stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Pohl EE et al. | Changes of intrinsic membrane potentials induced by flip-flop of long-chain fatty acids. | 2000 | Biochemistry | pmid:10677234 |
Rey H et al. | Development of matrix-based theophylline sustained-release microtablets. | 2000 | Drug Dev Ind Pharm | pmid:10677806 |
Saito A et al. | Effects of capsaicin on biliary free fatty acids in rats. | 2000 | Int J Vitam Nutr Res | pmid:10683757 |
Chang RK and Hussain MA | Consolidation behavior of an experimental, cross-linked polyalkyl ammonium polymer. | 2000 | Drug Dev Ind Pharm | pmid:10697761 |
Willie BM et al. | Elemental and morphological identification of third-body particulate and calcium stearate inclusions in polyethylene components. | 2000 | J. Biomed. Mater. Res. | pmid:10713559 |
Jenkins TC | Feeding oleamide to lactating Jersey cows 1. Effects on lactation performance and milk fatty acid composition. | 2000 | J. Dairy Sci. | pmid:10714869 |
Sanders TA et al. | Influence of fatty acid chain length and cis/trans isomerization on postprandial lipemia and factor VII in healthy subjects (postprandial lipids and factor VII). | 2000 | Atherosclerosis | pmid:10729392 |
Shiromani PK and Clair J | Statistical comparison of high-shear versus low-shear granulation using a common formulation. | 2000 | Drug Dev Ind Pharm | pmid:10738654 |
el-Mahdi IM and Deasy PB | Tableting of coated ketoprofen pellets. | 2000 Mar-Apr | J Microencapsul | pmid:10738689 |
Muller D et al. | Niosomes as carriers of radiopaque contrast agents for X-ray imaging. | 2000 Mar-Apr | J Microencapsul | pmid:10738698 |
Florin-Christensen J et al. | Phosphatidylcholine formation is the predominant lipid biosynthetic event in the hemoparasite Babesia bovis. | 2000 | Mol. Biochem. Parasitol. | pmid:10743618 |
Plötz BM et al. | Characterization of a novel lipid A containing D-galacturonic acid that replaces phosphate residues. The structure of the lipid a of the lipopolysaccharide from the hyperthermophilic bacterium Aquifex pyrophilus. | 2000 | J. Biol. Chem. | pmid:10753930 |
Ahrabi SF et al. | Influence of neutron activation factors on matrix tablets for site specific delivery to the colon. | 2000 | Eur J Pharm Sci | pmid:10767600 |
Swaminathan V and Kildsig DO | The effect of particle morphology on the physical stability of pharmaceutical powder mixtures: the effect of surface roughness of the carrier on the stability of ordered mixtures. | 2000 | Drug Dev Ind Pharm | pmid:10769777 |
Schmider W et al. | Transport of heptafluorostearate across model membranes. Membrane transport of long-chain fatty acid anions I. | 2000 | J. Lipid Res. | pmid:10787438 |
Wissing S et al. | An investigation into the use of stepwise isothermal high sensitivity DSC as a means of detecting drug-excipient incompatibility. | 2000 | Int J Pharm | pmid:10802407 |
Min Y et al. | Pregnancy reduces arachidonic and docosahexaenoic in plasma triacylglycerols of Korean women. | 2000 | Int J Vitam Nutr Res | pmid:10804459 |
Pignatello R et al. | In vitro release kinetics of Tolmetin from tabletted Eudragit microparticles. | 2000 May-Jun | J Microencapsul | pmid:10819424 |
Tsuda K et al. | Role of insulin in the regulation of membrane fluidity of erythrocytes in essential hypertension: an electron paramagnetic resonance investigation. | 2000 | Am. J. Hypertens. | pmid:10821339 |
Aguilella VM et al. | Double layer potential and degree of dissociation in charged lipid monolayers. | 2000 | Chem. Phys. Lipids | pmid:10823470 |
Messier AM and Bizzozero OA | Conserved fatty acid composition of proteolipid protein during brain development and in myelin subfractions. | 2000 | Neurochem. Res. | pmid:10823577 |
Bessesen DH et al. | Trafficking of dietary oleic, linolenic, and stearic acids in fasted or fed lean rats. | 2000 | Am. J. Physiol. Endocrinol. Metab. | pmid:10827016 |
Ehinger AM and Kietzmann M | Tissue distribution of oxacillin and ampicillin in the isolated perfused bovine udder. | 2000 | J Vet Med A Physiol Pathol Clin Med | pmid:10842465 |
Richieri GV et al. | Fatty acid binding proteins from different tissues show distinct patterns of fatty acid interactions. | 2000 | Biochemistry | pmid:10852718 |
Zhang Q et al. | Studies on the cyclosporin A loaded stearic acid nanoparticles. | 2000 | Int J Pharm | pmid:10867245 |
