stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Takahashi R et al. | Fatty acid composition of serum phospholipids in an elderly institutionalized Japanese population. | 1991 | J. Nutr. Sci. Vitaminol. | pmid:1765844 |
DeÄneka SE et al. | [Experimental data on the effects of lead, barium, silver, zinc and calcium stearates on the cardiovascular system]. | 1991 | Gig Tr Prof Zabol | pmid:1794723 |
Applegate KR and Glomset JA | Effect of acyl chain unsaturation on the conformation of model diacylglycerols: a computer modeling study. | 1991 | J. Lipid Res. | pmid:1797944 |
Buttke TM et al. | Correlation between low-temperature immunosuppression and the absence of unsaturated fatty acid synthesis in murine T cells. | 1991 | Comp. Biochem. Physiol., B | pmid:1799970 |
Denke MA and Grundy SM | Effects of fats high in stearic acid on lipid and lipoprotein concentrations in men. | 1991 | Am. J. Clin. Nutr. | pmid:1845606 |
Morgan H et al. | Proton transport at the monolayer-water interface. | 1991 | Biochim. Biophys. Acta | pmid:1848448 |
YashRoy RC | Protein heat denaturation and study of membrane lipid-protein interactions by spin label ESR. | 1991 | J. Biochem. Biophys. Methods | pmid:1848569 |
Qian MW and Eaton JW | Iron translocation by free fatty acids. | 1991 | Am. J. Pathol. | pmid:1750512 |
Sakai T et al. | Chorea-acanthocytosis: abnormal composition of covalently bound fatty acids of erythrocyte membrane proteins. | 1991 | Ann. Neurol. | pmid:1832532 |
Le Petit-Thevenin J et al. | Changes in pattern of phospholipid acylation during in vivo aging of rat red blood cells. | 1991 | Am. J. Physiol. | pmid:1887869 |
Squier TC et al. | Resolution of phospholipid conformational heterogeneity in model membranes by spin-label EPR and frequency-domain fluorescence spectroscopy. | 1991 | Biophys. J. | pmid:1646658 |
Streichman S et al. | EPR study of the hydrophobic interaction of spectrin with fatty acids. | 1991 | Biochim. Biophys. Acta | pmid:1648396 |
Irita K et al. | Substitution by fatty acids for phosphatidylserine in a reconstitution of phorbol ester binding to protein kinase C. | 1991 | Int. J. Biochem. | pmid:1650723 |
Townsend WE et al. | Effect of level of endophyte infection, nitrogen fertilization rate, grazing period, and paddock exchange on some chemical properties of four bovine tissues. | 1991 | J. Anim. Sci. | pmid:1653201 |
Koike R et al. | Physiological significance of fatty acid elongation system in adrenoleukodystrophy. | 1991 | J. Neurol. Sci. | pmid:1880537 |
Nelson JM et al. | Cadmium ion-induced alterations of phospholipid metabolism in endothelial cells. | 1991 | Am. J. Respir. Cell Mol. Biol. | pmid:1910817 |
Nagao M et al. | Arachidonic acid metabolism in articular chondrocytes. | 1991 | Clin. Orthop. Relat. Res. | pmid:1914309 |
Ulmann L et al. | Incorporation into liver microsomal lipids of linoleic and stearic acids and of their respective products of delta 6 and delta 9 desaturation, gamma-linolenic and oleic acids: effect of age and of blackcurrant seed oil. | 1991 | Biochim. Biophys. Acta | pmid:1657182 |
Duane PG et al. | Relationship of oxidant-mediated cytotoxicity to phospholipid metabolism in endothelial cells. | 1991 | Am. J. Respir. Cell Mol. Biol. | pmid:2021479 |
Bogataj M et al. | Eudragit E microspheres containing bacampicillin: preparation by solvent removal methods. | 1991 Jul-Sep | J Microencapsul | pmid:1941447 |
Smith DM and Waite M | Phosphatidylinositol hydrolysis by phospholipase A2 and C activities in human peripheral blood neutrophils. | 1992 | J. Leukoc. Biol. | pmid:1464738 |
