stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Dawes J et al. | Application of external lubrication during the roller compaction of adhesive pharmaceutical formulations. | 2013 | Pharm Dev Technol | pmid:22813432 |
Stanisz B et al. | Effect of pharmaceutical excipients on the stability of angiotensin-converting enzyme inhibitors in their solid dosage formulations. | 2013 | Drug Dev Ind Pharm | pmid:22348774 |
Mazel V et al. | The surface layer of pharmaceutical compacts: the role of the punch surface and its impact on the mechanical properties of the compacts. | 2013 | Int J Pharm | pmid:22902389 |
Qi B et al. | A Golgi and tonoplast localized S-acyl transferase is involved in cell expansion, cell division, vascular patterning and fertility in Arabidopsis. | 2013 | New Phytol. | pmid:23795888 |
Podczeck F et al. | Investigations into the tensile failure of doubly-convex cylindrical tablets under diametral loading using finite element methodology. | 2013 | Int J Pharm | pmid:23834836 |
Wang N et al. | The mechanism of hydrogen sulfide adsorption on fine rubber particle media (FRPM). | 2013 | J. Hazard. Mater. | pmid:23876257 |
Mohamed IO | Lipase-catalyzed acidolysis of palm mid fraction oil with palmitic and stearic Fatty Acid mixture for production of cocoa butter equivalent. | 2013 | Appl. Biochem. Biotechnol. | pmid:23877586 |
Vitturi DA et al. | Modulation of nitro-fatty acid signaling: prostaglandin reductase-1 is a nitroalkene reductase. | 2013 | J. Biol. Chem. | pmid:23878198 |
Saeedi Vahdat A et al. | Ultrasonic approach for viscoelastic and microstructure characterization of granular pharmaceutical tablets. | 2013 | Int J Pharm | pmid:23820132 |
Li L et al. | Drug release characteristics from chitosan-alginate matrix tablets based on the theory of self-assembled film. | 2013 | Int J Pharm | pmid:23624081 |
Neutsch L et al. | UPEC biomimickry at the urothelial barrier: lectin-functionalized PLGA microparticles for improved intravesical chemotherapy. | 2013 | Int J Pharm | pmid:23628404 |
Emken E | Human studies using isotope labeled fatty acids: answered and unanswered questions. | 2013 | J Oleo Sci | pmid:23648399 |
Dangarembizi R et al. | Aloe ferox seed: a potential source of oil for cosmetic and pharmaceutical use. | 2013 | Nat Prod Commun | pmid:23678824 |
Maia M et al. | A novel, direct, reagent-free method for the detection of beeswax adulteration by single-reflection attenuated total reflectance mid-infrared spectroscopy. | 2013 | Talanta | pmid:23598195 |
Li CC et al. | [In situ rat intestine absorption of paclitaxel-loaded solid lipid nanoparticles modified with cell-penetrating peptides]. | 2013 | Yao Xue Xue Bao | pmid:23600154 |
Salehi M et al. | Debinding mechanisms in thermoplastic processing of a Ba(0.5)Sr(0.5)Co(0.8)Fe(0.2)O(3-δ)- stearic acid-polystyrene mixture. | 2013 | ChemSusChem | pmid:23281298 |
He M et al. | Controllable stearic acid crystal induced high hydrophobicity on cellulose film surface. | 2013 | ACS Appl Mater Interfaces | pmid:23289586 |
Zhou QT et al. | Effect of surface coating with magnesium stearate via mechanical dry powder coating approach on the aerosol performance of micronized drug powders from dry powder inhalers. | 2013 | AAPS PharmSciTech | pmid:23196863 |
Van Hoeck V et al. | Oocyte developmental failure in response to elevated nonesterified fatty acid concentrations: mechanistic insights. | 2013 | Reproduction | pmid:23108110 |
Negi JS et al. | Development of solid lipid nanoparticles (SLNs) of lopinavir using hot self nano-emulsification (SNE) technique. | 2013 | Eur J Pharm Sci | pmid:23153618 |
Nakagawa H et al. | Real-time monitoring of lubrication properties of magnesium stearate using NIR spectrometer and thermal effusivity sensor. | 2013 | Int J Pharm | pmid:23174413 |
Otsuka Y et al. | Effects of polymorphic transformation on pharmaceutical properties of direct compressed tablets containing theophylline anhydrate bulk powder under high humidity. | 2013 | Colloids Surf B Biointerfaces | pmid:23178204 |
Azordegan N et al. | Carcinogenesis alters fatty acid profile in breast tissue. | 2013 | Mol. Cell. Biochem. | pmid:23180247 |
Delbecq F et al. | N-stearoyl amino acid derivatives: potent biomimetic hydro/organogelators as templates for preparation of gold nanoparticles. | 2013 | J Colloid Interface Sci | pmid:23089597 |
