stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Mottram AR et al. | Fatty acids antagonize bupivacaine-induced I(Na) blockade. | 2011 | Clin Toxicol (Phila) | pmid:21970771 |
Balducci AG et al. | Layered lipid microcapsules for mesalazine delayed-release in children. | 2011 | Int J Pharm | pmid:22001795 |
Kumar RV and Sinha VR | Tailoring of drug delivery of 5-fluorouracil to the colon via a mixed film coated unit system. | 2011 | Acta Pharm | pmid:21945913 |
Wang S et al. | Insertion of an esterase gene into a specific locust pathogen (Metarhizium acridum) enables it to infect caterpillars. | 2011 | PLoS Pathog. | pmid:21731492 |
Dani KG et al. | Structural and functional analyses of a saturated acyl ACP thioesterase, type B from immature seed tissue of Jatropha curcas. | 2011 | Plant Biol (Stuttg) | pmid:21489096 |
Haghjou N et al. | Sustained release intraocular drug delivery devices for treatment of uveitis. | 2011 | J Ophthalmic Vis Res | pmid:22454753 |
Huang HY et al. | Co-delivery of anti-vascular endothelial growth factor siRNA and doxorubicin by multifunctional polymeric micelle for tumor growth suppression. | 2011 | J Biomed Mater Res A | pmid:21465641 |
Hisazumi J et al. | Quantification of pharmaceutical polymorphs and prediction of dissolution rate using theophylline tablet by terahertz spectroscopy. | 2011 | Chem. Pharm. Bull. | pmid:21467671 |
Guntupalli R et al. | Phage Langmuir monolayers and Langmuir-Blodgett films. | 2011 | Colloids Surf B Biointerfaces | pmid:20843668 |
Saeed M et al. | Assessment of diffuse transmission and reflection modes in near-infrared quantification, part 2: DIFFuse reflection information depth. | 2011 | J Pharm Sci | pmid:20862671 |
Jishnu V et al. | Formulation and evaluation of cephalexin extended release matrix tablets using 3 factorial design. | 2011 | J Young Pharm | pmid:22224031 |
Wang K et al. | Oxaliplatin-incorporated micelles eliminate both cancer stem-like and bulk cell populations in colorectal cancer. | 2011 | Int J Nanomedicine | pmid:22238509 |
Du YZ et al. | Receptor-mediated gene delivery by folic acid-modified stearic acid-grafted chitosan micelles. | 2011 | Int J Nanomedicine | pmid:21845046 |
Oosterveer MH et al. | Resistance to diet-induced adiposity in cannabinoid receptor-1 deficient mice is not due to impaired adipocyte function. | 2011 | Nutr Metab (Lond) | pmid:22201701 |
Raynes Greenow CH et al. | Antibiotics for ureaplasma in the vagina in pregnancy. | 2011 | Cochrane Database Syst Rev | pmid:21901685 |
Wu DJ et al. | Metabonomics-based omics study and atherosclerosis. | 2011 | J Clin Bioinforma | pmid:22040517 |
Walash MI et al. | Development and validation of stability indicating method for determination of sertraline following ICH guidlines and its determination in pharmaceuticals and biological fluids. | 2011 | Chem Cent J | pmid:21996025 |
El-Enany NM et al. | Spectrofluorimetric determination of sertraline in dosage forms and human plasma through derivatization with 9-fluorenylmethyl chloroformate. | 2011 | Chem Cent J | pmid:21978386 |
Abdulrahman SA and Basavaiah K | Sensitive and selective spectrophotometric determination of gabapentin in capsules using two nitrophenols as chromogenic agents. | 2011 | Int J Anal Chem | pmid:21760787 |
Zenita O and Basavaiah K | Utility of N-bromosuccinimide for the titrimetric and spectrophotometric determination of famotidine in pharmaceutical formulations. | 2011 | Int J Anal Chem | pmid:21760785 |
Almer G et al. | Adiponectin-coated nanoparticles for enhanced imaging of atherosclerotic plaques. | 2011 | Int J Nanomedicine | pmid:21753879 |
Brown JD et al. | VLDL hydrolysis by hepatic lipase regulates PPARδ transcriptional responses. | 2011 | PLoS ONE | pmid:21750705 |
Fernandez C et al. | Altered desaturation and elongation of fatty acids in hormone-sensitive lipase null mice. | 2011 | PLoS ONE | pmid:21738729 |
Amaya KR et al. | Small molecule analysis and imaging of fatty acids in the zebra finch song system using time-of-flight-secondary ion mass spectrometry. | 2011 | J. Neurochem. | pmid:21496023 |
Duangjit S et al. | Characterization and In Vitro Skin Permeation of Meloxicam-Loaded Liposomes versus Transfersomes. | 2011 | J Drug Deliv | pmid:21490750 |
