| MeSH term | MeSH ID | Detail |
|---|---|---|
| Tuberculosis | D014376 | 20 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Ovarian Neoplasms | D010051 | 10 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
lysophosphatidic acid
lysophosphatidic acid is a lipid of Glycerophospholipids (GP) class. Lysophosphatidic acid is associated with abnormalities such as Atherosclerosis, Alzheimer's Disease, Asthma, Diabetes Mellitus, Non-Insulin-Dependent and Septicemia. The involved functions are known as Inflammation, Chemotaxis, Binding (Molecular Function), Polymerization and Inflammatory Response. Lysophosphatidic acid often locates in Cytoskeleton, Microfilaments, actin cytoskeleton, Extracellular and Structure of germinal center of lymph node. The associated genes with lysophosphatidic acid are TNF gene, MAPK3 gene, RHOA gene, CDC42 gene and ADRBK1 gene. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Lysophosphatidylcholines, Lysophospholipids and Phosphatidic Acid. The related experimental models are Knock-out, Transgenic Model, Rodent Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of lysophosphatidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lysophosphatidic acid?
lysophosphatidic acid is suspected in Atherosclerosis, Asthma, Dyslipidemias, Acute coronary syndrome, Pulmonary Fibrosis, Atherosclerosis of aorta and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lysophosphatidic acid
PubChem Associated disorders and diseases
What pathways are associated with lysophosphatidic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lysophosphatidic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lysophosphatidic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with lysophosphatidic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with lysophosphatidic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lysophosphatidic acid?
Knock-out
Knock-out are used in the study 'Source and role of intestinally derived lysophosphatidic acid in dyslipidemia and atherosclerosis.' (Navab M et al., 2015) and Knock-out are used in the study 'Lysophospholipid mediators in the vasculature.' (Mueller P et al., 2015).
Transgenic Model
Transgenic Model are used in the study 'Lysophosphatidic acid inhibits CD8 T cell activation and control of tumor progression.' (Oda SK et al., 2013).
Rodent Model
Rodent Model are used in the study 'Lysophosphatidic acid mediates fibrosis in injured joints by regulating collagen type I biosynthesis.' (Wu L et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lysophosphatidic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wang J et al. | Plasma lipidomic signatures of spontaneous obese rhesus monkeys. | 2019 | Lipids Health Dis | pmid:30621707 |
| Lei L et al. | The role of lysophosphatidic acid in the physiology and pathology of the skin. | 2019 | Life Sci. | pmid:30584899 |
| Yang F and Chen GX | Production of extracellular lysophosphatidic acid in the regulation of adipocyte functions and liver fibrosis. | 2018 | World J. Gastroenterol. | pmid:30271079 |
| Honjo M et al. | Autotaxin-Lysophosphatidic Acid Pathway in Intraocular Pressure Regulation and Glaucoma Subtypes. | 2018 | Invest. Ophthalmol. Vis. Sci. | pmid:29392315 |
| Schmid R et al. | ADSCs and adipocytes are the main producers in the autotaxin-lysophosphatidic acid axis of breast cancer and healthy mammary tissue in vitro. | 2018 | BMC Cancer | pmid:30567518 |
| Esmaeili A and Namazi S | Is melatonin effective for pruritus caused by liver disease? | 2018 | Med. Hypotheses | pmid:30396475 |
| Inoue M et al. | Addition of high load of lysophosphatidic acid to standard and high-fat chows causes no significant changes of its circulating and peripheral tissue levels but affects body weight and visceral fat mass of mice. | 2018 | Biofactors | pmid:30368958 |
| Srikanth M et al. | Lysophosphatidic acid and its receptor LPA mediate carrageenan induced inflammatory pain in mice. | 2018 | Eur. J. Pharmacol. | pmid:30321532 |
| Huang YL et al. | High Glucose Induces VEGF-C Expression via the LPA1/3-Akt-ROS-LEDGF Signaling Axis in Human Prostate Cancer PC-3 Cells. | 2018 | Cell. Physiol. Biochem. | pmid:30317243 |
