stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Christensen E et al. | Beta-oxidation of medium chain (C8-C14) fatty acids studied in isolated liver cells. | 1989 | Biochim. Biophys. Acta | pmid:2752017 |
Collins JM and Grogan WM | Comparison between flow cytometry and fluorometry for the kinetic measurement of membrane fluidity parameters. | 1989 | Cytometry | pmid:2917474 |
Garcia Zevallos M and Farkas T | Manipulation of plasma membrane physical state affects desaturase activity in rat lymphocytes. | 1989 | Arch. Biochem. Biophys. | pmid:2786374 |
Singh H et al. | Mitochondrial and peroxisomal beta-oxidation of stearic and lignoceric acids by rat brain. | 1989 | J. Neurochem. | pmid:2809586 |
Burrows GE et al. | A comparison of the various routes of administration of erythromycin in cattle. | 1989 | J. Vet. Pharmacol. Ther. | pmid:2810478 |
Wada M et al. | Mechanism of biosynthesis of unsaturated fatty acids in Pseudomonas sp. strain E-3, a psychrotrophic bacterium. | 1989 | J. Bacteriol. | pmid:2753856 |
Friedman E et al. | Fecal diglycerides as selective endogenous mitogens for premalignant and malignant human colonic epithelial cells. | 1989 | Cancer Res. | pmid:2910475 |
Demediuk P et al. | Changes in free fatty acids, phospholipids, and cholesterol following impact injury to the rat spinal cord. | 1989 | J. Neurosci. Res. | pmid:2520534 |
Yoshida S et al. | Effect of phospholipase A2 and free fatty acids on lipid-protein interactions in long- and very-long-chain fatty acyl-CoA elongation enzyme systems of brain microsomes. | 1989 | Biochim. Biophys. Acta | pmid:2502180 |
Wolf BA et al. | Secretagogue-induced diacylglycerol accumulation in isolated pancreatic islets. Mass spectrometric characterization of the fatty acyl content indicates multiple mechanisms of generation. | 1989 | Biochemistry | pmid:2504278 |
Furr HC et al. | The effect of dietary fatty acid composition on liver retinyl ester (vitamin A ester) composition in the rat. | 1989 | J. Nutr. | pmid:2703916 |
Thiel C and Kadenbach B | Influence of non-esterified fatty acids on respiratory control of reconstituted cytochrome-c oxidase. | 1989 | FEBS Lett. | pmid:2546826 |
Yodono H et al. | [A case of hepatocellular carcinoma effectively treated by intraarterial infusion of CDDP and other agents]. | 1989 | Gan To Kagaku Ryoho | pmid:2551253 |
Buttke TM et al. | Absence of unsaturated fatty acid synthesis in murine T lymphocytes. | 1989 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2569740 |
Beardshall K et al. | Saturation of fat and cholecystokinin release: implications for pancreatic carcinogenesis. | 1989 | Lancet | pmid:2572741 |
Hillered L and Chan PH | Brain mitochondrial swelling induced by arachidonic acid and other long chain free fatty acids. | 1989 | J. Neurosci. Res. | pmid:2531232 |
Leak RE and Woodford JD | Pharmaceutical development of ondansetron tablets. | 1989 | Eur J Cancer Clin Oncol | pmid:2533901 |
Rendu F et al. | Ajoene, the antiplatelet compound derived from garlic, specifically inhibits platelet release reaction by affecting the plasma membrane internal microviscosity. | 1989 | Biochem. Pharmacol. | pmid:2539823 |
Fenner GP and Parks LW | Gas chromatographic analysis of intact steryl esters in wild type Saccharomyces cerevisiae and in an ester accumulating mutant. | 1989 | Lipids | pmid:2674578 |
Hamedani P et al. | Acute and chronic Legionnaires' disease and co-existent tuberculosis: a trial of erythromycin. | 1989 | Curr Med Res Opin | pmid:2680287 |
