stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Jensen RG et al. | Parenteral infusion of a lactating woman with intralipid: changes in milk and plasma fatty acids. | 2001 | Adv. Exp. Med. Biol. | pmid:11787679 |
Comai K et al. | Analyses of renal medullary lipid droplets from normal, hydronephrotic, and indomethacin treated rabbits. | 1975 | Lipids | pmid:1177669 |
Mackin L et al. | The impact of low levels of amorphous material (<5%) on the blending characteristics of a direct compression formulation. | 2002 | Int J Pharm | pmid:11755273 |
Otsuka M et al. | Comparative evaluation of tableting compression behaviors by methods of internal and external lubricant addition: inhibition of enzymatic activity of trypsin preparation by using external lubricant addition during the tableting compression process. | 2001 | AAPS PharmSci | pmid:11741271 |
Kuppuswamy R et al. | Estimation of capping incidence by indentation fracture tests. | 2001 | AAPS PharmSci | pmid:11741256 |
Lee I and Kadenbach B | Palmitate decreases proton pumping of liver-type cytochrome c oxidase. | 2001 | Eur. J. Biochem. | pmid:11737187 |
Glew RH et al. | Fatty acid composition of the milk lipids of Nepalese women: correlation between fatty acid composition of serum phospholipids and melting point. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11728165 |
Chen DB et al. | In vitro and in vivo study of two types of long-circulating solid lipid nanoparticles containing paclitaxel. | 2001 | Chem. Pharm. Bull. | pmid:11724235 |
Carballeira NM et al. | Identification and total synthesis of novel fatty acids from the Siphonarid limpet Siphonaria denticulata. | 2001 | J. Nat. Prod. | pmid:11720525 |
Garzón Mde L and Villafuerte L | Compactibility of mixtures of calcium carbonate and microcrystalline cellulose. | 2002 | Int J Pharm | pmid:11719011 |
Futaki S et al. | Stearylated arginine-rich peptides: a new class of transfection systems. | 2001 Nov-Dec | Bioconjug. Chem. | pmid:11716693 |
Mironova GD et al. | Palmitic and stearic acids bind Ca2+ with high affinity and form nonspecific channels in black-lipid membranes. Possible relation to Ca2+-activated mitochondrial pores. | 2001 | J. Bioenerg. Biomembr. | pmid:11710807 |
Khabbaz F and Albertsson AC | Great advantages in using a natural rubber instead of a synthetic SBR in a pro-oxidant system for degradable LDPE. | 2000 | Biomacromolecules | pmid:11710197 |
Finley JW and Davis CD | Manganese absorption and retention in rats is affected by the type of dietary fat. | 2001 | Biol Trace Elem Res | pmid:11697763 |
Raila J et al. | Plasma transport and tissue distribution of beta-carotene, vitamin A and retinol-binding protein in domestic cats. | 2001 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:11691620 |
Stehlin C et al. | X-ray structure of the orphan nuclear receptor RORbeta ligand-binding domain in the active conformation. | 2001 | EMBO J. | pmid:11689423 |
Maynar M et al. | Menopause-induced changes in lipid fractions and total fatty acids in plasma. | 2001 | Endocr. Res. | pmid:11678583 |
Rahamatalla AB et al. | Changes in fatty acids composition during seed growth and physicochemical characteristics of oil extracted from four safflower cultivars. | 2001 | Plant Foods Hum Nutr | pmid:11678443 |
Voinovich D et al. | Melt pelletization in high shear mixer using a hydrophobic melt binder: influence of some apparatus and process variables. | 2001 | Eur J Pharm Biopharm | pmid:11677073 |
