stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Jenkins TC | Feeding oleamide to lactating Jersey cows 1. Effects on lactation performance and milk fatty acid composition. | 2000 | J. Dairy Sci. | pmid:10714869 |
Willie BM et al. | Elemental and morphological identification of third-body particulate and calcium stearate inclusions in polyethylene components. | 2000 | J. Biomed. Mater. Res. | pmid:10713559 |
Chang RK and Hussain MA | Consolidation behavior of an experimental, cross-linked polyalkyl ammonium polymer. | 2000 | Drug Dev Ind Pharm | pmid:10697761 |
Saito A et al. | Effects of capsaicin on biliary free fatty acids in rats. | 2000 | Int J Vitam Nutr Res | pmid:10683757 |
Rey H et al. | Development of matrix-based theophylline sustained-release microtablets. | 2000 | Drug Dev Ind Pharm | pmid:10677806 |
Pohl EE et al. | Changes of intrinsic membrane potentials induced by flip-flop of long-chain fatty acids. | 2000 | Biochemistry | pmid:10677234 |
Otz M and Thoma H | Effects of the metal type and the roughness of the die wall on the expended work for tablet ejection. | 2000 | Pharm Dev Technol | pmid:10669914 |
Alonso A et al. | Lipid chain dynamics in stratum corneum studied by spin label electron paramagnetic resonance. | 2000 | Chem. Phys. Lipids | pmid:10669304 |
Rukkwamsuk T et al. | Interrelation of fatty acid composition in adipose tissue, serum, and liver of dairy cows during the development of fatty liver postpartum. | 2000 | J. Dairy Sci. | pmid:10659963 |
Weston WL and Morelli JG | Steroid rosacea in prepubertal children. | 2000 | Arch Pediatr Adolesc Med | pmid:10632252 |
González MS and Brenner RR | Fatty acid delta9-desaturation in the Triatoma infestans fat body: response to food and trehalose administrations. | 1999 | Lipids | pmid:10606043 |
Klein J et al. | Fatty acid ethyl esters: a novel biologic marker for heavy in utero ethanol exposure: a case report. | 1999 | Ther Drug Monit | pmid:10604826 |
Wright LC et al. | The origin of 1H NMR-visible triacylglycerol in human neutrophils. Highfatty acid environments result in preferential sequestration of palmitic acid into plasma membrane triacylglycerol. | 2000 | Eur. J. Biochem. | pmid:10601852 |
Ceschel GC et al. | Optimization of a tablet containing chlorthalidone. | 1999 | Drug Dev Ind Pharm | pmid:10596354 |
Levy R and Herzberg GR | Hydrolysis of long-chain, n-3 fatty acid enriched chylomicrons by cardiac lipoprotein lipase. | 1999 | Can. J. Physiol. Pharmacol. | pmid:10588486 |
Liu CY et al. | Synthesis and analytical properties of a novel columnar metallomesogenic polymer. | 1999 | J Chromatogr A | pmid:10588341 |
Connor WE | Harbingers of coronary heart disease: dietary saturated fatty acids and cholesterol. Is chocolate benign because of its stearic acid content? | 1999 | Am. J. Clin. Nutr. | pmid:10584037 |
Kikuchi K et al. | Fatty acid composition of choline and ethanolamine glycerophospholipid subclasses in heart tissue of mammals and migratory and demersal fish. | 1999 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:10582315 |
Dürig T et al. | An investigation into the erosion behaviour of a high drug-load (85%) particulate system designed for an extended-release matrix tablet. Analysis of erosion kinetics in conjunction with variations in lubrication, porosity and compaction rate. | 1999 | J. Pharm. Pharmacol. | pmid:10579678 |
Bretillon L et al. | Effects of conjugated linoleic acid isomers on the hepatic microsomal desaturation activities in vitro. | 1999 | Lipids | pmid:10574661 |
Kumar VB et al. | Changes in membrane fatty acids and delta-9 desaturase in senescence accelerated (SAMP8) mouse hippocampus with aging. | 1999 | Life Sci. | pmid:10573183 |
Mano T et al. | Proton MR spectroscopy of Sjögren-Larsson's syndrome. | 1999 | AJNR Am J Neuroradiol | pmid:10543638 |
Xiao Y and Li X | Polyunsaturated fatty acids modify mouse hippocampal neuronal excitability during excitotoxic or convulsant stimulation. | 1999 | Brain Res. | pmid:10536218 |
Chajès V et al. | Fatty-acid composition in serum phospholipids and risk of breast cancer: an incident case-control study in Sweden. | 1999 | Int. J. Cancer | pmid:10521790 |
Vargas CI and Ghaly ES | Kinetic release of theophylline from hydrophilic swellable matrices. | 1999 | Drug Dev Ind Pharm | pmid:10518245 |
