stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
HÃ¥versen L et al. | Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages. | 2009 | Atherosclerosis | pmid:18599066 |
Pouget EM et al. | The initial stages of template-controlled CaCO3 formation revealed by cryo-TEM. | 2009 | Science | pmid:19286549 |
Yadav VR et al. | Novel formulation of solid lipid microparticles of curcumin for anti-angiogenic and anti-inflammatory activity for optimization of therapy of inflammatory bowel disease. | 2009 | J. Pharm. Pharmacol. | pmid:19222903 |
Okuda Y et al. | A new formulation for orally disintegrating tablets using a suspension spray-coating method. | 2009 | Int J Pharm | pmid:19686825 |
Huang J et al. | Quality by design case study: an integrated multivariate approach to drug product and process development. | 2009 | Int J Pharm | pmid:19664698 |
Cao C et al. | [Chemical study on petroleum ether portion of Sarcandra hainanensis]. | 2009 | Zhongguo Zhong Yao Za Zhi | pmid:19639789 |
Gupta A et al. | Difference in the lubrication efficiency of bovine and vegetable-derived magnesium stearate during tabletting. | 2009 | AAPS PharmSciTech | pmid:19390976 |
Sakuradani E et al. | Identification of a novel fatty acid elongase with a wide substrate specificity from arachidonic acid-producing fungus Mortierella alpina 1S-4. | 2009 | Appl. Microbiol. Biotechnol. | pmid:19415268 |
Shen J et al. | Mucoadhesive effect of thiolated PEG stearate and its modified NLC for ocular drug delivery. | 2009 | J Control Release | pmid:19393270 |
Wang YY et al. | [Studies on the chemical constituents of Sarcopyramis nepalensis]. | 2009 | Zhong Yao Cai | pmid:20034215 |
Swamy PV et al. | Preparation and evaluation of orodispersible tablets of pheniramine maleate by effervescent method. | 2009 | Indian J Pharm Sci | pmid:20336216 |
Costa MC et al. | The solid-liquid phase diagrams of binary mixtures of consecutive, even saturated fatty acids. | 2009 | Chem. Phys. Lipids | pmid:19520067 |
Wei Y et al. | Reduced endoplasmic reticulum luminal calcium links saturated fatty acid-mediated endoplasmic reticulum stress and cell death in liver cells. | 2009 | Mol. Cell. Biochem. | pmid:19444596 |
Weber K et al. | Lesions in the Larynx of Wistar RccHan: WIST Rats. | 2009 | J Toxicol Pathol | pmid:22271998 |
Kalman DS et al. | A prospective, randomized, double-blind, placebo-controlled parallel-group dual site trial to evaluate the effects of a Bacillus coagulans-based product on functional intestinal gas symptoms. | 2009 | BMC Gastroenterol | pmid:19922649 |
Fostok SF et al. | Interleukin-6 and Cyclooxygenase-2 downregulation by fatty-acid fractions of Ranunculus constantinopolitanus. | 2009 | BMC Complement Altern Med | pmid:19917107 |
Evans LM et al. | Stearate preferentially induces apoptosis in human breast cancer cells. | 2009 | Nutr Cancer | pmid:19838949 |
Ye YQ et al. | Enhanced cytotoxicity of core modified chitosan based polymeric micelles for doxorubicin delivery. | 2009 | J Pharm Sci | pmid:18563810 |
Cha KH et al. | Design of pH-independent extended release matrix tablets of minocycline hydrochloride for the treatment of dementia. | 2009 | Arch. Pharm. Res. | pmid:20091273 |
Hesta M et al. | The effect of vitamin C supplementation in healthy dogs on antioxidative capacity and immune parameters. | 2009 | J Anim Physiol Anim Nutr (Berl) | pmid:19386005 |
Thumma S and Repka MA | Compatibility studies of promethazine hydrochloride with tablet excipients by means of thermal and non-thermal methods. | 2009 | Pharmazie | pmid:19348341 |
Bolhuis GK et al. | Compaction properties of isomalt. | 2009 | Eur J Pharm Biopharm | pmid:19327398 |
Staiger K et al. | Protein kinase C iota mediates lipid-induced apoptosis of human coronary artery endothelial cells. | 2009 | Microvasc. Res. | pmid:19327373 |
Peter A et al. | Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo. | 2009 | Diabetes | pmid:19478146 |
Ussher JR et al. | Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase. | 2009 | Diabetes | pmid:19478144 |
Monajjemzadeh F et al. | Assessment of feasibility of maillard reaction between baclofen and lactose by liquid chromatography and tandem mass spectrometry, application to pre formulation studies. | 2009 | AAPS PharmSciTech | pmid:19455427 |
