stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Nadkarni MS et al. | Treatment of acute bacterial infections of the upper respiratory tract. | 1977 | Curr Med Res Opin | pmid:326492 |
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Burns CP et al. | Fatty acid utilization by L1210 murine leukemia cells. | 1977 | Cancer Res. | pmid:558821 |
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Sixsmith D | The properties of tablets containing microcrystalline cellulose. | 1977 | J. Pharm. Pharmacol. | pmid:15069 |
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Triggs EJ and Ashley JJ | Oral administration of erythromycin stearate: effect of dosage form on plasma levels. | 1978 | Med. J. Aust. | pmid:713930 |
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Ahmed M and Enever RP | The influence of magnesium stearate on physical properties and biological availability of sulphadiazine tablet formulations. | 1978 | Pharm Acta Helv | pmid:746045 |
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Meakin BJ et al. | The implication of stearate mould release agents in the loss of benzalkonium chloride from ophthalmic solutions in polyethylene bottles [proceedings]. | 1978 | J. Pharm. Pharmacol. | pmid:32268 |
Melander A | Influence of food on the bioavailability of drugs. | 1978 Sep-Oct | Clin Pharmacokinet | pmid:81118 |
Irvine RF et al. | The calcium-dependent phosphatidylinositol-phosphodiesterase of rat brain. Mechanisms of suppression and stimulation. | 1979 | Eur. J. Biochem. | pmid:227685 |
Butzler JP et al. | Clinical and pharmacological evaluation of different preparations of oral erythromycin. | 1979 | Chemotherapy | pmid:316377 |
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Welling PG et al. | Plasma levels following single and repeated doses of erythromycin estolate and erythromycin stearate. | 1979 | J Pharm Sci | pmid:423080 |
Lerk CF et al. | Effect of microcrystalline cellulose on liquid penetration in and disintegration of directly compressed tablets. | 1979 | J Pharm Sci | pmid:423092 |
Saarni H et al. | Erythromycin levels in serum during treatment with erythromycin stearate and base. | 1979 | Ann. Clin. Res. | pmid:397800 |
Tierno MA and Brenner RR | [Biochemistry of the developmental cycle of Triatoma infestans (Vinchuca). 2. Biosynthesis of fatty acids]. | 1979 | Acta Physiol Lat Am | pmid:400672 |
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Bhatia RP and Lordi NG | Conductivity and hardness changes in aged compacts. | 1979 | J Pharm Sci | pmid:458612 |
Holub BJ and Piekarski J | The formation of phosphatidylinositol by acylation of 2-acyl-sn-glycero-3-phosphorylinositol in rat liver microsomes. | 1979 | Lipids | pmid:459717 |
Berend N et al. | Plasma and saliva concentrations for a new formulation of erythromycin stearate. | 1979 | Curr Med Res Opin | pmid:467089 |
Doran TA et al. | Amniotic fluid lecithin/sphingomyelin ratio, palmitic acid, palmitic acid/stearic acid ratio, total cortisol, creatinine, and percentage of lipid-positive cells in assessment of fetal maturity and fetal pulmonary maturity: a comparison. | 1979 | Am. J. Obstet. Gynecol. | pmid:433991 |
Nielsen GD et al. | [Aspiration of talcum or powder containing zinc stearate by children]. | 1979 | Ugeskr. Laeg. | pmid:442270 |
Dunlop EM et al. | Penicillin levels in blood and CSF achieved by treatment of syphilis. | 1979 | JAMA | pmid:374763 |
Malmborg AS | Effect of food on absorption of erythromycin. A study of two derivatives, the stearate and the base. | 1979 | J. Antimicrob. Chemother. | pmid:500517 |
Wosilait WD and Ryan MP | The effects of oleic acid, tolbutamide, and oxyphenbutazone on the binding of warfarin by human serum albumin. | 1979 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:504792 |
Rutland J et al. | The influence of food on the bioavailability of new formulations of erythromycin stearate and base. | 1979 | Br J Clin Pharmacol | pmid:508509 |
Yakatan GJ et al. | Single-dose fasting bioequivalence assessment of erythromycin stearate tablets in man. | 1979 | J Pharmacokinet Biopharm | pmid:512842 |
Molloy PL and Eisenstadt JM | Erythromycin resistance in mouse L cells. | 1979 | Somatic Cell Genet. | pmid:531731 |
