stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
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Authors | Title | Published | Journal | PubMed Link |
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Tai Z et al. | Biodegradable stearylated peptide with internal disulfide bonds for efficient delivery of siRNA in vitro and in vivo. | 2015 | Biomacromolecules | pmid:25686200 |
Thakkar A et al. | Evaluation of ibuprofen loaded solid lipid nanoparticles and its combination regimens for pancreatic cancer chemoprevention. | 2015 | Int. J. Oncol. | pmid:25652350 |
Sagiri SS et al. | Stearic acid based oleogels: a study on the molecular, thermal and mechanical properties. | 2015 | Mater Sci Eng C Mater Biol Appl | pmid:25579972 |
Rana S et al. | A spatio-temporal cardiomyocyte targeted vector system for efficient delivery of therapeutic payloads to regress cardiac hypertrophy abating bystander effect. | 2015 | J Control Release | pmid:25575863 |
Wei X et al. | Structure and properties of moisture-resistant konjac glucomannan films coated with shellac/stearic acid coating. | 2015 | Carbohydr Polym | pmid:25542116 |
Zeng Q et al. | Cationic micelle delivery of Trp2 peptide for efficient lymphatic draining and enhanced cytotoxic T-lymphocyte responses. | 2015 | J Control Release | pmid:25540903 |
Piantoni P et al. | Milk production responses to dietary stearic acid vary by production level in dairy cattle. | 2015 | J. Dairy Sci. | pmid:25529423 |
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Schrank S et al. | The effect of the drying temperature on the properties of wet-extruded calcium stearate pellets: pellet microstructure, drug distribution, solid state and drug dissolution. | 2015 | Int J Pharm | pmid:25526671 |
Foraita S et al. | Impact of the oxygen defects and the hydrogen concentration on the surface of tetragonal and monoclinic ZrO2 on the reduction rates of stearic acid on Ni/ZrO2. | 2015 | Chemistry | pmid:25504844 |
Yan S et al. | Autoxidated linolenic acid inhibits aflatoxin biosynthesis in Aspergillus flavus via oxylipin species. | 2015 | Fungal Genet. Biol. | pmid:25498164 |
Yang Y et al. | Ligand-directed stearic acid grafted chitosan micelles to increase therapeutic efficacy in hepatic cancer. | 2015 | Mol. Pharm. | pmid:25495890 |
Yi HX et al. | Effect of anionic PEGylated polypeptide on gene transfection mediated by glycolipid conjugate micelles. | 2015 | Mol. Pharm. | pmid:25490413 |
Leonardi A et al. | Cationic solid lipid nanoparticles enhance ocular hypotensive effect of melatonin in rabbit. | 2015 | Int J Pharm | pmid:25448580 |
Bootello MA et al. | Effect of solvents on the fractionation of high oleic-high stearic sunflower oil. | 2015 | Food Chem | pmid:25442612 |
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Liu Z et al. | Process optimization and kinetic evaluation for biosynthesis of D-isoascorbyl stearate. | 2015 | Bioprocess Biosyst Eng | pmid:25407728 |
Cantor SL et al. | Development and optimization of taste-masked orally disintegrating tablets (ODTs) of clindamycin hydrochloride. | 2015 | Drug Dev Ind Pharm | pmid:25000481 |
Qu L et al. | Investigation of the potential for direct compaction of a fine ibuprofen powder dry-coated with magnesium stearate. | 2015 | Drug Dev Ind Pharm | pmid:24738790 |
Momoh MA et al. | Influence of magnesium stearate on the physicochemical and pharmacodynamic characteristics of insulin-loaded Eudragit entrapped mucoadhesive microspheres. | 2015 | Drug Deliv | pmid:24670092 |
Mohanty B et al. | Development and characterization of itraconazole-loaded solid lipid nanoparticles for ocular delivery. | 2015 | Pharm Dev Technol | pmid:24490828 |
Guadalupe Sánchez-González E et al. | The influence of polymorphism on the manufacturability and in vitro dissolution of sulindac-containing hard gelatin capsules. | 2015 | Pharm Dev Technol | pmid:24417644 |
Doignon F et al. | Requirement of Phosphoinositides Containing Stearic Acid To Control Cell Polarity. | 2015 | Mol. Cell. Biol. | pmid:26711260 |
Miyazaki Y et al. | Dry Powder Coating using Planetary Centrifugal Mixer. | 2015 | J Pharm Pharm Sci | pmid:26517137 |
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Iwao Y | [Efficient Pharmaceutical Formulation Designs and Their Development Using Mathematical and Statistical Analysis]. | 2015 | Yakugaku Zasshi | pmid:26423868 |
Liu Z et al. | A novel stearic acid-modified hirudin peptidomimetic with improved pharmacokinetic properties and anticoagulant activity. | 2015 | Sci Rep | pmid:26400022 |
Onishi H et al. | In vitro and in vivo evaluations of buccal tablet formulations of ritodrine hydrochloride. | 2015 | Biol. Pharm. Bull. | pmid:26027834 |