Ashes JR et al. | Incorporation of n-3 fatty acids of fish oil into tissue and serum lipids of ruminants. | 1992 | Lipids | pmid:1406074 |
Kritchevsky D | Herman Award Lecture, 1992: lipid nutrition--a personal perspective. | 1992 | Am. J. Clin. Nutr. | pmid:1414974 |
Emken EA | What is the metabolic fate of dietary long-chain fatty acids (especially stearic acid) in normal physiological states, and how might this relate to thrombosis? | 1992 | Am. J. Clin. Nutr. | pmid:1414985 |
Leinonen UI et al. | Physical and lubrication properties of magnesium stearate. | 1992 | J Pharm Sci | pmid:1491339 |
Giusto NM et al. | Effects of aging on the content, composition and synthesis of sphingomyelin in the central nervous system. | 1992 | Lipids | pmid:1491598 |
Dotson KD et al. | High-performance liquid chromatography of human milk triacylglycerols and gas chromatography of component fatty acids. | 1992 | Lipids | pmid:1491614 |
Judd AM and MacLeod RM | Thyrotropin-releasing hormone and lysine-bradykinin stimulate arachidonate liberation from rat anterior pituitary cells through different mechanisms. | 1992 | Endocrinology | pmid:1505463 |
Johnson PE et al. | Effects of stearic acid and beef tallow on iron utilization by the rat. | 1992 | Proc. Soc. Exp. Biol. Med. | pmid:1508937 |
Wheelan P and Clay KL | Albumin and fatty acid effects on the stimulated production of 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) by human polymorphonuclear leukocytes. | 1992 | Biochim. Biophys. Acta | pmid:1511005 |
Flynn TT et al. | Modification of plasma and hepatic lipids of guinea pigs by feeding high oleic acid pork compared with regular pork. | 1992 | J. Nutr. | pmid:1512635 |
Wieland SJ et al. | Differential modulation of a sodium conductance in skeletal muscle by intracellular and extracellular fatty acids. | 1992 | Am. J. Physiol. | pmid:1514578 |
NakonechnyÄ II et al. | [The atomic absorption determination of calcium, zinc, barium, lead and silver stearates in the air of a work area]. | 1992 | Gig Sanit | pmid:1427217 |
Mensink RP et al. | Effect of dietary cis and trans fatty acids on serum lipoprotein[a] levels in humans. | 1992 | J. Lipid Res. | pmid:1431574 |
Gozes I and Fridkin M | A fatty neuropeptide. Potential drug for noninvasive impotence treatment in a rat model. | 1992 | J. Clin. Invest. | pmid:1522236 |
Sauer LA and Dauchy RT | Uptake of plasma lipids by tissue-isolated hepatomas 7288CTC and 7777 in vivo. | 1992 | Br. J. Cancer | pmid:1503901 |
Cobb TK | Effects of dietary stearic acid on plasma cholesterol levels. | 1992 | South. Med. J. | pmid:1734530 |
Fatani W and Rosen D | Irradiation of Langmuir-Blodgett multilayer preparations of phospholipids and a fatty acid. 1: Effect of UV radiation. | 1992 | Int. J. Radiat. Biol. | pmid:1362756 |
Fatani W and Rosen D | Irradiation of Langmuir-Blodgett multilayer preparations of phospholipids and a fatty acid. 2: Effect of X-radiation. | 1992 | Int. J. Radiat. Biol. | pmid:1362757 |
Dennis M and Kolattukudy PE | A cobalt-porphyrin enzyme converts a fatty aldehyde to a hydrocarbon and CO. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1608940 |
el-Naghy MA et al. | Fungistatic action of natural oils and fatty acids on dermatophytic and saprophytic fungi. | 1992 | Zentralbl. Mikrobiol. | pmid:1609554 |
Mitra A et al. | Inhibition of human term placental and fetal liver glutathione-S-transferases by fatty acids and fatty acid esters. | 1992 | Toxicol. Lett. | pmid:1595087 |
