stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Dong X et al. | [Analysis of meibum by gas chromatography-mass spectrometry]. | 2015 | Zhonghua Yan Ke Za Zhi | pmid:26693651 |
Chen Y et al. | [Studies on chemical constituents of Forsythia suspensa (Thunb) Vahl]. | 1999 | Zhongguo Zhong Yao Za Zhi | pmid:12205888 |
Liu Z et al. | [Chemical constituents from root bark of Tripterygium hypoglaucum]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22256754 |
Tang HF et al. | [Studies on the chemical constituents from marine brown alga Ishige okamurai (3)]. | 2002 | Zhongguo Zhong Yao Za Zhi | pmid:12774370 |
Liu FX et al. | [Study on the encapsulation technique of high purity gamma-linolenic acid, part 1--saponification reaction and saponification value]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:15806965 |
Xiong W et al. | [Hydrothobic constituents of Nyssa sinensis Oliv]. | 1995 | Zhongguo Zhong Yao Za Zhi | pmid:8737471 |
Shu R et al. | [Chemical constituents of Cyclocarya paliurus (Batal.) Iljinsk]. | 1995 | Zhongguo Zhong Yao Za Zhi | pmid:8737472 |
Cao C et al. | [Chemical study on petroleum ether portion of Sarcandra hainanensis]. | 2009 | Zhongguo Zhong Yao Za Zhi | pmid:19639789 |
Gu W et al. | [Chemical composition of Fordia cauliflora Hemsl]. | 1999 | Zhongguo Zhong Yao Za Zhi | pmid:12242814 |
Zhao XY et al. | [Studies on chemical constituents from rhizome of Impatiens pritzellii var. hupehensis]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16011279 |
Hu SY et al. | [Studies on sustained release solid dispersion of tripterine carried by HPMC-stearic acid]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:23311152 |
Wei S et al. | [Chemical constituents in the stem of Premna crassa Hand. -Mazz]. | 1990 | Zhongguo Zhong Yao Za Zhi | pmid:2093323 |
Liang P et al. | [Chemical constituents of Pericampylus glaucus (Lam.) Merr]. | 1998 | Zhongguo Zhong Yao Za Zhi | pmid:11243154 |
Jian WX et al. | [Detection and analysis on plasma metabolomics in patient with coronary heart disease of Xin-blood stasis syndrome pattern]. | 2010 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:20815270 |
Zhang JW et al. | [Studies on the chemical constituents of Toricellia angulata var. intermedia]. | 2010 | Zhong Yao Cai | pmid:21434432 |
Chen M et al. | [Study on the chemical constituents from Fructus Toosendan (III)]. | 2011 | Zhong Yao Cai | pmid:22500422 |
Pi K et al. | [Study on liposoluble constituents of Teucrium labiosum]. | 2008 | Zhong Yao Cai | pmid:18973016 |
Yin AW and Huang SJ | [Research on chemical constituents of xuefu zhuyu decoction]. | 2011 | Zhong Yao Cai | pmid:22372145 |
Zeng XJ et al. | [Chemical constituents of Berchemia lineate]. | 2012 | Zhong Yao Cai | pmid:22822666 |
Duan J et al. | [Analysis of ethereal extracts from Odondotermes formosanus and fungus garden]. | 1999 | Zhong Yao Cai | pmid:12571918 |
Sun X et al. | [Studies on chemical constituents of fat oil of Polygala tenuifolia]. | 2000 | Zhong Yao Cai | pmid:12575116 |
Lian Z et al. | [Studies on chemical constituents of Choerospondias axillaris]. | 2003 | Zhong Yao Cai | pmid:12858769 |
Wang YN et al. | [Study on chemical constituents from Anoectochilus chapaensis]. | 2012 | Zhong Yao Cai | pmid:23236826 |