Rehman M et al. | Solid and liquid lipid-based binary solid lipid nanoparticles of diacerein: in vitro evaluation of sustained release, simultaneous loading of gold nanoparticles, and potential thermoresponsive behavior. | 2015 | Int J Nanomedicine | pmid:25897224 |
Harding SV et al. | Desaturation index versus isotopically measured de novo lipogenesis as an indicator of acute systemic lipogenesis. | 2015 | BMC Res Notes | pmid:25879456 |
Silva-Neta IC et al. | Expression of genes related to tolerance to low temperature for maize seed germination. | 2015 | Genet. Mol. Res. | pmid:25867416 |
Jung SW et al. | Mechanism of antibacterial activity of liposomal linolenic acid against Helicobacter pylori. | 2015 | PLoS ONE | pmid:25793403 |
Othman AR et al. | Elucidation of in-vitro anti-inflammatory bioactive compounds isolated from Jatropha curcas L. plant root. | 2015 | BMC Complement Altern Med | pmid:25652309 |
Aardema H et al. | Free fatty acid levels in fluid of dominant follicles at the preferred insemination time in dairy cows are not affected by early postpartum fatty acid stress. | 2015 | J. Dairy Sci. | pmid:25648816 |
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Veselỳ M et al. | Photocatalytic and Antimicrobial Activity of Printed Hybrid Titania/Silica Layers. | 2015 | J Nanosci Nanotechnol | pmid:26716211 |
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Sasakura D et al. | Application of the quantitative detection of a change in concentration of magnesium stearate in a feeder tube of tableting manufacture by real-time near-infrared spectroscopy. | 2015 | Pharmazie | pmid:26601418 |
Maphalla TG and Emmambux MN | Functionality of maize, wheat, teff and cassava starches with stearic acid and xanthan gum. | 2016 | Carbohydr Polym | pmid:26572436 |
Du J and Li L | Which one performs better for targeted lung cancer combination therapy: pre- or post-bombesin-decorated nanostructured lipid carriers? | 2016 | Drug Deliv | pmid:26455787 |
Kumar Gaur P et al. | Nanovesicles of nitrendipine with lipid complex for transdermal delivery: pharmacokinetic and pharmacodynamic studies. | 2016 | Artif Cells Nanomed Biotechnol | pmid:26375758 |
Li X et al. | Preparation of co-spray dried cushioning agent containing stearic acid for protecting pellet coatings when compressed. | 2016 | Drug Dev Ind Pharm | pmid:26289006 |
Uğurlu T and Halaçoğlu MD | Effects of hexagonal boron nitride on dry compression mixture of Avicel DG and Starch 1500. | 2016 | Pharm Dev Technol | pmid:25716058 |
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Pradhan M et al. | Influence of selected variables on fabrication of Triamcinolone acetonide loaded solid lipid nanoparticles for topical treatment of dermal disorders. | 2016 | Artif Cells Nanomed Biotechnol | pmid:25229831 |
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Guan Q et al. | Docetaxel-Loaded Self-Assembly Stearic Acid-Modified Bletilla striata Polysaccharide Micelles and Their Anticancer Effect: Preparation, Characterization, Cellular Uptake and In Vitro Evaluation. | 2016 | Molecules | pmid:27918445 |
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Li T et al. | Defense priming by non-jasmonate producing fatty acids in maize (Zea mays). | 2016 | Plant Signal Behav | pmid:27763804 |
Kanasaki Y et al. | Application of Quartz Crystal Microbalance as a Tool for Detergency Evaluation of Fatty Acid Contamination in Aqueous Systems. | 2016 | J Oleo Sci | pmid:27725481 |
Souza AF et al. | Waste Soybean Oil and Corn Steep Liquor as Economic Substrates for Bioemulsifier and Biodiesel Production by Candida lipolytica UCP 0998. | 2016 | Int J Mol Sci | pmid:27669227 |
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Meng T et al. | A spermine conjugated stearic acid-g-chitosan oligosaccharide polymer with different types of amino groups for efficient p53 gene therapy. | 2016 | Colloids Surf B Biointerfaces | pmid:27289311 |
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Zhao H et al. | Self-assembly of hydrogen-bonded supramolecular complexes of nucleic-acid-base and fatty-acid at the liquid-solid interface. | 2016 | Phys Chem Chem Phys | pmid:27170421 |
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Wang HJ et al. | Prolongation of the degradation period and improvement of the angiogenesis of zein porous scaffolds in vivo. | 2016 | J Mater Sci Mater Med | pmid:26979976 |
Cheng CL et al. | Spectral and morphological classification of different chronic and acute Taiwanese gallstones via FTIR, SEM and ESEM-EDX microanalyses. | 2016 | Dig Liver Dis | pmid:26976784 |
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Lu H et al. | Elevated circulating stearic acid leads to a major lipotoxic effect on mouse pancreatic beta cells in hyperlipidaemia via a miR-34a-5p-mediated PERK/p53-dependent pathway. | 2016 | Diabetologia | pmid:26969487 |
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