| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
stearic acid
stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with stearic acid?
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with stearic acid
PubChem Associated disorders and diseases
What pathways are associated with stearic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with stearic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with stearic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with stearic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with stearic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with stearic acid?
Knock-out
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with stearic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Rosenthal MD and Whitehurst MC | Selective effects of isomeric cis and trans fatty acids on fatty acyl delta 9 and delta 6 desaturation by human skin fibroblasts. | 1983 | Biochim. Biophys. Acta | pmid:6615875 |
| Bieri VG and Wallach DF | Variations of lipid-protein interactions in erythrocyte ghosts as a function of temperature and pH in physiological and non-physiological ranges. A study using a paramagnetic quenching of protein fluorescence by nitroxide lipid analogues. | 1975 | Biochim. Biophys. Acta | pmid:241415 |
| Swendsen CL et al. | Human neutrophils incorporate arachidonic acid and saturated fatty acids into separate molecular species of phospholipids. | 1987 | Biochim. Biophys. Acta | pmid:3105590 |
| Riordan JR et al. | Plasma membrane lipids of human diploid fibroblasts from normal individuals and patients with cystic fibrosis. | 1979 | Biochim. Biophys. Acta | pmid:476136 |
| Kogure K et al. | Effect of dicetylphosphate or stearic acid on spontaneous transfer of protein from influenza virus-infected cells to dimyristoylphosphatidylcholine liposomes. | 1997 | Biochim. Biophys. Acta | pmid:9370255 |
| Woldseth B et al. | Incorporation of stearic acid (18:0) and palmitic acid (16:0) in phospholipid molecular species studied in isolated rat liver cells. | 1993 | Biochim. Biophys. Acta | pmid:8481391 |
| Callaghan R et al. | Increased accumulation of drugs in a multidrug resistant cell line by alteration of membrane biophysical properties. | 1993 | Biochim. Biophys. Acta | pmid:8435444 |
| Murakami C et al. | A novel DNA polymerase inhibitor and a potent apoptosis inducer: 2-mono-O-acyl-3-O-(alpha-D-sulfoquinovosyl)-glyceride with stearic acid. | 2003 | Biochim. Biophys. Acta | pmid:12535613 |
| Streichman S et al. | Unique profile for erythrocyte membrane acetylcholinesterase in hereditary spherocytosis. | 1983 | Biochim. Biophys. Acta | pmid:6849970 |
| Arukuusk P et al. | New generation of efficient peptide-based vectors, NickFects, for the delivery of nucleic acids. | 2013 | Biochim. Biophys. Acta | pmid:23357356 |
| Holub BJ | The relative deacylation of different molecular species of endogenous phosphatidylethanolamine in rat liver microsomes by phospholipase activity. | 1982 | Biochim. Biophys. Acta | pmid:7093298 |
| MENZEL DB and OLCOTT HS | POSITIONAL DISTRIBUTION OF FATTY ACIDS IN FISH AND OTHER ANIMAL LECITHINS. | 1964 | Biochim. Biophys. Acta | pmid:14181289 |
| DAY AJ et al. | THE INCORPORATION OF 14-C-LABELLED ACETATE INTO LONG CHAIN FATTY ACIDS BY MACROPHAGES IN VITRO. | 1964 | Biochim. Biophys. Acta | pmid:14181291 |
| GELLHORN A and BENJAMIN W | THE INTRACELLULAR LOCALIZATION OF AN ENZYMATIC DEFECT OF LIPID METABOLISM IN DIABETIC RATS. | 1964 | Biochim. Biophys. Acta | pmid:14181293 |
| Katz AM et al. | Fatty acid effects on calcium influx and efflux in sarcoplasmic reticulum vesicles from rabbit skeletal muscle. | 1982 | Biochim. Biophys. Acta | pmid:7074105 |
| IKAWA M | OCCURRENCE AND IDENTIFICATION OF CIS-VACCENIC ACID IN LEUCONOSTOC MESENTEROIDES. | 1964 | Biochim. Biophys. Acta | pmid:14181302 |
| Slomiany BL et al. | Mucus glycoprotein of human saliva: differences in the associated and covalently bound lipids with caries. | 1986 | Biochim. Biophys. Acta | pmid:3518803 |
| BURTON RM and GIBBONS JM | LIPID COMPOSITION OF A RAT-BRAIN SYNAPTIC-VESICLE FRACTION. | 1964 | Biochim. Biophys. Acta | pmid:14181307 |
| Morgan H et al. | Proton transport at the monolayer-water interface. | 1991 | Biochim. Biophys. Acta | pmid:1848448 |
| ROWE CE | THE OCCURRENCE AND METABOLISM IN VITRO OF UNESTERIFIED FATTY ACID IN MOUSE BRAIN. | 1964 | Biochim. Biophys. Acta | pmid:14230816 |
| KELLERMAN GM and JOLLOW DJ | CONVERSION OF STEARIC ACID INTO OLEIC ACID IN ADIPOSE TISSUE. | 1964 | Biochim. Biophys. Acta | pmid:14230826 |
| Møller JK et al. | Effect of nitrosylmyoglobin and saturated fatty acid anions on metmyoglobin-catalyzed oxidation of aqueous methyl linoleate emulsions. | 2002 | Biochim. Biophys. Acta | pmid:11985897 |
| Baker RR and Chang HY | A comparison of lysophosphatidylcholine acyltransferase activities in neuronal nuclei and microsomes isolated from immature rabbit cerebral cortex. | 1981 | Biochim. Biophys. Acta | pmid:7306562 |
