stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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DAVIDOFF F and KORN ED | Synthesis of unsaturated fatty acids in the cellular slime mold. | 1962 | Biochem. Biophys. Res. Commun. | pmid:14025332 |
CREASEY WA | Observations on the activation of stearic acid by rat-liver preparations. | 1962 | Biochim. Biophys. Acta | pmid:14023748 |
WELD JT et al. | Production of octadecenoic acid in plasma by Staphylococcus aureus. | 1963 | Proc. Soc. Exp. Biol. Med. | pmid:13999824 |
WALLEN LL et al. | The microbiological production of 10-hydroxystearic acid from oleic acid. | 1962 | Arch. Biochem. Biophys. | pmid:13998583 |
TROUT DL and ESTES EH | Factors affecting liver uptake of serum free stearic acid-1-C14. | 1962 | Am. J. Physiol. | pmid:13994303 |
ROSENBERG MD | Cell guidance by alterations in monomolecular films. | 1963 | Science | pmid:13974905 |
BAKER RW et al. | Fatty-acid composition of brain lecithins in multiple sclerosis. | 1963 | Lancet | pmid:13969172 |
BONSER GM et al. | A further study of bladder implantation in the mouse as a means of detecting carcinogenic activity: use of crushed paraffin wax or stearic acid as the vehicle. | 1963 | Br. J. Cancer | pmid:13968883 |
BONE GJ and PARENT G | Stearic acid, an essential growth factor for Trypanosoma cruzi. | 1963 | J. Gen. Microbiol. | pmid:13968755 |
BIOZZI G et al. | [Stimulation and depression of the phagocytic function of the reticuloendothelial system by lipid emulsions. Relation to some immunological phenomena]. | 1963 | Rev Fr Etud Clin Biol | pmid:13968394 |
BARGONI N and SISINI A | [Inhibition and reactivation of the hydrolases of digestion]. | 1962 | Boll. Soc. Ital. Biol. Sper. | pmid:13966663 |
FOTI L et al. | [In vitro liver biosynthesis of cholesterol from acetate, stearate and linoleate 1-C-14]. | 1961 | Boll. Soc. Ital. Biol. Sper. | pmid:13958917 |
FOSSA T | [Inhibition of hepatic glucose-6-phosphatase by fatty acids and zinc ions]. | 1962 | Boll. Soc. Ital. Biol. Sper. | pmid:13958874 |
JAMES AT | [Studies on the biosynthesis of 18 carbon mono-and tri-unsaturated fatty acids by gas phase chromatography]. | 1962 | Bull. Soc. Chim. Biol. | pmid:13957228 |
HUEPER WC and PAYNE WW | Polyoxyethylene(8)stearate. Carcinogenic studies. | 1963 | Arch. Environ. Health | pmid:13955486 |
HALL PF et al. | Synthesis of fatty acids by testicular tissue in vitro. | 1963 | Can J Biochem Physiol | pmid:13952129 |
GUTIERREZ J et al. | Lipid metabolism of rumen ciliates and bacteria. I. Uptake of fatty acids by Isotricha prostoma and Entodinium simplex. | 1962 | Appl Microbiol | pmid:13951437 |
OSTWALD R | Fat content and fatty acids in some commercial mixes for baked products. | 1963 | J Am Diet Assoc | pmid:13940620 |
NIELSEN K and SCHMIDT H | [Should the standard treatment of gonorrhea be changed? Effects of the treatment of gonorrhea in 1960 in ambulant and hospitalized patients]. | 1962 | Manedsskr Prakt Laegegern | pmid:13938514 |
NAKAGAKI M and NISHINO M | [Studies on the physicochemical properties of aluminum soap. II. Structural viscosity of aluminum stearate in benzene]. | 1963 | Yakugaku Zasshi | pmid:13937343 |
KUNUGI K | Studies on the syntheses of sucrose fatty acid esters. III. Re-esterification of sucrose monostearate. | 1963 | Chem. Pharm. Bull. | pmid:13927388 |
KUNUGI K | Studies on the syntheses of sucrose fatty acid esters. II. Separation of the alcoholyses products by liquid column chromatography and determination of the contents of sucrose monostearate. | 1963 | Chem. Pharm. Bull. | pmid:13927387 |
AGARWAL SC et al. | Blood-level duration limit test of procaine benzylpenicillin in sheep. | 1961 | Bull. World Health Organ. | pmid:13859560 |
Bengochea LA et al. | Changes in microsomal phospholipid fatty acids composition in cholestatic rats. | 1992 Mar-Apr | Arch Int Physiol Biochim Biophys | pmid:1379485 |
SHANES AM and GERSHFELD NL | Interactions of veratrum alkaloids, procaine, and calcium with monolayers of stearic acid and their implications for pharmacological action. | 1960 | J. Gen. Physiol. | pmid:13750673 |
