stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Otitis Media D010033 12 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Breast Neoplasms D001943 24 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Bacterial Infections D001424 21 associated lipids
Lung Neoplasms D008175 171 associated lipids
Burns D002056 34 associated lipids
Insulinoma D007340 28 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Reperfusion Injury D015427 65 associated lipids
Liver Neoplasms D008113 8 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Cattle Diseases D002418 24 associated lipids
Fatty Liver D005234 48 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Leukodystrophy, Metachromatic D007966 4 associated lipids
Coronary Disease D003327 70 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Acne Vulgaris D000152 35 associated lipids
Hypothyroidism D007037 32 associated lipids
Melanoma D008545 69 associated lipids
Occupational Diseases D009784 42 associated lipids
Weight Gain D015430 101 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Foreign Bodies D005547 5 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Thrombosis D013927 49 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Lymphoma D008223 18 associated lipids
Alzheimer Disease D000544 76 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Arteriosclerosis D001161 86 associated lipids
Neuroblastoma D009447 66 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Olfaction Disorders D000857 17 associated lipids
Acquired Immunodeficiency Syndrome D000163 12 associated lipids
Brain Edema D001929 20 associated lipids
Brain Diseases, Metabolic, Inborn D020739 10 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemia D007511 18 associated lipids
Seizures D012640 87 associated lipids
Birth Weight D001724 23 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Dermatitis D003872 30 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Hyperlipidemias D006949 73 associated lipids
Bronchitis D001991 6 associated lipids
Malignant Hyperthermia D008305 6 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Leukemia, Lymphoid D007945 18 associated lipids
Lymphoma, Non-Hodgkin D008228 6 associated lipids
Urticaria D014581 13 associated lipids
Tuberculosis, Pulmonary D014397 18 associated lipids
Adenoma D000236 40 associated lipids
Leprosy D007918 8 associated lipids
Mycobacterium Infections, Nontuberculous D009165 8 associated lipids
Tremor D014202 15 associated lipids
Lymphadenitis D008199 8 associated lipids
Skin Diseases, Infectious D012874 7 associated lipids
Hypopituitarism D007018 7 associated lipids
Prostatic Diseases D011469 4 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Atherosclerosis D050197 85 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Insulin Resistance D007333 99 associated lipids
Obesity, Abdominal D056128 3 associated lipids
Rosacea D012393 13 associated lipids
Amnesia D000647 12 associated lipids
Gonorrhea D006069 7 associated lipids
Calculi D002137 3 associated lipids
Cholestasis, Extrahepatic D001651 7 associated lipids
Abortion, Spontaneous D000022 12 associated lipids
Infertility D007246 3 associated lipids
Anemia, Dyserythropoietic, Congenital D000742 2 associated lipids
Hypothalamic Diseases D007027 3 associated lipids
Pneumoconiosis D011009 3 associated lipids
Gallbladder Neoplasms D005706 3 associated lipids
Legionnaires' Disease D007877 4 associated lipids
Whooping Cough D014917 6 associated lipids
Urethritis D014526 9 associated lipids
Boutonneuse Fever D001907 5 associated lipids
Yaws D015001 4 associated lipids
Syphilis, Congenital D013590 3 associated lipids
Syphilis, Latent D013592 4 associated lipids
Mycoplasmatales Infections D009180 6 associated lipids
Eczema, Dyshidrotic D011146 1 associated lipids
Chancroid D002602 4 associated lipids
Relapsing Fever D012061 3 associated lipids
Tenosynovitis D013717 3 associated lipids
Salivary Duct Calculi D012465 2 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

Download all related citations
Per page 10 20 50 100 | Total 3506
Authors Title Published Journal PubMed Link