Baines DL et al. | Fatty acid modulation and sequence identity of fetal guinea pig alveolar type II cell amiloride-sensitive Na+ channel. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11676504 |
Haastrup A et al. | Lipids stimulate the production of 6-keto-prostaglandin f(1alpha) in human dorsal hand veins. | 2001 | Hypertension | pmid:11641299 |
Bézaire V et al. | Effects of fasting on muscle mitochondrial energetics and fatty acid metabolism in Ucp3(-/-) and wild-type mice. | 2001 | Am. J. Physiol. Endocrinol. Metab. | pmid:11595653 |
Nakanishi M et al. | Characterisation of myogenic cell membrane: II. Dynamic changes in membrane lipids during the differentiation of mouse C2 myoblast cells. | 2001 | Cell Biol. Int. | pmid:11589611 |
Shen Z et al. | Fatty acid composition of lysophosphatidic acid and lysophosphatidylinositol in plasma from patients with ovarian cancer and other gynecological diseases. | 2001 | Gynecol. Oncol. | pmid:11585410 |
Moon YA et al. | Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteins. | 2001 | J. Biol. Chem. | pmid:11567032 |
Weaire PJ and Kekwick RG | The fractionation of the fatty acid synthetase activities of avocado mesocarp plastids. | 1975 | Biochem. J. | pmid:1156381 |
Fomuso LB and Akoh CC | Enzymatic modification of high-laurate canola to produce margarine fat. | 2001 | J. Agric. Food Chem. | pmid:11559158 |
Russell NJ and Harwood JL | Changes in the acyl lipid composition of photosynthetic bacteria grown under photosynthetic and non-photosynthetic conditions. | 1979 | Biochem. J. | pmid:115463 |
Boros LG and Williams RD | Isofenphos induced metabolic changes in K562 myeloid blast cells. | 2001 | Leuk. Res. | pmid:11532522 |
Ebba F et al. | Stress relaxation studies of granules as a function of different lubricants. | 2001 | Eur J Pharm Biopharm | pmid:11522488 |
Pierri EG et al. | Determination of oxamniquine in capsules by HPLC. | 2001 | J Pharm Biomed Anal | pmid:11516919 |
York P | Application of powder failure testing equipment in assessing effect on glidants on flowability of cohesive pharmaceutical powders. | 1975 | J Pharm Sci | pmid:1151687 |
Takamoto DY et al. | Stable ordering in Langmuir-Blodgett films. | 2001 | Science | pmid:11509723 |
Zaghloul AA et al. | Response surface methodology to obtain naproxen controlled release tablets from its microspheres with Eudragit L100-55. | J Microencapsul | pmid:11508770 | |
Hunter KA et al. | Effect of diets rich in oleic acid, stearic acid and linoleic acid on postprandial haemostatic factors in young healthy men. | 2001 | Br. J. Nutr. | pmid:11502234 |
Wu P et al. | Atemoyacin E, a bis-tetrahydrofuran annonaceous acetogenin from Annona atemoya seeds. | 2001 | J Asian Nat Prod Res | pmid:11491392 |
Choo CY et al. | The cytotoxicity and chemical constituents of the hexane fraction of Typhonium flagelliforme (Araceace). | 2001 | J Ethnopharmacol | pmid:11483390 |
Gupta SV and Khosla P | Palmitic and stearic acids similarly affect plasma lipoprotein metabolism in cynomolgus monkeys fed diets with adequate levels of linoleic acid. | 2001 | J. Nutr. | pmid:11481404 |
Lalman JA and Bagley DM | Anaerobic degradation and methanogenic inhibitory effects of oleic and stearic acids. | 2001 | Water Res. | pmid:11471698 |
Mu YM et al. | Saturated FFAs, palmitic acid and stearic acid, induce apoptosis in human granulosa cells. | 2001 | Endocrinology | pmid:11459807 |
Thompson GE and Darling KF | The hepatic uptake of individual free fatty acids in sheep during noradrenaline infusion. | 1975 | Res. Vet. Sci. | pmid:1144925 |