Kumaravelrajan R et al. | Development and evaluation of controlled porosity osmotic pump for nifedipine and metoprolol combination. | 2011 | Lipids Health Dis | pmid:21477386 |
Fabiano A et al. | Metabolomic analysis of bronchoalveolar lavage fluid in preterm infants complicated by respiratory distress syndrome: preliminary results. | 2011 | J. Matern. Fetal. Neonatal. Med. | pmid:21781003 |
Yee JK et al. | Organ-specific alterations in fatty acid de novo synthesis and desaturation in a rat model of programmed obesity. | 2011 | Lipids Health Dis | pmid:21569358 |
Shivanand K et al. | In vivo bioavailability studies of sumatriptan succinate buccal tablets. | 2011 | Daru | pmid:22615661 |
Gande S and Rao Y | Sustained-release effervescent floating matrix tablets of baclofen: development, optimization and in vitro-in vivo evaluation in healthy human volunteers. | 2011 | Daru | pmid:22615658 |
Varshosaz J et al. | Development of novel budesonide pellets based on CODES(TM) technology: In vitro/in vivo evaluation in induced colitis in rats. | 2011 | Daru | pmid:22615647 |
Dey S et al. | Formulation and optimization of sustained release Stavudine microspheres using response surface methodology. | 2011 | ISRN Pharm | pmid:22389855 |
Prajapati ST et al. | Formulation and evaluation of controlled-release tablet of zolpidem tartrate by melt granulation technique. | 2011 | ISRN Pharm | pmid:22389845 |
Flowers MT et al. | Metabolic changes in skin caused by Scd1 deficiency: a focus on retinol metabolism. | 2011 | PLoS ONE | pmid:21573029 |
Mantzaris MD et al. | Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver cells. | 2011 | FEBS J. | pmid:21182590 |
González-Mira E et al. | Potential use of nanostructured lipid carriers for topical delivery of flurbiprofen. | 2011 | J Pharm Sci | pmid:20575052 |
Wang GG et al. | Self-assembled biomimetic superhydrophobic CaCO3 coating inspired from fouling mineralization in geothermal water. | 2011 | Langmuir | pmid:21919516 |
Basu BJ and Manasa J | Effect of deposition parameters on the wettability and microstructure of superhydrophobic films with hierarchical micro-nano structures. | 2011 | J Colloid Interface Sci | pmid:21864844 |
Asahi H et al. | Plasmodium falciparum: differing effects of non-esterified fatty acids and phospholipids on intraerythrocytic growth in serum-free medium. | 2011 | Exp. Parasitol. | pmid:21095186 |
MacDonald AM et al. | A modified supported bilayer/diblock polymer--working towards a tunable coating for capillary electrophoresis. | 2011 | J Chromatogr A | pmid:21122870 |
Liu X et al. | Synthesis of high quality and stability CdS quantum dots with overlapped nucleation-growth process in large scale. | 2011 | J Colloid Interface Sci | pmid:21040929 |
Tamilvanan S et al. | In vitro and in vivo evaluation of hydrophilic and hydrophobic polymers-based nicorandil-loaded peroral tablet compared with its once-daily commercial sustained-release tablet. | 2011 | Drug Dev Ind Pharm | pmid:20923389 |
Aardema H et al. | Oleic acid prevents detrimental effects of saturated fatty acids on bovine oocyte developmental competence. | 2011 | Biol. Reprod. | pmid:21311036 |
Gremos S et al. | Direct enzymatic acylation of cellulose pretreated in BMIMCl ionic liquid. | 2011 | Bioresour. Technol. | pmid:20888759 |
Yu WL et al. | Modifications of the metabolic pathways of lipid and triacylglycerol production in microalgae. | 2011 | Microb. Cell Fact. | pmid:22047615 |
Andaloussi SE et al. | Application of PepFect peptides for the delivery of splice-correcting oligonucleotides. | 2011 | Methods Mol. Biol. | pmid:21053143 |
Yu DG et al. | Coaxial electrospinning with organic solvent for controlling the size of self-assembled nanoparticles. | 2011 | Chem. Commun. (Camb.) | pmid:21107459 |
Das SC et al. | Use of surface energy distributions by inverse gas chromatography to understand mechanofusion processing and functionality of lactose coated with magnesium stearate. | 2011 | Eur J Pharm Sci | pmid:21621612 |
Laverroux S et al. | Isomerization of vaccenic acid to cis and trans C18:1 isomers during biohydrogenation by rumen microbes. | 2011 | Lipids | pmid:21706384 |
