stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Muglia C et al. | Anaphylaxis to medications containing meat byproducts in an alpha-gal sensitized individual. | J Allergy Clin Immunol Pract | pmid:26003233 | |
Gadegbeku CA et al. | Insulin's actions on plasma free fatty acids are normal in patients with stage 2 to 3 chronic kidney disease. | J Am Soc Hypertens | pmid:20409874 | |
Klibanov AL et al. | Targeted ultrasound contrast agent for molecular imaging of inflammation in high-shear flow. | Contrast Media Mol Imaging | pmid:17191766 | |
Garg M et al. | Hepatic de novo lipogenesis in stable low-birth-weight infants during exclusive breast milk feedings and during parenteral nutrition. | JPEN J Parenter Enteral Nutr | pmid:15772384 | |
Adams ML et al. | Amphotericin B encapsulated in micelles based on poly(ethylene oxide)-block-poly(L-amino acid) derivatives exerts reduced in vitro hemolysis but maintains potent in vivo antifungal activity. | Biomacromolecules | pmid:12741794 | |
Sobal G and Sinzinger H | Binding of [99mTc]chondroitin sulfate to scavenger receptors on human chondrocytes as compared to binding of oxidized [125I]LDL on human macrophages. | J. Recept. Signal Transduct. Res. | pmid:12503634 | |
pmid: | ||||
pmid:9608395 | ||||
Zaghloul AA et al. | Response surface methodology to obtain naproxen controlled release tablets from its microspheres with Eudragit L100-55. | J Microencapsul | pmid:11508770 | |
Jenke D | Extraction of stearate salts from plastic materials used in pharmaceutical applications. | PDA J Pharm Sci Technol | pmid:21502020 | |
Geslin JM et al. | [Allergic respiratory disorders and vein sclerosis with lauromacrogol 400]. | Therapie | pmid:15789831 | |
Nelson B et al. | Effect of Dietary-Resistant Starch on Inhibition of Colonic Preneoplasia and Wnt Signaling in Azoxymethane-Induced Rodent Models. | Nutr Cancer | pmid:27367460 | |
Best CA et al. | Method to assess fatty acid ethyl ester binding to albumin. | Alcohol Alcohol. | pmid:16554377 | |
SWERN D et al. | Unsaturated alcohol esters of the 9,10-dihydroxystearic acids; preparation of elaidyl alcohol. | 1946 | J. Am. Chem. Soc. | pmid:20995013 |
VOLD RD and PHILIPSON JM | The behavior of sodium stearate with cetane and water. | 1946 | J Phys Chem | pmid:21010917 |
NIGHTINGALE G et al. | Effect of dihydroxystearic acid on vitamin K synthesis by rats. | 1947 | Arch Biochem | pmid:20291026 |
GREGORY JN and SPINK JA | Lubricating properties of molecular layers of stearic acid and calcium stearate on metal surfaces. | 1947 | Nature | pmid:20291788 |
WITTCOFF H and MILLER SE | Hydroxylated stearic acids; action of Prevost's reagent on oleic and elaidic esters; evidence for configuration of the hydroxy acids. | 1947 | J. Am. Chem. Soc. | pmid:18919716 |
LIEN ML and MILLER CE | Magnesium stearate; a comparative study of commercial samples. | 1948 | J Am Pharm Assoc Am Pharm Assoc | pmid:18865175 |
OULLET C and DUBOIS JT | [Not Available]. | 1948 | Can J Res | pmid:18913992 |
McKAY AF and BADER AR | The preparation and properties of the eight diastereoisomers of 9,10,12,13-tetrahydroxystearic acid. | 1948 | J. Org. Chem. | pmid:18917710 |
McKAY AF | Occurrence of stearic acid in bayberry tallow (wax). | 1948 | J. Org. Chem. | pmid:18917711 |
WAYNE EJ et al. | The use of procaine penicillin with aluminium monostearate in adults. | 1949 | Br Med J | pmid:15407914 |
EMERY JL and ROSE LM | The use in children of procaine penicillin with aluminium monostearate. | 1949 | Br Med J | pmid:18145953 |
KITCHEN DK et al. | Serum concentrations following five treatment schedules with procaine penicillin in oil with aluminum monostearate. | 1949 | J. Invest. Dermatol. | pmid:18110581 |
RIES HE et al. | Adsorption-desorption isotherm studies of catalysts; nitrogen and stearic acid adsorption by supported catalysts and their components. | 1949 | J Phys Colloid Chem | pmid:18130458 |
