stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Slomiany BL et al. | Lipid composition of the matrix of human submandibular salivary gland stones. | 1982 | Arch. Oral Biol. | pmid:6958224 |
Ahmad SN et al. | Fatty acid incorporation into membranes of dispersed rat submandibular salivary gland cells and their effect on adenylate cyclase activity. | 1990 | Arch. Oral Biol. | pmid:2281999 |
Mutalik S et al. | Preparation, in vitro, preclinical and clinical evaluations of once daily sustained release tablets of aceclofenac. | 2007 | Arch. Pharm. Res. | pmid:17366745 |
Lee SH et al. | End point determination of blending process for trimebutine tablets using principle component analysis (PCA) and partial least squares (PLS) regression. | 2012 | Arch. Pharm. Res. | pmid:23054717 |
Kim IS and Oh IJ | Preparation and characterization of stearic acid-pullulan nanoparticles. | 2010 | Arch. Pharm. Res. | pmid:20512475 |
Kasliwal N et al. | Formulation, development, and performance evaluation of metoclopramide HCl oro-dispersible sustained release tablet. | 2011 | Arch. Pharm. Res. | pmid:22076769 |
Jeong SH and Park K | Simple preparation of coated resin complexes and their incorporation into fast-disintegrating tablets. | 2010 | Arch. Pharm. Res. | pmid:20191352 |
Yu BT et al. | Enhanced liver targeting by synthesis of N1-stearyl-5-Fu and incorporation into solid lipid nanoparticles. | 2003 | Arch. Pharm. Res. | pmid:14723346 |
Cha KH et al. | Design of pH-independent extended release matrix tablets of minocycline hydrochloride for the treatment of dementia. | 2009 | Arch. Pharm. Res. | pmid:20091273 |
Peura P et al. | The effect of ethanol on the release of free fatty acids from the brain in vivo; a study with push-pull cannula. | 1986 | Arch. Toxicol. Suppl. | pmid:3468932 |
Zhou X et al. | The effect of saturated fatty acids on methanogenesis and cell viability of Methanobrevibacter ruminantium. | 2013 | Archaea | pmid:23710130 |
MALJKOVIC I | [A CASE OF CHRONIC OCCUPATIONAL POISONING WITH LEAD STEARATE AND CARBONATE]. | 1964 | Arh Hig Rada Toksikol | pmid:14342211 |
NadtochiÄ VV and BrodskiÄ RA | [Absorption routes of stearic acid and leucine in the small intestine of the rat after gamma irradiation]. | 1983 | Arkh Anat Gistol Embriol | pmid:6639383 |
Mitropoulos KA et al. | Dietary fat induces changes in factor VII coagulant activity through effects on plasma free stearic acid concentration. | 1994 | Arterioscler. Thromb. | pmid:8305411 |
Anderson EK et al. | Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis. | 2012 | Arterioscler. Thromb. Vasc. Biol. | pmid:22556332 |
Turpeinen AM et al. | Similar effects of diets rich in stearic acid or trans-fatty acids on platelet function and endothelial prostacyclin production in humans. | 1998 | Arterioscler. Thromb. Vasc. Biol. | pmid:9484999 |
Mennen L et al. | Factor VIIa response to a fat-rich meal does not depend on fatty acid composition: a randomized controlled trial. | 1998 | Arterioscler. Thromb. Vasc. Biol. | pmid:9555866 |
Loscalzo J et al. | Unsaturated fatty acids enhance low density lipoprotein uptake and degradation by peripheral blood mononuclear cells. | 1987 Sep-Oct | Arteriosclerosis | pmid:3675304 |
Tulenko TN and Rabinowitz JL | Metabolism of C14 mevalonate by adult and fetal arteries. | 1983 | Artery | pmid:6677248 |
Krzeski P et al. | Development of musculoskeletal toxicity without clear benefit after administration of PG-116800, a matrix metalloproteinase inhibitor, to patients with knee osteoarthritis: a randomized, 12-month, double-blind, placebo-controlled study. | 2007 | Arthritis Res. Ther. | pmid:17958901 |
Chiang EP et al. | Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis. | 2005 | Arthritis Res. Ther. | pmid:16277693 |
Kumar Gaur P et al. | Nanovesicles of nitrendipine with lipid complex for transdermal delivery: pharmacokinetic and pharmacodynamic studies. | 2016 | Artif Cells Nanomed Biotechnol | pmid:26375758 |
Yan G et al. | Preparation and evaluation of liver-targeting micelles loaded with oxaliplatin. | 2016 | Artif Cells Nanomed Biotechnol | pmid:25287740 |
Pradhan M et al. | Influence of selected variables on fabrication of Triamcinolone acetonide loaded solid lipid nanoparticles for topical treatment of dermal disorders. | 2016 | Artif Cells Nanomed Biotechnol | pmid:25229831 |
