stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Abortion, Spontaneous D000022 12 associated lipids
Acne Vulgaris D000152 35 associated lipids
Acquired Immunodeficiency Syndrome D000163 12 associated lipids
Adenoma D000236 40 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Alzheimer Disease D000544 76 associated lipids
Amnesia D000647 12 associated lipids
Anemia, Dyserythropoietic, Congenital D000742 2 associated lipids
Olfaction Disorders D000857 17 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Arteriosclerosis D001161 86 associated lipids
Bacterial Infections D001424 21 associated lipids
Cholestasis, Extrahepatic D001651 7 associated lipids
Birth Weight D001724 23 associated lipids
Body Weight D001835 333 associated lipids
Boutonneuse Fever D001907 5 associated lipids
Brain Edema D001929 20 associated lipids
Breast Neoplasms D001943 24 associated lipids
Bronchitis D001991 6 associated lipids
Burns D002056 34 associated lipids
Calculi D002137 3 associated lipids
Cattle Diseases D002418 24 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Chancroid D002602 4 associated lipids
Coronary Disease D003327 70 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Decalcification, Pathologic D003649 1 associated lipids
Dermatitis D003872 30 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Edema D004487 152 associated lipids
Fatty Liver D005234 48 associated lipids
Foreign Bodies D005547 5 associated lipids
Gallbladder Neoplasms D005706 3 associated lipids
Gonorrhea D006069 7 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hyperlipidemias D006949 73 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Hypopituitarism D007018 7 associated lipids
Hypothalamic Diseases D007027 3 associated lipids
Hypothyroidism D007037 32 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Infertility D007246 3 associated lipids
Insulin Resistance D007333 99 associated lipids
Insulinoma D007340 28 associated lipids
Ischemia D007511 18 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Legionnaires' Disease D007877 4 associated lipids
Leprosy D007918 8 associated lipids
Leukemia, Lymphoid D007945 18 associated lipids
Leukodystrophy, Metachromatic D007966 4 associated lipids
Liver Neoplasms D008113 8 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Lung Neoplasms D008175 171 associated lipids
Lymphadenitis D008199 8 associated lipids
Lymphoma D008223 18 associated lipids
Lymphoma, Non-Hodgkin D008228 6 associated lipids
Malignant Hyperthermia D008305 6 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Melanoma D008545 69 associated lipids
Mycobacterium Infections, Nontuberculous D009165 8 associated lipids
Mycoplasmatales Infections D009180 6 associated lipids
Neuroblastoma D009447 66 associated lipids
Occupational Diseases D009784 42 associated lipids
Otitis Media D010033 12 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Pneumoconiosis D011009 3 associated lipids
Eczema, Dyshidrotic D011146 1 associated lipids
Prostatic Diseases D011469 4 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Relapsing Fever D012061 3 associated lipids
Rosacea D012393 13 associated lipids
Salivary Duct Calculi D012465 2 associated lipids
Seizures D012640 87 associated lipids
Skin Diseases, Infectious D012874 7 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Syphilis, Congenital D013590 3 associated lipids
Syphilis, Latent D013592 4 associated lipids
Tenosynovitis D013717 3 associated lipids
Thrombosis D013927 49 associated lipids
Tremor D014202 15 associated lipids
Tuberculosis, Pulmonary D014397 18 associated lipids
Urethritis D014526 9 associated lipids
Urticaria D014581 13 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Whooping Cough D014917 6 associated lipids
Yaws D015001 4 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Reperfusion Injury D015427 65 associated lipids
Weight Gain D015430 101 associated lipids
