stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Abortion, Spontaneous D000022 12 associated lipids
Acne Vulgaris D000152 35 associated lipids
Acquired Immunodeficiency Syndrome D000163 12 associated lipids
Adenoma D000236 40 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Alzheimer Disease D000544 76 associated lipids
Amnesia D000647 12 associated lipids
Anemia, Dyserythropoietic, Congenital D000742 2 associated lipids
Olfaction Disorders D000857 17 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Arteriosclerosis D001161 86 associated lipids
Bacterial Infections D001424 21 associated lipids
Cholestasis, Extrahepatic D001651 7 associated lipids
Birth Weight D001724 23 associated lipids
Body Weight D001835 333 associated lipids
Boutonneuse Fever D001907 5 associated lipids
Brain Edema D001929 20 associated lipids
Breast Neoplasms D001943 24 associated lipids
Bronchitis D001991 6 associated lipids
Burns D002056 34 associated lipids
Calculi D002137 3 associated lipids
Cattle Diseases D002418 24 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Chancroid D002602 4 associated lipids
Coronary Disease D003327 70 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Decalcification, Pathologic D003649 1 associated lipids
Dermatitis D003872 30 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Edema D004487 152 associated lipids
Fatty Liver D005234 48 associated lipids
Foreign Bodies D005547 5 associated lipids
Gallbladder Neoplasms D005706 3 associated lipids
Gonorrhea D006069 7 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hyperlipidemias D006949 73 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Hypopituitarism D007018 7 associated lipids
Hypothalamic Diseases D007027 3 associated lipids
Hypothyroidism D007037 32 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Infertility D007246 3 associated lipids
Insulin Resistance D007333 99 associated lipids
Insulinoma D007340 28 associated lipids
Ischemia D007511 18 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Legionnaires' Disease D007877 4 associated lipids
Leprosy D007918 8 associated lipids
Leukemia, Lymphoid D007945 18 associated lipids
Leukodystrophy, Metachromatic D007966 4 associated lipids
Liver Neoplasms D008113 8 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Lung Neoplasms D008175 171 associated lipids
Lymphadenitis D008199 8 associated lipids
Lymphoma D008223 18 associated lipids
Lymphoma, Non-Hodgkin D008228 6 associated lipids
Malignant Hyperthermia D008305 6 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Melanoma D008545 69 associated lipids
Mycobacterium Infections, Nontuberculous D009165 8 associated lipids
Mycoplasmatales Infections D009180 6 associated lipids
Neuroblastoma D009447 66 associated lipids
Occupational Diseases D009784 42 associated lipids
Otitis Media D010033 12 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Pneumoconiosis D011009 3 associated lipids
Eczema, Dyshidrotic D011146 1 associated lipids
Prostatic Diseases D011469 4 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Relapsing Fever D012061 3 associated lipids
Rosacea D012393 13 associated lipids
Salivary Duct Calculi D012465 2 associated lipids
Seizures D012640 87 associated lipids
Skin Diseases, Infectious D012874 7 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Syphilis, Congenital D013590 3 associated lipids
Syphilis, Latent D013592 4 associated lipids
Tenosynovitis D013717 3 associated lipids
Thrombosis D013927 49 associated lipids
Tremor D014202 15 associated lipids
Tuberculosis, Pulmonary D014397 18 associated lipids
Urethritis D014526 9 associated lipids
Urticaria D014581 13 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Whooping Cough D014917 6 associated lipids
Yaws D015001 4 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Reperfusion Injury D015427 65 associated lipids
Weight Gain D015430 101 associated lipids
Brain Diseases, Metabolic, Inborn D020739 10 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Atherosclerosis D050197 85 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

