stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Obesity, Abdominal D056128 3 associated lipids
Atherosclerosis D050197 85 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Brain Diseases, Metabolic, Inborn D020739 10 associated lipids
Weight Gain D015430 101 associated lipids
Reperfusion Injury D015427 65 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Yaws D015001 4 associated lipids
Whooping Cough D014917 6 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Urticaria D014581 13 associated lipids
Urethritis D014526 9 associated lipids
Tuberculosis, Pulmonary D014397 18 associated lipids
Tremor D014202 15 associated lipids
Thrombosis D013927 49 associated lipids
Tenosynovitis D013717 3 associated lipids
Syphilis, Latent D013592 4 associated lipids
Syphilis, Congenital D013590 3 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Skin Diseases, Infectious D012874 7 associated lipids
Seizures D012640 87 associated lipids
Salivary Duct Calculi D012465 2 associated lipids
Rosacea D012393 13 associated lipids
Relapsing Fever D012061 3 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Prostatic Diseases D011469 4 associated lipids
Eczema, Dyshidrotic D011146 1 associated lipids
Pneumoconiosis D011009 3 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Otitis Media D010033 12 associated lipids
Occupational Diseases D009784 42 associated lipids
Neuroblastoma D009447 66 associated lipids
Mycoplasmatales Infections D009180 6 associated lipids
Mycobacterium Infections, Nontuberculous D009165 8 associated lipids
Melanoma D008545 69 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Malignant Hyperthermia D008305 6 associated lipids
Lymphoma, Non-Hodgkin D008228 6 associated lipids
Lymphoma D008223 18 associated lipids
Lymphadenitis D008199 8 associated lipids
Lung Neoplasms D008175 171 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Liver Neoplasms D008113 8 associated lipids
Leukodystrophy, Metachromatic D007966 4 associated lipids
Leukemia, Lymphoid D007945 18 associated lipids
Leprosy D007918 8 associated lipids
Legionnaires' Disease D007877 4 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Ischemia D007511 18 associated lipids
Insulinoma D007340 28 associated lipids
Insulin Resistance D007333 99 associated lipids
Infertility D007246 3 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Hypothyroidism D007037 32 associated lipids
Hypothalamic Diseases D007027 3 associated lipids
Hypopituitarism D007018 7 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Hyperlipidemias D006949 73 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hemolysis D006461 131 associated lipids
Gonorrhea D006069 7 associated lipids
Gallbladder Neoplasms D005706 3 associated lipids
Foreign Bodies D005547 5 associated lipids
Fatty Liver D005234 48 associated lipids
Edema D004487 152 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Dermatitis D003872 30 associated lipids
Decalcification, Pathologic D003649 1 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Coronary Disease D003327 70 associated lipids
Chancroid D002602 4 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Brain Ischemia D002545 89 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Cattle Diseases D002418 24 associated lipids
Calculi D002137 3 associated lipids
Burns D002056 34 associated lipids
Bronchitis D001991 6 associated lipids
Breast Neoplasms D001943 24 associated lipids
Brain Edema D001929 20 associated lipids
Boutonneuse Fever D001907 5 associated lipids
Body Weight D001835 333 associated lipids
Birth Weight D001724 23 associated lipids
Cholestasis, Extrahepatic D001651 7 associated lipids
Bacterial Infections D001424 21 associated lipids
Arteriosclerosis D001161 86 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Olfaction Disorders D000857 17 associated lipids
Anemia, Dyserythropoietic, Congenital D000742 2 associated lipids
Amnesia D000647 12 associated lipids
Alzheimer Disease D000544 76 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Adenoma D000236 40 associated lipids
Acquired Immunodeficiency Syndrome D000163 12 associated lipids