Fernandes CP et al. | Triterpene esters and biological activities from edible fruits of Manilkara subsericea (Mart.) Dubard, Sapotaceae. | 2013 | Biomed Res Int | pmid:23509702 |
You J et al. | Specific tumor delivery of paclitaxel using glycolipid-like polymer micelles containing gold nanospheres. | 2013 | Biomaterials | pmid:23510855 |
John CT et al. | Formulating weakly basic HCl salts: relative ability of common excipients to induce disproportionation and the unique deleterious effects of magnesium stearate. | 2013 | Pharm. Res. | pmid:23512680 |
Stank K and Steckel H | Physico-chemical characterisation of surface modified particles for inhalation. | 2013 | Int J Pharm | pmid:23518364 |
Kumar N et al. | Salt dependent stability of stearic acid Langmuir-Blodgett films exposed to aqueous electrolytes. | 2013 | Langmuir | pmid:23565719 |
Han SH et al. | Bioinspired self-assembled peptide nanofibers with thermostable multivalent α-helices. | 2013 | Biomacromolecules | pmid:23550841 |
Khan AA et al. | Design, synthesis and in vitro anticancer evaluation of a stearic acid-based ester conjugate. | 2013 | Anticancer Res. | pmid:23749903 |
Li C et al. | Enhanced performance and interfacial investigation of mineral-based composite phase change materials for thermal energy storage. | 2013 | Sci Rep | pmid:23712069 |
Lakio S et al. | Challenges in detecting magnesium stearate distribution in tablets. | 2013 | AAPS PharmSciTech | pmid:23378252 |
Järvinen MA et al. | Continuous direct tablet compression: effects of impeller rotation rate, total feed rate and drug content on the tablet properties and drug release. | 2013 | Drug Dev Ind Pharm | pmid:23163644 |
Schrank S et al. | Microstructure of calcium stearate matrix pellets: a function of the drying process. | 2013 | J Pharm Sci | pmid:23983150 |
Hagen RM et al. | Conjugated linoleate reduces prostate cancer viability whereas the effects of oleate and stearate are cell line-dependent. | 2013 | Anticancer Res. | pmid:24123008 |
Guo H et al. | Self-assembled nanoparticles based on galactosylated O-carboxymethyl chitosan-graft-stearic acid conjugates for delivery of doxorubicin. | 2013 | Int J Pharm | pmid:24140544 |
Cvetković Z et al. | Distribution of plasma fatty acids is associated with response to chemotherapy in non-Hodgkin's lymphoma patients. | 2013 | Med. Oncol. | pmid:24085546 |
Jin Q et al. | A novel cationic microbubble coated with stearic acid-modified polyethylenimine to enhance DNA loading and gene delivery by ultrasound. | 2013 | PLoS ONE | pmid:24086748 |
Eltayeb M et al. | Electrosprayed core-shell polymer-lipid nanoparticles for active component delivery. | 2013 | Nanotechnology | pmid:24164775 |
Boshtam M et al. | Serum paraoxonase 1 activity is associated with fatty acid composition of high density lipoprotein. | 2013 | Dis. Markers | pmid:24167374 |
Shibata E et al. | Free fatty acids inhibit protein tyrosine phosphatase 1B and activate Akt. | 2013 | Cell. Physiol. Biochem. | pmid:24107614 |
Zhang W et al. | Stearylated antimicrobial peptide melittin and its retro isomer for efficient gene transfection. | 2013 | Bioconjug. Chem. | pmid:24107137 |
Li P et al. | Effect of non-esterified fatty acids on fatty acid metabolism-related genes in calf hepatocytes cultured in vitro. | 2013 | Cell. Physiol. Biochem. | pmid:24335176 |
Wahl PR et al. | Inline monitoring and a PAT strategy for pharmaceutical hot melt extrusion. | 2013 | Int J Pharm | pmid:23911343 |
Michailidou VN et al. | Anisotropic diffusion of concentrated hard-sphere colloids near a hard wall studied by evanescent wave dynamic light scattering. | 2013 | J Chem Phys | pmid:24182077 |
Hosseini A et al. | Direct compression of cushion-layered ethyl cellulose-coated extended release pellets into rapidly disintegrating tablets without changes in the release profile. | 2013 | Int J Pharm | pmid:23892153 |
Neupane YR et al. | Lipid drug conjugate nanoparticle as a novel lipid nanocarrier for the oral delivery of decitabine: ex vivo gut permeation studies. | 2013 | Nanotechnology | pmid:24061410 |
Yan J et al. | Effect of proteins with different isoelectric points on the gene transfection efficiency mediated by stearic acid grafted chitosan oligosaccharide micelles. | 2013 | Mol. Pharm. | pmid:23679858 |
Kwan HY et al. | The anticancer effect of oridonin is mediated by fatty acid synthase suppression in human colorectal cancer cells. | 2013 | J. Gastroenterol. | pmid:22722903 |