KAGAN BM et al. | Studies of penicillin in pediatrics; III. Procaine penicillin G in sesame oil, in peanut oil with 2% aluminum monostearate and in water with sodium carboxymethylcellulose. | 1950 | Pediatrics | pmid:15417267 |
KOSS FH and LIEBSCHNER K | [Significance of alpha alpha-dimethylstearic acid in tuberculosis]. | 1950 | Klin. Wochenschr. | pmid:14804983 |
SPINK JA | Structure of stearic acid films on copper. | 1950 | Nature | pmid:15416726 |
ZABIN I | On the conversion of palmitic acid to stearic acid in animal tissues. | 1951 | J. Biol. Chem. | pmid:14832248 |
KIVITS M | [Frambesia therapy with oil procaine-penicillin with aluminium stearate]. | 1951 | Ann Soc Belg Med Trop (1920) | pmid:14838448 |
WEITZEL G and WOJAHN J | [Biochemistry of branched carboxylic acids. VII. Preparation of racemic monomethyl-stearic acids]. | 1951 | Hoppe-Seyler's Z. Physiol. Chem. | pmid:14860764 |
WEINMAN EO et al. | Conversion of first and sixth carbons of stearic acid to carbon dioxide by rats. | 1951 | J. Biol. Chem. | pmid:14861197 |
BERNHARD K and GLOOR U | [Some other fatty acids with vitamin F effect]. | 1953 | Helv Physiol Pharmacol Acta | pmid:13128629 |
MUNZEL K and AMMANN R | [On the washable fat-in-water ointments. I. Description and characteristics of fat-in-water ointments]. | 1953 | Pharm Acta Helv | pmid:13133659 |
DOXIADIS SA | Procaine penicillin with aluminium monostearate; infrequent injections for children. | 1953 | Lancet | pmid:13085786 |
VALADE P and COSTE E | [Toxicity of the organic lead salts; experimental study]. | 1953 | Arch Mal Prof | pmid:13149301 |
BUTCHER EO | Penetration of radioactive stearic acid into the skin of the rat. | 1953 | J. Invest. Dermatol. | pmid:13096866 |
SKOU JC | Local anaesthetics. V. The action of local anaesthetics on monomolecular layers of stearic acid. | 1954 | Acta Pharmacol Toxicol (Copenh) | pmid:14398295 |
MUNZEL K and AMMANN R | [Washable oil-water ointments. V. Complex-emulsified ointments; differences between stearate- and complex-emulsified ointments]. | 1954 | Pharm Acta Helv | pmid:13194353 |
SCRIBANTE P and FAVARGER P | [Studies on digestibility of stearic acid and its glyceric esters in rat]. | 1954 | Helv Physiol Pharmacol Acta | pmid:13201008 |
MUNZEL K and AMMANN R | [On washable fat-in-water ointments. IV. Stearate ointments]. | 1954 | Pharm Acta Helv | pmid:13166515 |
DUNCOMBE WG and GLASCOCK RF | The contribution of dietary stearic acid to milk fat. | 1954 | Biochem. J. | pmid:13172205 |
BERGSTROM S et al. | Intestinal absorption and metabolism of 2:2-dimethylstearic acid in the rat. | 1954 | Biochem. J. | pmid:13230010 |
GLASCOCK RF and REINIUS LR | Location of tritium in stearic acid produced by catalytic tritiation of elaidic acid. | 1954 | Biochem. J. | pmid:13230049 |
SHAFER JK and SMITH CA | Treatment of early infectious syphilis with N,N'-dibenzylethylenediamine dipenicillin G; a second report. | 1954 | Bull. World Health Organ. | pmid:13182589 |
CSIPKE Z | [Advanced training in prescription filling]. | 1954 | Gyogyszeresz | pmid:24551927 |
MUNZEL K and AMMANN R | [Contributions on the character of water-soluble fatty ointments. X. Quasiviscosity determination of stearate ointments]. | 1955 | Pharm Acta Helv | pmid:13289260 |
SULMAN FG | A note on the resorption and excretion of riboflavine from aluminium monostearate suspensions in the rat. | 1955 | J. Pharm. Pharmacol. | pmid:14392601 |
POLYOXYETHYLENE stearates in food. | 1955 | Nutr. Rev. | pmid:14394517 | |
DAMMANN F | [Antiphlogistic percutaneous therapy with choline stearate (chomelan)]. | 1955 | Medizinische | pmid:14355526 |
GEYER RP et al. | Aerobic C14O2 formation from carboxyl-labeled stearic and palmitic acids in the presence of ascorbic acid. | 1955 | Arch. Biochem. Biophys. | pmid:14377605 |
GLASCOCK RF and REINIUS LR | Studies on the origin of milk fat. 1. The location of tritium in stearic acid produced by the catalytic addition of tritium to elaidic acid. | 1956 | Biochem. J. | pmid:13315207 |
