stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Hommelberg PP et al. | Fatty acid-induced NF-kappaB activation and insulin resistance in skeletal muscle are chain length dependent. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:18957619 |
Montell E et al. | DAG accumulation from saturated fatty acids desensitizes insulin stimulation of glucose uptake in muscle cells. | 2001 | Am. J. Physiol. Endocrinol. Metab. | pmid:11158925 |
Dasu MR and Jialal I | Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors. | 2011 | Am. J. Physiol. Endocrinol. Metab. | pmid:20959532 |
O'Byrne SM et al. | Multiple pathways ensure retinoid delivery to milk: studies in genetically modified mice. | 2010 | Am. J. Physiol. Endocrinol. Metab. | pmid:20040693 |
Labonté ED et al. | Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1-/- mice. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:18718999 |
Yao Y et al. | Regulation of triacylglycerol and phospholipid trafficking by fatty acids in newborn swine enterocytes. | 2002 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11960778 |
Kakisaka K et al. | Mechanisms of lysophosphatidylcholine-induced hepatocyte lipoapoptosis. | 2012 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:21995961 |
Chalé-Rush A et al. | Multiple routes of chemosensitivity to free fatty acids in humans. | 2007 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:17234892 |
Bederman I et al. | Altered de novo lipogenesis contributes to low adipose stores in cystic fibrosis mice. | 2012 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:22679004 |
Tappia PS et al. | Phospholipid profile of developing heart of rats exposed to low-protein diet in pregnancy. | 2005 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:16020521 |
Conde-Sieira M et al. | Hypothalamic fatty acid sensing in Senegalese sole (Solea senegalensis): response to long-chain saturated, monounsaturated, and polyunsaturated (n-3) fatty acids. | 2015 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:26468264 |
Feldkamp T et al. | Alleviation of fatty acid and hypoxia-reoxygenation-induced proximal tubule deenergization by ADP/ATP carrier inhibition and glutamate. | 2007 | Am. J. Physiol. Renal Physiol. | pmid:17244890 |
Nelson JM et al. | Cadmium ion-induced alterations of phospholipid metabolism in endothelial cells. | 1991 | Am. J. Respir. Cell Mol. Biol. | pmid:1910817 |
Duane PG et al. | Relationship of oxidant-mediated cytotoxicity to phospholipid metabolism in endothelial cells. | 1991 | Am. J. Respir. Cell Mol. Biol. | pmid:2021479 |
Pritzker KP et al. | Adrenal and hepatic calcium stearate crystal deposits in dogs fed a thiamine-deficient diet. | 1982 | Am. J. Vet. Res. | pmid:7103233 |
Colmano G et al. | Activation of antibacterial silver coatings on surgical implants by direct current: preliminary studies in rabbits. | 1980 | Am. J. Vet. Res. | pmid:7436092 |
Kim CH et al. | Effects of emulsified octadecanic acids on gas production and cellulolysis by the rumen anaerobic fungus, Piromyces communis M014. | 2008 | Anaerobe | pmid:17996466 |
Fu X et al. | A rapid and universal bacteria-counting approach using CdSe/ZnS/SiO2 composite nanoparticles as fluorescence probe. | 2010 | Anal Bioanal Chem | pmid:20016878 |
Simonsick WJ and Petkovska VI | Detailed structural elucidation of polyesters and acrylates using Fourier transform mass spectrometry. | 2008 | Anal Bioanal Chem | pmid:18719895 |
Hefnawy MM et al. | Direct enantiomeric resolution of betaxolol with application to analysis of pharmaceutical products. | 2007 | Anal Chem Insights | pmid:19690633 |