Stewart AG et al. | The release of a model low-dose drug (riboflavine) from hard gelatin capsule formulations. | 1979 | J. Pharm. Pharmacol. | pmid:32357 |
Fraschini F et al. | Bactericidal action of an average dose of erythromycin in the bronchi. | 1979 | Curr Med Res Opin | pmid:38063 |
Russell NJ and Harwood JL | Changes in the acyl lipid composition of photosynthetic bacteria grown under photosynthetic and non-photosynthetic conditions. | 1979 | Biochem. J. | pmid:115463 |
Lassus A et al. | Erythromycin and lymecycline treatment in chlamydia-positive and Chlamydia-negative non-gonococcal urethritis--a partner-controlled study. | 1979 | Acta Derm. Venereol. | pmid:87096 |
Kaur R and Grant DJ | Solid dispersions of drugs in polyoxyethylene 40 stearate: dissolution rates and physico-chemical interactions [proceedings]. | 1979 | J. Pharm. Pharmacol. | pmid:42723 |
Eccleston GM | The structure and stability of O/W emulsions stabilised by polyethylene glycol 1000 monostearate/fatty alcohols [proceedings]. | 1979 | J. Pharm. Pharmacol. | pmid:42725 |
Moody G et al. | Lubricity measurements of magnesium stearate [proceedings]. | 1979 | J. Pharm. Pharmacol. | pmid:42749 |
Rambaut PC and Johnston RS | Prolonged weightlessness and calcium loss in man. | 1979 | Acta Astronaut | pmid:11883480 |
Nicoletti R et al. | [Palmitic acid-stearic acid ratio with reference to the fatty tissue properties in the human species]. | 1979 May-Jun | Arch Kriminol | pmid:573992 |
Pinzauti S and La Porta E | Assay of a cetylpyridinium-dequalinium chlorides combination in compressed lozenges: uptake of quaternary ammonium salts by magnesium stearate. | 1979 Sep-Oct | J Pharm Belg | pmid:512830 |
Sanders KL et al. | Relapse of Legionnaires' disease in a renal transplant recipient. | 1980 | Arch. Intern. Med. | pmid:6992727 |
Fraser DG | Selection of an oral erythromycin product. | 1980 | Am J Hosp Pharm | pmid:6998290 |
Selenke WM et al. | Nonantibiotic effects of macrolide antibiotics of the oleandomycin-erythromycin group with special reference to their "steroid-sparing" effects. | 1980 | J. Allergy Clin. Immunol. | pmid:6966289 |
Hambleton PL et al. | Dietary fat and exercise conditioning effect on metabolic parameters in the horse. | 1980 | J. Anim. Sci. | pmid:7204274 |
Nakagawa H et al. | [Effects of particle size of rifampicin and addition of magnesium stearate on release of rifampicin from hard gelatin capsules (author's transl)]. | 1980 | Yakugaku Zasshi | pmid:7205556 |
Wenzel DG and Kleoppel JW | Incorporation of saturated and cis- and trans-unsaturated long chain fatty acids in rat myocytes and increased susceptibility to arrhythmias. | 1980 | Toxicology | pmid:7210021 |
Oriel JD and Ridgway GL | Comparison of erythromycin and oxytetracycline in the treatment of cervical infection by Chlamydia trachomatis. | 1980 | J. Infect. | pmid:7185927 |
Chien JL and Hogan EL | Characterization of two gangliosides of the paragloboside series from chicken skeletal muscle. | 1980 | Biochim. Biophys. Acta | pmid:7236652 |
Jordan BR and Harwood JL | Fatty acid elongation by a particulate fraction from germinating pea. | 1980 | Biochem. J. | pmid:7283974 |
Thompson SE et al. | Gonococcal tenosynovitis-dermatitis and septic arthritis. Intravenous penicillin vs oral erythromycin. | 1980 | JAMA | pmid:7411761 |
Baker RR and Chang H | The fatty acid composition of lipids of neuronal and glial nuclear fractions isolated from 15-day-old rabbit cerebral cortex. | 1980 | Can. J. Biochem. | pmid:6161681 |
Hyono A et al. | ESR studies on the membrane properties of a moderately halophilic bacterium. I. Physical properties of lipid bilayers in whole cells. | 1980 | J. Biochem. | pmid:6257661 |
Pollard MR and Stumpf PK | Biosynthesis of C(20) and C(22) Fatty Acids by Developing Seeds of Limnanthes alba: CHAIN ELONGATION AND Delta5 DESATURATION. | 1980 | Plant Physiol. | pmid:16661496 |
Udeala OK et al. | Preliminary evaluation of dika fat, a new tablet lubricant. | 1980 | J. Pharm. Pharmacol. | pmid:6102130 |
Clarke CW et al. | A new formulation of erythromycin stearate: blood and sputum levels in patients with chronic lower respiratory tract infection. | 1980 | J. Antimicrob. Chemother. | pmid:7400071 |
Matocha M and Wood R | Changes in host animal plasma lipids during hepatoma growth. | 1980 | Lipids | pmid:7401940 |
