stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Abortion, Spontaneous D000022 12 associated lipids
Acne Vulgaris D000152 35 associated lipids
Acquired Immunodeficiency Syndrome D000163 12 associated lipids
Adenoma D000236 40 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Alzheimer Disease D000544 76 associated lipids
Amnesia D000647 12 associated lipids
Anemia, Dyserythropoietic, Congenital D000742 2 associated lipids
Olfaction Disorders D000857 17 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Arteriosclerosis D001161 86 associated lipids
Bacterial Infections D001424 21 associated lipids
Cholestasis, Extrahepatic D001651 7 associated lipids
Birth Weight D001724 23 associated lipids
Body Weight D001835 333 associated lipids
Boutonneuse Fever D001907 5 associated lipids
Brain Edema D001929 20 associated lipids
Breast Neoplasms D001943 24 associated lipids
Bronchitis D001991 6 associated lipids
Burns D002056 34 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

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Per page 10 20 50 100 | Total 3506
Authors Title Published Journal PubMed Link
Li X et al. Preparation of co-spray dried cushioning agent containing stearic acid for protecting pellet coatings when compressed. 2016 Drug Dev Ind Pharm pmid:26289006
Ocloo FCK et al. Effects of stearic acid and gamma irradiation, alone and in combination, on pasting properties of high amylose maize starch. 2016 Food Chem pmid:26212935
Jójárt I et al. Study of the compressibility of chewing gum and its applicability as an oral drug delivery system. 2016 Pharm Dev Technol pmid:25673279
Patadia R et al. Investigating critical effects of variegated lubricants, glidants and hydrophilic additives on lag time of press coated ethylcellulose tablets. 2016 Pharm Dev Technol pmid:25566928
Li T et al. Defense priming by non-jasmonate producing fatty acids in maize (Zea mays). 2016 Plant Signal Behav pmid:27763804
Kanasaki Y et al. Application of Quartz Crystal Microbalance as a Tool for Detergency Evaluation of Fatty Acid Contamination in Aqueous Systems. 2016 J Oleo Sci pmid:27725481
Souza AF et al. Waste Soybean Oil and Corn Steep Liquor as Economic Substrates for Bioemulsifier and Biodiesel Production by Candida lipolytica UCP 0998. 2016 Int J Mol Sci pmid:27669227
Teh SS et al. Incorporation of Palmitic Acid or Stearic Acid into Soybean Oils Using Enzymatic Interesterification. 2016 J Oleo Sci pmid:27477075
Sun Y et al. Plasma fatty acids, oxylipins, and risk of myocardial infarction: the Singapore Chinese Health Study. 2016 J. Lipid Res. pmid:27371261
Du H et al. Modification of the fatty acid composition in Arabidopsis and maize seeds using a stearoyl-acyl carrier protein desaturase-1 (ZmSAD1) gene. 2016 BMC Plant Biol. pmid:27297560
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Hashemi Goradel N et al. Improvement of Liver Cell Therapy in Rats by Dietary Stearic Acid. 2016 Iran. Biomed. J. pmid:27090202
Ma Y et al. Silymarin-Loaded Nanoparticles Based on Stearic Acid-Modified Bletilla striata Polysaccharide for Hepatic Targeting. 2016 Molecules pmid:26938513
Šrámek J et al. p38 MAPK Is Activated but Does Not Play a Key Role during Apoptosis Induction by Saturated Fatty Acid in Human Pancreatic β-Cells. 2016 Int J Mol Sci pmid:26861294
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Monteyne T et al. Stearic acid and high molecular weight PEO as matrix for the highly water soluble metoprolol tartrate in continuous twin-screw melt granulation. 2016 Int J Pharm pmid:27452420
Ariyasu A et al. Delay effect of magnesium stearate on tablet dissolution in acidic medium. 2016 Int J Pharm pmid:27444551
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Krasnou I et al. Permeability of water and oleic acid in composite films of phase separated polypropylene and cellulose stearate blends. 2016 Carbohydr Polym pmid:27516292
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Lu H et al. Elevated circulating stearic acid leads to a major lipotoxic effect on mouse pancreatic beta cells in hyperlipidaemia via a miR-34a-5p-mediated PERK/p53-dependent pathway. 2016 Diabetologia pmid:26969487
Thilakarathna SH et al. Investigations of in vitro bioaccessibility from interesterified stearic and oleic acid-rich blends. 2016 Food Funct pmid:26961726
Ma F et al. Improvement of β-TCP/PLLA biodegradable material by surface modification with stearic acid. 2016 Mater Sci Eng C Mater Biol Appl pmid:26952440
Zhang C et al. Design and evaluation of an innovative floating and bioadhesive multiparticulate drug delivery system based on hollow structure. 2016 Int J Pharm pmid:26943975
Zhang Y et al. CO2/pH-Controllable Viscoelastic Nanostructured Fluid Based on Stearic Acid Soap and Bola-Type Quaternary Ammonium Salt. 2016 Langmuir pmid:26907546
Wang S et al. Linoleic acid and stearic acid elicit opposite effects on AgRP expression and secretion via TLR4-dependent signaling pathways in immortalized hypothalamic N38 cells. 2016 Biochem. Biophys. Res. Commun. pmid:26879142
Lohan SB et al. Investigation of cutaneous penetration properties of stearic acid loaded to dendritic core-multi-shell (CMS) nanocarriers. 2016 Int J Pharm pmid:26853315
Stahlberg S et al. Probing the Role of Ceramide Headgroup Polarity in Short-Chain Model Skin Barrier Lipid Mixtures by ²H Solid-State NMR Spectroscopy. 2016 Langmuir pmid:26828109
Lavergne SN et al. Potential cutaneous hypersensitivity reaction to an inactive ingredient of thyroid hormone supplements in a dog. 2016 Vet. Dermatol. pmid:26748887
Baig MS et al. Application of Box-Behnken design for preparation of levofloxacin-loaded stearic acid solid lipid nanoparticles for ocular delivery: Optimization, in vitro release, ocular tolerance, and antibacterial activity. 2016 Int. J. Biol. Macromol. pmid:26740466
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Zhang X et al. Effect of Chemicals on Morphology and Luminescence of CdSe Quantum Dots. 2015 J Nanosci Nanotechnol pmid:26353513
Bhattacharya S et al. Increasing the stearate content in seed oil of Brassica juncea by heterologous expression of MlFatB affects lipid content and germination frequency of transgenic seeds. 2015 Plant Physiol. Biochem. pmid:26351151
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Bera H et al. Alginate gel-coated oil-entrapped alginate-tamarind gum-magnesium stearate buoyant beads of risperidone. 2015 Int. J. Biol. Macromol. pmid:25861741
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Rozman Peterka T et al. Solid state compatibility study and characterization of a novel degradation product of tacrolimus in formulation. 2015 J Pharm Biomed Anal pmid:25804434
Kelidari HR et al. Formulation optimization and in vitro skin penetration of spironolactone loaded solid lipid nanoparticles. 2015 Colloids Surf B Biointerfaces pmid:25797482
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Phaechamud T et al. Chitosan-aluminum monostearate composite sponge dressing containing asiaticoside for wound healing and angiogenesis promotion in chronic wound. 2015 Mater Sci Eng C Mater Biol Appl pmid:25746264
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Castellanos-Tapia L et al. Apolipoprotein E isoforms 3/3 and 3/4 differentially interact with circulating stearic, palmitic, and oleic fatty acids and lipid levels in Alaskan Natives. 2015 Nutr Res pmid:25727313
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