stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Ion G et al. | Effects of canola and corn oil mimetic on Jurkat cells. | 2011 | Lipids Health Dis | pmid:21631947 |
Pniewski T et al. | Low-dose oral immunization with lyophilized tissue of herbicide-resistant lettuce expressing hepatitis B surface antigen for prototype plant-derived vaccine tablet formulation. | 2011 | J. Appl. Genet. | pmid:21107787 |
Yoo JY et al. | A randomized controlled trial of oral phosphate binders in the treatment of pseudoxanthoma elasticum. | 2011 | J. Am. Acad. Dermatol. | pmid:21496949 |
Chaturvedi K et al. | Floating matrix dosage form for propranolol hydrochloride based on gas formation technique: development and in vitro evaluation. | 2010 Oct-Dec | Sci Pharm | pmid:21179326 |
Terekhova EA et al. | [Stearic acid methyl ether: a new extracellular metabolite of the obligate methylotrophic bacterium Methylophilus quaylei]. | 2010 Mar-Apr | Prikl. Biokhim. Mikrobiol. | pmid:20391761 |
Kristó K et al. | Effect of lubricant on spreading of coating liquid on surface of tablets containing pancreatin. | 2010 Jul-Aug | Pharm Dev Technol | pmid:19772392 |
Badawy SI et al. | Effect of spray-dried mannitol on the performance of microcrystalline cellulose-based wet granulated tablet formulation. | 2010 Jul-Aug | Pharm Dev Technol | pmid:20088677 |
Kaur G et al. | Chitosan-carboxymethyl tamarind kernel powder interpolymer complexation: investigations for colon drug delivery. | 2010 Jan-Mar | Sci Pharm | pmid:21179370 |
Stanisz B et al. | Influence of humidity and hydroxypropyl cellulose, hydroxypropylmethyl cellulose, glyceryl behenate or magnesium stearate on the degradation kinetics of quinapril hydrochloride in solid phase. | 2010 Jan-Feb | Acta Pol Pharm | pmid:20210086 |
Aburahma MH et al. | Preparation and in vitro/in vivo characterization of porous sublingual tablets containing ternary kneaded solid system of vinpocetine with î-cyclodextrin and hydroxy Acid. | 2010 Apr-Jun | Sci Pharm | pmid:21179352 |
Singh B et al. | Formulation optimization of hydrodynamically balanced oral controlled release bioadhesive tablets of tramadol hydrochloride. | 2010 Apr-Jun | Sci Pharm | pmid:21179349 |
Chen Y et al. | A new method to obtain Fourier transform infrared spectra free from water vapor disturbance. | 2010 | Appl Spectrosc | pmid:20925991 |
Mukherjee S et al. | Stearic acid delivery to corneum from a mild and moisturizing cleanser. | 2010 | J Cosmet Dermatol | pmid:20883293 |
Fang X et al. | Development and analysis of an in vivo-compatible metabolic network of Mycobacterium tuberculosis. | 2010 | BMC Syst Biol | pmid:21092312 |
Rawat MK et al. | Effect of lipid matrix on repaglinide-loaded solid lipid nanoparticles for oral delivery. | 2010 | Ther Deliv | pmid:22816120 |
Westerbacka J et al. | Splanchnic balance of free fatty acids, endocannabinoids, and lipids in subjects with nonalcoholic fatty liver disease. | 2010 | Gastroenterology | pmid:20600015 |
Araújo J et al. | Optimization and physicochemical characterization of a triamcinolone acetonide-loaded NLC for ocular antiangiogenic applications. | 2010 | Int J Pharm | pmid:20362042 |
Bender K et al. | Metabolite concentrations in follicular fluid may explain differences in fertility between heifers and lactating cows. | 2010 | Reproduction | pmid:20385782 |
Pedersen PJ et al. | Liposomal formulation of retinoids designed for enzyme triggered release. | 2010 | J. Med. Chem. | pmid:20405849 |
Jain S et al. | Development of a floating dosage form of ranitidine hydrochloride by statistical optimization technique. | 2010 | J Young Pharm | pmid:21264091 |
Liew CV et al. | In-line quantification of drug and excipients in cohesive powder blends by near infrared spectroscopy. | 2010 | Int J Pharm | pmid:19922776 |
Naumova EA et al. | Influence of individual saliva secretion on fluoride bioavailability. | 2010 | Open Dent J | pmid:21221176 |
Patel BP et al. | Formulation and evaluation of mouth dissolving tablets of cinnarizine. | 2010 | Indian J Pharm Sci | pmid:21218071 |
Kotagale NR et al. | Carbopol 934-Sodium Alginate-Gelatin Mucoadhesive Ondansetron Tablets for Buccal Delivery: Effect of pH Modifiers. | 2010 | Indian J Pharm Sci | pmid:21218058 |
Luan L et al. | [Studies on the chemical constituents of extract with water from Forsythia suspensa]. | 2010 | Zhong Yao Cai | pmid:20575415 |