Holub BJ et al. | Relative suitability of 1-palmitoyl and 1-stearoyl homologues of 1-acyl-sn-glycerylphosphorylcholine and different acyl donors for phosphatidylcholine synthesis via acyl-CoA:1-acyl-sn-glycero-3-phosphorylcholine acyltransferase in rat lung microsomes. | 1980 | Can. J. Biochem. | pmid:7407680 |
Morimoto K and Kanoh H | The role of the de novo synthetic pathway in forming molecular species of phospholipids in resting lymphocytes from human tonsils. | 1980 | Biochim. Biophys. Acta | pmid:7353023 |
Shepherd J et al. | Effects of saturated and polyunsaturated fat diets on the chemical composition and metabolism of low density lipoproteins in man. | 1980 | J. Lipid Res. | pmid:7354257 |
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Herrmann H and Gercken G | Incorporation of [1-14C]octadecanol into the lipids of Leishmania donovani. | 1980 | Lipids | pmid:7374369 |
Craven PA et al. | Calcium-dependent action of osmolality on adenosine 3',5'-monophosphate accumulation in rat renal inner medulla: evidence for a relationship to calcium-responsive arachidonate release and prostaglandin synthesis. | 1980 | J. Clin. Invest. | pmid:6243313 |
Marlin GE et al. | Plasma and sputum erythromycin concentrations in chronic bronchitis. | 1980 | Thorax | pmid:7434299 |
Søndergaard D et al. | Magnesium stearate given perorally to rats. A short term study. | 1980 | Toxicology | pmid:7434368 |
Colmano G et al. | Activation of antibacterial silver coatings on surgical implants by direct current: preliminary studies in rabbits. | 1980 | Am. J. Vet. Res. | pmid:7436092 |
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Polnikorn N et al. | Penicillin concentrations in cerebrospinal fluid after different treatment regimens for syphilis. | 1980 | Br J Vener Dis | pmid:7448578 |
Stavchansky S et al. | Correlation of in vivo bioavailability of erythromycin stearate tablets with in vitro tests. | 1980 | J Pharm Sci | pmid:7452460 |
Kaur R et al. | Comparison of polyethylene glycol and polyoxyethylene stearate as excipients for solid dispersion systems of griseofulvin and tolbutamide I: phase equilibria. | 1980 | J Pharm Sci | pmid:7452463 |
Kaur R et al. | Comparison of polyethylene glycol and polyoxyethylene stearate as excipients for solid dispersion systems of griseofulvin and tolbutamide II: dissolution and solubility studies. | 1980 | J Pharm Sci | pmid:7452464 |
Light ND and Bailey AJ | Polymeric C-terminal cross-linked material from type-I collagen. A modified method for purification, anomalous behaviour on gel filtration, molecular weight estimation, carbohydrate content and lipid content. | 1980 | Biochem. J. | pmid:7458897 |
Bonini de Romanelli IC et al. | Phosphatidic acid, phosphatidylinositol, phosphatidylserine and cardiolipin in the course of early embryonic development. Fatty acid composition and content in whole toad embryos and in mitochondrial fractions. | 1981 | Biochim. Biophys. Acta | pmid:6791698 |
Yamauchi T et al. | Thermal adaptation of Tetrahymena membranes with special reference to mitochondria. Role of cardiolipin in fluidity of mitochondrial membranes. | 1981 | Biochim. Biophys. Acta | pmid:6797472 |
Walsh C et al. | Arachidonate metabolism by neutrophils. | 1981 | Prog. Lipid Res. | pmid:6804984 |
Teyssier G et al. | [Adult-type respiratory distress syndrome in children. Course of the palmitic acid/stearic acid ratio in tracheal aspirations]. | 1981 | Nouv Presse Med | pmid:7290945 |
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Rosenthal MD | Accumulation of neutral lipids by human skin fibroblasts: differential effects of saturated and unsaturated fatty acids. | 1981 | Lipids | pmid:7219087 |
Kudoh T et al. | Metabolism of fatty acid-labeled cerebroside sulfate in cultured cells from controls and metachromatic leukodystrophy patients. Use in the prenatal identification of a false positive fetus. | 1981 | J. Lab. Clin. Med. | pmid:6117597 |
Mesiha MS and El-Bitar HI | Hypoglycaemic effect of oral insulin preparations containing Brij 35, 52, 58 or 92 and stearic acid. | 1981 | J. Pharm. Pharmacol. | pmid:6118416 |
Yue KT et al. | Effect of glucose on plasma concentrations of individual non-esterified fatty acids of non-diabetic and insulin-independent diabetic men. | 1981 | Postgrad Med J | pmid:7335561 |