Junk MJ et al. DEER in biological multispin-systems: a case study on the fatty acid binding to human serum albumin. 2011 J. Magn. Reson. pmid:21450500
Franch-Lage F et al. Fast assessment of the surface distribution of API and excipients in tablets using NIR-hyperspectral imaging. 2011 Int J Pharm pmid:21419207
Xu QC et al. Enhanced photocatalytic activity of C-N-codoped TiO2 films prepared via an organic-free approach. 2011 J. Hazard. Mater. pmid:21316842
Zhou QT et al. Characterization of the surface properties of a model pharmaceutical fine powder modified with a pharmaceutical lubricant to improve flow via a mechanical dry coating approach. 2011 J Pharm Sci pmid:21455980
Sheikh KA et al. Influence of hydration state and homologue composition of magnesium stearate on the physical chemical properties of liquid paraffin lipogels. 2011 Int J Pharm pmid:21457766
Severino P et al. Polymorphism, crystallinity and hydrophilic-lipophilic balance of stearic acid and stearic acid-capric/caprylic triglyceride matrices for production of stable nanoparticles. 2011 Colloids Surf B Biointerfaces pmid:21543196
Zhou QT et al. Investigation of the extent of surface coating via mechanofusion with varying additive levels and the influences on bulk powder flow properties. 2011 Int J Pharm pmid:21527321
Dong Z et al. Preparation and in vitro, in vivo evaluations of norfloxacin-loaded solid lipid nanopartices for oral delivery. 2011 Drug Deliv pmid:21554156
Zhang Y et al. α-Linolenic acid prevents endoplasmic reticulum stress-mediated apoptosis of stearic acid lipotoxicity on primary rat hepatocytes. 2011 Lipids Health Dis pmid:21592363
Ting TC et al. Increased lipogenesis and stearate accelerate vascular calcification in calcifying vascular cells. 2011 J. Biol. Chem. pmid:21596756
Pingali K et al. Evaluation of strain-induced hydrophobicity of pharmaceutical blends and its effect on drug release rate under multiple compression conditions. 2011 Drug Dev Ind Pharm pmid:20942612
Sharma S et al. RP-HPLC Method for Simultaneous Estimation of Nitazoxanide and Ofloxacin in Tablets. 2011 Indian J Pharm Sci pmid:22131628
Lavigne JP et al. Propolis can potentialise the anti-adhesion activity of proanthocyanidins on uropathogenic Escherichia coli in the prevention of recurrent urinary tract infections. 2011 BMC Res Notes pmid:22126300
Steidl S et al. Mâ‚… muscarinic receptors mediate striatal dopamine activation by ventral tegmental morphine and pedunculopontine stimulation in mice. 2011 PLoS ONE pmid:22102904
Meissner M et al. Bile acid sequestration reduces plasma glucose levels in db/db mice by increasing its metabolic clearance rate. 2011 PLoS ONE pmid:22087215
Guschina I et al. Lipid classes and fatty acid patterns are altered in the brain of γ-synuclein null mutant mice. 2011 Lipids pmid:20963507
Yin AW and Huang SJ [Research on chemical constituents of xuefu zhuyu decoction]. 2011 Zhong Yao Cai pmid:22372145
Bailey JA et al. Rivastigmine lowers Aβ and increases sAPPα levels, which parallel elevated synaptic markers and metabolic activity in degenerating primary rat neurons. 2011 PLoS ONE pmid:21799757
Protière M et al. Rational design of the gram-scale synthesis of nearly monodisperse semiconductor nanocrystals. 2011 Nanoscale Res Lett pmid:21791060
Rajendraprasad N et al. Titrimetric and spectrophotometric assay of oxcarbazepine in pharmaceuticals using N-bromosuccinimide and bromopyrogallol red. 2011 Int J Anal Chem pmid:21785594
Bhope SG et al. Design and development of a stable polyherbal formulation based on the results of compatibility studies. 2011 Pharmacognosy Res pmid:21772756
Williams KJ et al. The Mycobacterium tuberculosis β-oxidation genes echA5 and fadB3 are dispensable for growth in vitro and in vivo. 2011 Tuberculosis (Edinb) pmid:21764638
Chabukswar A et al. Six sigma: process of understanding the control and capability of ranitidine hydrochloride tablet. 2011 J Young Pharm pmid:21607050
Lacaze C et al. The initial pharmaceutical development of an artesunate/amodiaquine oral formulation for the treatment of malaria: a public-private partnership. 2011 Malar. J. pmid:21605361
Houmard JA et al. Is there a metabolic program in the skeletal muscle of obese individuals? 2011 J Obes pmid:21603262