Acne Vulgaris D000152 35 associated lipids
Per page 10 20 50 100 | Total 101

PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with stearic acid

Download all related citations
Per page 10 20 50 100 | Total 3506
Authors Title Published Journal PubMed Link
Dougherty RM et al. Effects of diets containing high or low amounts of stearic acid on plasma lipoprotein fractions and fecal fatty acid excretion of men. 1995 Am. J. Clin. Nutr. pmid:7733038
Yu S et al. Plasma cholesterol-predictive equations demonstrate that stearic acid is neutral and monounsaturated fatty acids are hypocholesterolemic. 1995 Am. J. Clin. Nutr. pmid:7733039
Connor WE Harbingers of coronary heart disease: dietary saturated fatty acids and cholesterol. Is chocolate benign because of its stearic acid content? 1999 Am. J. Clin. Nutr. pmid:10584037
Mensink RP Effects of the individual saturated fatty acids on serum lipids and lipoprotein concentrations. 1993 Am. J. Clin. Nutr. pmid:8475888
Granot E et al. Breast-fed and formula-fed infants do not differ in immunocompetent cell cytokine production despite differences in cell membrane fatty acid composition. 2000 Am. J. Clin. Nutr. pmid:11063450
Aro A et al. Stearic acid, trans fatty acids, and dairy fat: effects on serum and lipoprotein lipids, apolipoproteins, lipoprotein(a), and lipid transfer proteins in healthy subjects. 1997 Am. J. Clin. Nutr. pmid:9129471
SINGLETON WS CHARACTERIZED OILS FOR USE IN INTRAVENOUS FAT EMULSIONS. 1965 Am. J. Clin. Nutr. pmid:14262113
Jones PJ et al. Whole body oxidation of dietary fatty acids: implications for energy utilization. 1985 Am. J. Clin. Nutr. pmid:3933323
Caglayan S et al. Is medical therapy effective for regional lymphadenitis following BCG vaccination? 1987 Am. J. Dis. Child. pmid:3673975
Rafi MA et al. Correction of sulfatide metabolism after transfer of prosaposin cDNA to cultured cells from a patient with SAP-1 deficiency. 1992 Am. J. Hum. Genet. pmid:1350885
Tsuda K et al. Role of insulin in the regulation of membrane fluidity of erythrocytes in essential hypertension: an electron paramagnetic resonance investigation. 2000 Am. J. Hypertens. pmid:10821339
Coyle P et al. Severe lead poisoning in the plastics industry: a report of three cases. 2005 Am. J. Ind. Med. pmid:15662640
SCHWARTZ S et al. LIPID THROMBOPLASTINS AND MYOCARDIAL INFARCTION. 1965 Am. J. Med. Sci. pmid:14254823
WILSON LW et al. THE HEMODYNAMIC EFFECTS OF INFUSIONS OF LONG CHAIN SATURATED FATTY ACIDS INTO DOGS. 1965 Am. J. Med. Sci. pmid:14254833
Doran TA et al. Amniotic fluid lecithin/sphingomyelin ratio, palmitic acid, palmitic acid/stearic acid ratio, total cortisol, creatinine, and percentage of lipid-positive cells in assessment of fetal maturity and fetal pulmonary maturity: a comparison. 1979 Am. J. Obstet. Gynecol. pmid:433991
Zackler J et al. A mass screening program for the detection of gonorrhea. 1972 Am. J. Obstet. Gynecol. pmid:4623083
Quinn PA et al. Efficacy of antibiotic therapy in preventing spontaneous pregnancy loss among couples colonized with genital mycoplasmas. 1983 Am. J. Obstet. Gynecol. pmid:6849358
COX AJ and DEEDS F Dietary production of lipogranuloma in rats. 1958 Mar-Apr Am. J. Pathol. pmid:13520907
Qian MW and Eaton JW Iron translocation by free fatty acids. 1991 Am. J. Pathol. pmid:1750512
Wieland SJ et al. Differential modulation of a sodium conductance in skeletal muscle by intracellular and extracellular fatty acids. 1992 Am. J. Physiol. pmid:1514578
TROUT DL and ESTES EH Factors affecting liver uptake of serum free stearic acid-1-C14. 1962 Am. J. Physiol. pmid:13994303
Sarel I and Widmaier EP Stimulation of steroidogenesis in cultured rat adrenocortical cells by unsaturated fatty acids. 1995 Am. J. Physiol. pmid:7611525
Steffen DG and Platner WS Subcellular membrane fatty acids of rat heart after cold acclimation or thyroxine. 1976 Am. J. Physiol. pmid:961919
Michiels C et al. Stimulation of prostaglandin synthesis by human endothelial cells exposed to hypoxia. 1993 Am. J. Physiol. pmid:8476019
