stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Abortion, Spontaneous D000022 12 associated lipids
Acne Vulgaris D000152 35 associated lipids
Acquired Immunodeficiency Syndrome D000163 12 associated lipids
Adenoma D000236 40 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Alzheimer Disease D000544 76 associated lipids
Amnesia D000647 12 associated lipids
Anemia, Dyserythropoietic, Congenital D000742 2 associated lipids
Olfaction Disorders D000857 17 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Arteriosclerosis D001161 86 associated lipids
Bacterial Infections D001424 21 associated lipids
Cholestasis, Extrahepatic D001651 7 associated lipids
Birth Weight D001724 23 associated lipids
Body Weight D001835 333 associated lipids
Boutonneuse Fever D001907 5 associated lipids
Brain Edema D001929 20 associated lipids
Breast Neoplasms D001943 24 associated lipids
Bronchitis D001991 6 associated lipids
Burns D002056 34 associated lipids
Calculi D002137 3 associated lipids
Cattle Diseases D002418 24 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Chancroid D002602 4 associated lipids
Coronary Disease D003327 70 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Decalcification, Pathologic D003649 1 associated lipids
Dermatitis D003872 30 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Edema D004487 152 associated lipids
Fatty Liver D005234 48 associated lipids
Foreign Bodies D005547 5 associated lipids
Gallbladder Neoplasms D005706 3 associated lipids
Gonorrhea D006069 7 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hyperlipidemias D006949 73 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Hypopituitarism D007018 7 associated lipids
Hypothalamic Diseases D007027 3 associated lipids
Hypothyroidism D007037 32 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Infertility D007246 3 associated lipids
Insulin Resistance D007333 99 associated lipids
Insulinoma D007340 28 associated lipids
Ischemia D007511 18 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Legionnaires' Disease D007877 4 associated lipids
Leprosy D007918 8 associated lipids
Leukemia, Lymphoid D007945 18 associated lipids
Leukodystrophy, Metachromatic D007966 4 associated lipids
Liver Neoplasms D008113 8 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Lung Neoplasms D008175 171 associated lipids
Lymphadenitis D008199 8 associated lipids
Lymphoma D008223 18 associated lipids
Lymphoma, Non-Hodgkin D008228 6 associated lipids
Malignant Hyperthermia D008305 6 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Melanoma D008545 69 associated lipids
Mycobacterium Infections, Nontuberculous D009165 8 associated lipids
Mycoplasmatales Infections D009180 6 associated lipids
Neuroblastoma D009447 66 associated lipids
Occupational Diseases D009784 42 associated lipids
Otitis Media D010033 12 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Pneumoconiosis D011009 3 associated lipids
Eczema, Dyshidrotic D011146 1 associated lipids
Prostatic Diseases D011469 4 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Relapsing Fever D012061 3 associated lipids
Rosacea D012393 13 associated lipids
Salivary Duct Calculi D012465 2 associated lipids
Seizures D012640 87 associated lipids
Skin Diseases, Infectious D012874 7 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Syphilis, Congenital D013590 3 associated lipids
Syphilis, Latent D013592 4 associated lipids
Tenosynovitis D013717 3 associated lipids
Thrombosis D013927 49 associated lipids
Tremor D014202 15 associated lipids
Tuberculosis, Pulmonary D014397 18 associated lipids
Urethritis D014526 9 associated lipids
Urticaria D014581 13 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Whooping Cough D014917 6 associated lipids
Yaws D015001 4 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Reperfusion Injury D015427 65 associated lipids
Weight Gain D015430 101 associated lipids
Brain Diseases, Metabolic, Inborn D020739 10 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Atherosclerosis D050197 85 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

Download all related citations
Per page 10 20 50 100 | Total 3506
Authors Title Published Journal PubMed Link