Nyadong L et al. | Combining two-dimensional diffusion-ordered nuclear magnetic resonance spectroscopy, imaging desorption electrospray ionization mass spectrometry, and direct analysis in real-time mass spectrometry for the integral investigation of counterfeit pharmaceuticals. | 2009 | Anal. Chem. | pmid:19453162 |
Qureshi J et al. | Chronomodulated drug delivery system of salbutamol sulphate for the treatment of nocturnal asthma. | 2008 May-Jun | Indian J Pharm Sci | pmid:20046744 |
Issa MM et al. | Novel atomic absorption spectrometric and rapid spectrophotometric methods for the quantitation of paracetamol in saliva: application to pharmacokinetic studies. | 2008 May-Jun | Indian J Pharm Sci | pmid:20046743 |
Gohel MC and Sarvaiya KG | Exploration of cold extrusion for the preparation of enteric minitablets of isoniazid. | 2008 May-Jun | Indian J Pharm Sci | pmid:20046736 |
Gohel MC et al. | Modulation of venlafaxine hydrochloride release from press coated matrix tablet. | 2008 May-Jun | Indian J Pharm Sci | pmid:20046735 |
Bhise SB and Aloorkar NH | Formulation and in vitro Evaluation of Floating Capsules of Theophylline. | 2008 Mar-Apr | Indian J Pharm Sci | pmid:20046717 |
Setty CM et al. | Development of fast dispersible aceclofenac tablets: effect of functionality of superdisintegrants. | 2008 Mar-Apr | Indian J Pharm Sci | pmid:20046709 |
Masareddy RS et al. | Development of mouth dissolving tablets of clozapine using two different techniques. | 2008 Jul-Aug | Indian J Pharm Sci | pmid:20046788 |
Syed AA and Syeda A | Spectrophotometric determination of certain benzimidazole proton pump inhibitors. | 2008 Jul-Aug | Indian J Pharm Sci | pmid:20046782 |
Baldania SL et al. | RP-HPLC Estimation of Risperidone in Tablet Dosage Forms. | 2008 Jul-Aug | Indian J Pharm Sci | pmid:20046778 |
Ganesh S et al. | In vitro Evaluation of the Effect of Combination of Hydrophilic and Hydrophobic Polymers on Controlled Release Zidovudine Matrix Tablets. | 2008 Jul-Aug | Indian J Pharm Sci | pmid:20046771 |
Cocchi M et al. | [Membrane platelet fatty acids: biochemical characterisation of the ischemic cardiovascular disease, characteristics of the paediatric age, through an artificial neural network interpretation]. | 2008 Jan-Feb | Pediatr Med Chir | pmid:18491675 |
Shah RB et al. | Stability indicating validated HPLC method for quantification of levothyroxine with eight degradation peaks in the presence of excipients. | 2008 | Int J Pharm | pmid:18524511 |
Whitby CP et al. | Effect of oil soluble surfactant in emulsions stabilised by clay particles. | 2008 | J Colloid Interface Sci | pmid:18452938 |
He X et al. | Formulation development and process scale up of a high shear wet granulation formulation containing a poorly wettable drug. | 2008 | J Pharm Sci | pmid:18449937 |
John Wallace R | Gut microbiology - broad genetic diversity, yet specific metabolic niches. | 2008 | Animal | pmid:22443591 |
Bermúdez L et al. | A candidate gene survey of quantitative trait loci affecting chemical composition in tomato fruit. | 2008 | J. Exp. Bot. | pmid:18552354 |
Chen Y et al. | Isolation of 5-hydroxypyrrolidin-2-one and other constituents from the young fronds of Pteridium aquilinum. | 2008 | J Nat Med | pmid:18437503 |
Riegler J et al. | Blue shift of CdSe/ZnS nanocrystal-labels upon DNA-hybridization. | 2008 | J Nanobiotechnology | pmid:18489732 |
Simon MN et al. | Persistent activation of Akt or ERK prevents the toxicity induced by saturated and polyunsaturated fatty acids in RINm5F β-cells. | 2008 | Toxicol In Vitro | pmid:18395405 |
Arida AI and Al-Tabakha MM | Cellactose a co-processed excipient: a comparison study. | 2008 | Pharm Dev Technol | pmid:18379907 |
Ranji A et al. | Determination of calcium stearate in polyolefin samples by gas chromatographic technique after performing dispersive liquid-liquid microextraction. | 2008 | Anal Sci | pmid:18469468 |
Jones PJ | Dietary agents that target gastrointestinal and hepatic handling of bile acids and cholesterol. | 2008 | J Clin Lipidol | pmid:21291720 |
Shah RB et al. | Comparative evaluation of flow for pharmaceutical powders and granules. | 2008 | AAPS PharmSciTech | pmid:18446489 |
