stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Tadros MI and Fahmy RH | Controlled-release triple anti-inflammatory therapy based on novel gastroretentive sponges: characterization and magnetic resonance imaging in healthy volunteers. | 2014 | Int J Pharm | pmid:24928130 |
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Loften JR et al. | Invited review: palmitic and stearic acid metabolism in lactating dairy cows. | 2014 | J. Dairy Sci. | pmid:24913651 |
Uğurlu T and Halaçoğlu MD | Effects of some lubricants and evaluation of compression parameters on directly compressible powders. | 2014 | Pharm Dev Technol | pmid:23590449 |
Chen FY et al. | TNYL peptide functional chitosan-g-stearate conjugate micelles for tumor specific targeting. | 2014 | Int J Nanomedicine | pmid:25298734 |
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Aljaberi A et al. | Understanding and optimizing the dual excipient functionality of sodium lauryl sulfate in tablet formulation of poorly water soluble drug: wetting and lubrication. | 2013 Mar-Apr | Pharm Dev Technol | pmid:23009028 |
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Di Vaio C et al. | Influence of some environmental factors on drupe maturation and olive oil composition. | 2013 | J. Sci. Food Agric. | pmid:22936522 |
Ruddle P et al. | Effect of a novel mutation in a Δ9-stearoyl-ACP-desaturase on soybean seed oil composition. | 2013 | Theor. Appl. Genet. | pmid:22961205 |
Chu X et al. | Sterol regulatory element-binding protein-1c mediates increase of postprandial stearic acid, a potential target for improving insulin resistance, in hyperlipidemia. | 2013 | Diabetes | pmid:22966071 |
Hu FQ et al. | Effective antitumor gene therapy delivered by polyethylenimine-conjugated stearic acid-g-chitosan oligosaccharide micelles. | 2013 | Gene Ther. | pmid:22951455 |
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Mirani ZA and Jamil N | Role of extra-cellular fatty acids in vancomycin induced biofilm formation by vancomycin resistant Staphylococcus aureus. | 2013 | Pak J Pharm Sci | pmid:23455211 |
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Risley DS et al. | Analysis of magnesium from magnesium stearate in pharmaceutical tablet formulations using hydrophilic interaction liquid chromatography with nano quantity analyte detection. | 2013 | J Pharm Biomed Anal | pmid:23474810 |
Zamora-Rojas E et al. | Prediction of fatty acids content in pig adipose tissue by near infrared spectroscopy: at-line versus in-situ analysis. | 2013 | Meat Sci. | pmid:23793086 |
Song W et al. | Importance of size and distribution of Ni nanoparticles for the hydrodeoxygenation of microalgae oil. | 2013 | Chemistry | pmid:23794421 |
Vitturi DA et al. | Modulation of nitro-fatty acid signaling: prostaglandin reductase-1 is a nitroalkene reductase. | 2013 | J. Biol. Chem. | pmid:23878198 |
Saeedi Vahdat A et al. | Ultrasonic approach for viscoelastic and microstructure characterization of granular pharmaceutical tablets. | 2013 | Int J Pharm | pmid:23820132 |
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Li L et al. | Drug release characteristics from chitosan-alginate matrix tablets based on the theory of self-assembled film. | 2013 | Int J Pharm | pmid:23624081 |
MužÃková J and Sináglová P | A study of a new co-processed dry binder based on spray-dried lactose and microcrystalline cellulose. | 2013 | Ceska Slov Farm | pmid:23961814 |
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Dangarembizi R et al. | Aloe ferox seed: a potential source of oil for cosmetic and pharmaceutical use. | 2013 | Nat Prod Commun | pmid:23678824 |
Maia M et al. | A novel, direct, reagent-free method for the detection of beeswax adulteration by single-reflection attenuated total reflectance mid-infrared spectroscopy. | 2013 | Talanta | pmid:23598195 |
Li CC et al. | [In situ rat intestine absorption of paclitaxel-loaded solid lipid nanoparticles modified with cell-penetrating peptides]. | 2013 | Yao Xue Xue Bao | pmid:23600154 |
Salehi M et al. | Debinding mechanisms in thermoplastic processing of a Ba(0.5)Sr(0.5)Co(0.8)Fe(0.2)O(3-δ)- stearic acid-polystyrene mixture. | 2013 | ChemSusChem | pmid:23281298 |
He M et al. | Controllable stearic acid crystal induced high hydrophobicity on cellulose film surface. | 2013 | ACS Appl Mater Interfaces | pmid:23289586 |
Wan Q et al. | Self-assembled magnetic theranostic nanoparticles for highly sensitive MRI of minicircle DNA delivery. | 2013 | Nanoscale | pmid:23224057 |
Dhasaiyan P et al. | Influence of the sophorolipid molecular geometry on their self-assembled structures. | 2013 | Chem Asian J | pmid:23208802 |