Li C et al. Prevention of carcinogenesis and inhibition of breast cancer tumor burden by dietary stearate. 2011 Carcinogenesis pmid:21586513
Mahdi ES et al. Effect of surfactant and surfactant blends on pseudoternary phase diagram behavior of newly synthesized palm kernel oil esters. 2011 Drug Des Devel Ther pmid:21792294
Sahu SK et al. Hydrophobically modified carboxymethyl chitosan nanoparticles targeted delivery of paclitaxel. 2011 J Drug Target pmid:20367067
Green CD and Olson LK Modulation of palmitate-induced endoplasmic reticulum stress and apoptosis in pancreatic β-cells by stearoyl-CoA desaturase and Elovl6. 2011 Am. J. Physiol. Endocrinol. Metab. pmid:21266672
Peter A et al. Relationships between hepatic stearoyl-CoA desaturase-1 activity and mRNA expression with liver fat content in humans. 2011 Am. J. Physiol. Endocrinol. Metab. pmid:21045174
Han L et al. Starch stearate as a novel encapsulation wall material and its effect on oil-water interfacial tension. 2011 J Control Release pmid:22195872
Dasu MR and Jialal I Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors. 2011 Am. J. Physiol. Endocrinol. Metab. pmid:20959532
Goto T et al. Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist. 2011 Biochem. J. pmid:21605082
Kushner J et al. Examining the impact of excipient material property variation on drug product quality attributes: a quality-by-design study for a roller compacted, immediate release tablet. 2011 J Pharm Sci pmid:21319161
de Sousa Neto D et al. Effect of the ω-acylceramides on the lipid organization of stratum corneum model membranes evaluated by X-ray diffraction and FTIR studies (Part I). 2011 Chem. Phys. Lipids pmid:21238439
Seow LJ et al. Anti-angiogenic activity of Gynura segetum leaf extracts and its fractions. 2011 J Ethnopharmacol pmid:21167271
Price ER et al. Carnitine palmitoyl transferase activity and whole muscle oxidation rates vary with fatty acid substrate in avian flight muscles. 2011 J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. pmid:21153644
Liu H et al. A surfactant-free recipe for shape-controlled synthesis of CdSe nanocrystals. 2011 Nanotechnology pmid:21169661
de Morais e Silva FA et al. Rosacea fulminans in pregnancy with ocular perforation. 2011 J Dtsch Dermatol Ges pmid:21366860
Morinaga N et al. Synthesis of fatty acid sterol esters using cholesterol esterase from Trichoderma sp. AS59. 2011 Enzyme Microb. Technol. pmid:22113022
Tuei VC et al. Effects of human serum albumin complexed with free fatty acids on cell viability and insulin secretion in the hamster pancreatic β-cell line HIT-T15. 2011 Life Sci. pmid:21396379
Corvis Y et al. Physicochemical stability of solid dispersions of enantiomeric or racemic ibuprofen in stearic acid. 2011 J Pharm Sci pmid:21905027
Gao Q et al. Synthesis and characterization of novel amphiphilic copolymer stearic acid-coupled F127 nanoparticles for nano-technology based drug delivery system. 2011 Colloids Surf B Biointerfaces pmid:21906917
Khan FN and Dehghan MH Enhanced bioavailability of atorvastatin calcium from stabilized gastric resident formulation. 2011 AAPS PharmSciTech pmid:21879394
Lee DM et al. Oxidative stress and inflammation in renal patients and healthy subjects. 2011 PLoS ONE pmid:21829457
Du YZ et al. Quaternary complexes composed of plasmid DNA/protamine/fish sperm DNA/stearic acid grafted chitosan oligosaccharide micelles for gene delivery. 2011 Int. J. Biol. Macromol. pmid:21035503
Bhattacharjee A et al. Deposition of stearate-oleate rich seed fat in Mangifera indica is mediated by a FatA type acyl-ACP thioesterase. 2011 Phytochemistry pmid:21130480
Yuan H et al. Stearic acid-g-chitosan polymeric micelle for oral drug delivery: in vitro transport and in vivo absorption. 2011 Mol. Pharm. pmid:21138243
Krogmann A et al. Inflammatory response of human coronary artery endothelial cells to saturated long-chain fatty acids. 2011 Microvasc. Res. pmid:21112343
Pereira MG et al. Trypanosoma cruzi epimastigotes are able to store and mobilize high amounts of cholesterol in reservosome lipid inclusions. 2011 PLoS ONE pmid:21818313