stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Maphalla TG and Emmambux MN | Functionality of maize, wheat, teff and cassava starches with stearic acid and xanthan gum. | 2016 | Carbohydr Polym | pmid:26572436 |
Du J and Li L | Which one performs better for targeted lung cancer combination therapy: pre- or post-bombesin-decorated nanostructured lipid carriers? | 2016 | Drug Deliv | pmid:26455787 |
Kumar Gaur P et al. | Nanovesicles of nitrendipine with lipid complex for transdermal delivery: pharmacokinetic and pharmacodynamic studies. | 2016 | Artif Cells Nanomed Biotechnol | pmid:26375758 |
Li X et al. | Preparation of co-spray dried cushioning agent containing stearic acid for protecting pellet coatings when compressed. | 2016 | Drug Dev Ind Pharm | pmid:26289006 |
Uğurlu T and Halaçoğlu MD | Effects of hexagonal boron nitride on dry compression mixture of Avicel DG and Starch 1500. | 2016 | Pharm Dev Technol | pmid:25716058 |
Jójárt I et al. | Study of the compressibility of chewing gum and its applicability as an oral drug delivery system. | 2016 | Pharm Dev Technol | pmid:25673279 |
Yan G et al. | Preparation and evaluation of liver-targeting micelles loaded with oxaliplatin. | 2016 | Artif Cells Nanomed Biotechnol | pmid:25287740 |
Pradhan M et al. | Influence of selected variables on fabrication of Triamcinolone acetonide loaded solid lipid nanoparticles for topical treatment of dermal disorders. | 2016 | Artif Cells Nanomed Biotechnol | pmid:25229831 |
Martins AB and Santana RM | Effect of carboxylic acids as compatibilizer agent on mechanical properties of thermoplastic starch and polypropylene blends. | 2016 | Carbohydr Polym | pmid:26453854 |
Yin L et al. | Benzyl butyl phthalate promotes adipogenesis in 3T3-L1 preadipocytes: A High Content Cellomics and metabolomic analysis. | 2016 | Toxicol In Vitro | pmid:26820058 |
Guan Q et al. | Docetaxel-Loaded Self-Assembly Stearic Acid-Modified Bletilla striata Polysaccharide Micelles and Their Anticancer Effect: Preparation, Characterization, Cellular Uptake and In Vitro Evaluation. | 2016 | Molecules | pmid:27918445 |
Shur J et al. | From single excipients to dual excipient platforms in dry powder inhaler products. | 2016 | Int J Pharm | pmid:27262269 |
Li T et al. | Defense priming by non-jasmonate producing fatty acids in maize (Zea mays). | 2016 | Plant Signal Behav | pmid:27763804 |
Kanasaki Y et al. | Application of Quartz Crystal Microbalance as a Tool for Detergency Evaluation of Fatty Acid Contamination in Aqueous Systems. | 2016 | J Oleo Sci | pmid:27725481 |
Souza AF et al. | Waste Soybean Oil and Corn Steep Liquor as Economic Substrates for Bioemulsifier and Biodiesel Production by Candida lipolytica UCP 0998. | 2016 | Int J Mol Sci | pmid:27669227 |
Teh SS et al. | Incorporation of Palmitic Acid or Stearic Acid into Soybean Oils Using Enzymatic Interesterification. | 2016 | J Oleo Sci | pmid:27477075 |
Simon C et al. | Screening of endocrine activity of compounds migrating from plastic baby bottles using a multi-receptor panel of in vitro bioassays. | 2016 | Toxicol In Vitro | pmid:27633901 |
Shah RM et al. | Microwave-assisted formulation of solid lipid nanoparticles loaded with non-steroidal anti-inflammatory drugs. | 2016 | Int J Pharm | pmid:27789371 |
Abreu P et al. | Contractile function recovery in severely injured gastrocnemius muscle of rats treated with either oleic or linoleic acid. | 2016 | Exp. Physiol. | pmid:27579497 |
Garba L et al. | Heterologous Expression of PA8FAD9 and Functional Characterization of a Δ9-Fatty Acid Desaturase from a Cold-Tolerant Pseudomonas sp. A8. | 2016 | Mol. Biotechnol. | pmid:27629791 |
Mazel V et al. | Reevaluation of the diametral compression test for tablets using the flattened disc geometry. | 2016 | Int J Pharm | pmid:27702696 |
Yang D et al. | Delivery of siRNA Using Cationic Liposomes Incorporating Stearic Acid-modified Octa-Arginine. | 2016 | Anticancer Res. | pmid:27354583 |
Liu H et al. | Self-assembled dual-modality contrast agents for non-invasive stem cell tracking via near-infrared fluorescence and magnetic resonance imaging. | 2016 | J Colloid Interface Sci | pmid:27299677 |
Démuth B et al. | Lubricant-Induced Crystallization of Itraconazole From Tablets Made of Electrospun Amorphous Solid Dispersion. | 2016 | J Pharm Sci | pmid:27290626 |