Lee YH et al. | Separation and determination of polyethylene glycol fatty acid esters in cosmetics by a reversed-phase HPLC/ELSD. | 2008 | Talanta | pmid:18371826 |
Darole PS et al. | Formulation and evaluation of microemulsion based delivery system for amphotericin B. | 2008 | AAPS PharmSciTech | pmid:18446472 |
Flasiński M et al. | Per-6-O-(tert-butyldimethylsilyl)cyclodextrins (TBDMS-CDs) in Langmuir monolayers: the importance of a spreading solvent in the preparation of LB layers suitable for sensor application. | 2008 | J Phys Chem B | pmid:18358030 |
Lee DY and Fiehn O | High quality metabolomic data for Chlamydomonas reinhardtii. | 2008 | Plant Methods | pmid:18442406 |
Kim CH et al. | Effects of emulsified octadecanic acids on gas production and cellulolysis by the rumen anaerobic fungus, Piromyces communis M014. | 2008 | Anaerobe | pmid:17996466 |
Hu FQ et al. | Cellular uptake and cytotoxicity of shell crosslinked stearic acid-grafted chitosan oligosaccharide micelles encapsulating doxorubicin. | 2008 | Eur J Pharm Biopharm | pmid:17997293 |
Vögler O et al. | Structure-effect relation of C18 long-chain fatty acids in the reduction of body weight in rats. | 2008 | Int J Obes (Lond) | pmid:18059405 |
Jose R et al. | Dependence of luminescence efficiency of cdse quantum dots on chemical environments. | 2008 | J Nanosci Nanotechnol | pmid:19198279 |
Ruths M et al. | Friction of fatty acids in nanometer-sized contacts of different adhesive strength. | 2008 | Langmuir | pmid:18085802 |
Harding L et al. | The development of microthermal analysis and photothermal microspectroscopy as novel approaches to drug-excipient compatibility studies. | 2008 | Int J Pharm | pmid:18162342 |
Desai D et al. | Solid-state interaction of stearic acid with povidone and its effect on dissolution stability of capsules. | 2008 | Int J Pharm | pmid:18194844 |
Garay AS and Rodrigues DE | Effects of the inclusion of the spin label 10-doxyl-stearic acid on the structure and dynamics of model bilayers in water: stearic acid and stearic acid/cholesterol (50:20). | 2008 | J Phys Chem B | pmid:18198858 |
Widjaja E and Seah RK | Application of Raman microscopy and band-target entropy minimization to identify minor components in model pharmaceutical tablets. | 2008 | J Pharm Biomed Anal | pmid:17980994 |
Piao ZZ et al. | Colonic release and reduced intestinal tissue damage of coated tablets containing naproxen inclusion complex. | 2008 | Int J Pharm | pmid:17928177 |
Jones OA et al. | A metabolomics based approach to assessing the toxicity of the polyaromatic hydrocarbon pyrene to the earthworm Lumbricus rubellus. | 2008 | Chemosphere | pmid:17928029 |
El-Enany N et al. | Spectrofluorimetric determination of oxamniquine in dosage forms and spiked human plasma through derivatization with 1-dimethylaminonaphthalene-5-sulphonyl chloride. | 2008 | J Fluoresc | pmid:18058206 |
Rhee YS et al. | Application of instrumental evaluation of color for the pre-formulation and formulation of rabeprazole. | 2008 | Int J Pharm | pmid:17919858 |
Vehring R | Pharmaceutical particle engineering via spray drying. | 2008 | Pharm. Res. | pmid:18040761 |
Wu H et al. | Process analytical technology (PAT): quantification approaches in terahertz spectroscopy for pharmaceutical application. | 2008 | J Pharm Sci | pmid:17722101 |
Nyblom HK et al. | Glucose-induced de novo synthesis of fatty acyls causes proportional increases in INS-1E cellular lipids. | 2008 | NMR Biomed | pmid:17691080 |
Werle M | Natural and synthetic polymers as inhibitors of drug efflux pumps. | 2008 | Pharm. Res. | pmid:17896100 |
Abbasi M et al. | Further investigation of lipid-substituted poly(L-Lysine) polymers for transfection of human skin fibroblasts. | 2008 | Biomacromolecules | pmid:18498191 |
Hernández ML et al. | The utilization and desaturation of oleate and linoleate during glycerolipid biosynthesis in olive (Olea europaea L.) callus cultures. | 2008 | J. Exp. Bot. | pmid:18515829 |
Fang YP et al. | Physicochemical and safety evaluation of 5-aminolevulinic acid in novel liposomes as carrier for skin delivery. | 2008 | J Liposome Res | pmid:18348070 |
Dou M et al. | [Orthogonal experiments for optimizing the formulation and preparation conditions of temozolomide solid lipid nanoparticles]. | 2008 | Sheng Wu Yi Xue Gong Cheng Xue Za Zhi | pmid:19024463 |
