stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Taveira SF et al. | Development of cationic solid lipid nanoparticles with factorial design-based studies for topical administration of doxorubicin. | 2012 | J Biomed Nanotechnol | pmid:22515073 |
de Bari O et al. | Ezetimibe: its novel effects on the prevention and the treatment of cholesterol gallstones and nonalcoholic Fatty liver disease. | 2012 | J Lipids | pmid:22132342 |
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Yuan H et al. | Preparation and evaluation of SiO2-deposited stearic acid-g-chitosan nanoparticles for doxorubicin delivery. | 2012 | Int J Nanomedicine | pmid:23055724 |
Brown PN et al. | Determination of major phenolic compounds in Echinacea spp. raw materials and finished products by high-performance liquid chromatography with ultraviolet detection: single-laboratory validation matrix extension. | 2011 Sep-Oct | J AOAC Int | pmid:22165004 |
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BozdaÄŸ-Pehlivan S et al. | Evaluation of drug-excipient interaction in the formulation of celecoxib tablets. | 2011 May-Jun | Acta Pol Pharm | pmid:21648198 |
Malik K et al. | Taste masked microspheres of ofloxacin: formulation and evaluation of orodispersible tablets. | 2011 Jul-Sep | Sci Pharm | pmid:21886910 |
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Franch-Lage F et al. | Fast assessment of the surface distribution of API and excipients in tablets using NIR-hyperspectral imaging. | 2011 | Int J Pharm | pmid:21419207 |
Xu QC et al. | Enhanced photocatalytic activity of C-N-codoped TiO2 films prepared via an organic-free approach. | 2011 | J. Hazard. Mater. | pmid:21316842 |
Zhou QT et al. | Characterization of the surface properties of a model pharmaceutical fine powder modified with a pharmaceutical lubricant to improve flow via a mechanical dry coating approach. | 2011 | J Pharm Sci | pmid:21455980 |
Sheikh KA et al. | Influence of hydration state and homologue composition of magnesium stearate on the physical chemical properties of liquid paraffin lipogels. | 2011 | Int J Pharm | pmid:21457766 |
Severino P et al. | Polymorphism, crystallinity and hydrophilic-lipophilic balance of stearic acid and stearic acid-capric/caprylic triglyceride matrices for production of stable nanoparticles. | 2011 | Colloids Surf B Biointerfaces | pmid:21543196 |
Dong Z et al. | Preparation and in vitro, in vivo evaluations of norfloxacin-loaded solid lipid nanopartices for oral delivery. | 2011 | Drug Deliv | pmid:21554156 |
Zhang Y et al. | α-Linolenic acid prevents endoplasmic reticulum stress-mediated apoptosis of stearic acid lipotoxicity on primary rat hepatocytes. | 2011 | Lipids Health Dis | pmid:21592363 |
Ting TC et al. | Increased lipogenesis and stearate accelerate vascular calcification in calcifying vascular cells. | 2011 | J. Biol. Chem. | pmid:21596756 |
Pingali K et al. | Evaluation of strain-induced hydrophobicity of pharmaceutical blends and its effect on drug release rate under multiple compression conditions. | 2011 | Drug Dev Ind Pharm | pmid:20942612 |
Sharma S et al. | RP-HPLC Method for Simultaneous Estimation of Nitazoxanide and Ofloxacin in Tablets. | 2011 | Indian J Pharm Sci | pmid:22131628 |
Lavigne JP et al. | Propolis can potentialise the anti-adhesion activity of proanthocyanidins on uropathogenic Escherichia coli in the prevention of recurrent urinary tract infections. | 2011 | BMC Res Notes | pmid:22126300 |
Guschina I et al. | Lipid classes and fatty acid patterns are altered in the brain of γ-synuclein null mutant mice. | 2011 | Lipids | pmid:20963507 |