Zhu SH et al. | [Study on the chemical constituents of Dichrocephala integrifolia]. | 2010 | Zhong Yao Cai | pmid:20518304 |
Luan L et al. | [Studies on the chemical constituents of extract with water from Forsythia suspensa]. | 2010 | Zhong Yao Cai | pmid:20575415 |
Wang YY et al. | [Studies on the chemical constituents of Sarcopyramis nepalensis]. | 2009 | Zhong Yao Cai | pmid:20034215 |
Cai JY et al. | [Studies on chemical constituents from Anoectochilus roxburghii]. | 2008 | Zhong Yao Cai | pmid:18619237 |
Li YW et al. | [Studies on the chemical constituents of Ficus microcarpa]. | 2010 | Zhong Yao Cai | pmid:21049616 |
Ma BJ et al. | [Chemical constituents study on the fruiting bodies of Lactarius rufus]. | 2008 | Zhong Yao Cai | pmid:18619269 |
Wang Y et al. | [Analysis of plasma metabonomics of mini-swines with qi deficiency and blood stasis syndrome due to chronic myocardial ischemia]. | 2011 | Zhong Xi Yi Jie He Xue Bao | pmid:21288451 |
Zakhariv OIa and Ianovich VG | [The utilization of [9,10-(3)H] stearic and [1-(14)C] linolenic acids in the in-vitro synthesis of lipids in ruminant tissues]. | 1995 Jul-Aug | Zh. Evol. Biokhim. Fiziol. | pmid:8779280 |
el-Naghy MA et al. | Fungistatic action of natural oils and fatty acids on dermatophytic and saprophytic fungi. | 1992 | Zentralbl. Mikrobiol. | pmid:1609554 |
Kankofer M et al. | The analysis of fatty acid content and phospholipase A2 activity in placenta of cows with and without retained fetal membranes. | 1996 | Zentralbl Veterinarmed A | pmid:8940891 |
Kraus G et al. | [The modification of different element levels in human blood by occupational cadmium exposure]. | 1988 | Zentralbl Bakteriol Mikrobiol Hyg B | pmid:3138836 |
Shani J et al. | Efficacy of sustained-release radioprotective drugs in vivo. | 1987 Nov-Dec | Z. Naturforsch., C, J. Biosci. | pmid:2966504 |
Simpson JT et al. | Identification of major lipids from the scent gland secretions of Dumeril's ground boa (Acrantophis dumerili Jan) by gas chromatography-mass spectrometry. | 1988 Nov-Dec | Z. Naturforsch., C, J. Biosci. | pmid:3245880 |
Murkovic M et al. | Variability of fatty acid content in pumpkin seeds (Cucurbita pepo L.). | 1996 | Z Lebensm Unters Forsch | pmid:8873459 |
Gonzalez-Castro MY et al. | Effects of blanching, freezing and freeze-drying on the fatty acid contents of green beans. | 1996 | Z Lebensm Unters Forsch | pmid:9123974 |
Schmidt P et al. | [Animal experiments on barium stearate toxicity]. | 1975 | Z Gesamte Hyg | pmid:1189478 |
Schmidt P et al. | [Acute inhalation toxicity of cadmium stearate]. | 1971 | Z Gesamte Hyg | pmid:5123074 |
Chung DJ et al. | Black cohosh and St. John's wort (GYNO-Plus) for climacteric symptoms. | 2007 | Yonsei Med. J. | pmid:17461529 |
Hatipoglu ON and Tasan Y | A comparative efficacy and safety study of clarithromycin, roxithromycin and erythromycin stearate in mild pneumonia. | 2000 | Yonsei Med. J. | pmid:10957888 |
Chen JM et al. | [Comparison of seed oil physicochemical characteristics among three cultivars of Jatropha curcas L]. | 2009 | Ying Yong Sheng Tai Xue Bao | pmid:20353052 |
Bai YJ et al. | [Structure identification of jujuboside E]. | 2003 | Yao Xue Xue Bao | pmid:15040089 |
Chen DB et al. | [In vitro and in vivo study of two kinds of long-circulating solid lipid nanoparticles containing paclitaxel]. | 2002 | Yao Xue Xue Bao | pmid:12579901 |
