stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Yang P et al. | Transcriptome analysis of the Chinese white wax scale Ericerus pela with focus on genes involved in wax biosynthesis. | 2012 | PLoS ONE | pmid:22536429 |
Nagpal M et al. | Formulation development and evaluation of alginate microspheres of Ibuprofen. | 2012 | J Young Pharm | pmid:22523454 |
Vijay J et al. | Formulation and Evaluation of Cephalexin Extended-release Matrix Tablets Using Hydroxy Propyl Methyl Cellulose as Rate-controlling Polymer. | 2012 | J Young Pharm | pmid:22523453 |
Baratta F et al. | Diffusion of counterfeit drugs in developing countries and stability of galenics stored for months under different conditions of temperature and relative humidity. | 2012 | Croat. Med. J. | pmid:22522996 |
Zanon NC et al. | Immbolization of uricase enzyme in Langmuir and Langmuir-Blodgett films of fatty acids: possible use as a uric acid sensor. | 2012 | J Colloid Interface Sci | pmid:21875709 |
Kwon Y et al. | Arabidopsis serine decarboxylase mutants implicate the roles of ethanolamine in plant growth and development. | 2012 | Int J Mol Sci | pmid:22489147 |
Sabir A et al. | The fatty acid and tocopherol constituents of the seed oil extracted from 21 grape varieties (Vitis spp.). | 2012 | J. Sci. Food Agric. | pmid:22271548 |
Arya A et al. | Chloroform Fraction of Centratherum anthelminticum (L.) Seed Inhibits Tumor Necrosis Factor Alpha and Exhibits Pleotropic Bioactivities: Inhibitory Role in Human Tumor Cells. | 2012 | Evid Based Complement Alternat Med | pmid:22474512 |
Vega Mercado F et al. | Modulation of the domain topography of biphasic monolayers of stearic acid and dimyristoyl phosphatidylcholine. | 2012 | Chem. Phys. Lipids | pmid:22274694 |
Morales A et al. | Quantitative analysis of hydroperoxy-, keto- and hydroxy-dienes in refined vegetable oils. | 2012 | J Chromatogr A | pmid:22321954 |
Nussbaum M and Paz Y | Ultra-thin SiO2 layers on TiO2: improved photocatalysis by enhancing products' desorption. | 2012 | Phys Chem Chem Phys | pmid:22298253 |
Ahn BJ et al. | Solvent-free acid-catalyzed ring-opening of epoxidized oleochemicals using stearates/stearic acid, and its applications. | 2012 | J. Agric. Food Chem. | pmid:22304525 |
Li D et al. | Ruminal microbe of biohydrogenation of trans-vaccenic acid to stearic acid in vitro. | 2012 | BMC Res Notes | pmid:22336099 |
Schaab M et al. | Novel regulatory mechanisms for generation of the soluble leptin receptor: implications for leptin action. | 2012 | PLoS ONE | pmid:22545089 |
Kim S et al. | Lipid-binding properties of TRIM72. | 2012 | BMB Rep | pmid:22281009 |
El-Enany NM et al. | Development and validation of a repharsed phase- HPLC method for simultaneous determination of rosiglitazone and glimepiride in combined dosage forms and human plasma. | 2012 | Chem Cent J | pmid:22277722 |
Anton N et al. | A new application of lipid nanoemulsions as coating agent, providing zero-order hydrophilic drug release from tablets. | 2012 | J Drug Deliv | pmid:22272376 |
Zhen Z and Xie J | Development of manganese-based nanoparticles as contrast probes for magnetic resonance imaging. | 2012 | Theranostics | pmid:22272218 |
Han K et al. | Novel gene transfer vectors based on artificial recombinant multi-functional oligopeptides. | 2012 | Int J Pharm | pmid:22796172 |
Kottala N et al. | Influence of compaction properties and interfacial topography on the performance of bilayer tablets. | 2012 | Int J Pharm | pmid:22728259 |
Xie YT et al. | Brain-targeting study of stearic acid-grafted chitosan micelle drug-delivery system. | 2012 | Int J Nanomedicine | pmid:22802685 |
El Semary NA | The antimicrobial profile of extracts of a Phormidium-like cyanobacterium changes with phosphate levels. | 2012 | World J. Microbiol. Biotechnol. | pmid:22806854 |
Busignies V et al. | Prediction of the compressibility of complex mixtures of pharmaceutical powders. | 2012 | Int J Pharm | pmid:22759643 |
Jubie S et al. | Synthesis, antidepressant and antimicrobial activities of some novel stearic acid analogues. | 2012 | Eur J Med Chem | pmid:22770606 |
Krogager TP et al. | Identification of a potential biomarker panel for the intake of the common dietary trans fat elaidic acid (trans∆9-C18:1). | 2012 | J Proteomics | pmid:22483997 |
