stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Bertram J and Erwin JA | Isolation of a stearoyl CoA Desaturase form Tetrahymena thermophila. | 1981 | J. Protozool. | pmid:6114174 |
Udeala OK et al. | Preliminary evaluation of dika fat, a new tablet lubricant. | 1980 | J. Pharm. Pharmacol. | pmid:6102130 |
Zentner GM et al. | Free fatty acid-induced platelet aggregation: studies with solubilized and nonsolubilized fatty acids. | 1981 | J Pharm Sci | pmid:6101166 |
Ohki K et al. | Effect of alpha-tocopherol on lipid peroxidation and acyl chain mobility of liver microsomes from vitamin E-difficient rat. | 1984 | J. Nutr. Sci. Vitaminol. | pmid:6092586 |
Roguinsky M and Serieys F | [Treatment of mastitis in dry cows: treatment of all cows vs treatment of infected cows only (author's transl)]. | 1977 | Ann. Rech. Vet. | pmid:606146 |
Oriel JD et al. | Comparison of erythromycin stearate and oxytetracycline in the treatment of non-gonococcal urethritis: their efficacy against Chlamydia trachomatis. | 1977 | Scott Med J | pmid:601555 |
Bolton P and Harwood JL | Fatty acid biosynthesis by a particulate preparation from germinating pea. | 1977 | Biochem. J. | pmid:579600 |
Nicoletti R et al. | [Palmitic acid-stearic acid ratio with reference to the fatty tissue properties in the human species]. | 1979 May-Jun | Arch Kriminol | pmid:573992 |
Yang YT et al. | Dietary lipid metabolism in lactating dairy cows. | 1978 | J. Dairy Sci. | pmid:568635 |
Burns CP et al. | Fatty acid utilization by L1210 murine leukemia cells. | 1977 | Cancer Res. | pmid:558821 |
Boggiano BG and Gleeson M | Gastric acid inactivation of erythromycin stearate in solid dosage forms. | 1976 | J Pharm Sci | pmid:5588 |
Smith DD | Clinical trial of erythromycin stearate suspension. | 1971 | Med. J. Aust. | pmid:5577264 |
Molloy PL and Eisenstadt JM | Erythromycin resistance in mouse L cells. | 1979 | Somatic Cell Genet. | pmid:531731 |
Bell SM | A comparison of absorption after oral administration of erythromycin estolate and erythromycin stearate. | 1971 | Med. J. Aust. | pmid:5134726 |
Yakatan GJ et al. | Single-dose fasting bioequivalence assessment of erythromycin stearate tablets in man. | 1979 | J Pharmacokinet Biopharm | pmid:512842 |
Pinzauti S and La Porta E | Assay of a cetylpyridinium-dequalinium chlorides combination in compressed lozenges: uptake of quaternary ammonium salts by magnesium stearate. | 1979 Sep-Oct | J Pharm Belg | pmid:512830 |
Caille MP et al. | [Acute forms of lead poisoning by lead stearate]. | 1971 | Arch Mal Prof | pmid:5123552 |
Schmidt P et al. | [Acute inhalation toxicity of cadmium stearate]. | 1971 | Z Gesamte Hyg | pmid:5123074 |
Rutland J et al. | The influence of food on the bioavailability of new formulations of erythromycin stearate and base. | 1979 | Br J Clin Pharmacol | pmid:508509 |
Patil GS et al. | Effect of ionization and cation selectivity on the expansion of stearic acid monolayers. | 1972 | J. Lipid Res. | pmid:5075503 |
Price CJ and Rowe CE | Stimulation of the production of unesterified fatty acids in nerve endings of guinea-pig brain in vitro by noradrenaline and 5-hydroxytryptamine. | 1972 | Biochem. J. | pmid:5075269 |
Lesslauer W and Blasie JK | Direct determination of the structure of barium stearate multilayers by x-ray diffraction. | 1972 | Biophys. J. | pmid:5057749 |
Conte U et al. | The effect of magnesium stearate and polytetrafluoroethylene as lubricants in direct compression of acetylsalicylic acid. | 1972 | Farmaco Prat | pmid:5049531 |
Wosilait WD and Ryan MP | The effects of oleic acid, tolbutamide, and oxyphenbutazone on the binding of warfarin by human serum albumin. | 1979 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:504792 |
Malmborg AS | Effect of food on absorption of erythromycin. A study of two derivatives, the stearate and the base. | 1979 | J. Antimicrob. Chemother. | pmid:500517 |
Carlisle HN and Saslaw S | Therapy of staphylococcal infections in monkeys. VI. Comparison of clindamycin, erythromycin, and methicillin. | 1971 | Appl Microbiol | pmid:4994902 |
