stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Wu JX et al. | Chemical imaging and solid state analysis at compact surfaces using UV imaging. | 2014 | Int J Pharm | pmid:25445531 |
MuselÃk J et al. | Influence of process parameters on content uniformity of a low dose active pharmaceutical ingredient in a tablet formulation according to GMP. | 2014 | Acta Pharm | pmid:25296681 |
Tsukada G et al. | Temperature triggered shape memory effect of transpolyisoprene-based polymer. | 2014 | J Endod | pmid:25260740 |
Pandey P et al. | Excipient-process interactions and their impact on tablet compaction and film coating. | 2014 | J Pharm Sci | pmid:25223603 |
Kushner J and Schlack H | Commercial scale validation of a process scale-up model for lubricant blending of pharmaceutical powders. | 2014 | Int J Pharm | pmid:25152166 |
Mateo-Ortiz D et al. | Analysis of powder phenomena inside a Fette 3090 feed frame using in-line NIR spectroscopy. | 2014 | J Pharm Biomed Anal | pmid:25128874 |
Horio T et al. | Effect of particle shape on powder flowability of microcrystalline cellulose as determined using the vibration shear tube method. | 2014 | Int J Pharm | pmid:25079435 |
Yodkhum K and Phaechamud T | Hydrophobic chitosan sponges modified by aluminum monostearate and dehydrothermal treatment as sustained drug delivery system. | 2014 | Mater Sci Eng C Mater Biol Appl | pmid:25063173 |
Han GR and Jang CH | Detection of heavy-metal ions using liquid crystal droplet patterns modulated by interaction between negatively charged carboxylate and heavy-metal cations. | 2014 | Talanta | pmid:25059128 |
Igne B et al. | Modeling strategies for pharmaceutical blend monitoring and end-point determination by near-infrared spectroscopy. | 2014 | Int J Pharm | pmid:25003830 |
Syamala US et al. | Assessment of formulation factors on the release behaviour of BCS Class II drug from tablet dosage form using DoE. | 2014 | Curr Drug Deliv | pmid:24975287 |
Liu J et al. | Functional investigations on embryonic stem cells labeled with clinically translatable iron oxide nanoparticles. | 2014 | Nanoscale | pmid:24969040 |
Tadros MI and Fahmy RH | Controlled-release triple anti-inflammatory therapy based on novel gastroretentive sponges: characterization and magnetic resonance imaging in healthy volunteers. | 2014 | Int J Pharm | pmid:24928130 |
Treffer D et al. | In-line implementation of an image-based particle size measurement tool to monitor hot-melt extruded pellets. | 2014 | Int J Pharm | pmid:24614578 |
Haware RV et al. | Application of multivariate methods to evaluate the functionality of bovine- and vegetable-derived magnesium stearate. | 2014 | J Pharm Sci | pmid:24596131 |
Guo H et al. | In vitro and in vivo study of Gal-OS self-assembled nanoparticles for liver-targeting delivery of doxorubicin. | 2014 | J Pharm Sci | pmid:24549734 |
Rico JE et al. | Compared with stearic acid, palmitic acid increased the yield of milk fat and improved feed efficiency across production level of cows. | 2014 | J. Dairy Sci. | pmid:24342689 |
Petridis L et al. | Spatial arrangement of organic compounds on a model mineral surface: implications for soil organic matter stabilization. | 2014 | Environ. Sci. Technol. | pmid:24328330 |
Mandal S et al. | Enhancement of survival of alginate-encapsulated Lactobacillus casei NCDC 298. | 2014 | J. Sci. Food Agric. | pmid:24307185 |
Uğurlu T and Halaçoğlu MD | Effects of some lubricants and evaluation of compression parameters on directly compressible powders. | 2014 | Pharm Dev Technol | pmid:23590449 |
Pavićević ID et al. | Fatty acids binding to human serum albumin: Changes of reactivity and glycation level of Cysteine-34 free thiol group with methylglyoxal. | 2014 | Chem. Biol. Interact. | pmid:25451573 |
Lorenzo JM | Changes on physico-chemical, textural, lipolysis and volatile compounds during the manufacture of dry-cured foal "cecina". | 2014 | Meat Sci. | pmid:23916960 |
Maghsoodi M | Floating-pulsatile release multiparticulate system for chronopharmacotherapy: effect of some hydrophobic additives on the buoyancy and release behavior of particles. | 2014 | Drug Res (Stuttg) | pmid:23950100 |
Gouk SW et al. | Stearic acids at sn-1, 3 positions of TAG are more efficient at limiting fat deposition than palmitic and oleic acids in C57BL/6 mice. | 2014 | Br. J. Nutr. | pmid:24286356 |
Chen FY et al. | TNYL peptide functional chitosan-g-stearate conjugate micelles for tumor specific targeting. | 2014 | Int J Nanomedicine | pmid:25298734 |