| George M and Chepenik KP | Phospholipase A activities in embryonic palate mesenchyme cells in vitro. | 1985 | Biochim. Biophys. Acta | pmid:3927980 |
| Morandi S et al. | Association of sugar-based carboranes with cationic liposomes: an electron spin resonance and light scattering study. | 2004 | Biochim. Biophys. Acta | pmid:15238258 |
| Höltje M et al. | Molecular dynamics simulations of stratum corneum lipid models: fatty acids and cholesterol. | 2001 | Biochim. Biophys. Acta | pmid:11248214 |
| ELOVSON J | CHAIN-SHORTENING OF STEARIC ACID IN THE INTACT RAT. | 1965 | Biochim. Biophys. Acta | pmid:14290835 |
| MCCARTHY RD et al. | THE CONVERSION OF STEARIC ACID TO OLEIC IN FRESHLY SECRETED MILK. | 1965 | Biochim. Biophys. Acta | pmid:14292868 |
| Malmberg P et al. | Localization of lipids in the aortic wall with imaging TOF-SIMS. | 2007 | Biochim. Biophys. Acta | pmid:17240191 |
| Ulmann L et al. | Incorporation into liver microsomal lipids of linoleic and stearic acids and of their respective products of delta 6 and delta 9 desaturation, gamma-linolenic and oleic acids: effect of age and of blackcurrant seed oil. | 1991 | Biochim. Biophys. Acta | pmid:1657182 |
| Haeffner EW and Friedel R | Induction of an endothermic transition in the Arrhenius plot of fatty acid uptake by lipid-depleted ascites tumor cells. | 1989 | Biochim. Biophys. Acta | pmid:2775760 |
| Ellingson JS and Seenaiah B | The selective use of stearoyl-polyunsaturated molecular species of phosphatidylcholine and phosphatidylethanolamine for the synthesis of phosphatidylserine. | 1994 | Biochim. Biophys. Acta | pmid:8011673 |
| Sivarajan M et al. | Regulation of intracellular arachidonate in normal and stressed endothelial cells. | 1984 | Biochim. Biophys. Acta | pmid:6433983 |
| Lagrost L | Differential effects of cis and trans fatty acid isomers, oleic and elaidic acids, on the cholesteryl ester transfer protein activity. | 1992 | Biochim. Biophys. Acta | pmid:1543738 |
| Tabachnick M and Korcek L | Effect of long-chain fatty acids on the binding of thyroxine and triiodothyronine to human thyroxine-binding globulin. | 1986 | Biochim. Biophys. Acta | pmid:2869786 |
| Watanabe L et al. | Structural insights for fatty acid binding in a Lys49-phospholipase A2: crystal structure of myotoxin II from Bothrops moojeni complexed with stearic acid. | 2005 | Biochimie | pmid:15760708 |
| Pollet S et al. | [Substrates and products of fatty acid elongation in mouse brain microsomes]. | 1975 | Biochimie | pmid:1222143 |
| Zhu S et al. | Lysosomal delivery of a lipophilic gemcitabine prodrug using novel acid-sensitive micelles improved its antitumor activity. | 2012 | Bioconjug. Chem. | pmid:22471294 |
| Zhang W et al. | Stearylated antimicrobial peptide melittin and its retro isomer for efficient gene transfection. | 2013 | Bioconjug. Chem. | pmid:24107137 |
| Futaki S et al. | Stearylated arginine-rich peptides: a new class of transfection systems. | 2001 Nov-Dec | Bioconjug. Chem. | pmid:11716693 |
| Fabianowski W et al. | Integrated circuits protection with the Langmuir-Blodgett Films. | 2005 | Bioelectrochemistry | pmid:15833702 |
| Petelska AD et al. | Interfacial tension of the lipid membrane formed from lipid-fatty acid and lipid-amine systems. | 2007 | Bioelectrochemistry | pmid:16713376 |
| Staritsyn SN et al. | [Mixed monolayers of amphiphile-modified nucleic bases and diynoic acids. I. Phase states at air-water interface and in Langmuir-Blodgett films]. | 2004 Jul-Aug | Biofizika | pmid:15458246 |
| Saatov TS et al. | [Content, intensity of exchange, and metabolic interaction of phospholipids and glycolipids in various tissues in experimental diabetes]. | 1983 | Biokhimiia | pmid:6671113 |
| Moore IM et al. | Methotrexate-induced alterations in beta-oxidation correlate with cognitive abilities in children with acute lymphoblastic leukemia. | 2008 | Biol Res Nurs | pmid:18398226 |
| Droke EA et al. | Fatty acids alter monolayer integrity, paracellular transport, and iron uptake and transport in Caco-2 cells. | 2003 | Biol Trace Elem Res | pmid:14665727 |
| Finley JW and Davis CD | Manganese absorption and retention in rats is affected by the type of dietary fat. | 2001 | Biol Trace Elem Res | pmid:11697763 |
| Miersch O and Wasternack C | Octadecanoid and jasmonate signaling in tomato (Lycopersicon esculentum Mill.) leaves: endogenous jasmonates do not induce jasmonate biosynthesis. | 2000 | Biol. Chem. | pmid:11030429 |
| Rüdiger M et al. | Are biochemical parameters of lung maturation from gastric, tracheal, and pharyngeal aspirates comparable? | 1998 | Biol. Neonate | pmid:9618052 |
| Tokudome Y and Otsuka M | Possibility of alveolar bone promoting enhancement by using lipophilic and/or hydrophilic zinc related compounds in zinc-deficient osteoporosis rats. | 2012 | Biol. Pharm. Bull. | pmid:22975500 |