzheimer's Disease, Asthma, Diabetes Mellitus, Non-Insulin-Dependent and Septicemia. The involved functions are known as Inflammation, Chemotaxis, Binding (Molecular Function), Polymerization and Inflammatory Response. Lysophosphatidic acid often locates in Cytoskeleton, Microfilaments, actin cytoskeleton, Extracellular and Structure of germinal center of lymph node. The associated genes with lysophosphatidic acid are TNF gene, MAPK3 gene, RHOA gene, CDC42 gene and ADRBK1 gene. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Lysophosphatidylcholines, Lysophospholipids and Phosphatidic Acid. The related experimental models are Knock-out, Transgenic Model, Rodent Model and Disease model.

Cross Reference

Introduction

To understand associated biological information of lysophosphatidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with lysophosphatidic acid?

lysophosphatidic acid is suspected in Atherosclerosis, Asthma, Dyslipidemias, Acute coronary syndrome, Pulmonary Fibrosis, Atherosclerosis of aorta and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with lysophosphatidic acid

MeSH term MeSH ID Detail
Atherosclerosis D050197 85 associated lipids
Plaque, Atherosclerotic D058226 7 associated lipids
Insulin Resistance D007333 99 associated lipids
Blister D001768 16 associated lipids
Neoplasm Invasiveness D009361 23 associated lipids
Adenomatous Polyposis Coli D011125 16 associated lipids
Carcinoma, Embryonal D018236 8 associated lipids
Cell Transformation, Viral D002472 26 associated lipids
Neoplasms, Glandular and Epithelial D009375 12 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with lysophosphatidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with lysophosphatidic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with lysophosphatidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with lysophosphatidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with lysophosphatidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with lysophosphatidic acid?

Knock-out

Knock-out are used in the study 'Source and role of intestinally derived lysophosphatidic acid in dyslipidemia and atherosclerosis.' (Navab M et al., 2015) and Knock-out are used in the study 'Lysophospholipid mediators in the vasculature.' (Mueller P et al., 2015).

Transgenic Model

Transgenic Model are used in the study 'Lysophosphatidic acid inhibits CD8 T cell activation and control of tumor progression.' (Oda SK et al., 2013).

Rodent Model

Rodent Model are used in the study 'Lysophosphatidic acid mediates fibrosis in injured joints by regulating collagen type I biosynthesis.' (Wu L et al., 2015).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with lysophosphatidic acid

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Authors Title Published Journal PubMed Link
Sun R et al. Different effects of lysophosphatidic acid on L-type calcium current in neonatal rat ventricular myocytes with and without H2O2 treatment. Prostaglandins Other Lipid Mediat. pmid:25841350