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Hu P et al. | Genotoxicity evaluation of stearic acid grafted chitosan oligosaccharide nanomicelles. | 2013 | Mutat. Res. | pmid:23274307 |
Wu X et al. | Alkanethiol-functionalized terahertz metamaterial as label-free, highly-sensitive and specific biosensor. | 2013 | Biosens Bioelectron | pmid:23261700 |
Zhou X et al. | The effect of saturated fatty acids on methanogenesis and cell viability of Methanobrevibacter ruminantium. | 2013 | Archaea | pmid:23710130 |
Gotoh K et al. | Evaluation of removal of model particulate and oily soils from poly(ethylene terephthalate) films by microscopic image analysis. | 2013 | J Oleo Sci | pmid:23391530 |
Silberstein T et al. | Saturated fatty acid composition of human milk in Israel: a comparison between Jewish and Bedouin women. | 2013 | Isr. Med. Assoc. J. | pmid:23781748 |
Ogata F et al. | Study on analysis of waste edible oil with deterioration and removal of acid value, carbonyl value, and free fatty acid by a food additive (calcium silicate). | 2013 | J Oleo Sci | pmid:23391535 |
Ishida Y et al. | Fatty acid solubilizer from the oral disk of the blowfly. | 2013 | PLoS ONE | pmid:23326317 |
Sharma P et al. | Structural insights into the dual strategy of recognition by peptidoglycan recognition protein, PGRP-S: structure of the ternary complex of PGRP-S with lipopolysaccharide and stearic acid. | 2013 | PLoS ONE | pmid:23326499 |
Tükel S et al. | Optimization of lipase-catalyzed synthesis of fructose stearate using response surface methodology. | 2013 | Artif Cells Nanomed Biotechnol | pmid:23305558 |
Lee W et al. | Intracellular Mycobacterium tuberculosis exploits host-derived fatty acids to limit metabolic stress. | 2013 | J. Biol. Chem. | pmid:23306194 |
Wu JH et al. | Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. | 2013 | Circ Cardiovasc Genet | pmid:23362303 |
Arukuusk P et al. | New generation of efficient peptide-based vectors, NickFects, for the delivery of nucleic acids. | 2013 | Biochim. Biophys. Acta | pmid:23357356 |
Nakagawa H et al. | Real-time monitoring of lubrication properties of magnesium stearate using NIR spectrometer and thermal effusivity sensor. | 2013 | Int J Pharm | pmid:23174413 |
Otsuka Y et al. | Effects of polymorphic transformation on pharmaceutical properties of direct compressed tablets containing theophylline anhydrate bulk powder under high humidity. | 2013 | Colloids Surf B Biointerfaces | pmid:23178204 |
Azordegan N et al. | Carcinogenesis alters fatty acid profile in breast tissue. | 2013 | Mol. Cell. Biochem. | pmid:23180247 |
Delbecq F et al. | N-stearoyl amino acid derivatives: potent biomimetic hydro/organogelators as templates for preparation of gold nanoparticles. | 2013 | J Colloid Interface Sci | pmid:23089597 |
Chen JJ et al. | New pterosin sesquiterpenes and antitubercular constituents from Pteris ensiformis. | 2013 | Chem. Biodivers. | pmid:24130033 |
Avalle P et al. | Interrogating erosion-based drug liberation phenomena from hydrophilic matrices using near infrared (NIR) spectroscopy. | 2013 | Eur J Pharm Sci | pmid:23059372 |
Desai SS et al. | Methods for reduction of cohesive forces between carrier and drug in DPI formulation. | 2013 | Drug Dev Ind Pharm | pmid:23050727 |
Vijayaraghavan M et al. | Suitability of polymer materials for production of pulmonary microparticles using a PGSS supercritical fluid technique: preparation of microparticles using PEG, fatty acids and physical or chemicals blends of PEG and fatty acids. | 2013 | Int J Pharm | pmid:23178217 |
John CT et al. | Formulating weakly basic HCl salts: relative ability of common excipients to induce disproportionation and the unique deleterious effects of magnesium stearate. | 2013 | Pharm. Res. | pmid:23512680 |
Stank K and Steckel H | Physico-chemical characterisation of surface modified particles for inhalation. | 2013 | Int J Pharm | pmid:23518364 |
Kumar N et al. | Salt dependent stability of stearic acid Langmuir-Blodgett films exposed to aqueous electrolytes. | 2013 | Langmuir | pmid:23565719 |
Han SH et al. | Bioinspired self-assembled peptide nanofibers with thermostable multivalent α-helices. | 2013 | Biomacromolecules | pmid:23550841 |
Khan AA et al. | Design, synthesis and in vitro anticancer evaluation of a stearic acid-based ester conjugate. | 2013 | Anticancer Res. | pmid:23749903 |
Sharma P et al. | Structural basis of the binding of fatty acids to peptidoglycan recognition protein, PGRP-S through second binding site. | 2013 | Arch. Biochem. Biophys. | pmid:23149273 |
Li C et al. | Enhanced performance and interfacial investigation of mineral-based composite phase change materials for thermal energy storage. | 2013 | Sci Rep | pmid:23712069 |