Summers LK et al. | Use of structured triacylglycerols containing predominantly stearic and oleic acids to probe early events in metabolic processing of dietary fat. | 1999 | J. Lipid Res. | pmid:10508209 |
Eliasen H et al. | Growth mechanisms in melt agglomeration with a low viscosity binder. | 1999 | Int J Pharm | pmid:10486433 |
Warnotte C et al. | Unbound rather than total concentration and saturation rather than unsaturation determine the potency of fatty acids on insulin secretion. | 1999 | Mol. Cell. Endocrinol. | pmid:10459862 |
Eliasen H et al. | Electrostatic charging during a melt agglomeration process. | 1999 | Int J Pharm | pmid:10425354 |
Muszbek L et al. | The pool of fatty acids covalently bound to platelet proteins by thioester linkages can be altered by exogenously supplied fatty acids. | 1999 | Lipids | pmid:10419194 |
Kelly FD et al. | Stearic acid-rich diets do not increase thrombotic risk factors in healthy males. | 1999 | Lipids | pmid:10419148 |
Murakami K et al. | Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferators-activated receptor alpha. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10403814 |
Adachi T et al. | A novel Lyn-binding peptide inhibitor blocks eosinophil differentiation, survival, and airway eosinophilic inflammation. | 1999 | J. Immunol. | pmid:10395690 |
Hidaka T et al. | Screening of microbial products modifying the action of leptin (obese gene product) by a biosensor. | 1999 | J. Antibiot. | pmid:10395281 |
Crocker I et al. | Significance of fatty acids in pregnancy-induced immunosuppression. | 1999 | Clin. Diagn. Lab. Immunol. | pmid:10391868 |
Facciotti MT et al. | Improved stearate phenotype in transgenic canola expressing a modified acyl-acyl carrier protein thioesterase. | 1999 | Nat. Biotechnol. | pmid:10385326 |
McKellop HA et al. | Effect of molecular weight, calcium stearate, and sterilization methods on the wear of ultra high molecular weight polyethylene acetabular cups in a hip joint simulator. | 1999 | J. Orthop. Res. | pmid:10376720 |
Alava MA et al. | Fatty acid desaturation: effect of alphafetoprotein on alpha-linolenic acid conversion by fetal rat hepatocytes. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10359023 |
Bardi L et al. | Saccharomyces cerevisiae cell fatty acid composition and release during fermentation without aeration and in absence of exogenous lipids. | 1999 | Int. J. Food Microbiol. | pmid:10357281 |
Jones AE et al. | Effect of fatty acid chain length and saturation on the gastrointestinal handling and metabolic disposal of dietary fatty acids in women. | 1999 | Br. J. Nutr. | pmid:10341674 |
Müller WE | The use of 8-anilino-1-naphthalenesulfonic acid as a reporter group molecule for circular dichroism and fluorescence measurements. The effect of stearic acid and sodium dodecylsulfate on the conformation of bovine and human serum albumin. | 1976 | Hoppe-Seyler's Z. Physiol. Chem. | pmid:1033907 |
Cavalli R et al. | Solid lipid nanoparticles as carriers of hydrocortisone and progesterone complexes with beta-cyclodextrins. | 1999 | Int J Pharm | pmid:10332075 |
Shen WW et al. | Effect of nonionic surfactants on percutaneous absorption of salicylic acid and sodium salicylate in the presence of dimethyl sulfoxide. | 1976 | J Pharm Sci | pmid:1032661 |
Horhota ST et al. | Effect of storage at specified temperature and humidity on properties of three directly compressible tablet formulations. | 1976 | J Pharm Sci | pmid:1032656 |
Pharmaceutical Reimbursement Board; final maximum allowable cost (MAC) determinations for certain drug products--Health Care Financing Administration. Final notice. | 1982 | Fed Regist | pmid:10259800 | |
Huang S et al. | Interleukin-1 stimulates Jun N-terminal/stress-activated protein kinase by an arachidonate-dependent mechanism in mesangial cells. | 1999 | Kidney Int. | pmid:10231436 |
Neumann D et al. | A comparison of sutures for adjustable strabismus surgery. | 1999 | J AAPOS | pmid:10221801 |
Hannuksela M et al. | Contact sensitivity to emulsifiers. | 1976 | Contact Derm. | pmid:1021350 |
Jarvis GN et al. | Isolation and characterization of two glycerol-fermenting clostridial strains from a pilot scale anaerobic digester treating high lipid-content slaughterhouse waste. | 1999 | J. Appl. Microbiol. | pmid:10196746 |
Brown ST | Treatment of secondary syphilis. | 1976 | J Am Vener Dis Assoc | pmid:1010778 |