McLeay AC and Beveridge J | Clinical trial of erythromycin stearate suspension. | 1971 | Med. J. Aust. | pmid:4929585 |
Beleslin DB et al. | Hyperthermic effect of palmitate sodium, stearate sodium and oleate sodium injected into the cerebral ventricles of conscious cats. | 1974 | Neuropharmacology | pmid:4840846 |
Caldwell HC | Dissolution of lithium and magnesium from lithium carbonate capsules containing magnesium stearate. | 1974 | J Pharm Sci | pmid:4830001 |
Miyake Y et al. | [Studies on packing-property of pharmaceutical powders. 3. Influence of calcium stearate content on compacting phenomenon of pharmaceutical powders (author's transl)]. | 1973 | Yakugaku Zasshi | pmid:4797567 |
Riordan JR et al. | Plasma membrane lipids of human diploid fibroblasts from normal individuals and patients with cystic fibrosis. | 1979 | Biochim. Biophys. Acta | pmid:476136 |
Arya OP and Bosa CB | In search of an ideal single-session penicillin schedule for the treatment of gonorrhoea in Uganda. | 1973 | Br J Vener Dis | pmid:4748409 |
McLeay A and Cooke P | Estolate and stearate forms of erythromycin in beta-haemolytic streptococcal pharyngitis. | 1973 | Med. J. Aust. | pmid:4694278 |
Miyake Y et al. | [Studies on packing-property of pharmaceutical powders. II. Compacting phenomenon of pharmaceutical powders in the course of mixing with calcium stearate]. | 1972 | Yakugaku Zasshi | pmid:4675495 |
Berend N et al. | Plasma and saliva concentrations for a new formulation of erythromycin stearate. | 1979 | Curr Med Res Opin | pmid:467089 |
Kabara JJ et al. | Fatty acids and derivatives as antimicrobial agents. | 1972 | Antimicrob. Agents Chemother. | pmid:4670656 |
Wahle KW and Garton GA | Desaturation of stearate by sheep tissue microsomal preparations. | 1972 | Biochem. J. | pmid:4643297 |
Zackler J et al. | A mass screening program for the detection of gonorrhea. | 1972 | Am. J. Obstet. Gynecol. | pmid:4623083 |
Holub BJ and Piekarski J | The formation of phosphatidylinositol by acylation of 2-acyl-sn-glycero-3-phosphorylinositol in rat liver microsomes. | 1979 | Lipids | pmid:459717 |
Antimicrobial efficacy of erythromycin stearate. A report from the general Practitioner Research Group. | 1974 | Practitioner | pmid:4591200 | |
Bhatia RP and Lordi NG | Conductivity and hardness changes in aged compacts. | 1979 | J Pharm Sci | pmid:458612 |
Ryan DC et al. | Estolate and stearate forms of erythromycin in the treatment of acute beta haemolytic streptococcal pharyngitis. | 1973 | Med. J. Aust. | pmid:4568626 |
Bond JM et al. | The second international reference preparation of procaine benzylpenicillin in oil with aluminium monostearate. | 1973 | Bull. World Health Organ. | pmid:4541152 |
Kasuya M et al. | Toxic effect of cadmium stearate on rat cerebellum in culture. | 1974 | Bull Environ Contam Toxicol | pmid:4474041 |
Nielsen GD et al. | [Aspiration of talcum or powder containing zinc stearate by children]. | 1979 | Ugeskr. Laeg. | pmid:442270 |
Doran TA et al. | Amniotic fluid lecithin/sphingomyelin ratio, palmitic acid, palmitic acid/stearic acid ratio, total cortisol, creatinine, and percentage of lipid-positive cells in assessment of fetal maturity and fetal pulmonary maturity: a comparison. | 1979 | Am. J. Obstet. Gynecol. | pmid:433991 |
Moody G et al. | Lubricity measurements of magnesium stearate [proceedings]. | 1979 | J. Pharm. Pharmacol. | pmid:42749 |
Eccleston GM | The structure and stability of O/W emulsions stabilised by polyethylene glycol 1000 monostearate/fatty alcohols [proceedings]. | 1979 | J. Pharm. Pharmacol. | pmid:42725 |
Kaur R and Grant DJ | Solid dispersions of drugs in polyoxyethylene 40 stearate: dissolution rates and physico-chemical interactions [proceedings]. | 1979 | J. Pharm. Pharmacol. | pmid:42723 |
Lerk CF et al. | Effect of microcrystalline cellulose on liquid penetration in and disintegration of directly compressed tablets. | 1979 | J Pharm Sci | pmid:423092 |