Stanley JC | VAT and fat. Taxing single nutrient is dangerous. | 2000 | BMJ | pmid:10877557 |
Robson H et al. | An investigation into the release of cefuroxime axetil from taste-masked stearic acid microspheres. III. The use of DSC and HSDSC as means of characterising the interaction of the microspheres with buffered media. | 2000 | Int J Pharm | pmid:10878327 |
Schweigert FJ and Bok V | Vitamin A in blood plasma and urine of dogs is affected by the dietary level of vitamin A. | 2000 | Int J Vitam Nutr Res | pmid:10883401 |
Le Hénaff M and Fontenelle C | Chemical analysis of processing of spiralin, the major lipoprotein of Spiroplasma melliferum. | 2000 May-Jun | Arch. Microbiol. | pmid:10896212 |
Bogataj M et al. | The influence of magnesium stearate on the characteristics of mucoadhesive microspheres. | 2000 Jul-Aug | J Microencapsul | pmid:10898089 |
Enjalbert F et al. | Effects of duodenal infusions of palmitic, stearic, or oleic acids on milk composition and physical properties of butter. | 2000 | J. Dairy Sci. | pmid:10908048 |
Russo LI and Ghaly ES | Drug release from Carbomer 934 matrices. | 2000 | P R Health Sci J | pmid:10909708 |
Vashchuk VV and Vashchuk VV | [The use of the catalase P-47 preparation for treating long-term nonhealing wounds and trophic ulcers]. | 1993 | Klin Khir | pmid:10912018 |
Lee WN et al. | Loss of regulation of lipogenesis in the Zucker diabetic (ZDF) rat. | 2000 | Am. J. Physiol. Endocrinol. Metab. | pmid:10913044 |
Siaan M et al. | Influence of Avicel PH-301 on the compressibility of alpha-methyldopa and phenobarbitone in direct compression. | 2000 | Drug Dev Ind Pharm | pmid:10914328 |
Robles Valderrama E et al. | [Application of gas chromatography in the identification of Enterobacter cloacae, Enterobacter aerogenes, and Enterobacter agglomerans]. | 1999 Jan-Mar | Rev. Latinoam. Microbiol. | pmid:10932747 |
Wardrop J et al. | Determination of erythromycin and related substances in enteric-coated tablet formulations by reversed-phase liquid chromatography. | 2000 | J Pharm Sci | pmid:10944374 |
Khalil MH et al. | Topical application of docosanol- or stearic acid-containing creams reduces severity of phenol burn wounds in mice. | 2000 | Contact Derm. | pmid:10945745 |
Kim YC et al. | Differential regulation of the stearoyl-CoA desaturase genes by thiazolidinediones in 3T3-L1 adipocytes. | 2000 | J. Lipid Res. | pmid:10946019 |
Ishioka T et al. | Infrared and XAFS study on structure and transition behavior of zinc stearate. | 2000 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:10952134 |
MuzÃk M and MuzÃková J | [Effect of magnesium stearate on internal failure of Avicel PH 101 tablets]. | 2000 | Ceska Slov Farm | pmid:10953461 |
Hennig B et al. | Fatty acid-mediated activation of vascular endothelial cells. | 2000 | Metab. Clin. Exp. | pmid:10954018 |
Hatipoglu ON and Tasan Y | A comparative efficacy and safety study of clarithromycin, roxithromycin and erythromycin stearate in mild pneumonia. | 2000 | Yonsei Med. J. | pmid:10957888 |
Hattori Y et al. | Role of phospholipase A2 in cholesterol gallstone formation is associated with biliary phospholipid species selection at the site of hepatic excretion: indirect evidence. | 2000 | Dig. Dis. Sci. | pmid:10961723 |
Broderick PA et al. | Monoamine neurotransmitters in resected hippocampal subparcellations from neocortical and mesial temporal lobe epilepsy patients: in situ microvoltammetric studies. | 2000 | Brain Res. | pmid:10996135 |
Willie BM et al. | Possible explanation for the white band artifact seen in clinically retrieved polyethylene tibial components. | 2000 | J. Biomed. Mater. Res. | pmid:11007625 |
DeLany JP et al. | Differential oxidation of individual dietary fatty acids in humans. | 2000 | Am. J. Clin. Nutr. | pmid:11010930 |
Mossab A et al. | Utilization of soybean oil and tallow in young turkeys compared with young chickens. | 2000 | Poult. Sci. | pmid:11020079 |
Engler MM et al. | Dietary docosahexaenoic acid affects stearic acid desaturation in spontaneously hypertensive rats. | 2000 | Lipids | pmid:11026622 |
Miersch O and Wasternack C | Octadecanoid and jasmonate signaling in tomato (Lycopersicon esculentum Mill.) leaves: endogenous jasmonates do not induce jasmonate biosynthesis. | 2000 | Biol. Chem. | pmid:11030429 |