Arslanagić N et al. | Eradication of endemic syphilis in Bosnia. | 1989 | Genitourin Med | pmid:2646207 |
Periti P et al. | Clinical pharmacokinetic properties of the macrolide antibiotics. Effects of age and various pathophysiological states (Part I). | 1989 | Clin Pharmacokinet | pmid:2656049 |
Judd JT et al. | Relationship of dietary fat to plasma fatty acids, blood pressure, and urinary eicosanoids in adult men. | 1989 | J Am Coll Nutr | pmid:2607069 |
Williams RO and McGinity JW | Compaction properties of microcrystalline cellulose and sodium sulfathiazole in combination with talc or magnesium stearate. | 1989 | J Pharm Sci | pmid:2614693 |
Kaukoranta-Tolvanen SS et al. | Effect of erythromycin acistrate and erythromycin stearate on human colonic microflora. | 1989 | Scand. J. Infect. Dis. | pmid:2617212 |
Luhrs CA and Slomiany BL | A human membrane-associated folate binding protein is anchored by a glycosyl-phosphatidylinositol tail. | 1989 | J. Biol. Chem. | pmid:2557328 |
Linden DJ and Routtenberg A | cis-Fatty acids, which activate protein kinase C, attenuate Na+ and Ca2+ currents in mouse neuroblastoma cells. | 1989 | J. Physiol. (Lond.) | pmid:2559978 |
Bora PS et al. | Purification to homogeneity and characterization of major fatty acid ethyl ester synthase from human myocardium. | 1989 | FEBS Lett. | pmid:2599089 |
Sharma BK and Erdman RA | In vitro degradation of choline from selected feedstuffs and choline supplements. | 1989 | J. Dairy Sci. | pmid:2600236 |
Punnonen K and Jansén CT | UVB irradiation and distribution of arachidonic acid (20:4) and stearic acid (18:0) in human keratinocytes. | 1989 | Photodermatol | pmid:2473452 |
Pahuja SL and Hochberg RB | A comparison of the fatty acid esters of estradiol and corticosterone synthesized by tissues of the rat. | 1989 | J. Biol. Chem. | pmid:2492532 |
Shires SE et al. | Effects of linoleic acid and mitogenic stimulation on the fatty acid composition of human lymphocytes. | 1989 | Biochim. Biophys. Acta | pmid:2493807 |
Severin SE et al. | Synapsin I from human brain. Phosphorylation by Ca2+, phospholipid-dependent protein kinase. | 1989 | FEBS Lett. | pmid:2513229 |
Adeyeye A et al. | Studies on the antigenic S-type lipopolysaccharides of Brucella abortus strains 7 and Mustapha. | 1989 | Int. J. Biol. Macromol. | pmid:2518732 |
Haeffner EW and Friedel R | Induction of an endothermic transition in the Arrhenius plot of fatty acid uptake by lipid-depleted ascites tumor cells. | 1989 | Biochim. Biophys. Acta | pmid:2775760 |
Broderick PA | Characterizing stearate probes in vitro for the electrochemical detection of dopamine and serotonin. | 1989 | Brain Res. | pmid:2776030 |
Burke JP and Fenton MR | Plasma and cellular zinc levels and membrane lipid composition in streptozotocin diabetic rats. | 1989 | Comp. Biochem. Physiol., B | pmid:2776432 |
Männistö PT et al. | Efficacy of erythromycin acistrate (2'-acetyl erythromycin stearate) and erythromycin stearate in experimental infections in mice. | 1989 | J. Pharmacol. Exp. Ther. | pmid:2778707 |
Paris A and Rao D | Biosynthesis of estradiol-17 beta fatty acyl esters by microsomes derived from bovine liver and adrenals. | 1989 | J. Steroid Biochem. | pmid:2779237 |
Deasy PB and O'Neill CT | Bioadhesive dosage form for peroral administration of timolol base. | 1989 | Pharm Acta Helv | pmid:2780757 |
Mohsenin V and Gee JL | Oxidation of alpha 1-protease inhibitor: role of lipid peroxidation products. | 1989 | J. Appl. Physiol. | pmid:2787317 |