Download all related citations
Per page 10 20 50 100 | Total 3506
Authors Title Published Journal PubMed Link
pmid:
pmid:9608395
Luo L et al. Polyoxyethylene 40 stearate modulates multidrug resistance and enhances antitumor activity of vinblastine sulfate. 2007 AAPS J pmid:18170979
Kuppuswamy R et al. Estimation of capping incidence by indentation fracture tests. 2001 AAPS PharmSci pmid:11741256
Otsuka M et al. Comparative evaluation of tableting compression behaviors by methods of internal and external lubricant addition: inhibition of enzymatic activity of trypsin preparation by using external lubricant addition during the tableting compression process. 2001 AAPS PharmSci pmid:11741271
Shah RB et al. Comparative evaluation of flow for pharmaceutical powders and granules. 2008 AAPS PharmSciTech pmid:18446489
Darole PS et al. Formulation and evaluation of microemulsion based delivery system for amphotericin B. 2008 AAPS PharmSciTech pmid:18446472
Kottala N et al. Evaluation of the performance characteristics of bilayer tablets: Part II. Impact of environmental conditions on the strength of bilayer tablets. 2012 AAPS PharmSciTech pmid:22965660
Patel S et al. Lubrication potential of magnesium stearate studied on instrumented rotary tablet press. 2007 AAPS PharmSciTech pmid:18181549
Daraghmeh N et al. Preparation and characterization of a novel co-processed excipient of chitin and crystalline mannitol. 2010 AAPS PharmSciTech pmid:21052880
Casiraghi A et al. The influence of the polar head and the hydrophobic chain on the skin penetration enhancement effect of poly(ethylene glycol) derivatives. 2012 AAPS PharmSciTech pmid:22232021
Almaya A and Aburub A Effect of particle size on compaction of materials with different deformation mechanisms with and without lubricants. 2008 AAPS PharmSciTech pmid:18431664
Patel K et al. Duloxetine HCl lipid nanoparticles: preparation, characterization, and dosage form design. 2012 AAPS PharmSciTech pmid:22167415
Morkhade DM et al. PEGylated rosin derivatives: novel microencapsulating materials for sustained drug delivery. 2007 AAPS PharmSciTech pmid:17622122
Ramirez-Dorronsoro JC et al. Chargeability measurements of selected pharmaceutical dry powders to assess their electrostatic charge control capabilities. 2006 AAPS PharmSciTech pmid:17285749
Navaneethan CV et al. Application of powder rheometer to determine powder flow properties and lubrication efficiency of pharmaceutical particulate systems. 2005 AAPS PharmSciTech pmid:16353997
Soares LA et al. Dry granulation and compression of spray-dried plant extracts. 2005 AAPS PharmSciTech pmid:16353993
Tatavarti AS et al. Assessment of NIR spectroscopy for nondestructive analysis of physical and chemical attributes of sulfamethazine bolus dosage forms. 2005 AAPS PharmSciTech pmid:16353969
Sovány T et al. Application of physicochemical properties and process parameters in the development of a neural network model for prediction of tablet characteristics. 2013 AAPS PharmSciTech pmid:23413109
Missaghi S and Fassihi R A novel approach in the assessment of polymeric film formation and film adhesion on different pharmaceutical solid substrates. 2004 AAPS PharmSciTech pmid:15760087
Ferrari F et al. The surface roughness of lactose particles can be modulated by wet-smoothing using a high-shear mixer. 2004 AAPS PharmSciTech pmid:15760057
Lyon RC et al. Near-infrared spectral imaging for quality assurance of pharmaceutical products: analysis of tablets to assess powder blend homogeneity. 2002 AAPS PharmSciTech pmid:12916932
Swaminathan V and Kildsig DO Effect of magnesium stearate on the content uniformity of active ingredient in pharmaceutical powder mixtures. 2002 AAPS PharmSciTech pmid:12916934
Gupta A et al. Difference in the lubrication efficiency of bovine and vegetable-derived magnesium stearate during tabletting. 2009 AAPS PharmSciTech pmid:19390976
Zhou QT et al. Effect of surface coating with magnesium stearate via mechanical dry powder coating approach on the aerosol performance of micronized drug powders from dry powder inhalers. 2013 AAPS PharmSciTech pmid:23196863