DÃaz R et al. | Identification of fatty acids in canine seminal plasma. | 2014 | Andrologia | pmid:23398451 |
Eiras CE et al. | Glycerine levels in the diets of crossbred bulls finished in feedlot: carcass characteristics and meat quality. | 2014 | Meat Sci. | pmid:24211551 |
Gillman JD et al. | Deletions of the SACPD-C locus elevate seed stearic acid levels but also result in fatty acid and morphological alterations in nitrogen fixing nodules. | 2014 | BMC Plant Biol. | pmid:24886084 |
Carrero-Colón M et al. | Mutations in SACPD-C result in a range of elevated stearic acid concentration in soybean seed. | 2014 | PLoS ONE | pmid:24846334 |
Gebauer SK et al. | Impact of stearic acid and oleic acid on hemostatic factors in the context of controlled diets consumed by healthy men. | 2014 | Eur J Clin Nutr | pmid:24736679 |
Liau CP et al. | Preparation and characterization of polyhydroxybutyrate/polycaprolactone nanocomposites. | 2014 | ScientificWorldJournal | pmid:24600329 |
Woo JO et al. | Development of a controlled release of salicylic acid loaded stearic acid-oleic acid nanoparticles in cream for topical delivery. | 2014 | ScientificWorldJournal | pmid:24578624 |
Yee JK et al. | High oleic/stearic fatty-acid desaturation index in cord plasma from infants of mothers with gestational diabetes. | 2014 | J Perinatol | pmid:24577432 |
Zhao X et al. | Diet modulation is an effective complementary agent in preventing and treating breast cancer lung metastasis. | 2014 | Clin. Exp. Metastasis | pmid:24832758 |
Aznar-Moreno JA et al. | Sunflower (Helianthus annuus) long-chain acyl-coenzyme A synthetases expressed at high levels in developing seeds. | 2014 | Physiol Plant | pmid:24102504 |
Huang FC et al. | Expression and characterization of CYP52 genes involved in the biosynthesis of sophorolipid and alkane metabolism from Starmerella bombicola. | 2014 | Appl. Environ. Microbiol. | pmid:24242247 |
Sassa T et al. | Lorenzo's oil inhibits ELOVL1 and lowers the level of sphingomyelin with a saturated very long-chain fatty acid. | 2014 | J. Lipid Res. | pmid:24489110 |
Maretti E et al. | Inhaled Solid Lipid Microparticles to target alveolar macrophages for tuberculosis. | 2014 | Int J Pharm | pmid:24374224 |
Samanta AK et al. | Energy-based analysis of cone milling process for the comminution of roller compacted flakes. | 2014 | Int J Pharm | pmid:24374608 |
Doig M et al. | Structure and friction of stearic acid and oleic acid films adsorbed on iron oxide surfaces in squalane. | 2014 | Langmuir | pmid:24364665 |
Sertoglu E et al. | Comparison of plasma and erythrocyte membrane fatty acid compositions in patients with end-stage renal disease and type 2 diabetes mellitus. | 2014 | Chem. Phys. Lipids | pmid:24384240 |
Khodadoust S et al. | Identification and determination of the fatty acid composition of Quercus brantii growing in southwestern Iran by GC-MS. | 2014 | Nat. Prod. Res. | pmid:24499169 |
Wu MH et al. | A novel sodium N-fatty acyl amino acid surfactant using silkworm pupae as stock material. | 2014 | Sci Rep | pmid:24651079 |
Kumar SS et al. | Synthesis and characterization of curcumin loaded polymer/lipid based nanoparticles and evaluation of their antitumor effects on MCF-7 cells. | 2014 | Biochim. Biophys. Acta | pmid:24440669 |
Wang J et al. | A soybean acyl carrier protein, GmACP, is important for root nodule symbiosis. | 2014 | Mol. Plant Microbe Interact. | pmid:24400939 |
Saerens L et al. | Validation of an in-line Raman spectroscopic method for continuous active pharmaceutical ingredient quantification during pharmaceutical hot-melt extrusion. | 2014 | Anal. Chim. Acta | pmid:24331054 |
Liu J et al. | Saturated fatty acids up-regulate COX-2 expression in prostate epithelial cells via toll-like receptor 4/NF-κB signaling. | 2014 | Inflammation | pmid:24221358 |
Kushner J et al. | A quality-by-design study for an immediate-release tablet platform: examining the relative impact of active pharmaceutical ingredient properties, processing methods, and excipient variability on drug product quality attributes. | 2014 | J Pharm Sci | pmid:24375069 |
Dou J et al. | Preparation and evaluation in vitro and in vivo of docetaxel loaded mixed micelles for oral administration. | 2014 | Colloids Surf B Biointerfaces | pmid:24157590 |
Meulenaar J et al. | Development of an extended-release formulation of capecitabine making use of in vitro-in vivo correlation modelling. | 2014 | J Pharm Sci | pmid:24311366 |