Bentejac M et al. | Utilization of high-density lipoprotein sphingomyelin by the developing and mature brain in the rat. | 1989 | J. Neurochem. | pmid:2709013 |
Mortimer BC et al. | The effect of added monoacylglycerols on the removal from plasma of chylomicron-like emulsions injected intravenously in rats. | 1989 | Biochim. Biophys. Acta | pmid:2713386 |
Mitropoulos KA et al. | The activation of the contact phase of coagulation by physiologic surfaces in plasma: the effect of large negatively charged liposomal vesicles. | 1989 | Blood | pmid:2713491 |
Biesalski HK and Weiser H | Sensitive analysis of retinyl esters by isocratic adsorption chromatography. | 1989 | J. Clin. Chem. Clin. Biochem. | pmid:2746165 |
Kitajima J et al. | [Studies on the constituents of trichosanthes root. III. Constituents of roots of Trichosanthes bracteata Voigt]. | 1989 | Yakugaku Zasshi | pmid:2760813 |
Brodersen R et al. | Serum albumin binding of palmitate and stearate. Multiple binding theory for insoluble ligands. | 1989 | Eur. J. Biochem. | pmid:2731550 |
Beck JC et al. | Growth of epithelium from a preneoplastic mammary outgrowth in response to mammary adipose tissue. | 1989 | In Vitro Cell. Dev. Biol. | pmid:2732196 |
Yamreudeewong W et al. | Effect of antacid coadministration on the bioavailability of erythromycin stearate. | 1989 | Clin Pharm | pmid:2743731 |
Skrede S et al. | The effects of alkylthioacetic acids (3-thia fatty acids) on fatty acid metabolism in isolated hepatocytes. | 1989 | Biochim. Biophys. Acta | pmid:2804058 |
Bulut-Oner F et al. | Sustained release isoniazid tablets. I--Formulation and in vitro evaluation. | 1989 Jul-Aug | Farmaco | pmid:2590371 |
Kosukhin AB et al. | [The mechanism of formation of spectrum of nonesterified fatty acids in biological fluids of rabbits with alimentary hypercholesterolemia]. | 1989 Mar-Apr | Vopr. Med. Khim. | pmid:2741412 |
Bly JE et al. | Differential effects of temperature and exogenous fatty acids on mitogen-induced proliferation in channel catfish T and B lymphocytes. | 1990 | Comp Biochem Physiol A Comp Physiol | pmid:1970529 |
Svedberg J et al. | Free-fatty acid inhibition of insulin binding, degradation, and action in isolated rat hepatocytes. | 1990 | Diabetes | pmid:2185108 |
Imamura K et al. | Colony-stimulating factor 1 activates protein kinase C in human monocytes. | 1990 | EMBO J. | pmid:2196173 |
Wei S et al. | [Chemical constituents in the stem of Premna crassa Hand. -Mazz]. | 1990 | Zhongguo Zhong Yao Za Zhi | pmid:2093323 |
Pourbohloul SC and Buttke TM | Identification of T-helper cells as the target of stearic acid-inhibition in primary antibody responses in vitro. | 1990 | Int. J. Immunopharmacol. | pmid:2149847 |
Schlame M et al. | Relationship between lipid saturation and lipid-protein interaction in liver mitochondria modified by catalytic hydrogenation with reference to cardiolipin molecular species. | 1990 | Biochem. J. | pmid:2154183 |
Guzmán A and GarcÃa R | Effects of fatty ethers and stearic acid on the gastrointestinal absorption of insulin. | 1990 | P R Health Sci J | pmid:2077554 |
AlegrÃa AE et al. | Semiquinones derived from anthraquinone-containing antitumor drugs can partition into phosphatidylcholine bilayers. | 1990 | Biochim. Biophys. Acta | pmid:2166575 |
Kitagawa S et al. | Inhibitory mechanism of cis-polyunsaturated fatty acids on platelet aggregation: the relation with their effects on Ca2+ mobilization, cyclic AMP levels and membrane fluidity. | 1990 | Biochim. Biophys. Acta | pmid:2166588 |