Garcia Marquez MA et al. | [The effect of two lubricants (magnesium stearate and pruv) in the formation of tablets of four anti-ulcer agents/ by means of direct compression]. | 1992 | Pharm Acta Helv | pmid:1631172 |
Bonanome A et al. | Metabolic effects of dietary stearic acid in mice: changes in the fatty acid composition of triglycerides and phospholipids in various tissues. | 1992 | Atherosclerosis | pmid:1632865 |
Zock PL and Katan MB | Hydrogenation alternatives: effects of trans fatty acids and stearic acid versus linoleic acid on serum lipids and lipoproteins in humans. | 1992 | J. Lipid Res. | pmid:1569387 |
Komata Y et al. | In vitro percutaneous absorption of thiamine disulfide from a mixture of propylene glycol and fatty acid. | 1992 | J Pharm Sci | pmid:1403716 |
Urquhart R et al. | omega-6 and omega-3 fatty acids: monolayer packing and effects on bilayer permeability and cholesterol exchange. | 1992 | Biochem. Int. | pmid:1535197 |
Lagrost L | Differential effects of cis and trans fatty acid isomers, oleic and elaidic acids, on the cholesteryl ester transfer protein activity. | 1992 | Biochim. Biophys. Acta | pmid:1543738 |
Rafi MA et al. | Correction of sulfatide metabolism after transfer of prosaposin cDNA to cultured cells from a patient with SAP-1 deficiency. | 1992 | Am. J. Hum. Genet. | pmid:1350885 |
Simões AP et al. | Incorporation of free fatty acids can explain alterations in the molecular species composition of phosphatidylcholine and phosphatidylethanolamine in human erythrocytes as induced by Plasmodium falciparum. | 1992 | Cell Biol. Int. Rep. | pmid:1327542 |
Fanjul LF et al. | Diacylglycerol rather than Ca2+ mediates GnRH inhibition of FSH induced steroidogenesis in ovarian granulosa cells. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1329745 |
Dwight JF et al. | Membrane incorporation of non-esterified fatty acids and effects on the sodium pump of human erythrocytes. | 1992 | Clin. Sci. | pmid:1310925 |
Gault MH et al. | Heparin, fatty acids and sodium, potassium-ATPase inhibition by plasma factors during hemodialysis. | 1992 | Nephron | pmid:1314335 |
Pirozhkov SV et al. | Effect of chronic consumption of ethanol and vitamin E on fatty acid composition and lipid peroxidation in rat heart tissue. | 1992 Jul-Aug | Alcohol | pmid:1637499 |
Boza J et al. | Influences of postnatal age and dietary nucleotides on plasma fatty acids in the weanling rat. | 1992 Jul-Aug | JPEN J Parenter Enteral Nutr | pmid:1322471 |
Bengochea LA et al. | Changes in microsomal phospholipid fatty acids composition in cholestatic rats. | 1992 Mar-Apr | Arch Int Physiol Biochim Biophys | pmid:1379485 |
Holian O and Nelson R | Action of long-chain fatty acids on protein kinase C activity: comparison of omega-6 and omega-3 fatty acids. | 1992 May-Jun | Anticancer Res. | pmid:1352441 |
Cisar LA et al. | Interleukin-1 selectively potentiates bradykinin-stimulated arachidonic acid release from human synovial fibroblasts. | 1993 | Cell. Signal. | pmid:8373725 |
Viswanathan R et al. | Strained-layer van der Waals epitaxy in a Langmuir-Blodgett film. | 1993 | Science | pmid:8392751 |
Emken EA et al. | Influence of linoleic acid on desaturation and uptake of deuterium-labeled palmitic and stearic acids in humans. | 1993 | Biochim. Biophys. Acta | pmid:8399342 |
Monsma CC and Ney DM | Interrelationship of stearic acid content and triacylglycerol composition of lard, beef tallow and cocoa butter in rats. | 1993 | Lipids | pmid:8355579 |