Chen Q et al. | Preparation and characterization of glycyrrhetinic acid-modified stearic acid-grafted chitosan micelles. | 2015 | Artif Cells Nanomed Biotechnol | pmid:24093764 |
Tükel S et al. | Optimization of lipase-catalyzed synthesis of fructose stearate using response surface methodology. | 2013 | Artif Cells Nanomed Biotechnol | pmid:23305558 |
Wang W et al. | Synthesis, self-assembly, and in vitro toxicity of fatty acids-modified Bletilla striata polysaccharide. | 2017 | Artif Cells Nanomed Biotechnol | pmid:26754958 |
Sastri MS et al. | In vitro and in vivo studies on slow release propranolol hydrochloride suppositories. Pharmacokinetic and pharmacodynamic evaluation. | 1993 | Arzneimittelforschung | pmid:8489559 |
Männistö P et al. | Absorption of erythromycin. A cross-over study in healthy volunteers. | 1975 | Arzneimittelforschung | pmid:1106445 |
Asgary S et al. | Evaluation of fatty acid content of some Iranian fast foods with emphasis on trans fatty acids. | 2009 | Asia Pac J Clin Nutr | pmid:19713177 |
Cohn JS et al. | Reduction in intestinal cholesterol absorption by various food components: mechanisms and implications. | 2010 | Atheroscler Suppl | pmid:20439167 |
Ebbesson SO et al. | Consumption of omega-3 fatty acids is not associated with a reduction in carotid atherosclerosis: the Genetics of Coronary Artery Disease in Alaska Natives study. | 2008 | Atherosclerosis | pmid:18054937 |
HÃ¥versen L et al. | Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages. | 2009 | Atherosclerosis | pmid:18599066 |
van Greevenbroek MM et al. | Effects of saturated, mono-, and polyunsaturated fatty acids on the secretion of apo B containing lipoproteins by Caco-2 cells. | 1996 | Atherosclerosis | pmid:8678919 |
Berlin E et al. | Influence of saturated and unsaturated fats on platelet fatty acids in cholesterol-fed rabbits. | 1987 | Atherosclerosis | pmid:3827974 |
Sanders TA et al. | Influence of fatty acid chain length and cis/trans isomerization on postprandial lipemia and factor VII in healthy subjects (postprandial lipids and factor VII). | 2000 | Atherosclerosis | pmid:10729392 |
van Tol A et al. | Dietary trans fatty acids increase serum cholesterylester transfer protein activity in man. | 1995 | Atherosclerosis | pmid:7669083 |
Bonanome A et al. | Metabolic effects of dietary stearic acid in mice: changes in the fatty acid composition of triglycerides and phospholipids in various tissues. | 1992 | Atherosclerosis | pmid:1632865 |
Uehara Y et al. | Unsaturated fatty acids suppress the expression of the ATP-binding cassette transporter G1 (ABCG1) and ABCA1 genes via an LXR/RXR responsive element. | 2007 | Atherosclerosis | pmid:16730733 |
Spigoni V et al. | Stearic acid at physiologic concentrations induces in vitro lipotoxicity in circulating angiogenic cells. | 2017 | Atherosclerosis | pmid:28892713 |
Artwohl M et al. | Fatty acids induce apoptosis in human smooth muscle cells depending on chain length, saturation, and duration of exposure. | 2009 | Atherosclerosis | pmid:18597758 |
Ishikado A et al. | Soy phosphatidylcholine inhibited TLR4-mediated MCP-1 expression in vascular cells. | 2009 | Atherosclerosis | pmid:19215923 |
Cooksley WG and Powell LW | Erythromycin jaundice: diagnosis by an in vitro challenge test. | 1977 | Aust N Z J Med | pmid:269690 |
Green B et al. | Qualitative and quantitative changes in milk fat during lactation in the tammar wallaby (Macropus eugenii). | 1983 | Aust. J. Biol. Sci. | pmid:6675645 |
Weber J et al. | [Can zinc stearate cause lung fibrosis? (Case report)]. | 1976 | Beitr Silikoseforsch Pneumokoniose | pmid:990095 |
Basseri S and Austin RC | Endoplasmic reticulum stress and lipid metabolism: mechanisms and therapeutic potential. | 2012 | Biochem Res Int | pmid:22195283 |
ERWIN J and BLOCH K | POLYUNSATURATED FATTY ACIDS IN SOME PHOTOSYNTHETIC MICROORGANISMS. | 1963 | Biochem Z | pmid:14087318 |
Liu K et al. | Isolation and biochemical characterization of two lipases from a metagenomic library of China Holstein cow rumen. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19486892 |
Eitel K et al. | Different role of saturated and unsaturated fatty acids in beta-cell apoptosis. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12470657 |
Yonezawa T et al. | Regulation of hormone-sensitive lipase expression by saturated fatty acids and hormones in bovine mammary epithelial cells. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18755148 |