Brain Diseases, Metabolic, Inborn D020739 10 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Atherosclerosis D050197 85 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

Download all related citations
Per page 10 20 50 100 | Total 3506
Authors Title Published Journal PubMed Link
SULMAN FG A note on the resorption and excretion of riboflavine from aluminium monostearate suspensions in the rat. 1955 J. Pharm. Pharmacol. pmid:14392601
GEYER RP et al. Aerobic C14O2 formation from carboxyl-labeled stearic and palmitic acids in the presence of ascorbic acid. 1955 Arch. Biochem. Biophys. pmid:14377605
GLASCOCK RF and REINIUS LR Studies on the origin of milk fat. 1. The location of tritium in stearic acid produced by the catalytic addition of tritium to elaidic acid. 1956 Biochem. J. pmid:13315207
TOVE SB et al. Turnover of palmitic, stearic, and unsaturated fatty acids in rat liver. 1956 J. Biol. Chem. pmid:13278335
MEAD JF et al. Metabolism of the essential fatty acids. II. The metabolism of stearate, oleate, and linoleate by fat-deficient and normal mice. 1956 J. Biol. Chem. pmid:13278347
BLOMSTRAND R et al. On the intestinal absorption of 2, 2-dimethylstearic acid fed as free acid or as glyceride. 1956 Acta Physiol. Scand. pmid:13339456
KERN W et al. [Suggestions for the composition of the general section on ointments and salve bases and emulsifiers in the German Pharmacopeia (DAB 6, Annex). II]. 1956 Hautarzt pmid:13345190
Buensod M and Favarger P [Observations on the digestibility of palmitic and stearic acids and their glyceric esters in rats]. 1956 Helv Physiol Pharmacol Acta pmid:13405350
COOKE NJ et al. The branched-chain fatty acids of mutton fat. 3. The isolation of 16-methylheptadecanoic acid (isostearic acid). 1956 Biochem. J. pmid:13363830
JAMES AT and MARTIN AJ Gas-liquid chromatography: the separation and identification of the methyl esters of saturated and unsaturated acids from formic acid to n-octadecanoic acid. 1956 Biochem. J. pmid:13315260
HUME JC and FACIO G An analysis of the results of the treatment of yaws with a single injection of procaine penicillin with 2% aluminium monostearate. 1956 Bull. World Health Organ. pmid:13404472
FABER JS A note on the assay of zinc stearate. 1957 J Am Pharm Assoc Am Pharm Assoc pmid:13491438
BRZEZINSKI A et al. Prolonged effect of riboflavin: aluminum monostearate suspensions in man. 1957 J Am Pharm Assoc Am Pharm Assoc pmid:13438726
KARVINEN E et al. Effect of palmitic and stearic acid on cholesterol absorption in man. 1957 J Appl Physiol pmid:13462909
LONG CL et al. Studies on absorption and metabolism of propylene glycol distearate. 1958 Arch. Biochem. Biophys. pmid:13584006
LONG CL et al. An investigation of the in vivo hydrolysis and absorption of propylene glycol distearate. 1958 Arch. Biochem. Biophys. pmid:13584007
CONIGLIO JG and CATE DL The distribution and biosynthesis of palmitic and stearic acids in liver, intestine, and carcass of intact normal and fasted rats. 1958 J. Biol. Chem. pmid:13549425
DAWSON RM The labelling of ram semen in vivo with radioactive phosphate and [carboxy-14C] stearic acid. 1958 Biochem. J. pmid:13522653
HARDING HE Some enquiries into the toxicology of zinc stearate. 1958 Br J Ind Med pmid:13523087
RUTSTEIN DD et al. Effects of linolenic and stearic acids on cholesterol-induced lipoid deposition in human aortic cells in tissue-culture. 1958 Lancet pmid:13515277
COX AJ and DEEDS F Dietary production of lipogranuloma in rats. 1958 Mar-Apr Am. J. Pathol. pmid:13520907
KELLERSHOHN C and BENICHOUX R [Comparative study of the drainage through the lymphatic vessels of a radioactive fat, ethyl diiodosterate labeled with I 131, and a radioactive colloidal substance, colloidal gold 198]. 1958 May-Jun Minerva Nucl pmid:13565747
GERSHFELD NL and SHANES AM Antagonism of veratrine by calcium ion in monolayers of stearic acid. 1959 Science pmid:13658972