French SJ et al. The effects of intestinal infusion of long-chain fatty acids on food intake in humans. 2000 Gastroenterology pmid:11040181
Janicki RS et al. Comparison of erythromycin ethyl succinate, stearate and estolate treatments of group A streptococcal infections of the upper respiratory tract. 1975 Clin Pediatr (Phila) pmid:1104241
Granot E et al. Breast-fed and formula-fed infants do not differ in immunocompetent cell cytokine production despite differences in cell membrane fatty acid composition. 2000 Am. J. Clin. Nutr. pmid:11063450
Männistö P et al. Absorption of erythromycin. A cross-over study in healthy volunteers. 1975 Arzneimittelforschung pmid:1106445
Daubresse JC [Atherosclerosis and nutrition]. 2000 Rev Med Brux pmid:11068494
Schwarzmann G et al. Using biotinylated gangliosides to study their distribution and traffic in cells by immunoelectron microscopy. 2000 Meth. Enzymol. pmid:11070901
Podczeck F and Newton JM Powder and capsule filling properties of lubricated granulated cellulose powder. 2000 Eur J Pharm Biopharm pmid:11072194
Knopp RH et al. One-year effects of increasingly fat-restricted, carbohydrate-enriched diets on lipoprotein levels in free-living subjects. 2000 Proc. Soc. Exp. Biol. Med. pmid:11082213
Chayabutra C et al. Rhamnolipid production by Pseudomonas aeruginosa under denitrification: effects of limiting nutrients and carbon substrates. 2001 Biotechnol. Bioeng. pmid:11084590
Hannah VC et al. Unsaturated fatty acids down-regulate srebp isoforms 1a and 1c by two mechanisms in HEK-293 cells. 2001 J. Biol. Chem. pmid:11085986
Mizukoshi Y et al. Preparation of platinum nanoparticles by sonochemical reduction of the Pt(IV) ions: role of surfactants. 2001 Ultrason Sonochem pmid:11105315
Fitch CD et al. A role for linoleic acid in erythrocytes infected with Plasmodium berghei. 2000 Biochim. Biophys. Acta pmid:11113630
Williams EE et al. The curvature and cholesterol content of phospholipid bilayers alter the transbilayer distribution of specific molecular species of phosphatidylethanolamine. 2000 Jul-Sep Mol. Membr. Biol. pmid:11128974
Leese GP et al. Effects of growth hormone treatment on red cell plasma membrane fatty acid constituents in hypopituitary adults. 2000 Scott Med J pmid:11130294
Wu J et al. Influence of wet granulation and lubrication on the powder and tableting properties of codried product of microcrystalline cellulose with beta-cyclodextrin. 2001 Eur J Pharm Biopharm pmid:11154905
Smith AM et al. Phase I/II study of G17-DT, an anti-gastrin immunogen, in advanced colorectal cancer. 2000 Clin. Cancer Res. pmid:11156225
Montell E et al. DAG accumulation from saturated fatty acids desensitizes insulin stimulation of glucose uptake in muscle cells. 2001 Am. J. Physiol. Endocrinol. Metab. pmid:11158925
Sakuma S et al. The effects of fatty acyl CoA esters on the formation of prostaglandin and arachidonoyl-CoA formed from arachidonic acid in rabbit kidney medulla microsomes. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11161586
Fukui E et al. An in vitro investigation of the suitability of press-coated tablets with hydroxypropylmethylcellulose acetate succinate (HPMCAS) and hydrophobic additives in the outer shell for colon targeting. 2001 J Control Release pmid:11166411
Kita K et al. Characterization of the reversible nature of the reaction catalyzed by sphingolipid ceramide N-deacylase. A novel form of reverse hydrolysis reaction. 2001 Eur. J. Biochem. pmid:11168398
Byrdwell WC et al. Triacylglycerol analysis of potential margarine base stocks by high-performance liquid chromatography with atmospheric pressure chemical ionization mass spectrometry and flame ionization detection. 2001 J. Agric. Food Chem. pmid:11170612
Kaushik N and Vir S Variations in fatty acid composition of neem seeds collected from the Rajasthan state of India. 2000 Biochem. Soc. Trans. pmid:11171243
Parveez GK et al. Transgenic oil palm: production and projection. 2000 Biochem. Soc. Trans. pmid:11171275
Habán P et al. Oleic acid serum phospholipid content is linked with the serum total- and LDL-cholesterol in elderly subjects. 2000 Nov-Dec Med. Sci. Monit. pmid:11208461