| Thompson KE et al. | Prevention and treatment of secretory diarrhea by the lysophosphatidic acid analog Rx100. | 2018 | Exp. Biol. Med. (Maywood) | pmid:30253666 |
| Kurabayashi N et al. | The LPA-LPA4 axis is required for establishment of bipolar morphology and radial migration of newborn cortical neurons. | 2018 | Development | pmid:30217809 |
| Ninou I et al. | Pharmacologic targeting of the ATX/LPA axis attenuates bleomycin-induced pulmonary fibrosis. | 2018 | Pulm Pharmacol Ther | pmid:30201409 |
| Lidgerwood GE et al. | Roles of lysophosphatidic acid and sphingosine-1-phosphate in stem cell biology. | 2018 | Prog. Lipid Res. | pmid:30196008 |
| Gokul C et al. | Lysophosphatidic acid enhances PGE2 to PGF2α ratio and nitric oxide level in nonpregnant buffalo uterus. | 2018 | Theriogenology | pmid:30092374 |
| Neary G et al. | Development and biological evaluation of fluorophosphonate-modified hydroxyapatite for orthopaedic applications. | 2018 | J Mater Sci Mater Med | pmid:30032456 |
| Onallah H et al. | Activity and clinical relevance of autotaxin and lysophosphatidic acid pathways in high-grade serous carcinoma. | 2018 | Virchows Arch. | pmid:30032361 |
| Fukasawa K et al. | Qualitative and quantitative comparison of cyclic phosphatidic acid and its related lipid species in rat serum using hydrophilic interaction liquid chromatography with tandem-mass spectrometry. | 2018 | J Chromatogr A | pmid:30017223 |
| Zhou ZB et al. | Lysophosphatidic Acid Promotes Expression and Activation of Matrix Metalloproteinase 9 (MMP9) in THP-1 Cells via Toll-Like Receptor 4/Nuclear Factor-κB (TLR4/NF-κB) Signaling Pathway. | 2018 | Med. Sci. Monit. | pmid:30005060 |
| Zhu X et al. | Early development of porcine parthenogenetic embryos and reduced expression of primed pluripotent marker genes under the effect of lysophosphatidic acid. | 2018 | Reprod. Domest. Anim. | pmid:29974990 |
| Broström JM et al. | Toluene diisocyanate exposure and autotaxin-lysophosphatidic acid signalling. | 2018 | Toxicol. Appl. Pharmacol. | pmid:29940203 |
| Ueda H et al. | Involvement of lysophosphatidic acid-induced astrocyte activation underlying the maintenance of partial sciatic nerve injury-induced neuropathic pain. | 2018 | Pain | pmid:29939962 |
| Ramesh S et al. | Autotaxinâ»Lysophosphatidic Acid Signaling in Alzheimer's Disease. | 2018 | Int J Mol Sci | pmid:29933579 |
| Jing X et al. | Proliferation and differentiation of rat adipose‑derived stem cells are regulated by yes‑associated protein. | 2018 | Int. J. Mol. Med. | pmid:29916531 |
| Masago K et al. | Lysophosphatidic acid receptor, LPA, regulates endothelial blood-brain barrier function: Implication for hepatic encephalopathy. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29778535 |
| Shen X et al. | Lysophosphatidic acid enhances neointimal hyperplasia following vascular injury through modulating proliferation, autophagy, inflammation and oxidative stress. | 2018 | Mol Med Rep | pmid:29749484 |
| Kim EY et al. | Serum lipidomic analysis for the discovery of biomarkers for major depressive disorder in drug-free patients. | 2018 | Psychiatry Res | pmid:29719272 |
| Zou W et al. | LC-Q-TOF-MS based plasma metabolomic profile of subclinical pelvic inflammatory disease: A pilot study. | 2018 | Clin. Chim. Acta | pmid:29709453 |
| Ho LTY et al. | Lysophosphatidic Acid Induces ECM Production via Activation of the Mechanosensitive YAP/TAZ Transcriptional Pathway in Trabecular Meshwork Cells. | 2018 | Invest. Ophthalmol. Vis. Sci. | pmid:29677358 |
| Wang C et al. | Lysophosphatidic acid induces neuronal cell death via activation of asparagine endopeptidase in cerebral ischemia-reperfusion injury. | 2018 | Exp. Neurol. | pmid:29673933 |
| Li C et al. | Targeting the RhoA-ROCK pathway to regulate T-cell homeostasis in hypoxia-induced pulmonary arterial hypertension. | 2018 | Pulm Pharmacol Ther | pmid:29673911 |
| Lidgerwood GE et al. | Role of lysophosphatidic acid in the retinal pigment epithelium and photoreceptors. | 2018 | Biochim Biophys Acta Mol Cell Biol Lipids | pmid:29660533 |
