stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Yarkala S et al. | Role of excipients on N-oxide raloxifene generation from raloxifene-excipients binary mixtures. | 2009 | Chem. Pharm. Bull. | pmid:19801885 |
Nouri A et al. | Effect of process control agent on the porous structure and mechanical properties of a biomedical Ti-Sn-Nb alloy produced by powder metallurgy. | 2010 | Acta Biomater | pmid:19815096 |
Jun HY et al. | Long residence time of ultrasound microbubbles targeted to integrin in murine tumor model. | 2010 | Acad Radiol | pmid:19815430 |
Liu TY and Lin YL | Novel pH-sensitive chitosan-based hydrogel for encapsulating poorly water-soluble drugs. | 2010 | Acta Biomater | pmid:19819354 |
Yoshizawa H and Koishi M | The coating and the encapsulation of an interactive powder mixture and its application to sustained release preparations. | 1990 | J. Pharm. Pharmacol. | pmid:1982136 |
Evans LM et al. | Stearate preferentially induces apoptosis in human breast cancer cells. | 2009 | Nutr Cancer | pmid:19838949 |
Chen CY et al. | Chemical constituents from the whole plant of Gaultheria itoana Hayata. | 2009 | Chem. Biodivers. | pmid:19842133 |
Yonezawa T et al. | Saturated fatty acids stimulate and insulin suppresses BMCP1 expression in bovine mammary epithelial cells. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19852928 |
Nokhodchi A et al. | Cogrinding as a tool to produce sustained release behavior for theophylline particles containing magnesium stearate. | 2009 | AAPS PharmSciTech | pmid:19862623 |
Iwado H et al. | Mutagenicity and antimutagenicity of air-borne particulates. | 1991 | Mutat. Res. | pmid:1986270 |
Cardwell RJ et al. | Palmitate and stearate kinetics in the rat during sepsis and trauma. | 1991 | J. Surg. Res. | pmid:1987431 |
Gohel M and Bariya SH | Advanced formulation design of venlafaxine hydrochloride coated and triple-layer tablets containing hypromellose. | 2009 | Pharm Dev Technol | pmid:19883254 |
Horwitz J | Bradykinin activates a phospholipase D that hydrolyzes phosphatidylcholine in PC12 cells. | 1991 | J. Neurochem. | pmid:1988554 |
Balani PN et al. | Influence of excipients in comilling on mitigating milling-induced amorphization or structural disorder of crystalline pharmaceutical actives. | 2010 | J Pharm Sci | pmid:19902526 |
Paavolainen M et al. | Penetration of erythromycin stearate into maxillary sinus mucosa and secretion in chronic maxillary sinusitis. | 1977 Sep-Oct | Acta Otolaryngol. | pmid:199040 |
Jayakumar OD et al. | Water dispersible Fe3O4 nanoparticles carrying doxorubicin for cancer therapy. | 2009 | J Nanosci Nanotechnol | pmid:19908532 |
Uchimoto T et al. | Lubrication properties of potential alternative lubricants, glycerin fatty acid esters, to magnesium stearate. | 2010 | Int J Pharm | pmid:19913080 |
Fostok SF et al. | Interleukin-6 and Cyclooxygenase-2 downregulation by fatty-acid fractions of Ranunculus constantinopolitanus. | 2009 | BMC Complement Altern Med | pmid:19917107 |
Kalman DS et al. | A prospective, randomized, double-blind, placebo-controlled parallel-group dual site trial to evaluate the effects of a Bacillus coagulans-based product on functional intestinal gas symptoms. | 2009 | BMC Gastroenterol | pmid:19922649 |
Liew CV et al. | In-line quantification of drug and excipients in cohesive powder blends by near infrared spectroscopy. | 2010 | Int J Pharm | pmid:19922776 |
Harvey KA et al. | Long-chain saturated fatty acids induce pro-inflammatory responses and impact endothelial cell growth. | 2010 | Clin Nutr | pmid:19926177 |
Mukherjee S and Datta A | Morphology and structural evolution in cobalt stearate Langmuir-Blodgett films. | 2009 | J Nanosci Nanotechnol | pmid:19928206 |
Pingali KC et al. | Practical methods for improving flow properties of active pharmaceutical ingredients. | 2009 | Drug Dev Ind Pharm | pmid:19929205 |
Baki G et al. | Role of surface free energy and spreading coefficient in the formulation of active agent-layered pellets. | 2010 | Eur J Pharm Biopharm | pmid:19931611 |
Zhang LJ et al. | Hot-injection synthesis of highly luminescent and monodisperse CdS nanocrystals using thioacetamide and cadmium source with proper reactivity. | 2010 | J Colloid Interface Sci | pmid:19932894 |