BLOMSTRAND R et al. Asymmetric incorporation of linoleic acid-1-C14 and stearic acid-1-C14 into human lymph lecithins during fat absorption. 1959 Proc. Soc. Exp. Biol. Med. pmid:13645714
FITZHUGH OG et al. Chronic oral toxicities of four stearic acid emulsifiers. 1959 Toxicol. Appl. Pharmacol. pmid:13659539
SKIPSKI VP et al. Identification of 2-hydroxystearic acid in spinal cord phrenosine by chromatographic separation of hydroxy fatty acids. 1959 Arch. Biochem. Biophys. pmid:13661981
HURLEY HJ and SHELLEY WB The colloidal state as a stimulus for non-allergic epithelioid granulomas: experimental studies in man with pure sodium stearate and palmitate. 1959 J. Invest. Dermatol. pmid:14405513
LIN TM et al. Effect of stearic acid and cholesterol on biosynthesis of sterol by the chicken liver. 1960 Am. J. Physiol. pmid:14417022
SHANES AM and GERSHFELD NL Interactions of veratrum alkaloids, procaine, and calcium with monolayers of stearic acid and their implications for pharmacological action. 1960 J. Gen. Physiol. pmid:13750673
FOTI L et al. [In vitro liver biosynthesis of cholesterol from acetate, stearate and linoleate 1-C-14]. 1961 Boll. Soc. Ital. Biol. Sper. pmid:13958917
AGARWAL SC et al. Blood-level duration limit test of procaine benzylpenicillin in sheep. 1961 Bull. World Health Organ. pmid:13859560
DAVIDOFF F and KORN ED Synthesis of unsaturated fatty acids in the cellular slime mold. 1962 Biochem. Biophys. Res. Commun. pmid:14025332
DEYKIN D and GOODMAN DS The hydrolysis of long-chain fatty acid esters of cholesterol with rat liver enzymes. 1962 J. Biol. Chem. pmid:14027461
TROUT DL and ESTES EH Factors affecting liver uptake of serum free stearic acid-1-C14. 1962 Am. J. Physiol. pmid:13994303
WALLEN LL et al. The microbiological production of 10-hydroxystearic acid from oleic acid. 1962 Arch. Biochem. Biophys. pmid:13998583
CREASEY WA Observations on the activation of stearic acid by rat-liver preparations. 1962 Biochim. Biophys. Acta pmid:14023748
JAMES AT [Studies on the biosynthesis of 18 carbon mono-and tri-unsaturated fatty acids by gas phase chromatography]. 1962 Bull. Soc. Chim. Biol. pmid:13957228
FOSSA T [Inhibition of hepatic glucose-6-phosphatase by fatty acids and zinc ions]. 1962 Boll. Soc. Ital. Biol. Sper. pmid:13958874
BARGONI N and SISINI A [Inhibition and reactivation of the hydrolases of digestion]. 1962 Boll. Soc. Ital. Biol. Sper. pmid:13966663
NIELSEN K and SCHMIDT H [Should the standard treatment of gonorrhea be changed? Effects of the treatment of gonorrhea in 1960 in ambulant and hospitalized patients]. 1962 Manedsskr Prakt Laegegern pmid:13938514
GUTIERREZ J et al. Lipid metabolism of rumen ciliates and bacteria. I. Uptake of fatty acids by Isotricha prostoma and Entodinium simplex. 1962 Appl Microbiol pmid:13951437
GOUERE P [BIOCHEMICAL ASPECT AND DIETETIC ROLE OF GRAPE SEED OIL]. 1963 Aliment Vie pmid:14135213
LAMBIOTTE M [USE OF RADIOACTIVE CHOLESTEROL IN THE STUDY OF THE INFLUENCE OF DIETARY LIPIDS ON CHOLESTEROL METABOLISM]. 1963 Ann Nutr Aliment pmid:14048747
SHIFRINE M and MARR AG THE REQUIREMENT OF FATTY ACIDS BY PITYROSPORUM OVALE. 1963 J. Gen. Microbiol. pmid:14053273
SOLOFF LA and WIEDEMAN MP BIOMICROSCOPIC OBSERVATIONS ON VASOCONSTRICTIVE AND THROMBOGENIC EFFECTS PRODUCED BY LONG-CHAIN SATURATED FATTY ACIDS WITHIN THE VASCULATURE OF THE WING OF AN UNANAESTHETIZED BAT. 1963 Nature pmid:14058613
ROUS S and FAVARGER P [ROLE OF DEGRADATION IN THE MAINTENANCE OF THE COMPOSITION OF RESERVE FATTY ACIDS]. 1963 Helv Physiol Pharmacol Acta pmid:14058926
GOMPERTZ SM and SAMMONS HG THE ORIGIN OF FAECAL LIPIDS. THE COMPOSITION OF FAECAL FATSIN HUMAN SUBJECTS. 1963 Clin. Chim. Acta pmid:14063975
HALL PF et al. Synthesis of fatty acids by testicular tissue in vitro. 1963 Can J Biochem Physiol pmid:13952129
RAZIN S and ROTTEM S FATTY ACID REQUIREMENTS OF MYCOPLASMA LAIDLAWII. 1963 J. Gen. Microbiol. pmid:14114935
HJORTH N and TROLLE-LASSEN C SKIN REACTIONS TO OINTMENT BASES. 1963 Trans St Johns Hosp Dermatol Soc pmid:14116129