Hilpert B et al. | Isolation and characterization of signal transduction mutants of Arabidopsis thaliana that constitutively activate the octadecanoid pathway and form necrotic microlesions. | 2001 | Plant J. | pmid:11439130 |
Radwan SS et al. | Effects of lipids on n-alkane attenuation in media supporting oil-utilizing microorganisms from the oily Arabian Gulf coasts. | 2001 | FEMS Microbiol. Lett. | pmid:11430415 |
Kim JY et al. | Lipid and fatty acid analysis of fresh and frozen-thawed immature and in vitro matured bovine oocytes. | 2001 | Reproduction | pmid:11425337 |
Liang X et al. | Heterogeneous fatty acylation of Src family kinases with polyunsaturated fatty acids regulates raft localization and signal transduction. | 2001 | J. Biol. Chem. | pmid:11423543 |
Morita YS and Englund PT | Fatty acid remodeling of glycosyl phosphatidylinositol anchors in Trypanosoma brucei: incorporation of fatty acids other than myristate. | 2001 | Mol. Biochem. Parasitol. | pmid:11420102 |
Zhang L et al. | Isolation and characterization of the human stearoyl-CoA desaturase gene promoter: requirement of a conserved CCAAT cis-element. | 2001 | Biochem. J. | pmid:11415448 |
Hashimoto F et al. | Accumulation of medium chain acyl-CoAs during beta-oxidation of long chain fatty acid by isolated peroxisomes from rat liver. | 2001 | Biol. Pharm. Bull. | pmid:11411544 |
Kamm W et al. | Analysis of steryl esters in cocoa butter by on-line liquid chromatography-gas chromatography. | 2001 | J Chromatogr A | pmid:11407581 |
Chen H et al. | Effect of cholesterol on miscibility and phase behavior in binary mixtures with synthetic ceramide 2 and octadecanoic acid. Infrared studies. | 2001 | Biochim. Biophys. Acta | pmid:11406112 |
Bolhuis GK et al. | DC calcium lactate, a new filler-binder for direct compaction of tablets. | 2001 | Int J Pharm | pmid:11397569 |
Parkes JG and Thompson W | Phosphatidylethanolamine in liver mitochondria and endoplasmic reticulum: molecular species distribution and turnover. | 1975 | Can. J. Biochem. | pmid:1139407 |
Kuksis A et al. | Distribution of newly formed palmitate and stearate among molecular species of choline and ethanolamine phosphatides. | 1975 | Can. J. Biochem. | pmid:1139395 |
Kuksis A et al. | Distribution of newly formed fatty acids among glycerolipids of isolated perfused rat liver. | 1975 | Can. J. Biochem. | pmid:1139394 |
Yu HY et al. | Saturated non-esterified fatty acids stimulate de novo diacylglycerol synthesis and protein kinase c activity in cultured aortic smooth muscle cells. | 2001 | Diabetologia | pmid:11380080 |
Clouet P et al. | Mitochondrial respiration on rumenic and linoleic acids. | 2001 | Biochem. Soc. Trans. | pmid:11356175 |
Waddington E et al. | Identification and quantitation of unique fatty acid oxidation products in human atherosclerotic plaque using high-performance liquid chromatography. | 2001 | Anal. Biochem. | pmid:11355856 |
Ghanouni P et al. | Agonist-induced conformational changes in the G-protein-coupling domain of the beta 2 adrenergic receptor. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11353823 |
DePeters EJ et al. | Fatty acid and triglyceride composition of milk fat from lactating Holstein cows in response to supplemental canola oil. | 2001 | J. Dairy Sci. | pmid:11352169 |
Ferreira JA et al. | Hydrophobic interactions between spin-label 5-SASL and humic acid as revealed by ESR spectroscopy. | 2001 | Environ. Sci. Technol. | pmid:11349289 |
Hong CY | Discovery of gemifloxacin (Factive, LB20304a): a quinolone of a new generation. | 2001 Jan-Feb | Farmaco | pmid:11347965 |
