stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
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Authors | Title | Published | Journal | PubMed Link |
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pmid:9608395 | ||||
Luo L et al. | Polyoxyethylene 40 stearate modulates multidrug resistance and enhances antitumor activity of vinblastine sulfate. | 2007 | AAPS J | pmid:18170979 |
Kuppuswamy R et al. | Estimation of capping incidence by indentation fracture tests. | 2001 | AAPS PharmSci | pmid:11741256 |
Otsuka M et al. | Comparative evaluation of tableting compression behaviors by methods of internal and external lubricant addition: inhibition of enzymatic activity of trypsin preparation by using external lubricant addition during the tableting compression process. | 2001 | AAPS PharmSci | pmid:11741271 |
Shah RB et al. | Comparative evaluation of flow for pharmaceutical powders and granules. | 2008 | AAPS PharmSciTech | pmid:18446489 |
Darole PS et al. | Formulation and evaluation of microemulsion based delivery system for amphotericin B. | 2008 | AAPS PharmSciTech | pmid:18446472 |
Patel S et al. | Lubrication potential of magnesium stearate studied on instrumented rotary tablet press. | 2007 | AAPS PharmSciTech | pmid:18181549 |
Patel K et al. | Duloxetine HCl lipid nanoparticles: preparation, characterization, and dosage form design. | 2012 | AAPS PharmSciTech | pmid:22167415 |
Missaghi S and Fassihi R | A novel approach in the assessment of polymeric film formation and film adhesion on different pharmaceutical solid substrates. | 2004 | AAPS PharmSciTech | pmid:15760087 |
Ferrari F et al. | The surface roughness of lactose particles can be modulated by wet-smoothing using a high-shear mixer. | 2004 | AAPS PharmSciTech | pmid:15760057 |
Mir VG et al. | Application of crustacean chitin as a co-diluent in direct compression of tablets. | 2010 | AAPS PharmSciTech | pmid:20238188 |
Lakio S et al. | Challenges in detecting magnesium stearate distribution in tablets. | 2013 | AAPS PharmSciTech | pmid:23378252 |
Zhang SW et al. | A method to evaluate the effect of contact with excipients on the surface crystallization of amorphous drugs. | 2014 | AAPS PharmSciTech | pmid:25037732 |
Räsänen E et al. | A new method to predict flowability using a microscale fluid bed. | 2003 | AAPS PharmSciTech | pmid:15198548 |
Swaminathan V and Kildsig DO | An examination of the moisture sorption characteristics of commercial magnesium stearate. | 2001 | AAPS PharmSciTech | pmid:14727865 |
Kumar R and Sinha VR | Lipid Nanocarrier: an Efficient Approach Towards Ocular Delivery of Hydrophilic Drug (Valacyclovir). | 2017 | AAPS PharmSciTech | pmid:27368921 |
Spaniol B et al. | Compressional behavior of a mixture of granules containing high load of Phyllanthus niruri spray-dried extract and granules of adjuvants: comparison between eccentric and rotary tablet machines. | 2009 | AAPS PharmSciTech | pmid:19662537 |
Schrank S et al. | Ibuprofen-loaded calcium stearate pellets: drying-induced variations in dosage form properties. | 2012 | AAPS PharmSciTech | pmid:22552931 |
Ahmed TA et al. | Miconazole nitrate oral disintegrating tablets: in vivo performance and stability study. | 2012 | AAPS PharmSciTech | pmid:22585373 |