Sekharan TR et al. | Formulation and Evaluation of Hydroxypropyl Methylcellulose-based Controlled Release Matrix Tablets for Theophylline. | 2011 | Indian J Pharm Sci | pmid:22707833 |
Nagarsekar KS et al. | Antioxidant and antilipid peroxidation potential of supercritical fluid extract and ethanol extract of leaves of vitex negundo linn. | 2011 | Indian J Pharm Sci | pmid:22707827 |
Masareddy R et al. | Development of Orodispersible Tizanidine HCl Tablets Using Spray Dried Coprocessed Exipient Bases. | 2011 | Indian J Pharm Sci | pmid:22707822 |
Lan DM et al. | A novel cold-active lipase from Candida albicans: cloning, expression and characterization of the recombinant enzyme. | 2011 | Int J Mol Sci | pmid:21747717 |
Chaturvedi K et al. | Floating matrix dosage form for propranolol hydrochloride based on gas formation technique: development and in vitro evaluation. | 2010 Oct-Dec | Sci Pharm | pmid:21179326 |
Terekhova EA et al. | [Stearic acid methyl ether: a new extracellular metabolite of the obligate methylotrophic bacterium Methylophilus quaylei]. | 2010 Mar-Apr | Prikl. Biokhim. Mikrobiol. | pmid:20391761 |
Kristó K et al. | Effect of lubricant on spreading of coating liquid on surface of tablets containing pancreatin. | 2010 Jul-Aug | Pharm Dev Technol | pmid:19772392 |
Badawy SI et al. | Effect of spray-dried mannitol on the performance of microcrystalline cellulose-based wet granulated tablet formulation. | 2010 Jul-Aug | Pharm Dev Technol | pmid:20088677 |
Kaur G et al. | Chitosan-carboxymethyl tamarind kernel powder interpolymer complexation: investigations for colon drug delivery. | 2010 Jan-Mar | Sci Pharm | pmid:21179370 |
Stanisz B et al. | Influence of humidity and hydroxypropyl cellulose, hydroxypropylmethyl cellulose, glyceryl behenate or magnesium stearate on the degradation kinetics of quinapril hydrochloride in solid phase. | 2010 Jan-Feb | Acta Pol Pharm | pmid:20210086 |
Aburahma MH et al. | Preparation and in vitro/in vivo characterization of porous sublingual tablets containing ternary kneaded solid system of vinpocetine with î-cyclodextrin and hydroxy Acid. | 2010 Apr-Jun | Sci Pharm | pmid:21179352 |
Singh B et al. | Formulation optimization of hydrodynamically balanced oral controlled release bioadhesive tablets of tramadol hydrochloride. | 2010 Apr-Jun | Sci Pharm | pmid:21179349 |
Patra S et al. | In vitro evaluation of domperidone mouth dissolving tablets. | 2010 | Indian J Pharm Sci | pmid:21969764 |
Akpa MM et al. | Inhibition of insulin and T3-induced fatty acid synthase by hexanoate. | 2010 | Lipids | pmid:20811782 |
Lin YK et al. | Combination of calcipotriol and methotrexate in nanostructured lipid carriers for topical delivery. | 2010 | Int J Nanomedicine | pmid:20309398 |
Seerapu S and Srinivasan BP | Development and Validation of RP-HPLC Method for the Estimation of Ivabradine Hydrochloride in Tablets. | 2010 | Indian J Pharm Sci | pmid:21695008 |
Kharia AA et al. | Design and optimization of floating drug delivery system of acyclovir. | 2010 | Indian J Pharm Sci | pmid:21694992 |
Liew CV et al. | In-line quantification of drug and excipients in cohesive powder blends by near infrared spectroscopy. | 2010 | Int J Pharm | pmid:19922776 |
Harvey KA et al. | Long-chain saturated fatty acids induce pro-inflammatory responses and impact endothelial cell growth. | 2010 | Clin Nutr | pmid:19926177 |
Zhou Q et al. | Improving powder flow properties of a cohesive lactose monohydrate powder by intensive mechanical dry coating. | 2010 | J Pharm Sci | pmid:19795479 |
Uchimoto T et al. | Lubrication properties of potential alternative lubricants, glycerin fatty acid esters, to magnesium stearate. | 2010 | Int J Pharm | pmid:19913080 |
Akazawa Y et al. | Palmitoleate attenuates palmitate-induced Bim and PUMA up-regulation and hepatocyte lipoapoptosis. | 2010 | J. Hepatol. | pmid:20206402 |
Song HJ et al. | Effect of probiotic Lactobacillus (Lacidofil® cap) for the prevention of antibiotic-associated diarrhea: a prospective, randomized, double-blind, multicenter study. | 2010 | J. Korean Med. Sci. | pmid:21165295 |
Chen JL et al. | Metabolomics of gastric cancer metastasis detected by gas chromatography and mass spectrometry. | 2010 | World J. Gastroenterol. | pmid:21155010 |