Lakio S et al. | Challenges in detecting magnesium stearate distribution in tablets. | 2013 | AAPS PharmSciTech | pmid:23378252 |
Järvinen MA et al. | Continuous direct tablet compression: effects of impeller rotation rate, total feed rate and drug content on the tablet properties and drug release. | 2013 | Drug Dev Ind Pharm | pmid:23163644 |
Schrank S et al. | Microstructure of calcium stearate matrix pellets: a function of the drying process. | 2013 | J Pharm Sci | pmid:23983150 |
Yang C et al. | Production of aviation fuel via catalytic hydrothermal decarboxylation of fatty acids in microalgae oil. | 2013 | Bioresour. Technol. | pmid:23973977 |
Barber E et al. | Comparative actions of omega-3 fatty acids on in-vitro lipid droplet formation. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24012207 |
Cunha TA et al. | Effect of stearic acid on enalapril stability and dissolution from multiparticulate solid dosage forms. | 2013 | AAPS PharmSciTech | pmid:23897034 |
Jaumot J et al. | Blending process modeling and control by multivariate curve resolution. | 2013 | Talanta | pmid:24209372 |
Uchimoto T et al. | Determination of useful ranges of mixing conditions for glycerin Fatty Acid ester by multiple regression analysis. | 2013 | Chem. Pharm. Bull. | pmid:24189302 |
Tsuchiya A et al. | Stearic acid serves as a potent inhibitor of protein tyrosine phosphatase 1B. | 2013 | Cell. Physiol. Biochem. | pmid:24296476 |
Camacho-Chab JC et al. | Emulsifying activity and stability of a non-toxic bioemulsifier synthesized by Microbacterium sp. MC3B-10. | 2013 | Int J Mol Sci | pmid:24065097 |
Šašiċ S et al. | Raman chemical mapping of magnesium stearate delivered by a punch-face lubrication system on the surface of placebo and active tablets. | 2013 | Appl Spectrosc | pmid:24067639 |
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Liu Z et al. | Changes in the electron paramagnetic resonance spectra of albumin-associated spin-labeled stearic acid as a diagnostic parameter of colorectal cancer. | 2013 | World J Surg Oncol | pmid:24025321 |
Osorio JG and Muzzio FJ | Effects of powder flow properties on capsule filling weight uniformity. | 2013 | Drug Dev Ind Pharm | pmid:23902366 |
Vadakkan MV et al. | Dry powder cationic lipopolymeric nanomicelle inhalation for targeted delivery of antitubercular drug to alveolar macrophage. | 2013 | Int J Nanomedicine | pmid:23990716 |
Jin Q et al. | A novel cationic microbubble coated with stearic acid-modified polyethylenimine to enhance DNA loading and gene delivery by ultrasound. | 2013 | PLoS ONE | pmid:24086748 |
Eltayeb M et al. | Electrosprayed core-shell polymer-lipid nanoparticles for active component delivery. | 2013 | Nanotechnology | pmid:24164775 |
Boshtam M et al. | Serum paraoxonase 1 activity is associated with fatty acid composition of high density lipoprotein. | 2013 | Dis. Markers | pmid:24167374 |
Shibata E et al. | Free fatty acids inhibit protein tyrosine phosphatase 1B and activate Akt. | 2013 | Cell. Physiol. Biochem. | pmid:24107614 |
Høstmark AT et al. | Increased serum triglycerides and reduced HDL cholesterol in male rats after intake of ammonium chloride for 3 weeks. | 2013 | Lipids Health Dis | pmid:23800210 |
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Saroja C and Lakshmi PK | Formulation and optimization of fenofibrate lipospheres using Taguchi's experimental design. | 2013 | Acta Pharm | pmid:23482314 |
Pethrick RA and Song M | Dielectric studies of amylose, amylopectin and amylose-stearic acid complexes. | 2013 | Carbohydr Polym | pmid:23399185 |
Yuan B et al. | Laboratory-scale column study for remediation of TCE-contaminated aquifers using three-section controlled-release potassium permanganate barriers. | 2013 | J Environ Sci (China) | pmid:24218827 |
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Hosseini A et al. | Direct compression of cushion-layered ethyl cellulose-coated extended release pellets into rapidly disintegrating tablets without changes in the release profile. | 2013 | Int J Pharm | pmid:23892153 |
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Yan J et al. | Effect of proteins with different isoelectric points on the gene transfection efficiency mediated by stearic acid grafted chitosan oligosaccharide micelles. | 2013 | Mol. Pharm. | pmid:23679858 |
Kwan HY et al. | The anticancer effect of oridonin is mediated by fatty acid synthase suppression in human colorectal cancer cells. | 2013 | J. Gastroenterol. | pmid:22722903 |
Subbaramaiah K et al. | Dietary polyphenols suppress elevated levels of proinflammatory mediators and aromatase in the mammary gland of obese mice. | 2013 | Cancer Prev Res (Phila) | pmid:23880231 |