Remya K et al. | Formulation development, evaluation and comparative study of effects of super disintegrants in cefixime oral disintegrating tablets. | 2010 | J Young Pharm | pmid:21042477 |
Contreras GA et al. | Lipomobilization in periparturient dairy cows influences the composition of plasma nonesterified fatty acids and leukocyte phospholipid fatty acids. | 2010 | J. Dairy Sci. | pmid:20494158 |
Sateesha S et al. | Influence of Organic Acids on Diltiazem HCl Release Kinetics from Hydroxypropyl Methyl Cellulose Matrix Tablets. | 2010 | J Young Pharm | pmid:21042476 |
Karande AD et al. | In-line quantification of micronized drug and excipients in tablets by near infrared (NIR) spectroscopy: Real time monitoring of tabletting process. | 2010 | Int J Pharm | pmid:20558264 |
Hurko O et al. | Ablation of the locus coeruleus increases oxidative stress in tg-2576 transgenic but not wild-type mice. | 2010 | Int J Alzheimers Dis | pmid:20981353 |
Kim IS and Oh IJ | Preparation and characterization of stearic acid-pullulan nanoparticles. | 2010 | Arch. Pharm. Res. | pmid:20512475 |
Wang J et al. | Solid-state interactions of a drug substance and excipients and their impact on tablet dissolution: a thermal-mechanical facilitated process-induced transformation or PIT. | 2010 | J Pharm Sci | pmid:20533436 |
Eftaiha AF et al. | Bioadhesive controlled metronidazole release matrix based on chitosan and xanthan gum. | 2010 | Mar Drugs | pmid:20559494 |
Normand-Lauzière F et al. | Increased postprandial nonesterified fatty acid appearance and oxidation in type 2 diabetes is not fully established in offspring of diabetic subjects. | 2010 | PLoS ONE | pmid:20532041 |
Rivera CA et al. | Toll-like receptor-2 deficiency enhances non-alcoholic steatohepatitis. | 2010 | BMC Gastroenterol | pmid:20509914 |
Barupal DK et al. | Hydrocarbon phenotyping of algal species using pyrolysis-gas chromatography mass spectrometry. | 2010 | BMC Biotechnol. | pmid:20492649 |
Harvey KA et al. | Oleic acid inhibits stearic acid-induced inhibition of cell growth and pro-inflammatory responses in human aortic endothelial cells. | 2010 | J. Lipid Res. | pmid:20852092 |
Blanco M and Peguero A | Influence of physical factors on the accuracy of calibration models for NIR spectroscopy. | 2010 | J Pharm Biomed Anal | pmid:20044229 |
Invernizzi G et al. | Sustained upregulation of stearoyl-CoA desaturase in bovine mammary tissue with contrasting changes in milk fat synthesis and lipogenic gene networks caused by lipid supplements. | 2010 | Funct. Integr. Genomics | pmid:20607344 |
Chon B et al. | Shell and ligand-dependent blinking of CdSe-based core/shell nanocrystals. | 2010 | Phys Chem Chem Phys | pmid:20607188 |
Lin SY et al. | Solid-state transformation of different gabapentin polymorphs upon milling and co-milling. | 2010 | Int J Pharm | pmid:20561572 |
Bunn RC et al. | Palmitate and insulin synergistically induce IL-6 expression in human monocytes. | 2010 | Cardiovasc Diabetol | pmid:21054880 |
Asai T and Fujimoto Y | Cyclic fatty acyl glycosides in the glandular trichome exudate of Silene gallica. | 2010 | Phytochemistry | pmid:20541780 |
Foster SP and Johnson CP | Feeding and hemolymph trehalose concentration influence sex pheromone production in virgin Heliothis virescens moths. | 2010 | J. Insect Physiol. | pmid:20540946 |
Thörn K and Bergsten P | Fatty acid-induced oxidation and triglyceride formation is higher in insulin-producing MIN6 cells exposed to oleate compared to palmitate. | 2010 | J. Cell. Biochem. | pmid:20524206 |
Nokhodchi A et al. | Physico-mechanical and dissolution behaviours of ibuprofen crystals crystallized in the presence of various additives. | 2010 | Daru | pmid:22615598 |
Milanovic J et al. | Microencapsulation of flavors in carnauba wax. | 2010 | Sensors (Basel) | pmid:22315575 |
Jun HY et al. | Long residence time of ultrasound microbubbles targeted to integrin in murine tumor model. | 2010 | Acad Radiol | pmid:19815430 |
Lai TY et al. | Alterations in serum fatty acid concentrations and desaturase activities in Bietti crystalline dystrophy unaffected by CYP4V2 genotypes. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:19797200 |
Thomas CP et al. | Phospholipid-esterified eicosanoids are generated in agonist-activated human platelets and enhance tissue factor-dependent thrombin generation. | 2010 | J. Biol. Chem. | pmid:20061396 |