Fujii H and Kakinuma K | Studies on the superoxide releasing site in plasma membranes of neutrophils with ESR spin-labels. | 1990 | J. Biochem. | pmid:2172228 |
Hsiao WL et al. | Effects of specific fatty acids on cell transformation induced by an activated c-H-ras oncogene. | 1990 | Oncogene | pmid:2107493 |
Anel A et al. | Fatty acid metabolism in human lymphocytes. II. Activation of fatty acid desaturase-elongase systems during blastic transformation. | 1990 | Biochim. Biophys. Acta | pmid:2114179 |
Nicholson ML et al. | Inhibition of experimental colorectal carcinogenesis by dietary N-6 polyunsaturated fats. | 1990 | Carcinogenesis | pmid:2124952 |
Fletcher JE et al. | Fatty acids modulate calcium-induced calcium release from skeletal muscle heavy sarcoplasmic reticulum fractions: implications for malignant hyperthermia. | 1990 | Biochem. Cell Biol. | pmid:2125224 |
Zaridze DG et al. | [Fatty acid composition of phospholipids of erythrocyte membranes and risk of breast cancer]. | 1990 | Vopr Onkol | pmid:2126901 |
Singh H et al. | Metabolism of branched chain fatty acids in peroxisomal disorders. | 1990 | J. Inherit. Metab. Dis. | pmid:1700192 |
Mensink RP and Katan MB | Effect of dietary trans fatty acids on high-density and low-density lipoprotein cholesterol levels in healthy subjects. | 1990 | N. Engl. J. Med. | pmid:2374566 |
Newman MJ | Inhibition of carcinoma and melanoma cell growth by type 1 transforming growth factor beta is dependent on the presence of polyunsaturated fatty acids. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2371287 |
Kedryna T et al. | Pyruvate kinase from cytosolic fractions of the Ehrlich ascites tumour, normal mouse liver and skeletal muscle. | 1990 | Biochim. Biophys. Acta | pmid:2354196 |
Ong CN et al. | Biological monitoring of workers exposed to lead stearate. | 1990 | J Appl Toxicol | pmid:2335713 |
Persad RA et al. | Erythrocyte stearic to oleic acid ratio in prostatic carcinoma. | 1990 | Br J Urol | pmid:2337746 |
Neoptolemos JP and Thomas BS | Erythrocyte membrane stearic acid: oleic acid ratios in colorectal cancer using tube capillary column gas liquid chromatography. | 1990 | Ann. Clin. Biochem. | pmid:2310156 |
Alakhov VYu AV et al. | Increasing cytostatic effects of ricin A chain and Staphylococcus aureus enterotoxin A through in vitro hydrophobization with fatty acid residues. | 1990 | Biotechnol. Appl. Biochem. | pmid:2310510 |
Ahmad SN et al. | Fatty acid incorporation into membranes of dispersed rat submandibular salivary gland cells and their effect on adenylate cyclase activity. | 1990 | Arch. Oral Biol. | pmid:2281999 |
Bentejac M et al. | Metabolic fate of sphingomyelin of high-density lipoprotein in rat plasma. | 1990 | Lipids | pmid:2079870 |
Metz SA and Dunlop M | Production of phosphatidylethanol by phospholipase D phosphatidyl transferase in intact or dispersed pancreatic islets: evidence for the in situ metabolism of phosphatidylethanol. | 1990 | Arch. Biochem. Biophys. | pmid:2125821 |
Trinchera M et al. | Recycling of glucosylceramide and sphingosine for the biosynthesis of gangliosides and sphingomyelin in rat liver. | 1990 | Biochem. J. | pmid:2241913 |
Kelly SB et al. | Erythrocyte stearic acid desaturation in patients with colorectal carcinoma. | 1990 | Dis. Colon Rectum | pmid:2242696 |
Bogdarin IuA and Goncharov NP | [Effects of ovariectomy on the composition of fatty acids of phospholipids in Java macaques with cholestasis]. | 1990 | Biull Eksp Biol Med | pmid:2118815 |
