stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Decalcification, Pathologic D003649 1 associated lipids
Eczema, Dyshidrotic D011146 1 associated lipids
Salivary Duct Calculi D012465 2 associated lipids
Anemia, Dyserythropoietic, Congenital D000742 2 associated lipids
Obesity, Abdominal D056128 3 associated lipids
Syphilis, Congenital D013590 3 associated lipids
Hypothalamic Diseases D007027 3 associated lipids
Pneumoconiosis D011009 3 associated lipids
Gallbladder Neoplasms D005706 3 associated lipids
Calculi D002137 3 associated lipids
Relapsing Fever D012061 3 associated lipids
Tenosynovitis D013717 3 associated lipids
Infertility D007246 3 associated lipids
Yaws D015001 4 associated lipids
Leukodystrophy, Metachromatic D007966 4 associated lipids
Syphilis, Latent D013592 4 associated lipids
Prostatic Diseases D011469 4 associated lipids
Legionnaires' Disease D007877 4 associated lipids
Chancroid D002602 4 associated lipids
Foreign Bodies D005547 5 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

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Per page 10 20 50 100 | Total 3506
Authors Title Published Journal PubMed Link
Yamamoto K et al. Effect of Magnesium Stearate Mono- and Dihydrate Dispersibilities on Physical Properties of Tablets. 2017 Chem. Pharm. Bull. pmid:29093289
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Van Rafelghem MJ and Andersen ME The effects of perfluorodecanoic acid on hepatic stearoyl-coenzyme A desaturase and mixed function oxidase activities in rats. 1988 Fundam Appl Toxicol pmid:2906022
Jones RE and Plymate SR Evidence for the regulation of fatty acid utilization in human sperm by docosahexaenoic acid. 1988 Biol. Reprod. pmid:2905175
Beg S et al. QbD-driven development and evaluation of nanostructured lipid carriers (NLCs) of Olmesartan medoxomil employing multivariate statistical techniques. 2018 Drug Dev Ind Pharm pmid:29048242
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Liu W and Lu G Partial Hydrogenation of Sunflower Oil-derived FAMEs Catalyzed by the Efficient and Recyclable Palladium Nanoparticles in Polyethylene Glycol. 2017 J Oleo Sci pmid:28924078
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Kondo H et al. Effect of the External Lubrication Method for a Rotary Tablet Press on the Adhesion of the Film Coating Layer. 2017 Chem. Pharm. Bull. pmid:28867712
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Meng Y et al. Stearic acid suppresses mammary gland development by inhibiting PI3K/Akt signaling pathway through GPR120 in pubertal mice. 2017 Biochem. Biophys. Res. Commun. pmid:28712865
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Tabachnick M and Korcek L Effect of long-chain fatty acids on the binding of thyroxine and triiodothyronine to human thyroxine-binding globulin. 1986 Biochim. Biophys. Acta pmid:2869786
Johansson ME and Nicklasson M Investigation of the film formation of magnesium stearate by applying a flow-through dissolution technique. 1986 J. Pharm. Pharmacol. pmid:2869127
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Johansson ME Influence of the granulation technique and starting material properties on the lubricating effect of granular magnesium stearate. 1985 J. Pharm. Pharmacol. pmid:2867134
Crutchley DJ Hydroxyeicosatetraenoic acids and other unsaturated fatty acids inhibit endotoxin-induced thromboplastin activity in human monocytes. 1985 Biochem. Biophys. Res. Commun. pmid:2865954
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Naing C and Whittaker MA Anabolic steroids for treating pressure ulcers. 2017 Cochrane Database Syst Rev pmid:28631809
Bangudu AB and Pilpel N Effects of composition, moisture and stearic acid on the plasto-elasticity and tableting of paracetamol-microcrystalline cellulose mixtures. 1985 J. Pharm. Pharmacol. pmid:2862234
Zoeller RA and Wood R The importance of the stearoyl-CoA desaturase system in octadecenoate metabolism in the Morris hepatoma 7288C. 1985 Biochim. Biophys. Acta pmid:2860925
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Wang XH et al. High Fat Diet-Induced Hepatic 18-Carbon Fatty Acids Accumulation Up-Regulates CYP2A5/CYP2A6 via NF-E2-Related Factor 2. 2017 Front Pharmacol pmid:28555106
Wang Y et al. Docosahexaenoyl serotonin emerges as most potent inhibitor of IL-17 and CCL-20 released by blood mononuclear cells from a series of N-acyl serotonins identified in human intestinal tissue. 2017 Biochim. Biophys. Acta pmid:28526351
Cosenza G et al. A novel polymorphism in the oxytocin receptor encoding gene (OXTR) affects milk fatty acid composition in Italian Mediterranean river buffalo. 2017 J. Dairy Res. pmid:28524009
Soni K et al. Lipid drug conjugate nanoparticle as a potential nanocarrier for the oral delivery of pemetrexed diacid: Formulation design, characterization, ex vivo, and in vivo assessment. 2017 Int. J. Biol. Macromol. pmid:28499946
Chitprasert P and Ngamekaue N Stability Enhancement of Ocimum Sanctum Linn. Essential Oils Using Stearic Acid in Aluminum Carboxymethyl Cellulose Film-Coated Gelatin Microcapsules. 2017 J. Food Sci. pmid:28494101
Hoeg JM et al. Apolipoprotein B synthesized by Hep G2 cells undergoes fatty acid acylation. 1988 J. Lipid Res. pmid:2846736
Chang C et al. pH-responsive nanoparticle assembly from peptide amphiphiles for tumor targeting drug delivery. 2017 J Biomater Sci Polym Ed pmid:28467173
Shilpi D et al. Improved Stability and Enhanced Oral Bioavailability of Atorvastatin Loaded Stearic Acid Modified Gelatin Nanoparticles. 2017 Pharm. Res. pmid:28466393
Lakhssassi N et al. Stearoyl-Acyl Carrier Protein Desaturase Mutations Uncover an Impact of Stearic Acid in Leaf and Nodule Structure. 2017 Plant Physiol. pmid:28461402
Hara A et al. Human carbonyl reductase 1 participating in intestinal first-pass drug metabolism is inhibited by fatty acids and acyl-CoAs. 2017 Biochem. Pharmacol. pmid:28450226