stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Lee I and Kadenbach B | Palmitate decreases proton pumping of liver-type cytochrome c oxidase. | 2001 | Eur. J. Biochem. | pmid:11737187 |
Kuppuswamy R et al. | Estimation of capping incidence by indentation fracture tests. | 2001 | AAPS PharmSci | pmid:11741256 |
Otsuka M et al. | Comparative evaluation of tableting compression behaviors by methods of internal and external lubricant addition: inhibition of enzymatic activity of trypsin preparation by using external lubricant addition during the tableting compression process. | 2001 | AAPS PharmSci | pmid:11741271 |
Mackin L et al. | The impact of low levels of amorphous material (<5%) on the blending characteristics of a direct compression formulation. | 2002 | Int J Pharm | pmid:11755273 |
Comai K et al. | Analyses of renal medullary lipid droplets from normal, hydronephrotic, and indomethacin treated rabbits. | 1975 | Lipids | pmid:1177669 |
Jensen RG et al. | Parenteral infusion of a lactating woman with intralipid: changes in milk and plasma fatty acids. | 2001 | Adv. Exp. Med. Biol. | pmid:11787679 |
Yu MD et al. | The effect of formulation on reduced radioiodide thyroid uptake. | 2002 | J. Nucl. Med. | pmid:11801703 |
Pedrazzi V et al. | Tensile bond strength of a polymeric intra-buccal bioadhesive: the mucin role. | 2001 Nov-Dec | Boll Chim Farm | pmid:11822242 |
Papanikolaou S et al. | Kinetic profile of the cellular lipid composition in an oleaginous Yarrowia lipolytica capable of producing a cocoa-butter substitute from industrial fats. | 2001 | Antonie Van Leeuwenhoek | pmid:11827207 |
Bassilian S et al. | Loss of regulation of lipogenesis in the Zucker diabetic rat. II. Changes in stearate and oleate synthesis. | 2002 | Am. J. Physiol. Endocrinol. Metab. | pmid:11832351 |
Anderson RR et al. | Composition of cottontail rabbit milk from stomachs of young and directly from gland. | 1975 | J. Dairy Sci. | pmid:1184805 |
Shu T et al. | Studies of rapidly disintegrating tablets in the oral cavity using co-ground mixtures of mannitol with crospovidone. | 2002 | Chem. Pharm. Bull. | pmid:11848208 |
Gaginella TS et al. | Actions of ricinoleic acid and structurally related fatty acids on the gastrointestinal tract. II. Effects on water and electrolyte absorption in vitro. | 1975 | J. Pharmacol. Exp. Ther. | pmid:1185605 |
Kidokoro M et al. | Application of fluidized hot-melt granulation (FHMG) for the preparation of granules for tableting; properties of granules and tablets prepared by FHMG. | 2002 | Drug Dev Ind Pharm | pmid:11858526 |
Mosley EE et al. | Microbial biohydrogenation of oleic acid to trans isomers in vitro. | 2002 | J. Lipid Res. | pmid:11861671 |
Smith RW and Walsh A | Composition of liver lipids of the rat during pregnancy and lactation. | 1975 | Lipids | pmid:1186452 |
Lippacher A et al. | Semisolid SLN dispersions for topical application: influence of formulation and production parameters on viscoelastic properties. | 2002 | Eur J Pharm Biopharm | pmid:11879997 |
Rambaut PC and Johnston RS | Prolonged weightlessness and calcium loss in man. | 1979 | Acta Astronaut | pmid:11883480 |
Schmidt P et al. | [Animal experiments on barium stearate toxicity]. | 1975 | Z Gesamte Hyg | pmid:1189478 |
Pan J and Chung FL | Formation of cyclic deoxyguanosine adducts from omega-3 and omega-6 polyunsaturated fatty acids under oxidative conditions. | 2002 | Chem. Res. Toxicol. | pmid:11896684 |
Palma S et al. | Design of Peumus boldus tablets by direct compression using a novel dry plant extract. | 2002 | Int J Pharm | pmid:11897423 |
MuzÃková J | [Effect of magnesium stearate on the tensile strength of tablets made with the binder Prosolv SMCC 90]. | 2002 | Ceska Slov Farm | pmid:11910741 |
Long GT et al. | Hard to swallow dry: kinetics and mechanism of the anhydrous thermal decomposition of acetylsalicylic acid. | 2002 | J Pharm Sci | pmid:11920766 |
Yokoyama K et al. | Computerized posturography with sway frequency analysis: application in occupational and environmental health. | 2002 | Ind Health | pmid:11926510 |
Gravena C et al. | Acute effects of fatty acids on insulin secretion from rat and human islets of Langerhans. | 2002 | J. Endocrinol. | pmid:11927386 |
