stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
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Authors | Title | Published | Journal | PubMed Link |
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GLASCOCK RF and REINIUS LR | Studies on the origin of milk fat. 1. The location of tritium in stearic acid produced by the catalytic addition of tritium to elaidic acid. | 1956 | Biochem. J. | pmid:13315207 |
Fanjul LF et al. | Diacylglycerol rather than Ca2+ mediates GnRH inhibition of FSH induced steroidogenesis in ovarian granulosa cells. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1329745 |
MUNZEL K and AMMANN R | [Contributions on the character of water-soluble fatty ointments. X. Quasiviscosity determination of stearate ointments]. | 1955 | Pharm Acta Helv | pmid:13289260 |
MEAD JF et al. | Metabolism of the essential fatty acids. II. The metabolism of stearate, oleate, and linoleate by fat-deficient and normal mice. | 1956 | J. Biol. Chem. | pmid:13278347 |
TOVE SB et al. | Turnover of palmitic, stearic, and unsaturated fatty acids in rat liver. | 1956 | J. Biol. Chem. | pmid:13278335 |
Simões AP et al. | Incorporation of free fatty acids can explain alterations in the molecular species composition of phosphatidylcholine and phosphatidylethanolamine in human erythrocytes as induced by Plasmodium falciparum. | 1992 | Cell Biol. Int. Rep. | pmid:1327542 |
GLASCOCK RF and REINIUS LR | Location of tritium in stearic acid produced by catalytic tritiation of elaidic acid. | 1954 | Biochem. J. | pmid:13230049 |
BERGSTROM S et al. | Intestinal absorption and metabolism of 2:2-dimethylstearic acid in the rat. | 1954 | Biochem. J. | pmid:13230010 |
Boza J et al. | Influences of postnatal age and dietary nucleotides on plasma fatty acids in the weanling rat. | 1992 Jul-Aug | JPEN J Parenter Enteral Nutr | pmid:1322471 |
SCRIBANTE P and FAVARGER P | [Studies on digestibility of stearic acid and its glyceric esters in rat]. | 1954 | Helv Physiol Pharmacol Acta | pmid:13201008 |
MUNZEL K and AMMANN R | [Washable oil-water ointments. V. Complex-emulsified ointments; differences between stearate- and complex-emulsified ointments]. | 1954 | Pharm Acta Helv | pmid:13194353 |
SHAFER JK and SMITH CA | Treatment of early infectious syphilis with N,N'-dibenzylethylenediamine dipenicillin G; a second report. | 1954 | Bull. World Health Organ. | pmid:13182589 |
DUNCOMBE WG and GLASCOCK RF | The contribution of dietary stearic acid to milk fat. | 1954 | Biochem. J. | pmid:13172205 |
MUNZEL K and AMMANN R | [On washable fat-in-water ointments. IV. Stearate ointments]. | 1954 | Pharm Acta Helv | pmid:13166515 |
VALADE P and COSTE E | [Toxicity of the organic lead salts; experimental study]. | 1953 | Arch Mal Prof | pmid:13149301 |
Gault MH et al. | Heparin, fatty acids and sodium, potassium-ATPase inhibition by plasma factors during hemodialysis. | 1992 | Nephron | pmid:1314335 |
MUNZEL K and AMMANN R | [On the washable fat-in-water ointments. I. Description and characteristics of fat-in-water ointments]. | 1953 | Pharm Acta Helv | pmid:13133659 |
BERNHARD K and GLOOR U | [Some other fatty acids with vitamin F effect]. | 1953 | Helv Physiol Pharmacol Acta | pmid:13128629 |
Dwight JF et al. | Membrane incorporation of non-esterified fatty acids and effects on the sodium pump of human erythrocytes. | 1992 | Clin. Sci. | pmid:1310925 |
BUTCHER EO | Penetration of radioactive stearic acid into the skin of the rat. | 1953 | J. Invest. Dermatol. | pmid:13096866 |
DOXIADIS SA | Procaine penicillin with aluminium monostearate; infrequent injections for children. | 1953 | Lancet | pmid:13085786 |
Topping DL and Targ ME | Time-course of changes in blood glucose and ketone bodies, plasma lipids and liver fatty acid composition in streptozotocin-diabetic male rats. | 1975 | Horm. Res. | pmid:130333 |
Kajikawa M et al. | MpFAE3, a beta-ketoacyl-CoA synthase gene in the liverwort Marchantia polymorpha L., is preferentially involved in elongation of palmitic acid to stearic acid. | 2003 | Biosci. Biotechnol. Biochem. | pmid:12951498 |
Zeng F et al. | [Analysis on infrared spectrum of human body gallstone with comparative method]. | 2001 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:12947655 |