Kim IS and Oh IJ | Preparation and characterization of stearic acid-pullulan nanoparticles. | 2010 | Arch. Pharm. Res. | pmid:20512475 |
Wang J et al. | Solid-state interactions of a drug substance and excipients and their impact on tablet dissolution: a thermal-mechanical facilitated process-induced transformation or PIT. | 2010 | J Pharm Sci | pmid:20533436 |
Karande AD et al. | Calibration sampling paradox in near infrared spectroscopy: a case study of multi-component powder blend. | 2010 | Int J Pharm | pmid:20472048 |
Akihisa T et al. | Triterpene alcohol and fatty acid composition of shea nuts from seven African countries. | 2010 | J Oleo Sci | pmid:20513968 |
Tripathi B and Platel K | Finger millet (Eleucine coracana) flour as a vehicle for fortification with zinc. | 2010 | J Trace Elem Med Biol | pmid:20122580 |
Huang WH et al. | Development of liposomal salbutamol sulfate dry powder inhaler formulation. | 2010 | Biol. Pharm. Bull. | pmid:20190418 |
Phaechamud T et al. | Preparation of Coated Valproic Acid and Sodium Valproate Sustained-release Matrix Tablets. | 2010 | Indian J Pharm Sci | pmid:20838520 |
Huthmacher C et al. | Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis. | 2010 | BMC Syst Biol | pmid:20807400 |
Noguchi Y et al. | Ketogenic essential amino acids modulate lipid synthetic pathways and prevent hepatic steatosis in mice. | 2010 | PLoS ONE | pmid:20706589 |
Maher AC et al. | Women have higher protein content of beta-oxidation enzymes in skeletal muscle than men. | 2010 | PLoS ONE | pmid:20700461 |
Wang Q et al. | One-Step Synthesis of Monodisperse In-Doped ZnO Nanocrystals. | 2010 | Nanoscale Res Lett | pmid:20672040 |
Pöllänen E et al. | Power training and postmenopausal hormone therapy affect transcriptional control of specific co-regulated gene clusters in skeletal muscle. | 2010 | Age (Dordr) | pmid:20640546 |
Swanson EJ et al. | Phospholipid-stabilized microbubble foam for injectable oxygen delivery. | 2010 | Langmuir | pmid:20873807 |
Yasuda A et al. | Self-organizing map analysis using multivariate data from theophylline powders predicted by a thin-plate spline interpolation. | 2010 | J Pharm Sci | pmid:20845452 |
Dasu K et al. | Hydrolysis of fluorotelomer compounds leading to fluorotelomer alcohol production during solvent extractions of soils. | 2010 | Chemosphere | pmid:20801485 |
Moore F et al. | Improving the hardness of dry granulated tablets containing sodium lauryl sulfate. | 2010 | Int J Pharm | pmid:20801204 |
Shidhaye SS et al. | Buccal drug delivery of pravastatin sodium. | 2010 | AAPS PharmSciTech | pmid:20300898 |
Ion G et al. | Maternal consumption of canola oil suppressed mammary gland tumorigenesis in C3(1) TAg mice offspring. | 2010 | BMC Cancer | pmid:20205934 |
Mas S et al. | Local non-esterified fatty acids correlate with inflammation in atheroma plaques of patients with type 2 diabetes. | 2010 | Diabetes | pmid:20200316 |
van den Berg SA et al. | High levels of dietary stearate promote adiposity and deteriorate hepatic insulin sensitivity. | 2010 | Nutr Metab (Lond) | pmid:20346174 |
Romanowicz L and Bańkowski E | Sphingolipids of human umbilical cord vein and their alteration in preeclampsia. | 2010 | Mol. Cell. Biochem. | pmid:20155487 |
Abdel-Mottaleb MM et al. | In vitro drug release mechanism from lipid nanocapsules (LNC). | 2010 | Int J Pharm | pmid:20149853 |
Taneri F et al. | In vitro and in vivo evaluation of oral tablet formulations prepared with ketoconazole and hydroxypropyl-beta-cyclodextrin. | 2010 | Drug Deliv | pmid:20148713 |
Wang J et al. | Lubrication in tablet formulations. | 2010 | Eur J Pharm Biopharm | pmid:20096779 |
Dong J et al. | Cation-controlled crystal growth of silver stearate: cryo-TEM investigation of lithium vs sodium stearate. | 2010 | Langmuir | pmid:20017506 |
Kushner J and Moore F | Scale-up model describing the impact of lubrication on tablet tensile strength. | 2010 | Int J Pharm | pmid:20667504 |
Yeop Han C et al. | Differential effect of saturated and unsaturated free fatty acids on the generation of monocyte adhesion and chemotactic factors by adipocytes: dissociation of adipocyte hypertrophy from inflammation. | 2010 | Diabetes | pmid:19934003 |