SKIPSKI VP et al. | Identification of 2-hydroxystearic acid in spinal cord phrenosine by chromatographic separation of hydroxy fatty acids. | 1959 | Arch. Biochem. Biophys. | pmid:13661981 |
FITZHUGH OG et al. | Chronic oral toxicities of four stearic acid emulsifiers. | 1959 | Toxicol. Appl. Pharmacol. | pmid:13659539 |
GERSHFELD NL and SHANES AM | Antagonism of veratrine by calcium ion in monolayers of stearic acid. | 1959 | Science | pmid:13658972 |
BLOMSTRAND R et al. | Asymmetric incorporation of linoleic acid-1-C14 and stearic acid-1-C14 into human lymph lecithins during fat absorption. | 1959 | Proc. Soc. Exp. Biol. Med. | pmid:13645714 |
Fatani W and Rosen D | Irradiation of Langmuir-Blodgett multilayer preparations of phospholipids and a fatty acid. 2: Effect of X-radiation. | 1992 | Int. J. Radiat. Biol. | pmid:1362757 |
Fatani W and Rosen D | Irradiation of Langmuir-Blodgett multilayer preparations of phospholipids and a fatty acid. 1: Effect of UV radiation. | 1992 | Int. J. Radiat. Biol. | pmid:1362756 |
LONG CL et al. | An investigation of the in vivo hydrolysis and absorption of propylene glycol distearate. | 1958 | Arch. Biochem. Biophys. | pmid:13584007 |
LONG CL et al. | Studies on absorption and metabolism of propylene glycol distearate. | 1958 | Arch. Biochem. Biophys. | pmid:13584006 |
KELLERSHOHN C and BENICHOUX R | [Comparative study of the drainage through the lymphatic vessels of a radioactive fat, ethyl diiodosterate labeled with I 131, and a radioactive colloidal substance, colloidal gold 198]. | 1958 May-Jun | Minerva Nucl | pmid:13565747 |
CONIGLIO JG and CATE DL | The distribution and biosynthesis of palmitic and stearic acids in liver, intestine, and carcass of intact normal and fasted rats. | 1958 | J. Biol. Chem. | pmid:13549425 |
Holian O and Nelson R | Action of long-chain fatty acids on protein kinase C activity: comparison of omega-6 and omega-3 fatty acids. | 1992 May-Jun | Anticancer Res. | pmid:1352441 |
HARDING HE | Some enquiries into the toxicology of zinc stearate. | 1958 | Br J Ind Med | pmid:13523087 |
DAWSON RM | The labelling of ram semen in vivo with radioactive phosphate and [carboxy-14C] stearic acid. | 1958 | Biochem. J. | pmid:13522653 |
COX AJ and DEEDS F | Dietary production of lipogranuloma in rats. | 1958 Mar-Apr | Am. J. Pathol. | pmid:13520907 |
RUTSTEIN DD et al. | Effects of linolenic and stearic acids on cholesterol-induced lipoid deposition in human aortic cells in tissue-culture. | 1958 | Lancet | pmid:13515277 |
Rafi MA et al. | Correction of sulfatide metabolism after transfer of prosaposin cDNA to cultured cells from a patient with SAP-1 deficiency. | 1992 | Am. J. Hum. Genet. | pmid:1350885 |
FABER JS | A note on the assay of zinc stearate. | 1957 | J Am Pharm Assoc Am Pharm Assoc | pmid:13491438 |
KARVINEN E et al. | Effect of palmitic and stearic acid on cholesterol absorption in man. | 1957 | J Appl Physiol | pmid:13462909 |
BRZEZINSKI A et al. | Prolonged effect of riboflavin: aluminum monostearate suspensions in man. | 1957 | J Am Pharm Assoc Am Pharm Assoc | pmid:13438726 |
Buensod M and Favarger P | [Observations on the digestibility of palmitic and stearic acids and their glyceric esters in rats]. | 1956 | Helv Physiol Pharmacol Acta | pmid:13405350 |
HUME JC and FACIO G | An analysis of the results of the treatment of yaws with a single injection of procaine penicillin with 2% aluminium monostearate. | 1956 | Bull. World Health Organ. | pmid:13404472 |
COOKE NJ et al. | The branched-chain fatty acids of mutton fat. 3. The isolation of 16-methylheptadecanoic acid (isostearic acid). | 1956 | Biochem. J. | pmid:13363830 |
KERN W et al. | [Suggestions for the composition of the general section on ointments and salve bases and emulsifiers in the German Pharmacopeia (DAB 6, Annex). II]. | 1956 | Hautarzt | pmid:13345190 |
BLOMSTRAND R et al. | On the intestinal absorption of 2, 2-dimethylstearic acid fed as free acid or as glyceride. | 1956 | Acta Physiol. Scand. | pmid:13339456 |
JAMES AT and MARTIN AJ | Gas-liquid chromatography: the separation and identification of the methyl esters of saturated and unsaturated acids from formic acid to n-octadecanoic acid. | 1956 | Biochem. J. | pmid:13315260 |