Bailey JA et al. | Rivastigmine lowers Aβ and increases sAPPα levels, which parallel elevated synaptic markers and metabolic activity in degenerating primary rat neurons. | 2011 | PLoS ONE | pmid:21799757 |
Protière M et al. | Rational design of the gram-scale synthesis of nearly monodisperse semiconductor nanocrystals. | 2011 | Nanoscale Res Lett | pmid:21791060 |
Rajendraprasad N et al. | Titrimetric and spectrophotometric assay of oxcarbazepine in pharmaceuticals using N-bromosuccinimide and bromopyrogallol red. | 2011 | Int J Anal Chem | pmid:21785594 |
Chabukswar A et al. | Six sigma: process of understanding the control and capability of ranitidine hydrochloride tablet. | 2011 | J Young Pharm | pmid:21607050 |
Lacaze C et al. | The initial pharmaceutical development of an artesunate/amodiaquine oral formulation for the treatment of malaria: a public-private partnership. | 2011 | Malar. J. | pmid:21605361 |
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Mahdi ES et al. | Effect of surfactant and surfactant blends on pseudoternary phase diagram behavior of newly synthesized palm kernel oil esters. | 2011 | Drug Des Devel Ther | pmid:21792294 |
Green CD and Olson LK | Modulation of palmitate-induced endoplasmic reticulum stress and apoptosis in pancreatic β-cells by stearoyl-CoA desaturase and Elovl6. | 2011 | Am. J. Physiol. Endocrinol. Metab. | pmid:21266672 |
Peter A et al. | Relationships between hepatic stearoyl-CoA desaturase-1 activity and mRNA expression with liver fat content in humans. | 2011 | Am. J. Physiol. Endocrinol. Metab. | pmid:21045174 |
Han L et al. | Starch stearate as a novel encapsulation wall material and its effect on oil-water interfacial tension. | 2011 | J Control Release | pmid:22195872 |
Goto T et al. | Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist. | 2011 | Biochem. J. | pmid:21605082 |
Kushner J et al. | Examining the impact of excipient material property variation on drug product quality attributes: a quality-by-design study for a roller compacted, immediate release tablet. | 2011 | J Pharm Sci | pmid:21319161 |
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de Morais e Silva FA et al. | Rosacea fulminans in pregnancy with ocular perforation. | 2011 | J Dtsch Dermatol Ges | pmid:21366860 |
Tuei VC et al. | Effects of human serum albumin complexed with free fatty acids on cell viability and insulin secretion in the hamster pancreatic β-cell line HIT-T15. | 2011 | Life Sci. | pmid:21396379 |
Corvis Y et al. | Physicochemical stability of solid dispersions of enantiomeric or racemic ibuprofen in stearic acid. | 2011 | J Pharm Sci | pmid:21905027 |
Gao Q et al. | Synthesis and characterization of novel amphiphilic copolymer stearic acid-coupled F127 nanoparticles for nano-technology based drug delivery system. | 2011 | Colloids Surf B Biointerfaces | pmid:21906917 |
Khan FN and Dehghan MH | Enhanced bioavailability of atorvastatin calcium from stabilized gastric resident formulation. | 2011 | AAPS PharmSciTech | pmid:21879394 |
Du YZ et al. | Quaternary complexes composed of plasmid DNA/protamine/fish sperm DNA/stearic acid grafted chitosan oligosaccharide micelles for gene delivery. | 2011 | Int. J. Biol. Macromol. | pmid:21035503 |
Bhattacharjee A et al. | Deposition of stearate-oleate rich seed fat in Mangifera indica is mediated by a FatA type acyl-ACP thioesterase. | 2011 | Phytochemistry | pmid:21130480 |
Yuan H et al. | Stearic acid-g-chitosan polymeric micelle for oral drug delivery: in vitro transport and in vivo absorption. | 2011 | Mol. Pharm. | pmid:21138243 |
Pereira MG et al. | Trypanosoma cruzi epimastigotes are able to store and mobilize high amounts of cholesterol in reservosome lipid inclusions. | 2011 | PLoS ONE | pmid:21818313 |