Sun Y et al. | [The study of the microwave reaction of stearic acid and pentyl amine]. | 2000 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:12945403 |
Dave PC et al. | Calculating order parameter profiles utilizing magnetically aligned phospholipid bilayers for 2H solid-state NMR studies. | 2003 Sep-Nov | Solid State Nucl Magn Reson | pmid:12943910 |
Sirri F et al. | Fatty acid composition and productive traits of broiler fed diets containing conjugated linoleic acid. | 2003 | Poult. Sci. | pmid:12943310 |
Liu CL et al. | [Effect of surface decoration on the spectral characteristics of alpha-Fe2O3 ultrafine particles]. | 2003 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:12939995 |
El-Assaad W et al. | Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death. | 2003 | Endocrinology | pmid:12933690 |
Bracconi P et al. | Structural properties of magnesium stearate pseudopolymorphs: effect of temperature. | 2003 | Int J Pharm | pmid:12927393 |
Ohta KM et al. | Effect of geometric structure and surface wettability of glidant on tablet hardness. | 2003 | Int J Pharm | pmid:12927389 |
MuzÃková J and Horácek J | [The dry binders, Vivapur 102, Vivapur 12 and the effect of magnesium stearate on the strength of tablets containing these substances]. | 2003 | Ceska Slov Farm | pmid:12924068 |
Swaminathan V and Kildsig DO | Effect of magnesium stearate on the content uniformity of active ingredient in pharmaceutical powder mixtures. | 2002 | AAPS PharmSciTech | pmid:12916934 |
Lyon RC et al. | Near-infrared spectral imaging for quality assurance of pharmaceutical products: analysis of tablets to assess powder blend homogeneity. | 2002 | AAPS PharmSciTech | pmid:12916932 |
Yassin AA et al. | Effect of enzymatic interesterification on melting point of palm olein. | 2003 | Appl. Biochem. Biotechnol. | pmid:12909731 |
Mashek DG and Grummer RR | Effects of long chain fatty acids on lipid and glucose metabolism in monolayer cultures of bovine hepatocytes. | 2003 | J. Dairy Sci. | pmid:12906057 |
Jin F et al. | Oxidation reaction of high molecular weight carboxylic acids in supercritical water. | 2003 | Environ. Sci. Technol. | pmid:12901673 |
Ceschel GC et al. | Degradation of components in drug formulations: a comparison between HPLC and DSC methods. | 2003 | J Pharm Biomed Anal | pmid:12899995 |
Duong NH et al. | A homogeneity study using NIR spectroscopy: tracking magnesium stearate in Bohle bin-blender. | 2003 | Drug Dev Ind Pharm | pmid:12889786 |
Mantipragada SB et al. | Lipid-protein interactions and effect of local anesthetics in acetylcholine receptor-rich membranes from Torpedo marmorata electric organ. | 2003 | Biochemistry | pmid:12885251 |
Lian Z et al. | [Studies on chemical constituents of Choerospondias axillaris]. | 2003 | Zhong Yao Cai | pmid:12858769 |
McNamara S et al. | Effect of offering rumen-protected fat supplements on fertility and performance in spring-calving Holstein-Friesian cows. | 2003 | Anim. Reprod. Sci. | pmid:12853178 |
Yang L et al. | Peroxisome proliferator-activated receptor gamma and ligands inhibit surfactant protein B gene expression in the lung. | 2003 | J. Biol. Chem. | pmid:12829715 |
Mittendorfer B et al. | What does the measurement of whole-body fatty acid rate of appearance in plasma by using a fatty acid tracer really mean? | 2003 | Diabetes | pmid:12829627 |
Wu PC et al. | Preparation and evaluation of sustained release microspheres of potassium chloride prepared with ethylcellulose. | 2003 | Int J Pharm | pmid:12818816 |
del Carmen RamÃrez-Medeles M et al. | Amino acid sequence, biochemical characterization, and comparative modeling of a nonspecific lipid transfer protein from Amaranthus hypochondriacus. | 2003 | Arch. Biochem. Biophys. | pmid:12801509 |
Brunengraber DZ et al. | Influence of diet on the modeling of adipose tissue triglycerides during growth. | 2003 | Am. J. Physiol. Endocrinol. Metab. | pmid:12799315 |
Tholstrup T et al. | Difference in effect of myristic and stearic acid on plasma HDL cholesterol within 24 h in young men. | 2003 | Eur J Clin Nutr | pmid:12792657 |
Wu PC et al. | Design and evaluation of sustained release microspheres of potassium chloride prepared by Eudragit. | 2003 | Eur J Pharm Sci | pmid:12791413 |
Ogwal S and Xide TU | Bioavailability and stability of erythromycin delayed release tablets. | 2001 | Afr Health Sci | pmid:12789122 |