Meng T et al. | A spermine conjugated stearic acid-g-chitosan oligosaccharide polymer with different types of amino groups for efficient p53 gene therapy. | 2016 | Colloids Surf B Biointerfaces | pmid:27289311 |
Schrank S et al. | Pore blocking: An innovative formulation strategy for the design of alcohol resistant multi-particulate dosage forms. | 2016 | Int J Pharm | pmid:27282540 |
Eltayeb M et al. | Electrosprayed nanoparticle delivery system for controlled release. | 2016 | Mater Sci Eng C Mater Biol Appl | pmid:27207047 |
Hu Y et al. | Sequential delivery of therapeutic agents using a rationally designed disulfide-linked glycolipid-like nanocarrier. | 2016 | Oncotarget | pmid:27825127 |
Zhao H et al. | Self-assembly of hydrogen-bonded supramolecular complexes of nucleic-acid-base and fatty-acid at the liquid-solid interface. | 2016 | Phys Chem Chem Phys | pmid:27170421 |
Afonso MS et al. | Dietary interesterified fat enriched with palmitic acid induces atherosclerosis by impairing macrophage cholesterol efflux and eliciting inflammation. | 2016 | J. Nutr. Biochem. | pmid:27142741 |
Haware RV et al. | Vegetable-derived magnesium stearate functionality evaluation by DM(3) approach. | 2016 | Eur J Pharm Sci | pmid:27108117 |
Wang HJ et al. | Prolongation of the degradation period and improvement of the angiogenesis of zein porous scaffolds in vivo. | 2016 | J Mater Sci Mater Med | pmid:26979976 |
Cheng CL et al. | Spectral and morphological classification of different chronic and acute Taiwanese gallstones via FTIR, SEM and ESEM-EDX microanalyses. | 2016 | Dig Liver Dis | pmid:26976784 |
Moazeni M et al. | Time to overcome fluconazole resistant Candida isolates: Solid lipid nanoparticles as a novel antifungal drug delivery system. | 2016 | Colloids Surf B Biointerfaces | pmid:26974361 |
Lu H et al. | Elevated circulating stearic acid leads to a major lipotoxic effect on mouse pancreatic beta cells in hyperlipidaemia via a miR-34a-5p-mediated PERK/p53-dependent pathway. | 2016 | Diabetologia | pmid:26969487 |
Thilakarathna SH et al. | Investigations of in vitro bioaccessibility from interesterified stearic and oleic acid-rich blends. | 2016 | Food Funct | pmid:26961726 |
Michaut A et al. | A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen. | 2016 | Toxicol. Appl. Pharmacol. | pmid:26739624 |
Ma F et al. | Improvement of β-TCP/PLLA biodegradable material by surface modification with stearic acid. | 2016 | Mater Sci Eng C Mater Biol Appl | pmid:26952440 |
Zhang C et al. | Design and evaluation of an innovative floating and bioadhesive multiparticulate drug delivery system based on hollow structure. | 2016 | Int J Pharm | pmid:26943975 |
Zhang Y et al. | CO2/pH-Controllable Viscoelastic Nanostructured Fluid Based on Stearic Acid Soap and Bola-Type Quaternary Ammonium Salt. | 2016 | Langmuir | pmid:26907546 |
Uvanesh K et al. | Effect of Span 60 on the Microstructure, Crystallization Kinetics, and Mechanical Properties of Stearic Acid Oleogels: An In-Depth Analysis. | 2016 | J. Food Sci. | pmid:26677007 |
Toral PG et al. | Does supplemental 18:0 alleviate fish oil-induced milk fat depression in dairy ewes? | 2016 | J. Dairy Sci. | pmid:26627853 |
Xu W et al. | Bilayers at High pH in the Fatty Acid Soap Systems and the Applications for the Formation of Foams and Emulsions. | 2015 | J Phys Chem B | pmid:26237503 |
Hoffmann M et al. | Investigation into process-induced de-aggregation of cohesive micronised API particles. | 2015 | Int J Pharm | pmid:26235919 |
Gong X et al. | Dependence of tablet brittleness on tensile strength and porosity. | 2015 | Int J Pharm | pmid:26226338 |
Liu G et al. | Cell membrane-inspired polymeric micelles as carriers for drug delivery. | 2015 | Biomater Sci | pmid:26222292 |
Qu L et al. | Influence of coating material on the flowability and dissolution of dry-coated fine ibuprofen powders. | 2015 | Eur J Pharm Sci | pmid:26215464 |
Wei X et al. | Structure and properties of moisture-resistant konjac glucomannan films coated with shellac/stearic acid coating. | 2015 | Carbohydr Polym | pmid:25542116 |
Zeng Q et al. | Cationic micelle delivery of Trp2 peptide for efficient lymphatic draining and enhanced cytotoxic T-lymphocyte responses. | 2015 | J Control Release | pmid:25540903 |
Piantoni P et al. | Milk production responses to dietary stearic acid vary by production level in dairy cattle. | 2015 | J. Dairy Sci. | pmid:25529423 |