Ye YQ et al. | [Preparation and characterization of stearic acid-grafted chitosan oligosaccharide polymeric micelles]. | 2004 | Yao Xue Xue Bao | pmid:15491108 |
Li CC et al. | [In situ rat intestine absorption of paclitaxel-loaded solid lipid nanoparticles modified with cell-penetrating peptides]. | 2013 | Yao Xue Xue Bao | pmid:23600154 |
Jiang RG et al. | [Effect of surface modification on surface energy of lactose and performance of dry powder inhalations]. | 2005 | Yao Xue Xue Bao | pmid:16011271 |
NAKAGAKI M and NISHINO M | [STUDIES ON THE PHYSICOCHEMICAL PROPERTIES OF ALUMINUM SOAPS. III. COMPOSITION OF ALUMINUM STEARATE AND STRUCTURAL VISCOSITY OF BENZENE SOLUTION]. | 1963 | Yakugaku Zasshi | pmid:14094211 |
NAKAGAKI M and NISHINO M | [STUDIES ON THE PHYSICOCHEMICAL PROPERTIES OF ALUMINUM SOAPS. IV. EFFECT OF THERMAL TREATMENT ON THE STRUCTURE OF THE SOAP]. | 1963 | Yakugaku Zasshi | pmid:14094212 |
Arai T and Hosoi Y | [Determination of magnesium stearate in pharmaceutical preparations using derivatization with 2-nitrophenylhydrazine and HPLC]. | 2005 | Yakugaku Zasshi | pmid:15738629 |
Sunagane N et al. | [Possibility of interactions between prescription drugs and OTC drugs (2nd report)--interaction between levodopa preparation and OTC Kampo medicines for upset stomach]. | 2006 | Yakugaku Zasshi | pmid:17077621 |
Goto S et al. | [Role of metal stearates in preparation of Eudragit RS-microcapsules containing sulfamethizole by evaporation process in water phase]. | 1986 | Yakugaku Zasshi | pmid:3701600 |
Goto S et al. | [Effect of magnesium stearate in preparation of eudragit RS-microcapsules containing drugs]. | 1985 | Yakugaku Zasshi | pmid:3835255 |
Nakagawa H et al. | [Effects of particle size of rifampicin and addition of magnesium stearate on release of rifampicin from hard gelatin capsules (author's transl)]. | 1980 | Yakugaku Zasshi | pmid:7205556 |
Nadai M et al. | [Correlation between in vitro dissolution characteristics of macrolide antibiotic tablets and bioavailability in man]. | 1987 | Yakugaku Zasshi | pmid:3437396 |
NAKAGAKI M and NISHINO M | [Studies on the physicochemical properties of aluminum soap. II. Structural viscosity of aluminum stearate in benzene]. | 1963 | Yakugaku Zasshi | pmid:13937343 |
Iwao Y | [Efficient Pharmaceutical Formulation Designs and Their Development Using Mathematical and Statistical Analysis]. | 2015 | Yakugaku Zasshi | pmid:26423868 |
Miyake Y et al. | [Studies on packing-property of pharmaceutical powders. 3. Influence of calcium stearate content on compacting phenomenon of pharmaceutical powders (author's transl)]. | 1973 | Yakugaku Zasshi | pmid:4797567 |
Miyake Y et al. | [Studies on packing-property of pharmaceutical powders. II. Compacting phenomenon of pharmaceutical powders in the course of mixing with calcium stearate]. | 1972 | Yakugaku Zasshi | pmid:4675495 |
NISHINO M | [STUDIES ON THE PHYSICOCHEMICAL PROPERTIES OF ALUMINUM SOAPS. V. STRUCTURAL VISCOSITY OF ALUMINUM STEARATES IN VEGETABLE OILS]. | 1964 | Yakugaku Zasshi | pmid:14266543 |
NAKAGAKI M and NISHINO M | [STUDIES ON THE PHYSICO-CHEMICAL PROPERTIES OF ALUMINUM SOAPS. VI. EFFECT OF ADDITIVES ON THE VISCOSITY OF BENZENE SOLUTION OF ALUMINUM DISTEARATE]. | 1964 | Yakugaku Zasshi | pmid:14266544 |