Dean DD et al. | Effect of polymer molecular weight and addition of calcium stearate on response of MG63 osteoblast-like cells to UHMWPE particles. | 2001 | J. Orthop. Res. | pmid:11347688 |
Ves-Losada A et al. | Incorporation and distribution of saturated and unsaturated fatty acids into nuclear lipids of hepatic cells. | 2001 | Lipids | pmid:11337983 |
Andrès C et al. | On the difficulty of assessing the specific surface area of magnesium stearate. | 2001 | Int J Pharm | pmid:11337159 |
Korkishko YN et al. | Characterization of alpha-phase soft proton-exchanged LiNbO3 optical waveguides. | 2001 | J Opt Soc Am A Opt Image Sci Vis | pmid:11336221 |
Ulmann L et al. | Brain and hippocampus fatty acid composition in phospholipid classes of aged-relative cognitive deficit rats. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11334555 |
Pacia SV et al. | Biogenic amines in the human neocortex in patients with neocortical and mesial temporal lobe epilepsy: identification with in situ microvoltammetry. | 2001 | Brain Res. | pmid:11311871 |
Oviedo JM et al. | Pulmonary surfactant protein SP-B is significantly more immunoreactive in anionic than in zwitterionic bilayers. | 2001 | FEBS Lett. | pmid:11311247 |
Kelly FD et al. | A stearic acid-rich diet improves thrombogenic and atherogenic risk factor profiles in healthy males. | 2001 | Eur J Clin Nutr | pmid:11305631 |
van den Bergh BA et al. | Elasticity of vesicles assessed by electron spin resonance, electron microscopy and extrusion measurements. | 2001 | Int J Pharm | pmid:11292538 |
Liu Q et al. | Genetic modification of cotton seed oil using inverted-repeat gene-silencing techniques. | 2000 | Biochem. Soc. Trans. | pmid:11288706 |
Fukui E et al. | Effect of magnesium stearate or calcium stearate as additives on dissolution profiles of diltiazem hydrochloride from press-coated tablets with hydroxypropylmethylcellulose acetate succinate in the outer shell. | 2001 | Int J Pharm | pmid:11274815 |
Harwood JL and James AT | Metabolism of trans-3-hexadecenoic acid in broad bean. | 1975 | Eur. J. Biochem. | pmid:1126340 |
Alves MM et al. | Effects of lipids and oleic acid on biomass development in anaerobic fixed-bed reactors. Part II: Oleic acid toxicity and biodegradability. | 2001 | Water Res. | pmid:11257881 |
Hatta I et al. | X-ray diffraction study on ordered, disordered and reconstituted intercellular lipid lamellar structure in stratum corneum. | 2001 | Biophys. Chem. | pmid:11254216 |
Nishioka Y and Yoshino H | Lymphatic targeting with nanoparticulate system. | 2001 | Adv. Drug Deliv. Rev. | pmid:11251245 |
Sabir A et al. | Formulation and process optimization to eliminate picking from market image tablets. | 2001 | Int J Pharm | pmid:11250098 |
Höltje M et al. | Molecular dynamics simulations of stratum corneum lipid models: fatty acids and cholesterol. | 2001 | Biochim. Biophys. Acta | pmid:11248214 |
Thosar SS et al. | A comparison of reflectance and transmittance near-infrared spectroscopic techniques in determining drug content in intact tablets. | 2001 | Pharm Dev Technol | pmid:11247272 |
Liang P et al. | [Chemical constituents of Pericampylus glaucus (Lam.) Merr]. | 1998 | Zhongguo Zhong Yao Za Zhi | pmid:11243154 |
Fatibello-Filho O and Vieira IC | Construction and analytical application of a biosensor based on stearic acid-graphite powder modified with sweet potato tissue in organic solvents. | 2000 | Fresenius J Anal Chem | pmid:11227501 |