Wang H et al. Apolipoprotein secretion and lipid synthesis: regulation by fatty acids in newborn swine intestinal epithelial cells. 1997 Am. J. Physiol. pmid:9176199
LIN TM et al. Effect of stearic acid and cholesterol on biosynthesis of sterol by the chicken liver. 1960 Am. J. Physiol. pmid:14417022
Hart CM et al. Supplemental fatty acids alter lipid peroxidation and oxidant injury in endothelial cells. 1991 Am. J. Physiol. pmid:2058691
Lee WN et al. Measurement of fractional lipid synthesis using deuterated water (2H2O) and mass isotopomer analysis. 1994 Am. J. Physiol. pmid:8166257
Le Petit-Thevenin J et al. Changes in pattern of phospholipid acylation during in vivo aging of rat red blood cells. 1991 Am. J. Physiol. pmid:1887869
Zoukhri D and Dartt DA Cholinergic activation of phospholipase D in lacrimal gland acini is independent of protein kinase C and calcium. 1995 Am. J. Physiol. pmid:7900776
Oe H et al. Calcium overload and cardiac myocyte cell damage induced by arachidonate lipoxygenation. 1994 Am. J. Physiol. pmid:7943384
Arnould T et al. Increased PMN adherence on endothelial cells after hypoxia: involvement of PAF, CD18/CD11b, and ICAM-1. 1993 Am. J. Physiol. pmid:8098907
Pickart LR and Thaler MM Free fatty acids and albumin as mediators of thrombin-stimulated fibrinogen synthesis. 1976 Am. J. Physiol. pmid:1267031
Kennett FF et al. Inhibition of myocardial rotenone-insensitive NADH cytochrome c reductase by amphiphilic compounds. 1984 Am. J. Physiol. pmid:6507637
Burt JM et al. Uncoupling of cardiac cells by fatty acids: structure-activity relationships. 1991 Am. J. Physiol. pmid:2003571
Lee WN et al. In vivo measurement of fatty acids and cholesterol synthesis using D2O and mass isotopomer analysis. 1994 Am. J. Physiol. pmid:8203508
Man TY et al. Dietary manipulation reveals an unexpected inverse relationship between fat mass and adipose 11β-hydroxysteroid dehydrogenase type 1. 2011 Am. J. Physiol. Endocrinol. Metab. pmid:21406612
Bessesen DH et al. Trafficking of dietary oleic, linolenic, and stearic acids in fasted or fed lean rats. 2000 Am. J. Physiol. Endocrinol. Metab. pmid:10827016
Wei Y et al. Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells. 2006 Am. J. Physiol. Endocrinol. Metab. pmid:16492686
Hodson L et al. Greater dietary fat oxidation in obese compared with lean men: an adaptive mechanism to prevent liver fat accumulation? 2010 Am. J. Physiol. Endocrinol. Metab. pmid:20628024
Lee WN et al. Loss of regulation of lipogenesis in the Zucker diabetic (ZDF) rat. 2000 Am. J. Physiol. Endocrinol. Metab. pmid:10913044
Brunengraber DZ et al. Influence of diet on the modeling of adipose tissue triglycerides during growth. 2003 Am. J. Physiol. Endocrinol. Metab. pmid:12799315
Hommelberg PP et al. Fatty acid-induced NF-kappaB activation and insulin resistance in skeletal muscle are chain length dependent. 2009 Am. J. Physiol. Endocrinol. Metab. pmid:18957619
Montell E et al. DAG accumulation from saturated fatty acids desensitizes insulin stimulation of glucose uptake in muscle cells. 2001 Am. J. Physiol. Endocrinol. Metab. pmid:11158925
Green CD and Olson LK Modulation of palmitate-induced endoplasmic reticulum stress and apoptosis in pancreatic β-cells by stearoyl-CoA desaturase and Elovl6. 2011 Am. J. Physiol. Endocrinol. Metab. pmid:21266672
Kadotani A et al. Different impacts of saturated and unsaturated free fatty acids on COX-2 expression in C(2)C(12) myotubes. 2009 Am. J. Physiol. Endocrinol. Metab. pmid:19755671
Peter A et al. Relationships between hepatic stearoyl-CoA desaturase-1 activity and mRNA expression with liver fat content in humans. 2011 Am. J. Physiol. Endocrinol. Metab. pmid:21045174
Dasu MR and Jialal I Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors. 2011 Am. J. Physiol. Endocrinol. Metab. pmid:20959532
Bézaire V et al. Effects of fasting on muscle mitochondrial energetics and fatty acid metabolism in Ucp3(-/-) and wild-type mice. 2001 Am. J. Physiol. Endocrinol. Metab. pmid:11595653
Bassilian S et al. Loss of regulation of lipogenesis in the Zucker diabetic rat. II. Changes in stearate and oleate synthesis. 2002 Am. J. Physiol. Endocrinol. Metab. pmid:11832351