TOVE SB et al. | Turnover of palmitic, stearic, and unsaturated fatty acids in rat liver. | 1956 | J. Biol. Chem. | pmid:13278335 |
MEAD JF et al. | Metabolism of the essential fatty acids. II. The metabolism of stearate, oleate, and linoleate by fat-deficient and normal mice. | 1956 | J. Biol. Chem. | pmid:13278347 |
BLOMSTRAND R et al. | On the intestinal absorption of 2, 2-dimethylstearic acid fed as free acid or as glyceride. | 1956 | Acta Physiol. Scand. | pmid:13339456 |
KERN W et al. | [Suggestions for the composition of the general section on ointments and salve bases and emulsifiers in the German Pharmacopeia (DAB 6, Annex). II]. | 1956 | Hautarzt | pmid:13345190 |
Buensod M and Favarger P | [Observations on the digestibility of palmitic and stearic acids and their glyceric esters in rats]. | 1956 | Helv Physiol Pharmacol Acta | pmid:13405350 |
COOKE NJ et al. | The branched-chain fatty acids of mutton fat. 3. The isolation of 16-methylheptadecanoic acid (isostearic acid). | 1956 | Biochem. J. | pmid:13363830 |
JAMES AT and MARTIN AJ | Gas-liquid chromatography: the separation and identification of the methyl esters of saturated and unsaturated acids from formic acid to n-octadecanoic acid. | 1956 | Biochem. J. | pmid:13315260 |
HUME JC and FACIO G | An analysis of the results of the treatment of yaws with a single injection of procaine penicillin with 2% aluminium monostearate. | 1956 | Bull. World Health Organ. | pmid:13404472 |
FABER JS | A note on the assay of zinc stearate. | 1957 | J Am Pharm Assoc Am Pharm Assoc | pmid:13491438 |
BRZEZINSKI A et al. | Prolonged effect of riboflavin: aluminum monostearate suspensions in man. | 1957 | J Am Pharm Assoc Am Pharm Assoc | pmid:13438726 |
KARVINEN E et al. | Effect of palmitic and stearic acid on cholesterol absorption in man. | 1957 | J Appl Physiol | pmid:13462909 |
LONG CL et al. | Studies on absorption and metabolism of propylene glycol distearate. | 1958 | Arch. Biochem. Biophys. | pmid:13584006 |
LONG CL et al. | An investigation of the in vivo hydrolysis and absorption of propylene glycol distearate. | 1958 | Arch. Biochem. Biophys. | pmid:13584007 |
CONIGLIO JG and CATE DL | The distribution and biosynthesis of palmitic and stearic acids in liver, intestine, and carcass of intact normal and fasted rats. | 1958 | J. Biol. Chem. | pmid:13549425 |
DAWSON RM | The labelling of ram semen in vivo with radioactive phosphate and [carboxy-14C] stearic acid. | 1958 | Biochem. J. | pmid:13522653 |
HARDING HE | Some enquiries into the toxicology of zinc stearate. | 1958 | Br J Ind Med | pmid:13523087 |
RUTSTEIN DD et al. | Effects of linolenic and stearic acids on cholesterol-induced lipoid deposition in human aortic cells in tissue-culture. | 1958 | Lancet | pmid:13515277 |
COX AJ and DEEDS F | Dietary production of lipogranuloma in rats. | 1958 Mar-Apr | Am. J. Pathol. | pmid:13520907 |
KELLERSHOHN C and BENICHOUX R | [Comparative study of the drainage through the lymphatic vessels of a radioactive fat, ethyl diiodosterate labeled with I 131, and a radioactive colloidal substance, colloidal gold 198]. | 1958 May-Jun | Minerva Nucl | pmid:13565747 |
GERSHFELD NL and SHANES AM | Antagonism of veratrine by calcium ion in monolayers of stearic acid. | 1959 | Science | pmid:13658972 |
BLOMSTRAND R et al. | Asymmetric incorporation of linoleic acid-1-C14 and stearic acid-1-C14 into human lymph lecithins during fat absorption. | 1959 | Proc. Soc. Exp. Biol. Med. | pmid:13645714 |
FITZHUGH OG et al. | Chronic oral toxicities of four stearic acid emulsifiers. | 1959 | Toxicol. Appl. Pharmacol. | pmid:13659539 |
SKIPSKI VP et al. | Identification of 2-hydroxystearic acid in spinal cord phrenosine by chromatographic separation of hydroxy fatty acids. | 1959 | Arch. Biochem. Biophys. | pmid:13661981 |
