stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Boiret M et al. | Setting local rank constraints by orthogonal projections for image resolution analysis: application to the determination of a low dose pharmaceutical compound. | 2015 | Anal. Chim. Acta | pmid:26388474 |
Veit M and Siche S | S-acylation of influenza virus proteins: Are enzymes for fatty acid attachment promising drug targets? | 2015 | Vaccine | pmid:26387429 |
Wang D et al. | One-pot synthesized hierarchical zeolite supported metal nanoparticles for highly efficient biomass conversion. | 2015 | Chem. Commun. (Camb.) | pmid:26361087 |
Xu L et al. | The Surface Modification and Antimicrobial Activity of Basic Magnesium Hypochlorite Nanoparticles. | 2015 | J Nanosci Nanotechnol | pmid:26353638 |
Zhang X et al. | Effect of Chemicals on Morphology and Luminescence of CdSe Quantum Dots. | 2015 | J Nanosci Nanotechnol | pmid:26353513 |
Bhattacharya S et al. | Increasing the stearate content in seed oil of Brassica juncea by heterologous expression of MlFatB affects lipid content and germination frequency of transgenic seeds. | 2015 | Plant Physiol. Biochem. | pmid:26351151 |
Rozman Peterka T et al. | Solid state compatibility study and characterization of a novel degradation product of tacrolimus in formulation. | 2015 | J Pharm Biomed Anal | pmid:25804434 |
Kelidari HR et al. | Formulation optimization and in vitro skin penetration of spironolactone loaded solid lipid nanoparticles. | 2015 | Colloids Surf B Biointerfaces | pmid:25797482 |
Seyedi S et al. | Improving the physical and moisture barrier properties of Lepidium perfoliatum seed gum biodegradable film with stearic and palmitic acids. | 2015 | Int. J. Biol. Macromol. | pmid:25795389 |
Su Y et al. | Redox-responsive polymer-drug conjugates based on doxorubicin and chitosan oligosaccharide-g-stearic acid for cancer therapy. | 2015 | Mol. Pharm. | pmid:25751168 |
Phaechamud T et al. | Chitosan-aluminum monostearate composite sponge dressing containing asiaticoside for wound healing and angiogenesis promotion in chronic wound. | 2015 | Mater Sci Eng C Mater Biol Appl | pmid:25746264 |
Jedinger N et al. | Alcohol dose dumping: The influence of ethanol on hot-melt extruded pellets comprising solid lipids. | 2015 | Eur J Pharm Biopharm | pmid:25733499 |
Castellanos-Tapia L et al. | Apolipoprotein E isoforms 3/3 and 3/4 differentially interact with circulating stearic, palmitic, and oleic fatty acids and lipid levels in Alaskan Natives. | 2015 | Nutr Res | pmid:25727313 |
Kerth CR et al. | Consumer sensory evaluation, fatty acid composition, and shelf-life of ground beef with subcutaneous fat trimmings from different carcass locations. | 2015 | Meat Sci. | pmid:25688688 |
Tai Z et al. | Biodegradable stearylated peptide with internal disulfide bonds for efficient delivery of siRNA in vitro and in vivo. | 2015 | Biomacromolecules | pmid:25686200 |
Vervaeck A et al. | Fatty acids for controlled release applications: A comparison between prilling and solid lipid extrusion as manufacturing techniques. | 2015 | Eur J Pharm Biopharm | pmid:26428938 |
Nandini PT et al. | Formulation and evaluation of gemcitabine-loaded solid lipid nanoparticles. | 2015 | Drug Deliv | pmid:24283392 |
Chen Q et al. | Preparation and characterization of glycyrrhetinic acid-modified stearic acid-grafted chitosan micelles. | 2015 | Artif Cells Nanomed Biotechnol | pmid:24093764 |
Fala AM et al. | Unsaturated fatty acids as high-affinity ligands of the C-terminal Per-ARNT-Sim domain from the Hypoxia-inducible factor 3α. | 2015 | Sci Rep | pmid:26237540 |
Senyilmaz D et al. | Regulation of mitochondrial morphology and function by stearoylation of TFR1. | 2015 | Nature | pmid:26214738 |
Gotoh K et al. | Introduction of Atmospheric Pressure Plasma to Aqueous Detergent Processes. | 2015 | J Oleo Sci | pmid:26179001 |
Astanina K et al. | Lipid droplets as a novel cargo of tunnelling nanotubes in endothelial cells. | 2015 | Sci Rep | pmid:26095213 |
VranÃková B et al. | Modern evaluation of liquisolid systems with varying amounts of liquid phase prepared using two different methods. | 2015 | Biomed Res Int | pmid:26075249 |
Patil PS et al. | Total synthesis of tetraacylated phosphatidylinositol hexamannoside and evaluation of its immunomodulatory activity. | 2015 | Nat Commun | pmid:26037164 |
Onishi H et al. | In vitro and in vivo evaluations of buccal tablet formulations of ritodrine hydrochloride. | 2015 | Biol. Pharm. Bull. | pmid:26027834 |