Privat JP et al. | Incorporation of spin-labeled fatty acids into bovine brain clathrin coated vesicles. | 1990 | Biochim. Biophys. Acta | pmid:2158352 |
Yoshizawa H and Koishi M | The coating and the encapsulation of an interactive powder mixture and its application to sustained release preparations. | 1990 | J. Pharm. Pharmacol. | pmid:1982136 |
McIlhinney RA and McGlone K | Evidence for a non-myristoylated pool of the 80 kDa protein kinase C substrate of rat brain. | 1990 | Biochem. J. | pmid:2244873 |
Bleyl DW and Przybilski H | [Diaplacental transition of selected fatty acids in the rat]. | 1991 | Nahrung | pmid:1865884 |
Chaudry A et al. | Essential fatty acid distribution in the plasma and tissue phospholipids of patients with benign and malignant prostatic disease. | 1991 | Br. J. Cancer | pmid:1764380 |
Takahashi R et al. | Fatty acid composition of serum phospholipids in an elderly institutionalized Japanese population. | 1991 | J. Nutr. Sci. Vitaminol. | pmid:1765844 |
DeÄneka SE et al. | [Experimental data on the effects of lead, barium, silver, zinc and calcium stearates on the cardiovascular system]. | 1991 | Gig Tr Prof Zabol | pmid:1794723 |
Applegate KR and Glomset JA | Effect of acyl chain unsaturation on the conformation of model diacylglycerols: a computer modeling study. | 1991 | J. Lipid Res. | pmid:1797944 |
Buttke TM et al. | Correlation between low-temperature immunosuppression and the absence of unsaturated fatty acid synthesis in murine T cells. | 1991 | Comp. Biochem. Physiol., B | pmid:1799970 |
Denke MA and Grundy SM | Effects of fats high in stearic acid on lipid and lipoprotein concentrations in men. | 1991 | Am. J. Clin. Nutr. | pmid:1845606 |
Steinbeck MJ et al. | Activation of the neutrophil NADPH-oxidase by free fatty acids requires the ionized carboxyl group and partitioning into membrane lipid. | 1991 | J. Leukoc. Biol. | pmid:1848271 |
Gilliam EB et al. | Phorbol ester plus calcium ionophore induces release of arachidonic acid from membrane phospholipids of a human B cell line. | 1991 | Cell. Immunol. | pmid:1905589 |
Wright S et al. | Essential fatty acids in plasma of patients with leprosy. | 1991 | Int. J. Lepr. Other Mycobact. Dis. | pmid:1906518 |
Mehta JR et al. | Lipid fluidity and composition of the erythrocyte membrane from healthy dogs and Labrador retrievers with hereditary muscular dystrophy. | 1991 | Neurochem. Res. | pmid:1908955 |
Nelson JM et al. | Cadmium ion-induced alterations of phospholipid metabolism in endothelial cells. | 1991 | Am. J. Respir. Cell Mol. Biol. | pmid:1910817 |
Nagao M et al. | Arachidonic acid metabolism in articular chondrocytes. | 1991 | Clin. Orthop. Relat. Res. | pmid:1914309 |
Ulmann L et al. | Incorporation into liver microsomal lipids of linoleic and stearic acids and of their respective products of delta 6 and delta 9 desaturation, gamma-linolenic and oleic acids: effect of age and of blackcurrant seed oil. | 1991 | Biochim. Biophys. Acta | pmid:1657182 |
Duane PG et al. | Relationship of oxidant-mediated cytotoxicity to phospholipid metabolism in endothelial cells. | 1991 | Am. J. Respir. Cell Mol. Biol. | pmid:2021479 |
Fletcher JE et al. | Fatty acids markedly lower the threshold for halothane-induced calcium release from the terminal cisternae in human and porcine normal and malignant hyperthermia susceptible skeletal muscle. | 1991 | Life Sci. | pmid:1943469 |