Nokhodchi A et al. Cogrinding as a tool to produce sustained release behavior for theophylline particles containing magnesium stearate. 2009 AAPS PharmSciTech pmid:19862623
Mir VG et al. Application of crustacean chitin as a co-diluent in direct compression of tablets. 2010 AAPS PharmSciTech pmid:20238188
Lakio S et al. Challenges in detecting magnesium stearate distribution in tablets. 2013 AAPS PharmSciTech pmid:23378252
Cunha TA et al. Effect of stearic acid on enalapril stability and dissolution from multiparticulate solid dosage forms. 2013 AAPS PharmSciTech pmid:23897034
iHoroz BB et al. Influence of aluminum tristearate and sucrose stearate as the dispersing agents on physical properties and release characteristics of eudragit RS microspheres. 2006 AAPS PharmSciTech pmid:16584146
Seitavuopio P et al. Monitoring tablet surface roughness during the film coating process. 2006 AAPS PharmSciTech pmid:16796349
Zhang SW et al. A method to evaluate the effect of contact with excipients on the surface crystallization of amorphous drugs. 2014 AAPS PharmSciTech pmid:25037732
Zaki Rizkalla CM et al. In vitro and in vivo evaluation of hydroxyzine hydrochloride microsponges for topical delivery. 2011 AAPS PharmSciTech pmid:21800216
Shidhaye SS et al. Buccal drug delivery of pravastatin sodium. 2010 AAPS PharmSciTech pmid:20300898
Räsänen E et al. A new method to predict flowability using a microscale fluid bed. 2003 AAPS PharmSciTech pmid:15198548
Li S et al. Preparation, characterization, pharmacokinetics and tissue distribution of solid lipid nanoparticles loaded with tetrandrine. 2011 AAPS PharmSciTech pmid:21811889
Waters LJ et al. Controlled microwave processing applied to the pharmaceutical formulation of ibuprofen. 2011 AAPS PharmSciTech pmid:21842309
Salbu L et al. Direct compression behavior of low- and high-methoxylated pectins. 2010 AAPS PharmSciTech pmid:20013080
Khan FN and Dehghan MH Enhanced bioavailability of atorvastatin calcium from stabilized gastric resident formulation. 2011 AAPS PharmSciTech pmid:21879394
Swaminathan V and Kildsig DO An examination of the moisture sorption characteristics of commercial magnesium stearate. 2001 AAPS PharmSciTech pmid:14727865
Fernández EG et al. Rapid development and optimization of tablet manufacturing using statistical tools. 2008 AAPS PharmSciTech pmid:18459048
Chang CK et al. Roller compaction, granulation and capsule product dissolution of drug formulations containing a lactose or mannitol filler, starch, and talc. 2008 AAPS PharmSciTech pmid:18459052
Kumar R and Sinha VR Lipid Nanocarrier: an Efficient Approach Towards Ocular Delivery of Hydrophilic Drug (Valacyclovir). 2017 AAPS PharmSciTech pmid:27368921
Spaniol B et al. Compressional behavior of a mixture of granules containing high load of Phyllanthus niruri spray-dried extract and granules of adjuvants: comparison between eccentric and rotary tablet machines. 2009 AAPS PharmSciTech pmid:19662537
Lau M et al. Investigation into the Manufacture and Properties of Inhalable High-Dose Dry Powders Produced by Comilling API and Lactose with Magnesium Stearate. 2017 AAPS PharmSciTech pmid:28070849
Thotakura N et al. Chitosan-Stearic Acid Based Polymeric Micelles for the Effective Delivery of Tamoxifen: Cytotoxic and Pharmacokinetic Evaluation. 2017 AAPS PharmSciTech pmid:27287243
Kelidari HR et al. Development and Optimisation of Spironolactone Nanoparticles for Enhanced Dissolution Rates and Stability. 2017 AAPS PharmSciTech pmid:27834054
Monajjemzadeh F et al. Assessment of feasibility of maillard reaction between baclofen and lactose by liquid chromatography and tandem mass spectrometry, application to pre formulation studies. 2009 AAPS PharmSciTech pmid:19455427
Schrank S et al. Ibuprofen-loaded calcium stearate pellets: drying-induced variations in dosage form properties. 2012 AAPS PharmSciTech pmid:22552931
Ahmed TA et al. Miconazole nitrate oral disintegrating tablets: in vivo performance and stability study. 2012 AAPS PharmSciTech pmid:22585373