Streit MR et al. | High survival in young patients using a second generation uncemented total hip replacement. | 2012 | Int Orthop | pmid:22113735 |
Pijls BG et al. | Polyethylene thickness is a risk factor for wear necessitating insert exchange. | 2012 | Int Orthop | pmid:22105569 |
Chapple IL et al. | Adjunctive daily supplementation with encapsulated fruit, vegetable and berry juice powder concentrates and clinical periodontal outcomes: a double-blind RCT. | 2012 | J. Clin. Periodontol. | pmid:22093005 |
Reddy KR et al. | Rationale, challenges, and participants in a Phase II trial of a botanical product for chronic hepatitis C. | 2012 | Clin Trials | pmid:22058086 |
Ruiz M et al. | A cardiac-specific robotized cellular assay identified families of human ligands as inducers of PGC-1α expression and mitochondrial biogenesis. | 2012 | PLoS ONE | pmid:23056435 |
Zhang ZH et al. | Solid lipid nanoparticles modified with stearic acid-octaarginine for oral administration of insulin. | 2012 | Int J Nanomedicine | pmid:22848162 |
Liu J et al. | Stearoyl-acyl carrier protein desaturase gene from the oleaginous microalga Chlorella zofingiensis: cloning, characterization and transcriptional analysis. | 2012 | Planta | pmid:22855030 |
Carol D et al. | Synergistic effect of calcium stearate and photo treatment on the rate of biodegradation of low density polyethylene spent saline vials. | 2012 | Indian J. Exp. Biol. | pmid:22822530 |
Zeng XJ et al. | [Chemical constituents of Berchemia lineate]. | 2012 | Zhong Yao Cai | pmid:22822666 |
Hu FQ et al. | pH triggered doxorubicin delivery of PEGylated glycolipid conjugate micelles for tumor targeting therapy. | 2012 | Mol. Pharm. | pmid:22827551 |
Sellami M et al. | Enzymatic transesterification of palm stearin and olein blends to produce zero-trans margarine fat. | 2012 | BMC Biotechnol. | pmid:22889174 |
Li Y et al. | New bactericidal surgical suture coating. | 2012 | Langmuir | pmid:22877364 |
Kang JH et al. | Effects of solid carriers on the crystalline properties, dissolution and bioavailability of flurbiprofen in solid self-nanoemulsifying drug delivery system (solid SNEDDS). | 2012 | Eur J Pharm Biopharm | pmid:22119666 |
Schreiber R et al. | Retinyl ester hydrolases and their roles in vitamin A homeostasis. | 2012 | Biochim. Biophys. Acta | pmid:21586336 |
Wang YN et al. | [Study on chemical constituents from Anoectochilus chapaensis]. | 2012 | Zhong Yao Cai | pmid:23236826 |
Simmons DM and Gierer DS | A material sparing test to predict punch sticking during formulation development. | 2012 | Drug Dev Ind Pharm | pmid:22181042 |
Niu J et al. | Octreotide-modified and pH-triggering polymeric micelles loaded with doxorubicin for tumor targeting delivery. | 2012 | Eur J Pharm Sci | pmid:22119655 |
Jung HA and Augsburger LL | Application of a novel automatic disintegration apparatus for the development and evaluation of a direct compression rapidly disintegrating tablet. | 2012 | Drug Dev Ind Pharm | pmid:22091970 |
Tokudome Y and Otsuka M | Possibility of alveolar bone promoting enhancement by using lipophilic and/or hydrophilic zinc related compounds in zinc-deficient osteoporosis rats. | 2012 | Biol. Pharm. Bull. | pmid:22975500 |
Gören AC et al. | Fatty acid composition and chemotaxonomic evaluation of species of Stachys. | 2012 | Nat. Prod. Res. | pmid:21859257 |
Aissa I et al. | Synthesis of lipophilic tyrosyl esters derivatives and assessment of their antimicrobial and antileishmania activities. | 2012 | Lipids Health Dis | pmid:22264330 |
Masuda M et al. | Activating transcription factor 4 regulates stearate-induced vascular calcification. | 2012 | J. Lipid Res. | pmid:22628618 |
Toubiana D et al. | Metabolic profiling of a mapping population exposes new insights in the regulation of seed metabolism and seed, fruit, and plant relations. | 2012 | PLoS Genet. | pmid:22479206 |
Xie J et al. | Composition of fatty oils from semen ziziphi spinosae and its cardiotonic effect on isolated toad hearts. | 2012 | Nat. Prod. Res. | pmid:21707231 |
Slobodkina GB et al. | Deferrisoma camini gen. nov., sp. nov., a moderately thermophilic, dissimilatory iron(III)-reducing bacterium from a deep-sea hydrothermal vent that forms a distinct phylogenetic branch in the Deltaproteobacteria. | 2012 | Int. J. Syst. Evol. Microbiol. | pmid:22140176 |