Vartorelli MR et al. | Spin-labeled stearic acid behavior and perturbations on the structure of a gel-phase-lipid bilayer in water: 5-, 12- and 16-SASL. | 2008 | J Phys Chem B | pmid:19055388 |
Lasserre R et al. | Raft nanodomains contribute to Akt/PKB plasma membrane recruitment and activation. | 2008 | Nat. Chem. Biol. | pmid:18641634 |
Aoki PH et al. | Sensor array made with nanostructured films to detect a phenothiazine compound. | 2008 | J Nanosci Nanotechnol | pmid:19049023 |
Zhang JX et al. | Sex- and gonad-affecting scent compounds and 3 male pheromones in the rat. | 2008 | Chem. Senses | pmid:18515819 |
Kirtsreesakul V et al. | Microbiology and antimicrobial susceptibility patterns of commensal flora in the middle nasal meatus. | 2008 | Ann. Otol. Rhinol. Laryngol. | pmid:19140538 |
McNamara RK et al. | Deficits in docosahexaenoic acid and associated elevations in the metabolism of arachidonic acid and saturated fatty acids in the postmortem orbitofrontal cortex of patients with bipolar disorder. | 2008 | Psychiatry Res | pmid:18715653 |
Xu G and Fang Y | Studies of surface-enhanced Raman scattering of C60 Langmuir-Blodgett film on a new substrate. | 2008 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:17889595 |
Chatterjee A and Chowdhury R | Bile and unsaturated fatty acids inhibit the binding of cholera toxin and Escherichia coli heat-labile enterotoxin to GM1 receptor. | 2008 | Antimicrob. Agents Chemother. | pmid:17954701 |
Zeng Q et al. | Highly luminescent CdSe/ZnSe core-shell quantum dots of one-pot preparation in octadecene. | 2008 | J Nanosci Nanotechnol | pmid:18468151 |
Karoussi O and Hamouda AA | Macroscopic and nanoscale study of wettability alteration of oil-wet calcite surface in presence of magnesium and sulfate ions. | 2008 | J Colloid Interface Sci | pmid:17931645 |
Fujio J et al. | Regulation of gut-derived resistin-like molecule beta expression by nutrients. | 2008 | Diabetes Res. Clin. Pract. | pmid:17936398 |
Asadi A et al. | Interaction of bovine serum albumin with some novel PEG-containing diblock copolymers. | 2008 | Int. J. Biol. Macromol. | pmid:18602419 |
Miguélez-Morán AM et al. | The effect of lubrication on density distributions of roller compacted ribbons. | 2008 | Int J Pharm | pmid:18602976 |
Wan F et al. | Studies on PEG-modified SLNs loading vinorelbine bitartrate (I): preparation and evaluation in vitro. | 2008 | Int J Pharm | pmid:18450394 |
Richardson AD et al. | Central carbon metabolism in the progression of mammary carcinoma. | 2008 | Breast Cancer Res. Treat. | pmid:17879159 |
Kumon M et al. | Application and mechanism of inhalation profile improvement of DPI formulations by mechanofusion with magnesium stearate. | 2008 | Chem. Pharm. Bull. | pmid:18451547 |
Zhang XG et al. | Reversal activity of nanostructured lipid carriers loading cytotoxic drug in multi-drug resistant cancer cells. | 2008 | Int J Pharm | pmid:18586075 |
Liu C et al. | In situ intestinal absorption of cyclosporine A solid dispersion in rats. | 2008 | Drug Dev Ind Pharm | pmid:18568913 |
Gotoh K et al. | A quartz crystal microbalance simulation to examine the effect of ultraviolet light treatment on characteristics of polyethylene surface. | 2008 | J Oleo Sci | pmid:18685232 |
Adeagbo AA and Alebiowu G | Evaluation of cocoa butter as potential lubricant for coprocessing in pharmaceutical tablets. | 2008 | Pharm Dev Technol | pmid:18484488 |
Cai JY et al. | [Studies on chemical constituents from Anoectochilus roxburghii]. | 2008 | Zhong Yao Cai | pmid:18619237 |
Ma BJ et al. | [Chemical constituents study on the fruiting bodies of Lactarius rufus]. | 2008 | Zhong Yao Cai | pmid:18619269 |
Fini A et al. | Raman and thermal analysis of indomethacin/PVP solid dispersion enteric microparticles. | 2008 | Eur J Pharm Biopharm | pmid:18621516 |
Ling XY et al. | Supramolecular layer-by-layer assembly of 3D multicomponent nanostructures via multivalent molecular recognition. | 2008 | Int J Mol Sci | pmid:19325764 |
Li Y and Weng W | Surface modification of hydroxyapatite by stearic acid: characterization and in vitro behaviors. | 2008 | J Mater Sci Mater Med | pmid:17569011 |