stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Otitis Media D010033 12 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Breast Neoplasms D001943 24 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Bacterial Infections D001424 21 associated lipids
Lung Neoplasms D008175 171 associated lipids
Burns D002056 34 associated lipids
Insulinoma D007340 28 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Reperfusion Injury D015427 65 associated lipids
Liver Neoplasms D008113 8 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Cattle Diseases D002418 24 associated lipids
Fatty Liver D005234 48 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

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Per page 10 20 50 100 | Total 3506
Authors Title Published Journal PubMed Link
He H et al. VB12-coated Gel-Core-SLN containing insulin: Another way to improve oral absorption. 2015 Int J Pharm pmid:26253378
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Gong X et al. Dependence of tablet brittleness on tensile strength and porosity. 2015 Int J Pharm pmid:26226338
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Park JH et al. Development of DH-I-180-3 loaded lipid nanoparticle for photodynamic therapy. 2015 Int J Pharm pmid:26149935
de Paiva EJ et al. Influence of two different alcohols in the esterification of fatty acids over layered zinc stearate/palmitate. 2015 Bioresour. Technol. pmid:26143001
Ricci M et al. Growth and Dissolution of Calcite in the Presence of Adsorbed Stearic Acid. 2015 Langmuir pmid:26087312
Santos IC et al. Paired-ion electrospray ionization--triple quadrupole tandem mass spectrometry for quantification of anionic surfactants in waters. 2015 Talanta pmid:26078166
Rizzuti B et al. Fatty acid binding into the highest affinity site of human serum albumin observed in molecular dynamics simulation. 2015 Arch. Biochem. Biophys. pmid:26048999
Rana S et al. A spatio-temporal cardiomyocyte targeted vector system for efficient delivery of therapeutic payloads to regress cardiac hypertrophy abating bystander effect. 2015 J Control Release pmid:25575863
Wei X et al. Structure and properties of moisture-resistant konjac glucomannan films coated with shellac/stearic acid coating. 2015 Carbohydr Polym pmid:25542116
Zeng Q et al. Cationic micelle delivery of Trp2 peptide for efficient lymphatic draining and enhanced cytotoxic T-lymphocyte responses. 2015 J Control Release pmid:25540903
Piantoni P et al. Milk production responses to dietary stearic acid vary by production level in dairy cattle. 2015 J. Dairy Sci. pmid:25529423
Vercruysse J et al. Use of a continuous twin screw granulation and drying system during formulation development and process optimization. 2015 Eur J Pharm Biopharm pmid:25528462
Schrank S et al. The effect of the drying temperature on the properties of wet-extruded calcium stearate pellets: pellet microstructure, drug distribution, solid state and drug dissolution. 2015 Int J Pharm pmid:25526671
Foraita S et al. Impact of the oxygen defects and the hydrogen concentration on the surface of tetragonal and monoclinic ZrO2 on the reduction rates of stearic acid on Ni/ZrO2. 2015 Chemistry pmid:25504844
Yan S et al. Autoxidated linolenic acid inhibits aflatoxin biosynthesis in Aspergillus flavus via oxylipin species. 2015 Fungal Genet. Biol. pmid:25498164
Yang Y et al. Ligand-directed stearic acid grafted chitosan micelles to increase therapeutic efficacy in hepatic cancer. 2015 Mol. Pharm. pmid:25495890
Yi HX et al. Effect of anionic PEGylated polypeptide on gene transfection mediated by glycolipid conjugate micelles. 2015 Mol. Pharm. pmid:25490413
Leonardi A et al. Cationic solid lipid nanoparticles enhance ocular hypotensive effect of melatonin in rabbit. 2015 Int J Pharm pmid:25448580
Qu L et al. Investigation of the potential for direct compaction of a fine ibuprofen powder dry-coated with magnesium stearate. 2015 Drug Dev Ind Pharm pmid:24738790
Momoh MA et al. Influence of magnesium stearate on the physicochemical and pharmacodynamic characteristics of insulin-loaded Eudragit entrapped mucoadhesive microspheres. 2015 Drug Deliv pmid:24670092