Rehman M et al. | Solid and liquid lipid-based binary solid lipid nanoparticles of diacerein: in vitro evaluation of sustained release, simultaneous loading of gold nanoparticles, and potential thermoresponsive behavior. | 2015 | Int J Nanomedicine | pmid:25897224 |
Harding SV et al. | Desaturation index versus isotopically measured de novo lipogenesis as an indicator of acute systemic lipogenesis. | 2015 | BMC Res Notes | pmid:25879456 |
Silva-Neta IC et al. | Expression of genes related to tolerance to low temperature for maize seed germination. | 2015 | Genet. Mol. Res. | pmid:25867416 |
Li Y et al. | Effects of sustained-release composite on the oxygen levels and sediment phosphorus fractions of an urban river in Shanghai. | 2014 Sep-Oct | Environ Technol | pmid:25145170 |
Mu L et al. | Erythrocyte saturated fatty acids and systemic inflammation in adults. | 2014 Nov-Dec | Nutrition | pmid:25280420 |
Syamala US et al. | Assessment of formulation factors on the release behaviour of BCS Class II drug from tablet dosage form using DoE. | 2014 | Curr Drug Deliv | pmid:24975287 |
Liu J et al. | Functional investigations on embryonic stem cells labeled with clinically translatable iron oxide nanoparticles. | 2014 | Nanoscale | pmid:24969040 |
Tadros MI and Fahmy RH | Controlled-release triple anti-inflammatory therapy based on novel gastroretentive sponges: characterization and magnetic resonance imaging in healthy volunteers. | 2014 | Int J Pharm | pmid:24928130 |
Evoli S et al. | Molecular simulations of β-lactoglobulin complexed with fatty acids reveal the structural basis of ligand affinity to internal and possible external binding sites. | 2014 | Proteins | pmid:24916607 |
Loften JR et al. | Invited review: palmitic and stearic acid metabolism in lactating dairy cows. | 2014 | J. Dairy Sci. | pmid:24913651 |
Shah RM et al. | Physicochemical characterization of solid lipid nanoparticles (SLNs) prepared by a novel microemulsion technique. | 2014 | J Colloid Interface Sci | pmid:24910064 |
Park KH et al. | Elaidic acid (EA) generates dysfunctional high-density lipoproteins and consumption of EA exacerbates hyperlipidemia and fatty liver change in zebrafish. | 2014 | Mol Nutr Food Res | pmid:24863413 |
Salas JJ et al. | Biochemistry of high stearic sunflower, a new source of saturated fats. | 2014 | Prog. Lipid Res. | pmid:24858414 |
Gamble JF et al. | Monitoring process induced attrition of drug substance particles within formulated blends. | 2014 | Int J Pharm | pmid:24793838 |
Uğurlu T and Halaçoğlu MD | Effects of some lubricants and evaluation of compression parameters on directly compressible powders. | 2014 | Pharm Dev Technol | pmid:23590449 |
Chen FY et al. | TNYL peptide functional chitosan-g-stearate conjugate micelles for tumor specific targeting. | 2014 | Int J Nanomedicine | pmid:25298734 |
Li N et al. | Function of SREBP1 in the milk fat synthesis of dairy cow mammary epithelial cells. | 2014 | Int J Mol Sci | pmid:25250914 |
Shen MC et al. | Dietary stearic acid leads to a reduction of visceral adipose tissue in athymic nude mice. | 2014 | PLoS ONE | pmid:25222131 |
Chen Y et al. | Stepwise encapsulation and controlled two-stage release system for cis-Diamminediiodoplatinum. | 2014 | Int J Nanomedicine | pmid:25061294 |
Ashraf SN et al. | Compositional studies and Biological activities of Perovskia abrotanoides Kar. oils. | 2014 | Biol. Res. | pmid:25052892 |
Zhang SW et al. | A method to evaluate the effect of contact with excipients on the surface crystallization of amorphous drugs. | 2014 | AAPS PharmSciTech | pmid:25037732 |
Yao JJ et al. | Efficient gene delivery system mediated by cis-aconitate-modified chitosan-g-stearic acid micelles. | 2014 | Int J Nanomedicine | pmid:24971010 |
López-Cervantes J et al. | Effect of solvents and methods of stirring in extraction of lycopene, oleoresin and fatty acids from over-ripe tomato. | 2014 | Int J Food Sci Nutr | pmid:24111501 |
Saerens L et al. | Validation of an in-line Raman spectroscopic method for continuous active pharmaceutical ingredient quantification during pharmaceutical hot-melt extrusion. | 2014 | Anal. Chim. Acta | pmid:24331054 |
Crowe FL et al. | Circulating fatty acids and prostate cancer risk: individual participant meta-analysis of prospective studies. | 2014 | J. Natl. Cancer Inst. | pmid:25210201 |