KAKEMI K et al. | [STUDIES ON SUCROSE ESTERS. 3. EFFECT OF SUCROSE ESTERS ON THE ABSORPTION OF DRUGS FROM THE ALIMENTARY TRACT]. | 1964 | Yakugaku Zasshi | pmid:14266554 |
Kitajima J et al. | [Studies on the constituents of trichosanthes root. III. Constituents of roots of Trichosanthes bracteata Voigt]. | 1989 | Yakugaku Zasshi | pmid:2760813 |
El Semary NA | The antimicrobial profile of extracts of a Phormidium-like cyanobacterium changes with phosphate levels. | 2012 | World J. Microbiol. Biotechnol. | pmid:22806854 |
Chen JL et al. | Metabolomics of gastric cancer metastasis detected by gas chromatography and mass spectrometry. | 2010 | World J. Gastroenterol. | pmid:21155010 |
Liu Z et al. | Changes in the electron paramagnetic resonance spectra of albumin-associated spin-labeled stearic acid as a diagnostic parameter of colorectal cancer. | 2013 | World J Surg Oncol | pmid:24025321 |
Miranda LA et al. | Performance of UASB and DAEB reactors in the anaerobic digestion of synthetic wastewater containing sodium oleate and sodium stereate. | 2006 | Water Sci. Technol. | pmid:16939093 |
Alves MM et al. | Effects of lipids and oleic acid on biomass development in anaerobic fixed-bed reactors. Part II: Oleic acid toxicity and biodegradability. | 2001 | Water Res. | pmid:11257881 |
Lalman JA and Bagley DM | Anaerobic degradation and methanogenic inhibitory effects of oleic and stearic acids. | 2001 | Water Res. | pmid:11471698 |
Kosukhin AB et al. | [The mechanism of formation of spectrum of nonesterified fatty acids in biological fluids of rabbits with alimentary hypercholesterolemia]. | 1989 Mar-Apr | Vopr. Med. Khim. | pmid:2741412 |
Zaridze DG et al. | [Fatty acid composition of phospholipids of erythrocyte membranes and risk of breast cancer]. | 1990 | Vopr Onkol | pmid:2126901 |
Bridges CD et al. | Visual cycle in the mammalian eye. Retinoid-binding proteins and the distribution of 11-cis retinoids. | 1984 | Vision Res. | pmid:6543481 |
MacDonald RC et al. | Inhibition of sendai virus-induced hemolysis by long chain fatty acids. | 1984 | Virology | pmid:6324464 |
Nozawa CM and Apostolov K | Increase in the saturation of C18 fatty acids induced by coxsackie B6 virus in Vero cells. | 1982 | Virology | pmid:6285601 |
Kordyukova LV et al. | Site-specific attachment of palmitate or stearate to cytoplasmic versus transmembrane cysteines is a common feature of viral spike proteins. | 2010 | Virology | pmid:20006369 |
Lavergne SN et al. | Potential cutaneous hypersensitivity reaction to an inactive ingredient of thyroid hormone supplements in a dog. | 2016 | Vet. Dermatol. | pmid:26748887 |
Veit M and Siche S | S-acylation of influenza virus proteins: Are enzymes for fatty acid attachment promising drug targets? | 2015 | Vaccine | pmid:26387429 |
Colmano G et al. | Activated silver coatings for surgical implants. | 1979 | Va Med | pmid:316624 |
Yim B et al. | Sonolysis of surfactants in aqueous solutions: an accumulation of solute in the interfacial region of the cavitation bubbles. | 2002 | Ultrason Sonochem | pmid:12219583 |
Mizukoshi Y et al. | Preparation of platinum nanoparticles by sonochemical reduction of the Pt(IV) ions: role of surfactants. | 2001 | Ultrason Sonochem | pmid:11105315 |