Lurie E et al. | N-(2-hydroxybenzyl)-omega-amino carbonic acids and their derivatives as tools for biochemical and biophysical investigations. | 1993 | Biochem. Mol. Biol. Int. | pmid:8358340 |
Baer HH and Wu X | Synthesis of alpha,alpha-trehalose 2,3- and 2,3'-diesters with palmitic and stearic acid: potential immunoreactants for the serodiagnosis of tuberculosis. | 1993 | Carbohydr. Res. | pmid:8431934 |
Das T et al. | Characterization of cardiac fatty-acid-binding protein from human placenta. Comparison with placenta hepatic types. | 1993 | Eur. J. Biochem. | pmid:8436130 |
Poulos A et al. | Fatty acid synthesis from [2-14C]acetate in normal and peroxisome-deficient (Zellweger) fibroblasts. | 1993 | Lipids | pmid:8441343 |
Muriana FJ et al. | Lipid and fatty acid composition of hepatopancreatic brush-border membrane vesicles from the prawn Penaeus japonicus. | 1993 | J. Biochem. | pmid:8340355 |
Wada H et al. | In vitro ferredoxin-dependent desaturation of fatty acids in cyanobacterial thylakoid membranes. | 1993 | J. Bacteriol. | pmid:8419301 |
Raines DE and Miller KW | The role of charge in lipid selectivity for the nicotinic acetylcholine receptor. | 1993 | Biophys. J. | pmid:8386010 |
Imaizumi K et al. | Fat containing stearic acid increases fecal neutral steroid excretion and catabolism of low density lipoproteins without affecting plasma cholesterol concentration in hamsters fed a cholesterol-containing diet. | 1993 | J. Nutr. | pmid:8410360 |
Derr J et al. | The role of fatty acid saturation on plasma lipids, lipoproteins, and apolipoproteins: II. The plasma total and low-density lipoprotein cholesterol response of individual fatty acids. | 1993 | Metab. Clin. Exp. | pmid:8446040 |
Fujimoto T et al. | P-selectin is acylated with palmitic acid and stearic acid at cysteine 766 through a thioester linkage. | 1993 | J. Biol. Chem. | pmid:7684381 |
Keita Y et al. | Effect of free fatty acids on the binding kinetics at the benzodiazepine binding site of glycated human serum albumin. | 1993 | Int J Clin Pharmacol Ther Toxicol | pmid:7690351 |
Muszbek L and Laposata M | Myristoylation of proteins in platelets occurs predominantly through thioester linkages. | 1993 | J. Biol. Chem. | pmid:8463334 |
Sylvester PW et al. | Effects of specific fatty acids on prolactin-induced NB2 lymphoma cell proliferation. | 1993 | Life Sci. | pmid:8505862 |
Melik-Nubarov NS et al. | Interaction of hydrophobized antiviral antibodies with influenza virus infected MDCK cells. | 1993 | Biochem. Mol. Biol. Int. | pmid:8508145 |
Robert S et al. | Fatty acid acylation of RNase A using reversed micelles as microreactors. | 1993 | Biochem. Biophys. Res. Commun. | pmid:7692851 |
Hamilton KS et al. | Glycosphingolipid backbone conformation and behavior in cholesterol-containing phospholipid bilayers. | 1993 | Biochemistry | pmid:8471610 |
Hari PR and Sharma CP | Protein adsorption--effect of external lubricants at the interface. | 1993 | J Biomater Appl | pmid:8473987 |
Mensink RP | Effects of the individual saturated fatty acids on serum lipids and lipoprotein concentrations. | 1993 | Am. J. Clin. Nutr. | pmid:8475888 |
Michiels C et al. | Stimulation of prostaglandin synthesis by human endothelial cells exposed to hypoxia. | 1993 | Am. J. Physiol. | pmid:8476019 |
el-Sharkawy SH et al. | Microbiological transformations of lipids: acyl-specific hydrolysis of lard by yeasts. | 1993 | Appl. Environ. Microbiol. | pmid:8480999 |