| Sinderewicz E et al. | Expression of genes for enzymes synthesizing lysophosphatidic acid, its receptors and follicle developmental factors derived from the cumulus-oocyte complex is dependent on the ovarian follicle type in cows. | 2018 | Anim. Reprod. Sci. | pmid:29573844 |
| D'Souza K et al. | Lysophosphatidic Acid Signaling in Obesity and Insulin Resistance. | 2018 | Nutrients | pmid:29570618 |
| Jiang D et al. | Elevated lysophosphatidic acid levels in the serum and cerebrospinal fluid in patients with multiple sclerosis: therapeutic response and clinical implication. | 2018 | Neurol. Res. | pmid:29557721 |
| Hwang SU et al. | Lysophosphatidic acid increases in vitro maturation efficiency via uPA-uPAR signaling pathway in cumulus cells. | 2018 | Theriogenology | pmid:29554602 |
| Schoeman JC et al. | Development and application of a UHPLC-MS/MS metabolomics based comprehensive systemic and tissue-specific screening method for inflammatory, oxidative and nitrosative stress. | 2018 | Anal Bioanal Chem | pmid:29497765 |
| Zhou T et al. | Lysophosphatidic Acid Induces Ligamentum Flavum Hypertrophy Through the LPAR1/Akt Pathway. | 2018 | Cell. Physiol. Biochem. | pmid:29466791 |
| Afroz S et al. | Lysophosphatidic acid in medicinal herbs enhances prostaglandin E and protects against indomethacin-induced gastric cell damage in vivo and in vitro. | 2018 | Prostaglandins Other Lipid Mediat. | pmid:29462674 |
| Okabe-Kado J et al. | NM23 downregulation and lysophosphatidic acid receptor EDG2/lpa1 upregulation during myeloid differentiation of human leukemia cells. | 2018 | Leuk. Res. | pmid:29407582 |
| Takahashi K et al. | Effects of LPA and LPA on the regulation of colony formation activity in colon cancer cells treated with anticancer drugs. | 2018 | J. Recept. Signal Transduct. Res. | pmid:29369010 |
| Riquelme-Guzmán C et al. | Expression of CTGF/CCN2 in response to LPA is stimulated by fibrotic extracellular matrix via the integrin/FAK axis. | 2018 | Am. J. Physiol., Cell Physiol. | pmid:29351412 |
| Hidaka M et al. | Three lysophosphatidic acids with a distinct long chain moiety differently affect cell differentiation of human colon epithelial cells to goblet cells. | 2018 | Life Sci. | pmid:29412173 |
| Rogers LC et al. | Blocking LPA-dependent signaling increases ovarian cancer cell death in response to chemotherapy. | 2018 | Redox Biol | pmid:29331665 |
| Loskutov YV et al. | LPA signaling is regulated through the primary cilium: a novel target in glioblastoma. | 2018 | Oncogene | pmid:29321663 |
| Bergasa NV | The pruritus of cholestasis: From bile acids to opiate agonists: Relevant after all these years. | 2018 | Med. Hypotheses | pmid:29317077 |
| Bernacchioni C et al. | Lysophosphatidic Acid Signaling Axis Mediates Ceramide 1-Phosphate-Induced Proliferation of C2C12 Myoblasts. | 2018 | Int J Mol Sci | pmid:29300303 |
| Wang X et al. | Mutual regulation of the Hippo/Wnt/LPA/TGF‑β signaling pathways and their roles in glaucoma (Review). | 2018 | Int. J. Mol. Med. | pmid:29286147 |
| Nakajima S et al. | 2-O-Carba-oleoyl cyclic phosphatidic acid induces glial proliferation through the activation of lysophosphatidic acid receptor. | 2018 | Brain Res. | pmid:29278716 |
| Baader M et al. | Characterization of the properties of a selective, orally bioavailable autotaxin inhibitor in preclinical models of advanced stages of liver fibrosis. | 2018 | Br. J. Pharmacol. | pmid:29197066 |
| Takeda T et al. | In vivo evidence for possible up-regulating roles of lysophosphatidic acid around fertilization in rats. | 2018 | J. Vet. Med. Sci. | pmid:29162771 |
| Szepanowski F et al. | Lysophosphatidic acid propagates post-injury Schwann cell dedifferentiation through LPA signaling. | 2018 | Neurosci. Lett. | pmid:29051083 |
| Sinderewicz E et al. | Bovine ovarian follicular growth and development correlate with lysophosphatidic acid expression. | 2018 | Theriogenology | pmid:29028570 |
| Chandra M et al. | Cardiac-specific inactivation of LPP3 in mice leads to myocardial dysfunction and heart failure. | 2018 | Redox Biol | pmid:28982073 |