De Vriese SR et al. | The composition of saturated fatty acids in plasma phospholipids changes in a way to counteract changes in the mean melting point during pregnancy. | 2001 | Lipids | pmid:11214724 |
Habán P et al. | Oleic acid serum phospholipid content is linked with the serum total- and LDL-cholesterol in elderly subjects. | 2000 Nov-Dec | Med. Sci. Monit. | pmid:11208461 |
Parveez GK et al. | Transgenic oil palm: production and projection. | 2000 | Biochem. Soc. Trans. | pmid:11171275 |
Kaushik N and Vir S | Variations in fatty acid composition of neem seeds collected from the Rajasthan state of India. | 2000 | Biochem. Soc. Trans. | pmid:11171243 |
Byrdwell WC et al. | Triacylglycerol analysis of potential margarine base stocks by high-performance liquid chromatography with atmospheric pressure chemical ionization mass spectrometry and flame ionization detection. | 2001 | J. Agric. Food Chem. | pmid:11170612 |
Kita K et al. | Characterization of the reversible nature of the reaction catalyzed by sphingolipid ceramide N-deacylase. A novel form of reverse hydrolysis reaction. | 2001 | Eur. J. Biochem. | pmid:11168398 |
Fukui E et al. | An in vitro investigation of the suitability of press-coated tablets with hydroxypropylmethylcellulose acetate succinate (HPMCAS) and hydrophobic additives in the outer shell for colon targeting. | 2001 | J Control Release | pmid:11166411 |
Sakuma S et al. | The effects of fatty acyl CoA esters on the formation of prostaglandin and arachidonoyl-CoA formed from arachidonic acid in rabbit kidney medulla microsomes. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11161586 |
Montell E et al. | DAG accumulation from saturated fatty acids desensitizes insulin stimulation of glucose uptake in muscle cells. | 2001 | Am. J. Physiol. Endocrinol. Metab. | pmid:11158925 |
Smith AM et al. | Phase I/II study of G17-DT, an anti-gastrin immunogen, in advanced colorectal cancer. | 2000 | Clin. Cancer Res. | pmid:11156225 |
Wu J et al. | Influence of wet granulation and lubrication on the powder and tableting properties of codried product of microcrystalline cellulose with beta-cyclodextrin. | 2001 | Eur J Pharm Biopharm | pmid:11154905 |
Leese GP et al. | Effects of growth hormone treatment on red cell plasma membrane fatty acid constituents in hypopituitary adults. | 2000 | Scott Med J | pmid:11130294 |
Williams EE et al. | The curvature and cholesterol content of phospholipid bilayers alter the transbilayer distribution of specific molecular species of phosphatidylethanolamine. | 2000 Jul-Sep | Mol. Membr. Biol. | pmid:11128974 |
Fitch CD et al. | A role for linoleic acid in erythrocytes infected with Plasmodium berghei. | 2000 | Biochim. Biophys. Acta | pmid:11113630 |
Mizukoshi Y et al. | Preparation of platinum nanoparticles by sonochemical reduction of the Pt(IV) ions: role of surfactants. | 2001 | Ultrason Sonochem | pmid:11105315 |
Hannah VC et al. | Unsaturated fatty acids down-regulate srebp isoforms 1a and 1c by two mechanisms in HEK-293 cells. | 2001 | J. Biol. Chem. | pmid:11085986 |
Chayabutra C et al. | Rhamnolipid production by Pseudomonas aeruginosa under denitrification: effects of limiting nutrients and carbon substrates. | 2001 | Biotechnol. Bioeng. | pmid:11084590 |
Knopp RH et al. | One-year effects of increasingly fat-restricted, carbohydrate-enriched diets on lipoprotein levels in free-living subjects. | 2000 | Proc. Soc. Exp. Biol. Med. | pmid:11082213 |
Podczeck F and Newton JM | Powder and capsule filling properties of lubricated granulated cellulose powder. | 2000 | Eur J Pharm Biopharm | pmid:11072194 |