Kushibiki S et al. | Effect of beta-lactoglobulin on plasma retinol and triglyceride concentrations, and fatty acid composition in calves. | 2001 | J. Dairy Res. | pmid:11928954 |
Wanten GJ et al. | Saturated triglycerides and fatty acids activate neutrophils depending on carbon chain-length. | 2002 | Eur. J. Clin. Invest. | pmid:11952815 |
Sato M et al. | [Clinical studies on OE-7 chiefly in the treatment of acute respiratory infections (author's transl)]. | 1975 | Jpn J Antibiot | pmid:1195513 |
Yao Y et al. | Regulation of triacylglycerol and phospholipid trafficking by fatty acids in newborn swine enterocytes. | 2002 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11960778 |
Møller JK et al. | Effect of nitrosylmyoglobin and saturated fatty acid anions on metmyoglobin-catalyzed oxidation of aqueous methyl linoleate emulsions. | 2002 | Biochim. Biophys. Acta | pmid:11985897 |
Eromosele CO and Eromosele IC | Fatty acid compositions of seed oils of Haematostaphis barteri and Ximenia americana. | 2002 | Bioresour. Technol. | pmid:11991081 |
Ali J et al. | Buccoadhesive erodible disk for treatment of oro-dental infections: design and characterisation. | 2002 | Int J Pharm | pmid:11996813 |
Bolwell GP et al. | The apoplastic oxidative burst in response to biotic stress in plants: a three-component system. | 2002 | J. Exp. Bot. | pmid:11997382 |
Alhamami OM | The effects of some physico-chemical factors and pharmaceutical excipients on the bioavailability of nitrofurantoin oily and aqueous suspensions in rats. | 2002 | Drug Dev Ind Pharm | pmid:12026223 |
Dobbins RL et al. | The composition of dietary fat directly influences glucose-stimulated insulin secretion in rats. | 2002 | Diabetes | pmid:12031970 |
Kelly FD et al. | Short-term diets enriched in stearic or palmitic acids do not alter plasma lipids, platelet aggregation or platelet activation status. | 2002 | Eur J Clin Nutr | pmid:12032647 |
Hu PC and Chen BH | Effects of riboflavin and fatty acid methyl esters on cholesterol oxidation during illumination. | 2002 | J. Agric. Food Chem. | pmid:12033831 |
Cozzini P et al. | Simple, intuitive calculations of free energy of binding for protein-ligand complexes. 1. Models without explicit constrained water. | 2002 | J. Med. Chem. | pmid:12036355 |
Ohta N and Hatta I | Interaction among molecules in mixtures of ceramide/stearic acid, ceramide/cholesterol and ceramide/stearic acid/cholesterol. | 2002 | Chem. Phys. Lipids | pmid:12047901 |
Singhal R et al. | Immobilization of urease on poly(N-vinyl carbazole)/stearic acid Langmuir-Blodgett films for application to urea biosensor. | 2002 | Biosens Bioelectron | pmid:12052355 |
Kashefi K et al. | Geoglobus ahangari gen. nov., sp. nov., a novel hyperthermophilic archaeon capable of oxidizing organic acids and growing autotrophically on hydrogen with Fe(III) serving as the sole electron acceptor. | 2002 | Int. J. Syst. Evol. Microbiol. | pmid:12054231 |
Aveldano MI and Bazán NG | Rapid production of diacylglycerols enriched in arachidonate and stearate during early brain ischemia. | 1975 | J. Neurochem. | pmid:1206411 |
Williams RO et al. | Investigation of excipient type and level on drug release from controlled release tablets containing HPMC. | 2002 | Pharm Dev Technol | pmid:12066573 |
Liu Q et al. | High-oleic and high-stearic cottonseed oils: nutritionally improved cooking oils developed using gene silencing. | 2002 | J Am Coll Nutr | pmid:12071306 |
Schmidt LE and Dalhoff K | Food-drug interactions. | 2002 | Drugs | pmid:12093316 |
Liang X et al. | Mass spectrometric analysis of GAP-43/neuromodulin reveals the presence of a variety of fatty acylated species. | 2002 | J. Biol. Chem. | pmid:12105219 |
Anwar F et al. | Analytical characterization of Salicornia bigelovii seed oil cultivated in Pakistan. | 2002 | J. Agric. Food Chem. | pmid:12105947 |
Sebti I et al. | Edible bioactive fatty acid-cellulosic derivative composites used in food-packaging applications. | 2002 | J. Agric. Food Chem. | pmid:12105960 |
Østdal H et al. | Reaction between protein radicals and other biomolecules. | 2002 | Free Radic. Biol. Med. | pmid:12106816 |
Cao X et al. | Langmuir and Langmuir-Blodgett films of a novel tryptophan peptide lipid. | 2002 | Chem. Commun. (Camb.) | pmid:12122989 |