| Ray U and Roy SS | Aberrant lipid metabolism in cancer cells - the role of oncolipid-activated signaling. | 2018 | FEBS J. | pmid:28971574 |
| Avula LR et al. | Both NHERF3 and NHERF2 are necessary for multiple aspects of acute regulation of NHE3 by elevated Ca, cGMP, and lysophosphatidic acid. | 2018 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:28882822 |
| Schneider P et al. | Altered synaptic phospholipid signaling in PRG-1 deficient mice induces exploratory behavior and motor hyperactivity resembling psychiatric disorders. | 2018 | Behav. Brain Res. | pmid:28843862 |
| Beltrame JS et al. | Lysophosphatidic acid-triggered pathways promote the acquisition of trophoblast endovascular phenotype in vitro. | 2018 | J. Cell. Biochem. | pmid:28657680 |
| Tsukahara R et al. | LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model. | 2018 | J. Pharmacol. Sci. | pmid:29409686 |
| LaPorte ME et al. | Effects of LPA2R, LPA3R, or EP4R agonists on luteal or endometrial function in vivo or in vitro and sirtuin or EP1R, EP2R, EP3R or EP4R agonists on endometrial secretion of PGE and PGFin vitro. | 2017 | Theriogenology | pmid:28460684 |
| Fayyaz S et al. | Lysophosphatidic Acid Inhibits Insulin Signaling in Primary Rat Hepatocytes via the LPA3 Receptor Subtype and is Increased in Obesity. | 2017 | Cell. Physiol. Biochem. | pmid:28922661 |
| Hino K et al. | Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva. | 2017 | J. Clin. Invest. | pmid:28758906 |
| Davies MR et al. | Lysophosphatidic acid-induced RhoA signaling and prolonged macrophage infiltration worsens fibrosis and fatty infiltration following rotator cuff tears. | 2017 | J. Orthop. Res. | pmid:27505847 |
| Joncour A et al. | Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors. | 2017 | J. Med. Chem. | pmid:28731719 |
| Valdés-Rives SA and González-Arenas A | Autotaxin-Lysophosphatidic Acid: From Inflammation to Cancer Development. | 2017 | Mediators Inflamm. | pmid:29430083 |
| Plastira I et al. | Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype. | 2017 | J Neuroinflammation | pmid:29258556 |
| Bae GH et al. | Lysophosphatidic acid protects against acetaminophen-induced acute liver injury. | 2017 | Exp. Mol. Med. | pmid:29217823 |
| Benesch MGK et al. | Lysophosphatidate Signaling: The Tumor Microenvironment's New Nemesis. | 2017 | Trends Cancer | pmid:29120750 |
| Li N et al. | Lysophosphatidic acid enhances human umbilical cord mesenchymal stem cell viability without differentiation via LPA receptor mediating manner. | 2017 | Apoptosis | pmid:28766061 |
| Mirzoyan K et al. | Lysophosphatidic Acid Protects Against Endotoxin-Induced Acute Kidney Injury. | 2017 | Inflammation | pmid:28667502 |
| Bosetti M et al. | Injectable Graft Substitute Active on Bone Tissue Regeneration. | 2017 | Tissue Eng Part A | pmid:28530130 |
| Nsaibia MJ et al. | OxLDL-derived lysophosphatidic acid promotes the progression of aortic valve stenosis through a LPAR1-RhoA-NF-κB pathway. | 2017 | Cardiovasc. Res. | pmid:28472283 |
| Thorlakson HH et al. | Lysophosphatidic acid induces expression of genes in human oral keratinocytes involved in wound healing. | 2017 | Arch. Oral Biol. | pmid:28432900 |
| Sordelli MS et al. | Endogenous lysophosphatidic acid participates in vascularisation and decidualisation at the maternal-fetal interface in the rat. | 2017 | Reprod. Fertil. Dev. | pmid:28376314 |
| Zhang K et al. | Hypertrophy and Fibrosis of the Ligamentum Flavum in Lumbar Spinal Stenosis is Associated With Increased Expression of LPA and LPAR1. | 2017 | Clin Spine Surg | pmid:28323698 |
| Taddeo EP et al. | Lysophosphatidic acid counteracts glucagon-induced hepatocyte glucose production via STAT3. | 2017 | Sci Rep | pmid:28273928 |
| Ueda H | Lysophosphatidic acid signaling is the definitive mechanism underlying neuropathic pain. | 2017 | Pain | pmid:28151833 |
| Michalczyk A et al. | Lysophosphatidic acid plasma concentrations in healthy subjects: circadian rhythm and associations with demographic, anthropometric and biochemical parameters. | 2017 | Lipids Health Dis | pmid:28732508 |