De Vriese SR et al. The composition of saturated fatty acids in plasma phospholipids changes in a way to counteract changes in the mean melting point during pregnancy. 2001 Lipids pmid:11214724
Fatibello-Filho O and Vieira IC Construction and analytical application of a biosensor based on stearic acid-graphite powder modified with sweet potato tissue in organic solvents. 2000 Fresenius J Anal Chem pmid:11227501
Liang P et al. [Chemical constituents of Pericampylus glaucus (Lam.) Merr]. 1998 Zhongguo Zhong Yao Za Zhi pmid:11243154
Thosar SS et al. A comparison of reflectance and transmittance near-infrared spectroscopic techniques in determining drug content in intact tablets. 2001 Pharm Dev Technol pmid:11247272
Höltje M et al. Molecular dynamics simulations of stratum corneum lipid models: fatty acids and cholesterol. 2001 Biochim. Biophys. Acta pmid:11248214
Sabir A et al. Formulation and process optimization to eliminate picking from market image tablets. 2001 Int J Pharm pmid:11250098
Nishioka Y and Yoshino H Lymphatic targeting with nanoparticulate system. 2001 Adv. Drug Deliv. Rev. pmid:11251245
Hatta I et al. X-ray diffraction study on ordered, disordered and reconstituted intercellular lipid lamellar structure in stratum corneum. 2001 Biophys. Chem. pmid:11254216
Alves MM et al. Effects of lipids and oleic acid on biomass development in anaerobic fixed-bed reactors. Part II: Oleic acid toxicity and biodegradability. 2001 Water Res. pmid:11257881
Harwood JL and James AT Metabolism of trans-3-hexadecenoic acid in broad bean. 1975 Eur. J. Biochem. pmid:1126340
Fukui E et al. Effect of magnesium stearate or calcium stearate as additives on dissolution profiles of diltiazem hydrochloride from press-coated tablets with hydroxypropylmethylcellulose acetate succinate in the outer shell. 2001 Int J Pharm pmid:11274815
Liu Q et al. Genetic modification of cotton seed oil using inverted-repeat gene-silencing techniques. 2000 Biochem. Soc. Trans. pmid:11288706
van den Bergh BA et al. Elasticity of vesicles assessed by electron spin resonance, electron microscopy and extrusion measurements. 2001 Int J Pharm pmid:11292538
Kelly FD et al. A stearic acid-rich diet improves thrombogenic and atherogenic risk factor profiles in healthy males. 2001 Eur J Clin Nutr pmid:11305631
Oviedo JM et al. Pulmonary surfactant protein SP-B is significantly more immunoreactive in anionic than in zwitterionic bilayers. 2001 FEBS Lett. pmid:11311247
Pacia SV et al. Biogenic amines in the human neocortex in patients with neocortical and mesial temporal lobe epilepsy: identification with in situ microvoltammetry. 2001 Brain Res. pmid:11311871
Ulmann L et al. Brain and hippocampus fatty acid composition in phospholipid classes of aged-relative cognitive deficit rats. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11334555
Korkishko YN et al. Characterization of alpha-phase soft proton-exchanged LiNbO3 optical waveguides. 2001 J Opt Soc Am A Opt Image Sci Vis pmid:11336221
Andrès C et al. On the difficulty of assessing the specific surface area of magnesium stearate. 2001 Int J Pharm pmid:11337159
Ves-Losada A et al. Incorporation and distribution of saturated and unsaturated fatty acids into nuclear lipids of hepatic cells. 2001 Lipids pmid:11337983
Dean DD et al. Effect of polymer molecular weight and addition of calcium stearate on response of MG63 osteoblast-like cells to UHMWPE particles. 2001 J. Orthop. Res. pmid:11347688
Hong CY Discovery of gemifloxacin (Factive, LB20304a): a quinolone of a new generation. 2001 Jan-Feb Farmaco pmid:11347965
Ferreira JA et al. Hydrophobic interactions between spin-label 5-SASL and humic acid as revealed by ESR spectroscopy. 2001 Environ. Sci. Technol. pmid:11349289
DePeters EJ et al. Fatty acid and triglyceride composition of milk fat from lactating Holstein cows in response to supplemental canola oil. 2001 J. Dairy Sci. pmid:11352169
Ghanouni P et al. Agonist-induced conformational changes in the G-protein-coupling domain of the beta 2 adrenergic receptor. 2001 Proc. Natl. Acad. Sci. U.S.A. pmid:11353823
Waddington E et al. Identification and quantitation of unique fatty acid oxidation products in human atherosclerotic plaque using high-performance liquid chromatography. 2001 Anal. Biochem. pmid:11355856