Woldseth B et al. | Incorporation of stearic acid (18:0) and palmitic acid (16:0) in phospholipid molecular species studied in isolated rat liver cells. | 1993 | Biochim. Biophys. Acta | pmid:8481391 |
Sastri MS et al. | In vitro and in vivo studies on slow release propranolol hydrochloride suppositories. Pharmacokinetic and pharmacodynamic evaluation. | 1993 | Arzneimittelforschung | pmid:8489559 |
Vashchuk VV and Vashchuk VV | [The use of the catalase P-47 preparation for treating long-term nonhealing wounds and trophic ulcers]. | 1993 | Klin Khir | pmid:10912018 |
Nishihira J et al. | Identification of the hydrophobic ligand-binding region in recombinant glutathione S-transferase P and its binding effect on the conformational state of the enzyme. | 1993 | Arch. Biochem. Biophys. | pmid:8470890 |
Visioli F et al. | Free fatty acid and diacylglycerol accumulation in the rat brain during recurrent seizures is related to cortical oxygenation. | 1993 | J. Neurochem. | pmid:8228997 |
Doering TL et al. | Trypanosome metabolism of myristate, the fatty acid required for the variant surface glycoprotein membrane anchor. | 1993 | J. Biol. Chem. | pmid:8486622 |
Rich MR | Conformational analysis of arachidonic and related fatty acids using molecular dynamics simulations. | 1993 | Biochim. Biophys. Acta | pmid:8329458 |
Zock PL et al. | Effects of stearic acid and trans fatty acids versus linoleic acid on blood pressure in normotensive women and men. | 1993 | Eur J Clin Nutr | pmid:8365385 |
Sullivan JL et al. | Performance of dairy cows fed short staple, Pima, and cracked Pima cottonseed and feed characteristics. | 1993 | J. Dairy Sci. | pmid:8270698 |
Cardoso CM and De Meis L | Modulation by fatty acids of Ca2+ fluxes in sarcoplasmic-reticulum vesicles. | 1993 | Biochem. J. | pmid:7504458 |
Arnould T et al. | Increased PMN adherence on endothelial cells after hypoxia: involvement of PAF, CD18/CD11b, and ICAM-1. | 1993 | Am. J. Physiol. | pmid:8098907 |
Burdick S et al. | Different mechanisms of uptake of stearic acid and cholesterol into rabbit jejunal brush border membrane vesicles. | 1993 | Lipids | pmid:8121247 |
Ghaly ES et al. | Controlled release of theophylline from inert matrices: effect of channeling material on release rate. | 1993 | P R Health Sci J | pmid:8140202 |
Darmani H et al. | Effect of interferon-gamma on membrane conformation in the macrophage-like cell line P388D. | 1993 | J. Interferon Res. | pmid:8151138 |
Samochocki M and Strosznajder J | Modulatory action of arachidonic acid on GABAA/chloride channel receptor function in adult and aged brain cortex membranes. | 1993 | Neurochem. Int. | pmid:8220171 |
Hrelia S et al. | In vivo effect of chronic ethanol consumption on the fatty acid composition of phosphatidylinositols in resting and anti-CD3-activated lymphocytes. | 1993 | Alcohol. Clin. Exp. Res. | pmid:8279665 |
Ramanadham S et al. | Mass spectrometric characterization of arachidonate-containing plasmalogens in human pancreatic islets and in rat islet beta-cells and subcellular membranes. | 1993 | Biochemistry | pmid:8257685 |
Larner JM et al. | The isolation and characterization of estradiol-fatty acid esters in human ovarian follicular fluid. Identification of an endogenous long-lived and potent family of estrogens. | 1993 | J. Biol. Chem. | pmid:8314757 |
Tetzloff SU and Bizzozero OA | Proteolipid protein from the peripheral nervous system also contains covalently bound fatty acids. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8323550 |