| Oh YS et al. | Dynamic relocalization of NHERF1 mediates chemotactic migration of ovarian cancer cells toward lysophosphatidic acid stimulation. | 2017 | Exp. Mol. Med. | pmid:28684865 |
| Lötsch J et al. | Machine-Learned Data Structures of Lipid Marker Serum Concentrations in Multiple Sclerosis Patients Differ from Those in Healthy Subjects. | 2017 | Int J Mol Sci | pmid:28590455 |
| Rancoule C et al. | Lysophosphatidic acid (LPA) as a pro-fibrotic and pro-oncogenic factor: a pivotal target to improve the radiotherapy therapeutic index. | 2017 | Oncotarget | pmid:28402936 |
| Rojas JM et al. | Phospholipase D from Loxosceles laeta Spider Venom Induces IL-6, IL-8, CXCL1/GRO-α, and CCL2/MCP-1 Production in Human Skin Fibroblasts and Stimulates Monocytes Migration. | 2017 | Toxins (Basel) | pmid:28379166 |
| Zhang JB et al. | Plasma Phospholipids are Associated with Mild Cognitive Impairment in Type 2 Diabetic Patients. | 2017 | Curr Alzheimer Res | pmid:27915992 |
| Chen L et al. | Lysophosphatidic acid directly induces macrophage-derived foam cell formation by blocking the expression of SRBI. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28765047 |
| Tsukahara T et al. | Lysophosphatidic acid signaling regulates the KLF9-PPARγ axis in human induced pluripotent stem cell-derived neurons. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28716732 |
| An D et al. | CD14 is a key mediator of both lysophosphatidic acid and lipopolysaccharide induction of foam cell formation. | 2017 | J. Biol. Chem. | pmid:28705936 |
| Lopane C et al. | Implications of the lysophosphatidic acid signaling axis in liver cancer. | 2017 | Biochim Biophys Acta Rev Cancer | pmid:28591560 |
| Sarker R et al. | Phosphorylation of NHE3-S regulates NHE3 activity through the formation of multiple signaling complexes. | 2017 | Mol. Biol. Cell | pmid:28495796 |
| Contursi A et al. | Platelets as crucial partners for tumor metastasis: from mechanistic aspects to pharmacological targeting. | 2017 | Cell. Mol. Life Sci. | pmid:28488110 |
| Nikolaou A et al. | Autotaxin inhibitors: a patent review (2012-2016). | 2017 | Expert Opin Ther Pat | pmid:28447479 |
| McDougall JJ et al. | Lysophosphatidic acid provides a missing link between osteoarthritis and joint neuropathic pain. | 2017 | Osteoarthr. Cartil. | pmid:27651153 |
| Moreno-Fernández RD et al. | maLPA1-null mice as an endophenotype of anxious depression. | 2017 | Transl Psychiatry | pmid:28375206 |
| Thirunavukkarasu K et al. | Identification and pharmacological characterization of a novel inhibitor of autotaxin in rodent models of joint pain. | 2017 | Osteoarthr. Cartil. | pmid:27638130 |
| Saulnier-Blache JS et al. | Urinary lysophopholipids are increased in diabetic patients with nephropathy. | 2017 | J. Diabetes Complicat. | pmid:28506691 |
| Sakai N et al. | Lysophosphatidic acid signaling through its receptor initiates profibrotic epithelial cell fibroblast communication mediated by epithelial cell derived connective tissue growth factor. | 2017 | Kidney Int. | pmid:27927603 |
| Kang TS et al. | A rhodium(III)-based inhibitor of autotaxin with antiproliferative activity. | 2017 | Biochim Biophys Acta Gen Subj | pmid:27888146 |
| Niss Arfelt K et al. | Signaling via G proteins mediates tumorigenic effects of GPR87. | 2017 | Cell. Signal. | pmid:27865873 |
| Sattikar A et al. | Endogenous lysophosphatidic acid (LPA ) receptor agonists demonstrate ligand bias between calcium and ERK signalling pathways in human lung fibroblasts. | 2017 | Br. J. Pharmacol. | pmid:27864940 |
| Sinderewicz E et al. | Lysophosphatidic acid expression in theca cells depends on the type of bovine ovarian follicle. | 2017 | Reprod. Domest. Anim. | pmid:27644923 |
| Velasco M et al. | Lysophosphatidic acid receptors (LPARs): Potential targets for the treatment of neuropathic pain. | 2017 | Neuropharmacology | pmid:27059127 |
| Cheng L et al. | Interaction between mDia1 and ROCK in Rho-induced migration and adhesion of human dental pulp cells. | 2017 | Int Endod J | pmid:26609804 |