Yeop Han C et al. | Differential effect of saturated and unsaturated free fatty acids on the generation of monocyte adhesion and chemotactic factors by adipocytes: dissociation of adipocyte hypertrophy from inflammation. | 2010 | Diabetes | pmid:19934003 |
Hoppa MB et al. | Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca(2+) channels from secretory granules. | 2009 | Cell Metab. | pmid:19945403 |
Teraoka R et al. | Effect of pharmaceutical excipients on the stability of trichlormethiazide tablets under humid conditions. | 2009 | Chem. Pharm. Bull. | pmid:19952441 |
Roberts LD et al. | Increased hepatic oxidative metabolism distinguishes the action of Peroxisome proliferator-activated receptor delta from Peroxisome proliferator-activated receptor gamma in the ob/ob mouse. | 2009 | Genome Med | pmid:19968882 |
Hanlon PR et al. | Aqueous extracts from dietary supplements influence the production of inflammatory cytokines in immortalized and primary T lymphocytes. | 2009 | BMC Complement Altern Med | pmid:20003431 |
Kordyukova LV et al. | Site-specific attachment of palmitate or stearate to cytoplasmic versus transmembrane cysteines is a common feature of viral spike proteins. | 2010 | Virology | pmid:20006369 |
Salbu L et al. | Direct compression behavior of low- and high-methoxylated pectins. | 2010 | AAPS PharmSciTech | pmid:20013080 |
Zornetzer GA et al. | The length of the bound fatty acid influences the dynamics of the acyl carrier protein and the stability of the thioester bond. | 2010 | Biochemistry | pmid:20014832 |
Fu X et al. | A rapid and universal bacteria-counting approach using CdSe/ZnS/SiO2 composite nanoparticles as fluorescence probe. | 2010 | Anal Bioanal Chem | pmid:20016878 |
Dong J et al. | Cation-controlled crystal growth of silver stearate: cryo-TEM investigation of lithium vs sodium stearate. | 2010 | Langmuir | pmid:20017506 |
McLean S et al. | Effect of filtration on morphine and particle content of injections prepared from slow-release oral morphine tablets. | 2009 | Harm Reduct J | pmid:20025779 |
Collins JM et al. | De novo lipogenesis and stearoyl-CoA desaturase are coordinately regulated in the human adipocyte and protect against palmitate-induced cell injury. | 2010 | J. Biol. Chem. | pmid:20032470 |
Wang YY et al. | [Studies on the chemical constituents of Sarcopyramis nepalensis]. | 2009 | Zhong Yao Cai | pmid:20034215 |
Burt JM et al. | Uncoupling of cardiac cells by fatty acids: structure-activity relationships. | 1991 | Am. J. Physiol. | pmid:2003571 |
Pan PH et al. | Stearic acid attenuates cholestasis-induced liver injury. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20036638 |
O'Byrne SM et al. | Multiple pathways ensure retinoid delivery to milk: studies in genetically modified mice. | 2010 | Am. J. Physiol. Endocrinol. Metab. | pmid:20040693 |
Sadhu HG et al. | Poisoning of workers working in small lead-based units. | 2008 | Indian J Occup Environ Med | pmid:20040974 |
Blanco M and Peguero A | Influence of physical factors on the accuracy of calibration models for NIR spectroscopy. | 2010 | J Pharm Biomed Anal | pmid:20044229 |
Setty CM et al. | Development of fast dispersible aceclofenac tablets: effect of functionality of superdisintegrants. | 2008 Mar-Apr | Indian J Pharm Sci | pmid:20046709 |
Bhise SB and Aloorkar NH | Formulation and in vitro Evaluation of Floating Capsules of Theophylline. | 2008 Mar-Apr | Indian J Pharm Sci | pmid:20046717 |
Gohel MC et al. | Modulation of venlafaxine hydrochloride release from press coated matrix tablet. | 2008 May-Jun | Indian J Pharm Sci | pmid:20046735 |
Gohel MC and Sarvaiya KG | Exploration of cold extrusion for the preparation of enteric minitablets of isoniazid. | 2008 May-Jun | Indian J Pharm Sci | pmid:20046736 |
Issa MM et al. | Novel atomic absorption spectrometric and rapid spectrophotometric methods for the quantitation of paracetamol in saliva: application to pharmacokinetic studies. | 2008 May-Jun | Indian J Pharm Sci | pmid:20046743 |
Qureshi J et al. | Chronomodulated drug delivery system of salbutamol sulphate for the treatment of nocturnal asthma. | 2008 May-Jun | Indian J Pharm Sci | pmid:20046744 |
Ganesh S et al. | In vitro Evaluation of the Effect of Combination of Hydrophilic and Hydrophobic Polymers on Controlled Release Zidovudine Matrix Tablets. | 2008 Jul-Aug | Indian J Pharm Sci | pmid:20046771 |