Doignon F et al. Requirement of Phosphoinositides Containing Stearic Acid To Control Cell Polarity. 2015 Mol. Cell. Biol. pmid:26711260
Miyazaki Y et al. Dry Powder Coating using Planetary Centrifugal Mixer. 2015 J Pharm Pharm Sci pmid:26517137
Veselỳ M et al. Photocatalytic and Antimicrobial Activity of Printed Hybrid Titania/Silica Layers. 2015 J Nanosci Nanotechnol pmid:26716211
Li Y et al. Effects of sustained-release composite on the oxygen levels and sediment phosphorus fractions of an urban river in Shanghai. 2014 Sep-Oct Environ Technol pmid:25145170
Mu L et al. Erythrocyte saturated fatty acids and systemic inflammation in adults. 2014 Nov-Dec Nutrition pmid:25280420
Wu JX et al. Chemical imaging and solid state analysis at compact surfaces using UV imaging. 2014 Int J Pharm pmid:25445531
Muselík J et al. Influence of process parameters on content uniformity of a low dose active pharmaceutical ingredient in a tablet formulation according to GMP. 2014 Acta Pharm pmid:25296681
Haware RV et al. Application of multivariate methods to evaluate the functionality of bovine- and vegetable-derived magnesium stearate. 2014 J Pharm Sci pmid:24596131
Guo H et al. In vitro and in vivo study of Gal-OS self-assembled nanoparticles for liver-targeting delivery of doxorubicin. 2014 J Pharm Sci pmid:24549734
Rico JE et al. Compared with stearic acid, palmitic acid increased the yield of milk fat and improved feed efficiency across production level of cows. 2014 J. Dairy Sci. pmid:24342689
Petridis L et al. Spatial arrangement of organic compounds on a model mineral surface: implications for soil organic matter stabilization. 2014 Environ. Sci. Technol. pmid:24328330
Lorenzo JM Changes on physico-chemical, textural, lipolysis and volatile compounds during the manufacture of dry-cured foal "cecina". 2014 Meat Sci. pmid:23916960
Carrero-Colón M et al. Mutations in SACPD-C result in a range of elevated stearic acid concentration in soybean seed. 2014 PLoS ONE pmid:24846334
Gebauer SK et al. Impact of stearic acid and oleic acid on hemostatic factors in the context of controlled diets consumed by healthy men. 2014 Eur J Clin Nutr pmid:24736679
Liau CP et al. Preparation and characterization of polyhydroxybutyrate/polycaprolactone nanocomposites. 2014 ScientificWorldJournal pmid:24600329
Woo JO et al. Development of a controlled release of salicylic acid loaded stearic acid-oleic acid nanoparticles in cream for topical delivery. 2014 ScientificWorldJournal pmid:24578624
Yee JK et al. High oleic/stearic fatty-acid desaturation index in cord plasma from infants of mothers with gestational diabetes. 2014 J Perinatol pmid:24577432
Zhao X et al. Diet modulation is an effective complementary agent in preventing and treating breast cancer lung metastasis. 2014 Clin. Exp. Metastasis pmid:24832758
Aznar-Moreno JA et al. Sunflower (Helianthus annuus) long-chain acyl-coenzyme A synthetases expressed at high levels in developing seeds. 2014 Physiol Plant pmid:24102504
Huang FC et al. Expression and characterization of CYP52 genes involved in the biosynthesis of sophorolipid and alkane metabolism from Starmerella bombicola. 2014 Appl. Environ. Microbiol. pmid:24242247
Sassa T et al. Lorenzo's oil inhibits ELOVL1 and lowers the level of sphingomyelin with a saturated very long-chain fatty acid. 2014 J. Lipid Res. pmid:24489110
Liu J et al. Saturated fatty acids up-regulate COX-2 expression in prostate epithelial cells via toll-like receptor 4/NF-κB signaling. 2014 Inflammation pmid:24221358
Kushner J et al. A quality-by-design study for an immediate-release tablet platform: examining the relative impact of active pharmaceutical ingredient properties, processing methods, and excipient variability on drug product quality attributes. 2014 J Pharm Sci pmid:24375069
Dou J et al. Preparation and evaluation in vitro and in vivo of docetaxel loaded mixed micelles for oral administration. 2014 Colloids Surf B Biointerfaces pmid:24157590
Meulenaar J et al. Development of an extended-release formulation of capecitabine making use of in vitro-in vivo correlation modelling. 2014 J Pharm Sci pmid:24311366