Walzthöny D et al. | Ice crystals specifically decorate hydrophilic sites on freeze-fractured models membranes. | 1981 | Ultramicroscopy | pmid:7281365 |
Nielsen GD et al. | [Aspiration of talcum or powder containing zinc stearate by children]. | 1979 | Ugeskr. Laeg. | pmid:442270 |
Williams KJ et al. | The Mycobacterium tuberculosis β-oxidation genes echA5 and fadB3 are dispensable for growth in vitro and in vivo. | 2011 | Tuberculosis (Edinb) | pmid:21764638 |
Cutler RR et al. | The effect of polyoxyethylene stearate (POES) on the growth of mycobacteria in radiometric 7H12 Middlebrook TB medium. | 1987 | Tubercle | pmid:3448797 |
NadtochiÄ VV and BrodskiÄ RA | [Absorption study of 3H-stearic acid in the rat small intestine using electron microscopic autoradiography]. | 1982 | Tsitologiia | pmid:7135486 |
Meng W et al. | A clinical evaluation of amlexanox oral adhesive pellicles in the treatment of recurrent aphthous stomatitis and comparison with amlexanox oral tablets: a randomized, placebo controlled, blinded, multicenter clinical trial. | 2009 | Trials | pmid:19419555 |
Santos GM et al. | Negative regulation by nuclear receptors: a plethora of mechanisms. | 2011 | Trends Endocrinol. Metab. | pmid:21196123 |
HJORTH N and TROLLE-LASSEN C | SKIN REACTIONS TO OINTMENT BASES. | 1963 | Trans St Johns Hosp Dermatol Soc | pmid:14116129 |
Wenzel DG and Kleoppel JW | Incorporation of saturated and cis- and trans-unsaturated long chain fatty acids in rat myocytes and increased susceptibility to arrhythmias. | 1980 | Toxicology | pmid:7210021 |
Søndergaard D et al. | Magnesium stearate given perorally to rats. A short term study. | 1980 | Toxicology | pmid:7434368 |
Nohynek GJ et al. | Repeated topical treatment, in contrast to single oral doses, with Vitamin A-containing preparations does not affect plasma concentrations of retinol, retinyl esters or retinoic acids in female subjects of child-bearing age. | 2006 | Toxicol. Lett. | pmid:16243460 |
Mitra A et al. | Inhibition of human term placental and fetal liver glutathione-S-transferases by fatty acids and fatty acid esters. | 1992 | Toxicol. Lett. | pmid:1595087 |
Salminen S and Salminen E | Urinary excretion of orally administered oxalic acid in MYRJ 45-treated NMRI mice. | 1987 | Toxicol. Lett. | pmid:3590233 |
FITZHUGH OG et al. | Chronic oral toxicities of four stearic acid emulsifiers. | 1959 | Toxicol. Appl. Pharmacol. | pmid:13659539 |
Michaut A et al. | A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen. | 2016 | Toxicol. Appl. Pharmacol. | pmid:26739624 |
Simon MN et al. | Persistent activation of Akt or ERK prevents the toxicity induced by saturated and polyunsaturated fatty acids in RINm5F β-cells. | 2008 | Toxicol In Vitro | pmid:18395405 |
Abdel-Hameid NA | Protective role of dimethyl diphenyl bicarboxylate (DDB) against erythromycin induced hepatotoxicity in male rats. | 2007 | Toxicol In Vitro | pmid:17267170 |
Simon C et al. | Screening of endocrine activity of compounds migrating from plastic baby bottles using a multi-receptor panel of in vitro bioassays. | 2016 | Toxicol In Vitro | pmid:27633901 |
Azevedo-Martins AK et al. | Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells. | 2006 | Toxicol In Vitro | pmid:16644178 |