Baldania SL et al. | RP-HPLC Estimation of Risperidone in Tablet Dosage Forms. | 2008 Jul-Aug | Indian J Pharm Sci | pmid:20046778 |
Syed AA and Syeda A | Spectrophotometric determination of certain benzimidazole proton pump inhibitors. | 2008 Jul-Aug | Indian J Pharm Sci | pmid:20046782 |
Masareddy RS et al. | Development of mouth dissolving tablets of clozapine using two different techniques. | 2008 Jul-Aug | Indian J Pharm Sci | pmid:20046788 |
Guo L and Qing Li G | Olfactory perception of oviposition-deterring fatty acids and their methyl esters by the Asian corn borer, Ostrinia furnacalis. | 2009 | J. Insect Sci. | pmid:20053122 |
Thomas CP et al. | Phospholipid-esterified eicosanoids are generated in agonist-activated human platelets and enhance tissue factor-dependent thrombin generation. | 2010 | J. Biol. Chem. | pmid:20061396 |
Lu L et al. | Near infrared spectroscopy of stearic acid adsorbed on montmorillonite. | 2010 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:20071218 |
Roblegg E et al. | Development of lipophilic calcium stearate pellets using ibuprofen as model drug. | 2010 | Eur J Pharm Biopharm | pmid:20080179 |
Badawy SI et al. | Effect of spray-dried mannitol on the performance of microcrystalline cellulose-based wet granulated tablet formulation. | 2010 Jul-Aug | Pharm Dev Technol | pmid:20088677 |
Cha KH et al. | Design of pH-independent extended release matrix tablets of minocycline hydrochloride for the treatment of dementia. | 2009 | Arch. Pharm. Res. | pmid:20091273 |
Wang J et al. | Lubrication in tablet formulations. | 2010 | Eur J Pharm Biopharm | pmid:20096779 |
Taylor M and Elhissi AM | Predicting the physical properties of tablets from ATR-FTIR spectra using partial least squares regression. | 2011 | Pharm Dev Technol | pmid:20100067 |
Bolton B and Halpern BP | Orthonasal and retronasal but not oral-cavity-only discrimination of vapor-phase fatty acids. | 2010 | Chem. Senses | pmid:20100787 |
Darwish IA et al. | Simple spectrophotometric method for determination of paroxetine in tablets using 1,2-naphthoquinone-4-sulphonate as a chromogenic reagent. | 2009 | Int J Anal Chem | pmid:20107559 |
Darwish IA et al. | New spectrophotometric and fluorimetric methods for determination of fluoxetine in pharmaceutical formulations. | 2009 | Int J Anal Chem | pmid:20107560 |
Tripathi B and Platel K | Finger millet (Eleucine coracana) flour as a vehicle for fortification with zinc. | 2010 | J Trace Elem Med Biol | pmid:20122580 |
Cho KH et al. | Monoacylglycerol (MAG)-oleic acid has stronger antioxidant, anti-atherosclerotic, and protein glycation inhibitory activities than MAG-palmitic acid. | 2010 | J Med Food | pmid:20136442 |
Mahmoud AM | New sensitive kinetic spectrophotometric methods for determination of omeprazole in dosage forms. | 2009 | Int J Anal Chem | pmid:20140076 |
Mahmoud AM et al. | Selective Spectrophotometric and Spectrofluorometric Methods for the Determination of Amantadine Hydrochloride in Capsules and Plasma via Derivatization with 1,2-Naphthoquinone-4-sulphonate. | 2009 | Int J Anal Chem | pmid:20140080 |
Yang X et al. | In vitro skin permeation of hinokitiol loaded in vesicles composed of behenyltrimethylammonium chloride and stearic acid. | 2010 | Drug Dev Ind Pharm | pmid:20141448 |
Taneri F et al. | In vitro and in vivo evaluation of oral tablet formulations prepared with ketoconazole and hydroxypropyl-beta-cyclodextrin. | 2010 | Drug Deliv | pmid:20148713 |
Abdel-Mottaleb MM et al. | In vitro drug release mechanism from lipid nanocapsules (LNC). | 2010 | Int J Pharm | pmid:20149853 |
Li LO et al. | Early hepatic insulin resistance in mice: a metabolomics analysis. | 2010 | Mol. Endocrinol. | pmid:20150186 |
Romanowicz L and Bańkowski E | Sphingolipids of human umbilical cord vein and their alteration in preeclampsia. | 2010 | Mol. Cell. Biochem. | pmid:20155487 |
Mathew M et al. | Elevated plasma free fatty acids increase cardiovascular risk by inducing plasma biomarkers of endothelial activation, myeloperoxidase and PAI-1 in healthy subjects. | 2010 | Cardiovasc Diabetol | pmid:20158910 |