HURLEY HJ and SHELLEY WB | The colloidal state as a stimulus for non-allergic epithelioid granulomas: experimental studies in man with pure sodium stearate and palmitate. | 1959 | J. Invest. Dermatol. | pmid:14405513 |
LIN TM et al. | Effect of stearic acid and cholesterol on biosynthesis of sterol by the chicken liver. | 1960 | Am. J. Physiol. | pmid:14417022 |
SHANES AM and GERSHFELD NL | Interactions of veratrum alkaloids, procaine, and calcium with monolayers of stearic acid and their implications for pharmacological action. | 1960 | J. Gen. Physiol. | pmid:13750673 |
FOTI L et al. | [In vitro liver biosynthesis of cholesterol from acetate, stearate and linoleate 1-C-14]. | 1961 | Boll. Soc. Ital. Biol. Sper. | pmid:13958917 |
AGARWAL SC et al. | Blood-level duration limit test of procaine benzylpenicillin in sheep. | 1961 | Bull. World Health Organ. | pmid:13859560 |
DAVIDOFF F and KORN ED | Synthesis of unsaturated fatty acids in the cellular slime mold. | 1962 | Biochem. Biophys. Res. Commun. | pmid:14025332 |
DEYKIN D and GOODMAN DS | The hydrolysis of long-chain fatty acid esters of cholesterol with rat liver enzymes. | 1962 | J. Biol. Chem. | pmid:14027461 |
TROUT DL and ESTES EH | Factors affecting liver uptake of serum free stearic acid-1-C14. | 1962 | Am. J. Physiol. | pmid:13994303 |
WALLEN LL et al. | The microbiological production of 10-hydroxystearic acid from oleic acid. | 1962 | Arch. Biochem. Biophys. | pmid:13998583 |
CREASEY WA | Observations on the activation of stearic acid by rat-liver preparations. | 1962 | Biochim. Biophys. Acta | pmid:14023748 |
JAMES AT | [Studies on the biosynthesis of 18 carbon mono-and tri-unsaturated fatty acids by gas phase chromatography]. | 1962 | Bull. Soc. Chim. Biol. | pmid:13957228 |
FOSSA T | [Inhibition of hepatic glucose-6-phosphatase by fatty acids and zinc ions]. | 1962 | Boll. Soc. Ital. Biol. Sper. | pmid:13958874 |
BARGONI N and SISINI A | [Inhibition and reactivation of the hydrolases of digestion]. | 1962 | Boll. Soc. Ital. Biol. Sper. | pmid:13966663 |
NIELSEN K and SCHMIDT H | [Should the standard treatment of gonorrhea be changed? Effects of the treatment of gonorrhea in 1960 in ambulant and hospitalized patients]. | 1962 | Manedsskr Prakt Laegegern | pmid:13938514 |
GUTIERREZ J et al. | Lipid metabolism of rumen ciliates and bacteria. I. Uptake of fatty acids by Isotricha prostoma and Entodinium simplex. | 1962 | Appl Microbiol | pmid:13951437 |
BURNS TW et al. | EFFECT OF INSULIN ON PLASMA FREE FATTY ACIDS OF NORMAL SUBJECTS. | 1963 | J. Lab. Clin. Med. | pmid:14080865 |
CHAKRAVORTI KP and SADHU DP | STUDIES ON CHEMICAL COMPOSITION OF PROTEIN AND FAT IN THE OVIDUCT OF THE PIGEON, COLUMBA LIVIA GMELIN. | 1963 | Ann Biochem Exp Med | pmid:14082710 |
STEIN O and STEIN Y | METABOLISM OF FATTY ACIDS IN THE ISOLATED PERFUSED RAT HEART. | 1963 | Biochim. Biophys. Acta | pmid:14085937 |
LEVY G and GUMTOW RH | EFFECT OF CERTAIN TABLET FORMULATION FACTORS ON DISSOLUTION RATE OF THE ACTIVE INGREDIENT. III. TABLET LUBRICANTS. | 1963 | J Pharm Sci | pmid:14088962 |
NAKAGAKI M and NISHINO M | [STUDIES ON THE PHYSICOCHEMICAL PROPERTIES OF ALUMINUM SOAPS. III. COMPOSITION OF ALUMINUM STEARATE AND STRUCTURAL VISCOSITY OF BENZENE SOLUTION]. | 1963 | Yakugaku Zasshi | pmid:14094211 |
HAJRA AK and RADIN NS | IN VIVO CONVERSION OF LABELED FATTY ACIDS TO THE SPHINGOLIPID FATTY ACIDS IN RAT BRAIN. | 1963 | J. Lipid Res. | pmid:14168188 |
KUNUGI K | Studies on the syntheses of sucrose fatty acid esters. III. Re-esterification of sucrose monostearate. | 1963 | Chem. Pharm. Bull. | pmid:13927388 |
NAKAGAKI M and NISHINO M | [Studies on the physicochemical properties of aluminum soap. II. Structural viscosity of aluminum stearate in benzene]. | 1963 | Yakugaku Zasshi | pmid:13937343 |
OSTWALD R | Fat content and fatty acids in some commercial mixes for baked products. | 1963 | J Am Diet Assoc | pmid:13940620 |