Okada K et al. | Effect of fatty acids added to the milk replacer on white scour and excretion of fatty acids in Holstein calves. | 2009 | Anim. Sci. J. | pmid:20163618 |
Du YZ et al. | Stearic acid grafted chitosan oligosaccharide micelle as a promising vector for gene delivery system: factors affecting the complexation. | 2010 | Int J Pharm | pmid:20170716 |
Puzanowska-Tarasiewicz H et al. | Spectroscopic and electrochemical analysis of psychotropic drugs. | 2009 | Indian J Pharm Sci | pmid:20177449 |
Prajapati ST et al. | Studies on formulation and in vitro evaluation of floating matrix tablets of domperidone. | 2009 | Indian J Pharm Sci | pmid:20177450 |
Kurian GA et al. | Antioxidant effects of ethyl acetate extract of Desmodium gangeticum root on myocardial ischemia reperfusion injury in rat hearts. | 2010 | Chin Med | pmid:20180993 |
Huang WH et al. | Development of liposomal salbutamol sulfate dry powder inhaler formulation. | 2010 | Biol. Pharm. Bull. | pmid:20190418 |
Jeong SH and Park K | Simple preparation of coated resin complexes and their incorporation into fast-disintegrating tablets. | 2010 | Arch. Pharm. Res. | pmid:20191352 |
Mas S et al. | Local non-esterified fatty acids correlate with inflammation in atheroma plaques of patients with type 2 diabetes. | 2010 | Diabetes | pmid:20200316 |
Li Y et al. | Preparation and characterization of coverage-controlled CaCO3 nanoparticles. | 2010 | J Colloid Interface Sci | pmid:20202642 |
Ion G et al. | Maternal consumption of canola oil suppressed mammary gland tumorigenesis in C3(1) TAg mice offspring. | 2010 | BMC Cancer | pmid:20205934 |
Akazawa Y et al. | Palmitoleate attenuates palmitate-induced Bim and PUMA up-regulation and hepatocyte lipoapoptosis. | 2010 | J. Hepatol. | pmid:20206402 |
Ye S et al. | Polyunsaturated docosahexaenoic acid suppresses oxidative stress induced endothelial cell calcium influx by altering lipid composition in membrane caveolar rafts. | 2010 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20206488 |
Stanisz B et al. | Influence of humidity and hydroxypropyl cellulose, hydroxypropylmethyl cellulose, glyceryl behenate or magnesium stearate on the degradation kinetics of quinapril hydrochloride in solid phase. | 2010 Jan-Feb | Acta Pol Pharm | pmid:20210086 |
Duane PG et al. | Relationship of oxidant-mediated cytotoxicity to phospholipid metabolism in endothelial cells. | 1991 | Am. J. Respir. Cell Mol. Biol. | pmid:2021479 |
Xing Z et al. | The fabrication of novel nanobubble ultrasound contrast agent for potential tumor imaging. | 2010 | Nanotechnology | pmid:20220227 |
Desando MA et al. | Proton magnetic relaxation and the aggregation of n-octylammonium n-octadecanoate surfactant in deuterochloroform solution. | 2010 | J Colloid Interface Sci | pmid:20223468 |
Rajab M et al. | Optimization of a metformin effervescent floating tablet containing hydroxypropylmethylcellulose and stearic acid. | 2010 | Pharmazie | pmid:20225651 |
Choi JN et al. | Metabolomics revealed novel isoflavones and optimal cultivation time of Cordyceps militaris fermentation. | 2010 | J. Agric. Food Chem. | pmid:20225861 |
Xing Z et al. | Novel ultrasound contrast agent based on microbubbles generated from surfactant mixtures of Span 60 and polyoxyethylene 40 stearate. | 2010 | Acta Biomater | pmid:20226284 |
Mir VG et al. | Application of crustacean chitin as a co-diluent in direct compression of tablets. | 2010 | AAPS PharmSciTech | pmid:20238188 |
NIGHTINGALE G et al. | Effect of dihydroxystearic acid on vitamin K synthesis by rats. | 1947 | Arch Biochem | pmid:20291026 |
GREGORY JN and SPINK JA | Lubricating properties of molecular layers of stearic acid and calcium stearate on metal surfaces. | 1947 | Nature | pmid:20291788 |
Hsieh HT et al. | Facile synthesis of silver nanoparticles in CO2-expanded liquids from silver isostearate precursor. | 2010 | Langmuir | pmid:20297774 |
Shidhaye SS et al. | Buccal drug delivery of pravastatin sodium. | 2010 | AAPS PharmSciTech | pmid:20300898 |
Pantusa M and Bartucci R | Kinetics of stearic acid transfer between human serum albumin and sterically stabilized liposomes. | 2010 | Eur. Biophys. J. | pmid:20306030 |
Lin YK et al. | Combination of calcipotriol and methotrexate in nanostructured lipid carriers for topical delivery. | 2010 | Int J Nanomedicine | pmid:20309398 |